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1. 发明授权

US06891063B1 Salts of asiatic and madecassic acid suitable for the preparation of pharmaceutical and cosmetic compositions 失效
标题翻译：适用于制备药物和化妆品组合物的亚稳酸和十五碳酸的盐
公开(公告)号：US06891063B1
公开(公告)日：2005-05-10
申请号：US10018259
申请日：2000-04-19
申请人： Paolo Corvi Mora , Angelo Ranise
发明人： Paolo Corvi Mora , Angelo Ranise
IPC分类号： A61K8/30 , A61K8/00 , A61K8/36 , A61K8/368 , A61K31/19 , A61P9/14 , A61P17/00 , A61P17/02 , A61P27/02 , A61P29/00 , A61Q19/00 , C07C51/43 , C07C62/06 , C07C62/26 , C07C61/12 , A61K9/70 , C09B3/50 , A61K13/00
CPC分类号： C07C62/26
摘要： Salts of asiatic and madecassic acid with pharmaceutically acceptable organic bases, suitable for the preparation of pharmaceutical and cosmetic compositions for the topical and systemic treatment of erithema, varicose ulcers, venous insufficiency, bedsores, delayed cicatrization, ambustions, traumatic and surgery wounds, alloeosises of the cutaneous trophism, ophthalmic alloeosises and inflammatory processes.
摘要翻译：亚硫酸和十五碳四烯酸与药学上可接受的有机碱的盐，适用于制备用于局部和全身治疗黑质，静脉曲张溃疡，静脉功能不全，褥疮，延迟性瘢痕形成，气喘，创伤和手术伤口的药物和化妆品组合物，皮肤营养，眼部脱色和炎症过程。

2. 发明申请

US20060013891A1 Quarternary compounds comprising propolis as the active substance 失效
标题翻译：包含蜂胶作为活性物质的四元化合物
公开(公告)号：US20060013891A1
公开(公告)日：2006-01-19
申请号：US10537190
申请日：2003-12-02
申请人： Paolo Corvi Mora , Fabio Carli , Tiziana Canal
发明人： Paolo Corvi Mora , Fabio Carli , Tiziana Canal
IPC分类号： A61K35/64 , A61K31/724 , A61K31/704 , A61K31/198
CPC分类号： A61K9/0007 , A61K8/44 , A61K8/63 , A61K8/738 , A61K8/988 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K2800/56 , A61Q11/00 , A61Q19/00 , A61Q19/001
摘要： The present invention describes a quaternary composition consisting of propolis delivered in a hydrophilic carrier (cyclodextrin and cyclodextrin derivatives) and co ground with the aid of two compounds for the preparation thereof in the form of a finely divided powder. The composition exhibits advantageous dissolution characteristics in aqueous environments compared to native propolis, hence resulting in greater bioavailability of the active ingredients contained therein.
摘要翻译：本发明描述了由在亲水性载体（环糊精和环糊精衍生物）中递送的蜂胶组成的四元组合物，并借助于两种化合物共研磨，以制备细粉末形式。与天然蜂胶相比，该组合物在水性环境中表现出有利的溶解特性，因此导致其中所含的活性成分的生物利用度更高。

3. 发明授权

US08252334B2 Dry powder pharmaceutical compositions comprising surfactants, hydrophobic active principles, and water-soluble excipients, process of preparing, and stable aqueous suspensions thereof 有权
标题翻译：包含表面活性剂，疏水性活性成分和水溶性赋形剂的干粉药物组合物，制备方法及其稳定的水性悬浮液
公开(公告)号：US08252334B2
公开(公告)日：2012-08-28
申请号：US11578661
申请日：2005-04-21
申请人： Giovanni Caponetti , Mariella Artusi , Loretta Maggi , Paolo Corvi Mora
发明人： Giovanni Caponetti , Mariella Artusi , Loretta Maggi , Paolo Corvi Mora
IPC分类号： A61K9/00 , A61K9/10 , A61K9/14
CPC分类号： A61K9/145 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/143 , A61K31/192 , A61K31/573 , A61K31/58
摘要： Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
摘要翻译：包含至少一种疏水活性成分，至少一种水溶性赋形剂和至少一种表面活性剂的干粉形式的药物组合物，其中所述干粉状态的颗粒的体积平均直径VMDd大于体积平均直径VMDd，在由水介质中分散的标准条件下由所述药物组合物获得的悬浮液中的颗粒。还公开了制备这种干组合物和可从所述干组合物获得的用于吸入治疗的临时悬浮液的方法。

4. 发明授权

US06649658B1 (−)-Verbenone derivatives 失效
标题翻译：（ - ） - 韦本酮衍生物
公开(公告)号：US06649658B1
公开(公告)日：2003-11-18
申请号：US09958998
申请日：2001-10-15
申请人： Paolo Corvi Mora , Angelo Ranise
发明人： Paolo Corvi Mora , Angelo Ranise
IPC分类号： A61K3115
CPC分类号： C07D295/155 , C07C45/34 , C07C45/74 , C07C49/683 , C07C69/738 , C07C225/20 , C07C235/62 , C07C251/42 , C07C251/60 , C07C275/38 , C07C2602/42 , C07D295/033 , C07C49/627
摘要： A description is given here of novel solid and stable derivatives of (−)-verbenone having formula (I) wherein, when X=O Z=H, ═CHAr, ═C(OH)COOEt, ═NOR; Y=H, NH2, NH3+X1−, NHCOAr, NHCOR, NHCONHR, NHCONHAr, X1-=pharmaceutically acceptable anion; Ar-aryl or heteroaryl, preferably phenyl, 4-chlorophenyl, 2-furyl, 2-thienyl, 2-hydroxyphenyl, 2-acetoxyphenyl; R=H, C1-C4 alkyl, C4-C6 cycloalkyl, CH2COOH, CH2COOEt, CH2COCH3, CH2CN, CH2COCH2COOEt, CH2C6H5; and, when X=dimethylamino, diethylamino, pyrrolidino, piperidino or morpholino: Y=H; Z=H, CONHAr, COHNR; Ar=aryl, preferably phenyl; R=H, C1-C4 alkyl, C4-C6 cycloakyl. A description is also given of the processes for the preparation of these derivatives and of the novel intermediates used in those processes. The novel derivatives are characterized by their solubility in water; some of them also have a high anti-inflammatory activity.
摘要翻译：这里给出了具有式（I）的（ - ） - 马鞭烯酮的新型固体和稳定的衍生物，其中当X = O Z = H，= CHAr，= C（OH）COOEt = NOR时， Y = H，NH2，NH3 + X1-，NHCOAr，NHCOR，NHCONHR，NHCONHAr，X1- =药学上可接受的阴离子; 芳基或杂芳基，优选苯基，4-氯苯基，2-呋喃基，2-噻吩基，2-羟基苯基，2-乙酰氧基苯基; R = H，C 1 -C 4烷基，C 4 -C 6环烷基，CH 2 COOH，CH 2 COOEt，CH 2 COCH 3，CH 2 CN，CH 2 COCH 2 COOEt，CH 2 C 6 H 5; 当X =二甲基氨基，二乙基氨基，吡咯烷子基，哌啶子基或吗啉代时：Y = H; Z = H，CONHAr，COHNR; Ar =芳基，优选苯基; R = H，C 1 -C 4烷基，C 4 -C 6环烷基。还给出了这些衍生物的制备方法和用于这些方法的新型中间体的方法。新型衍生物的特征在于它们在水中的溶解度; 其中一些也具有高抗炎活性。

5. 发明申请

US20070224276A1 Dry Powder Pharmaceutical Composition, Its Preparation Process and Stable Aqueous Suspension Obtained from Such Composition 有权
标题翻译：干粉药物组合物，其制备方法和由这种组合物获得的稳定的水悬浮液
公开(公告)号：US20070224276A1
公开(公告)日：2007-09-27
申请号：US11578661
申请日：2005-04-21
申请人： Giovanni Caponetti , Mariella Artusi , Loretta Maggi , Paolo Corvi Mora
发明人： Giovanni Caponetti , Mariella Artusi , Loretta Maggi , Paolo Corvi Mora
IPC分类号： A61K9/16
CPC分类号： A61K9/145 , A61K9/0075 , A61K9/0078 , A61K9/14 , A61K9/143 , A61K31/192 , A61K31/573 , A61K31/58
摘要： Pharmaceutical composition in a dry powder form comprising at least one hydrophobic active principle, at least one water-soluble excipient and at least one surfactant, wherein the particles in said dry powder state have a Volume Mean Diameter VMDd greater than the Volume Mean Diameter VMDw of particles in a suspension obtained from said pharmaceutical composition at standard conditions of dispersion in a water-medium. It is also disclosed a process to prepare such dry composition and an extemporaneous suspension for inhalation therapy obtainable from said dry composition.
摘要翻译：包含至少一种疏水活性成分，至少一种水溶性赋形剂和至少一种表面活性剂的干粉形式的药物组合物，其中所述干燥粉末状态的颗粒具有体积平均直径VMD < 大于在水介质中在标准条件下从所述药物组合物获得的悬浮液中的颗粒的体积平均直径VMD 。还公开了制备这种干组合物和可从所述干组合物获得的用于吸入治疗的临时悬浮液的方法。

6. 发明申请

US20050255163A1 Co-grinding process for the preparation of a ternary composition 审中-公开
标题翻译：共研磨工艺制备三元组合物
公开(公告)号：US20050255163A1
公开(公告)日：2005-11-17
申请号：US10515097
申请日：2003-05-19
申请人： Fabio Carli , Paolo Corvi Mora , Tiziana Canal
发明人： Fabio Carli , Paolo Corvi Mora , Tiziana Canal
IPC分类号： A61K8/02 , A61K8/30 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/41 , A61K8/44 , A61K8/63 , A61K8/72 , A61K8/73 , A61K8/81 , A61K9/14 , A61K9/48 , A61K38/00 , A61K45/08 , A61K47/12 , A61K47/18 , A61K47/22 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/40 , A61K47/44 , A61Q17/04 , A61Q19/00 , A61Q19/08 , B02B5/02
CPC分类号： A61Q19/08 , A61K8/02 , A61K8/347 , A61K8/35 , A61K8/44 , A61K8/63 , A61K8/738 , A61K8/8152 , A61K8/8176 , A61K9/145 , A61K9/146 , A61K2800/56 , A61Q17/04 , A61Q19/00
摘要： A ternary composition comprising an active substance, a hydrophilic or hydrophobic carrier and a co-grinding auxiliary substance and a process for the preparation thereof by the co-grinding of the thee components, in which said process allows operating with drastically reduced co-grinding times with respect to the known art and to obtain ternary compositions in which the active substance shows characteristics of amorphisation, solubility and dissolution speed as requested for the various uses.
摘要翻译：包含活性物质，亲水或疏水性载体和共研磨辅助物质的三元组合物及其组合物的共研磨方法，其中所述方法允许以大大降低的共研磨时间进行操作相对于已知技术，并获得三元组合物，其中活性物质显示出各种用途所要求的非晶化特性，溶解度和溶解速度。

7. 发明授权

US07763282B2 Quaternary compounds comprising propolis as the active substance 失效
标题翻译：包含蜂胶作为活性物质的季铵化合物
公开(公告)号：US07763282B2
公开(公告)日：2010-07-27
申请号：US10537190
申请日：2003-12-02
申请人： Paolo Corvi Mora , Fabio Carli , Tiziana Canal
发明人： Paolo Corvi Mora , Fabio Carli , Tiziana Canal
IPC分类号： A61K35/64 , A61K31/724 , A61K31/704 , A61K31/198 , G01N33/00
CPC分类号： A61K9/0007 , A61K8/44 , A61K8/63 , A61K8/738 , A61K8/988 , A61K9/0056 , A61K9/145 , A61K9/146 , A61K2800/56 , A61Q11/00 , A61Q19/00 , A61Q19/001
摘要： The present invention describes a quaternary composition consisting of propolis delivered in a hydrophilic carrier (cyclodextrin and cyclodextrin derivatives) and co ground with the aid of two compounds for the preparation thereof in the form of a finely divided powder. The composition exhibits advantageous dissolution characteristics in aqueous environments compared to native propolis, hence resulting in greater bioavailability of the active ingredients contained therein.
摘要翻译：本发明描述了由在亲水性载体（环糊精和环糊精衍生物）中递送的蜂胶组成的四元组合物，并借助于两种化合物共研磨，以制备细粉末形式。与天然蜂胶相比，该组合物在水性环境中表现出有利的溶解特性，因此导致其中所含的活性成分的生物利用度更高。

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