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1. 发明授权

US08800906B2 Use of transforming growth factor-beta neutralizing antibodies and fusion proteins thereof in treating pain 有权
标题翻译：转化生长因子-β中和抗体及其融合蛋白在治疗疼痛中的应用
公开(公告)号：US08800906B2
公开(公告)日：2014-08-12
申请号：US13337249
申请日：2011-12-26
申请人： Pankaj J. Pasricha
发明人： Pankaj J. Pasricha
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395
CPC分类号： A61K31/7105 , A61K31/713 , A61K38/17 , A61K38/179 , A61K39/395 , A61K2039/505 , C07K16/22 , C07K2317/76
摘要： Provided herein are methods for treating pain and for reducing the excitability of nociceptors, comprising administering a TGF-β antagonist. In some embodiments, a TGF-β antagonist is a monoclonal TGF-β neutralizing antibody or a fusion product comprising a monoclonal TGF-β neutralizing antibody, a soluble receptor, an antisense oligodeoxynucleotides (ODNs), a ribozymes, a small inhibitory RNA (siRNA), Smad 6, Smad7, or a small molecule that blocks TGF-β signaling.
摘要翻译：本文提供了治疗疼痛和降低伤害感受器的兴奋性的方法，包括施用TGF- 拮抗剂。在一些实施方案中，TGF- 拮抗剂是单克隆TGF- 中和抗体或包含单克隆TGF-β1的融合产物; 中和抗体，可溶性受体，反义寡脱氧核苷酸（ODNs），核酶，小抑制性RNA（siRNA），Smad 6，Smad7或阻断TGF-β1的小分子; 信令。

2. 发明申请

US20110118747A1 HEPATIC ELECTRICAL STIMULATION 有权
标题翻译： HEPATIC电刺激
公开(公告)号：US20110118747A1
公开(公告)日：2011-05-19
申请号：US13009086
申请日：2011-01-19
申请人： Pankaj J. Pasricha , Jiande Chen
发明人： Pankaj J. Pasricha , Jiande Chen
IPC分类号： A61N1/36 , A61B17/00
CPC分类号： A61N1/36007 , A61N1/36014 , A61N1/362
摘要： The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.
摘要翻译：本发明涉及向受试者的肝脏提供电刺激的方法，其包括向受试者的肝脏提供一个或多个刺激电极并且向受试者的肝脏提供电刺激。本发明还涉及使用本发明的方法降低代谢综合征的危险因素，治疗糖尿病，治疗患有进食障碍的受试者并降低受试者的葡萄糖水平的方法。

3. 发明申请

US20130317529A1 METHODS AND DEVICES FOR METABOLIC SURGERY 审中-公开
标题翻译：代谢手术的方法和装置
公开(公告)号：US20130317529A1
公开(公告)日：2013-11-28
申请号：US13990862
申请日：2011-12-02
申请人： Steven S. Golden , Pankaj J. Pasricha , Herber E. Saravia
发明人： Steven S. Golden , Pankaj J. Pasricha , Herber E. Saravia
IPC分类号： A61B17/22
CPC分类号： A61B17/22 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32002 , A61B17/320725 , A61B17/320783 , A61B2010/0216 , A61B2017/00269 , A61B2017/00818 , A61B2017/00969 , A61B2017/22079 , A61B2017/2212 , A61B2017/306 , A61B2017/320004 , A61B2017/320064 , A61B2017/320733 , A61B2017/320791
摘要： The present disclosure relates to methods and devices for treatment of metabolic and/or gastrointestinal (GI) tract disorders and, more particularly, to surgical methods and devices for the treatment of type 2 diabetes mellitus and Barrett's Esophagus. Even more particularly, the present disclosure pertains to methods and devices for disrupting or removing cells from the GI tract, and methods and devices for harvesting cells from one section of the GI tract and implanting those cells in another section of the GI tract.
摘要翻译：本公开涉及用于治疗代谢和/或胃肠道（GI）道疾病的方法和装置，更具体地，涉及用于治疗2型糖尿病和Barrett食管的手术方法和装置。更具体地，本公开涉及用于从GI道破坏或去除细胞的方法和装置，以及用于从胃肠道的一个部分收获细胞并将这些细胞植入胃肠道另一部分的方法和装置。

4. 发明授权

US08273729B2 Treatment of irritable bowel syndrome and related bowel disease 有权
标题翻译：肠易激综合征及相关性肠病的治疗
公开(公告)号：US08273729B2
公开(公告)日：2012-09-25
申请号：US12798455
申请日：2010-04-05
申请人： Pankaj J. Pasricha
发明人： Pankaj J. Pasricha
IPC分类号： A61K31/56
CPC分类号： A61K31/57
摘要： The present invention discloses a method of treating an individual having irritable bowel syndrome or a related disorder, comprising the step of administering to said individual a pharmacologically effective dose of a luminally active anti-inflammatory or immunosuppressive compound with minimal or no systemic side effects. Further provided is a method of inhibiting the onset of symptoms of irritable bowel syndrome or a related disorder in an individual in need of such treatment, comprising the step of administering to the individual a prophylactically effective dose of a luminally active anti-inflammatory or immunosuppressive compound with minimal or no systemic side effects.
摘要翻译：本发明公开了一种治疗患有肠易激综合征或相关病症的个体的方法，包括向所述个体施用药理学有效剂量的具有最少或没有全身副作用的发光活性抗炎或免疫抑制化合物的步骤。还提供了抑制需要这种治疗的个体中肠易激综合征或相关病症症状的发生的方法，其包括向个体施用预防有效剂量的光活性抗炎或免疫抑制化合物具有最小或无全身副作用。

5. 发明申请

US20120071812A1 Methods and Systems for Submucosal Implantation of a Device for Diagnosis and Treatment with a Therapeutic Agent 有权
标题翻译：用于用治疗剂诊断和治疗的装置的粘膜下植入的方法和系统
公开(公告)号：US20120071812A1
公开(公告)日：2012-03-22
申请号：US13304055
申请日：2011-11-23
申请人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , Dennis L. McWilliams , Pankaj J. Pasricha
发明人： Vladimir Mitelberg , Donald K. Jones , David Y. Yuan , Brett E. Naglreiter , Dennis L. McWilliams , Pankaj J. Pasricha
IPC分类号： A61M37/00
CPC分类号： A61B17/3468 , A61B1/00165 , A61B1/2736 , A61B5/4839 , A61B17/22031 , A61B17/29 , A61B17/320016 , A61B17/3478 , A61B90/02 , A61B2017/00269 , A61B2017/00893 , A61B2017/2933 , A61B2017/2937 , A61B2017/306 , A61B2017/320044 , A61B2017/320048 , A61B2017/320056
摘要： Instruments, systems, implants, and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, and a mucosal resection device. A submucosal implant device for diagnosing and treating disorders of the body may be implanted. A passive submucosal implant device may take the form of a drug delivery depot in which a therapeutic agent within the depot elutes from the depot according to a predetermined elution profile. An active submucosal implant device may take the form of a drug delivery device that incorporates a self-contained diagnostic system to determine the appropriate delivery time and dosage of a therapeutic agent to be administered.
摘要翻译：提供了仪器，系统，植入物和方法，用于使用内窥镜检查在消化道的期望区域中进行粘膜下的医学过程。仪器包括安全进针针注射器械，粘膜下隧道仪器，粘膜下剥离仪器和粘膜切除装置。可以植入用于诊断和治疗身体疾病的粘膜下植入装置。被动粘膜下植入装置可以采取药物递送贮库的形式，其中贮库内的治疗剂根据预定的洗脱曲线从贮库中洗脱出来。活性粘膜下移植物装置可以采用药物递送装置的形式，其结合独立的诊断系统以确定要施用的治疗剂的适当递送时间和剂量。

6. 发明授权

US07881784B2 Hepatic electrical stimulation 有权
标题翻译：肝电刺激
公开(公告)号：US07881784B2
公开(公告)日：2011-02-01
申请号：US11763185
申请日：2007-06-14
申请人： Pankaj J. Pasricha , Jiande Chen
发明人： Pankaj J. Pasricha , Jiande Chen
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/36014 , A61N1/362
摘要： A method of providing electrical stimulation to a liver of a subject includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The method further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject.
摘要翻译：向受试者的肝脏提供电刺激的方法包括向受试者的肝脏提供一个或多个刺激电极并且向受试者的肝脏提供电刺激。该方法还涉及降低代谢综合征的危险因素，治疗糖尿病，治疗患有进食障碍的受试者和降低受试者的葡萄糖水平的方法。

7. 发明授权

US07863275B2 Uses of tetrahydrobiopterin and derivatives thereof 有权
标题翻译：四氢生物喋呤及其衍生物的用途
公开(公告)号：US07863275B2
公开(公告)日：2011-01-04
申请号：US11978335
申请日：2007-10-29
申请人： Pankaj J. Pasricha , Pandu R. R. Gangula
发明人： Pankaj J. Pasricha , Pandu R. R. Gangula
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985
摘要： The present invention discloses methods of treating diabetic gastroparesis by administering tetrahydrobiopterin or a derivative thereof.
摘要翻译：本发明公开了通过施用四氢生物蝶呤或其衍生物治疗糖尿病性胃轻瘫的方法。

8. 发明申请

US20100204313A1 Modulation of nerve pain activity by resiniferatoxin and uses thereof 审中-公开
标题翻译：通过树脂毒素调节神经疼痛活性及其用途
公开(公告)号：US20100204313A1
公开(公告)日：2010-08-12
申请号：US12799039
申请日：2010-04-16
申请人： Pankaj J. Pasricha
发明人： Pankaj J. Pasricha
IPC分类号： A61K31/357 , A61K31/165 , A61P1/00 , A61P1/18
CPC分类号： A61K31/165 , A61K31/357
摘要： The present invention is directed to the treatment of chronic pain that occurs in chronic disease such as chronic pancreatitis by the application, of the drug, resiniferatoxin, to a visceral organ, such as the stomach, which then reduces the pain present in a second visceral organ, such as the pancreas. The reduction of said pain associated with the chronic disease occurs through the drug-induced desensitization of primary pain-sensing neurons that are shared between the two visceral organs. Additionally, application of the drug resiniferatoxin into the first organ, reduces the inflammation that occurs in the second diseased organ. This modulation of shared nerve activity by application of resiniferatoxin, may also be directed to modulate the pain and inflammation in any two visceral organs that share a common spinal or vagal nerve. Finally, application of the drug resiniferatoxin to either the stomach or the jejunum may be used to treat disease and disorders that involve gastroparesis. The resiniferatoxin improves gastric emptying and reduces nausea, thus may be effective therapy for these conditions.
摘要翻译：本发明涉及通过使用药物，树脂毒素等慢性疾病如慢性胰腺炎发生在内脏器官如胃中的慢性疼痛的治疗，其然后减少在第二内脏中存在的疼痛器官，如胰腺。与慢性疾病相关的所述疼痛的减少通过药物诱导的两种内脏器官共享的原发性疼痛感觉神经元的脱敏而发生。此外，药物树脂毒素在第一器官中的应用减少了发生在第二个患病器官中的炎症。通过应用树脂毒素对共同的神经活动的这种调节也可以用于调节任何两个共享脊髓或迷走神经的内脏器官中的疼痛和炎症。最后，将药物树脂毒素施用于胃或空肠可用于治疗涉及胃轻瘫的疾病和病症。树脂毒素改善胃排空并减少恶心，因此可能是这些病症的有效治疗方法。

9. 发明申请

US20100197648A1 Treatment of irritable bowel syndrome and related bowel disease 有权
标题翻译：肠易激综合征及相关性肠病的治疗
公开(公告)号：US20100197648A1
公开(公告)日：2010-08-05
申请号：US12798455
申请日：2010-04-05
申请人： Pankaj J. Pasricha
发明人： Pankaj J. Pasricha
IPC分类号： A61K31/573 , A61P1/00
CPC分类号： A61K31/57
摘要： The present invention discloses a method of treating an individual having irritable bowel syndrome or a related disorder, comprising the step of administering to said individual a pharmacologically effective dose of a luminally active anti-inflammatory or immunosuppressive compound with minimal or no systemic side effects. Further provided is a method of inhibiting the onset of symptoms of irritable bowel syndrome or a related disorder in an individual in need of such treatment, comprising the step of administering to the individual a prophylactically effective dose of a luminally active anti-inflammatory or immunosuppressive compound with minimal or no systemic side effects.
摘要翻译：本发明公开了一种治疗患有肠易激综合征或相关病症的个体的方法，包括向所述个体施用药理学有效剂量的具有最少或没有全身副作用的发光活性抗炎或免疫抑制化合物的步骤。还提供了抑制需要这种治疗的个体中肠易激综合征或相关病症症状的发生的方法，其包括向个体施用预防有效剂量的光活性抗炎或免疫抑制化合物具有最小或无全身副作用。

10. 发明申请

US20090131302A1 Transient receptor potential vanilloid 1 and uses thereof 审中-公开
标题翻译：瞬时受体电位香草素1及其用途
公开(公告)号：US20090131302A1
公开(公告)日：2009-05-21
申请号：US12082281
申请日：2008-04-10
申请人： Pankaj J. Pasricha , John H. Winston
发明人： Pankaj J. Pasricha , John H. Winston
IPC分类号： A61K38/00 , A61K31/165 , A61P1/00
CPC分类号： A61K31/164 , A61K31/20
摘要： The present invention describes methods of retarding the development of visceral and somatic hypersensitivities in an individual. Further, the present invention describes a potentially important role for the transient receptor potential vanilloid 1 (TRPV1) in initiation and maintenance of the chronic visceral hypersensitivity and its role in development of irritable bowel syndrome.
摘要翻译：本发明描述了延缓个体内脏和体细胞超敏反应发展的方法。此外，本发明描述了瞬时受体潜在香草酸1（TRPV1）在起始和维持慢性内脏超敏反应中的潜在重要作用及其在肠易激综合征发展中的作用。

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