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2. 发明申请

WO2009009065A1 BIOFILM PREVENTION USING LACTOFERRIN 审中-公开
标题翻译：使用LACTOFERRIN预防生物防腐
公开(公告)号：WO2009009065A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/008415
申请日：2008-07-09
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , COHEN, Noam, A. , O'MALLEY, Bert, W., Jr. , CHIU, Alexander, G. , PALMER, James, N. , STEIGER, Jacob, D.
发明人： COHEN, Noam, A. , O'MALLEY, Bert, W., Jr. , CHIU, Alexander, G. , PALMER, James, N. , STEIGER, Jacob, D.
IPC分类号： A61K38/16
CPC分类号： A61K38/40 , A61K31/545 , A61K31/7036 , A61K45/06 , A61K2300/00
摘要： This invention relates to methods and compositions capable of inhibiting biofilm formation. Specifically, provided herein are methods and compositions using Lactoferrin for the inhibition of biofilm formation.
摘要翻译：本发明涉及能够抑制生物膜形成的方法和组合物。具体地，本文提供了使用乳铁蛋白抑制生物膜形成的方法和组合物。

3. 发明申请

WO2010033765A1 SOLDER FORMULATION AND USE IN TISSUE WELDING 审中-公开
标题翻译：焊接配方和使用组织焊接
公开(公告)号：WO2010033765A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057419
申请日：2009-09-18
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BLEIER, Benjamin, S. , COHEN, Noam A. , PALMER, James, N.
发明人： BLEIER, Benjamin, S. , COHEN, Noam A. , PALMER, James, N.
IPC分类号： A61L31/04 , A61L27/22 , A61L31/18
CPC分类号： A61L24/0031 , A61L24/001 , A61L24/043 , C08L89/00 , C08L5/08
摘要： Supersaturated gel formulations including a solution of chitosan, albumin, and a laser specific chromophore. Laser tissue welding methods using the gel formulations of the present invention are also described. In the methods, the gel formulation of the present invention is provided to a site for tissue repair and the laser specific chromophore within the gel is excited with a laser in order to fuse tissue by inducing protein denaturation. The gel formulations and laser tissue welding methods may be used, for example, to enable skull base repairs, aerodigestive endoscopic repairs, endoscopic endonasal surgical repairs, iatrogenic esophageal perforation repairs, laparoscopic abdominal surgical repairs, lung repairs, colon repairs, anastomosis of vessels, urologic/gynecologic endoscopic pelvic repairs, orofacial surgical repairs, dental replacement, skin closure, uterine closure and repairs after fibroidectomies and bladder surgery.
摘要翻译：超级凝胶制剂，包括壳聚糖，白蛋白和激光特异性发色团溶液。还描述了使用本发明的凝胶制剂的激光组织焊接方法。在这些方法中，将本发明的凝胶制剂提供到组织修复的部位，并且用激光激发凝胶内的激光特异性发色团，以通过诱导蛋白质变性来融合组织。可以使用凝胶制剂和激光组织焊接方法，例如能够进行颅底修复，气消食内窥镜修复，内窥镜鼻内窥镜修复，医源性食管穿孔修复，腹腔镜腹部手术修复，肺修复，结肠修复，血管吻合，泌尿科/妇科内窥镜骨盆修复，口腔手术修复，牙齿置换，皮肤闭合，子宫闭合和纤维瘤切除术和膀胱手术后的修复。

4. 发明申请

WO2021216759A1 QUININE AND ITS USE TO GENERATE INNATE IMMUNE RESPONSE 审中-公开
公开(公告)号：WO2021216759A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028463
申请日：2021-04-21
申请人： COHEN, Noam , LEE, Robert, J. , WEISS, Susan, R. , MASLOW, Joel, N. , ROBERTS, Christine, C. , CHERRY, Sara , KOHANSKI, Michael , ADAPPA, Nithin, D. , PALMER, James, N. , TAN, Li, Hui
发明人： COHEN, Noam , LEE, Robert, J. , WEISS, Susan, R. , MASLOW, Joel, N. , ROBERTS, Christine, C. , CHERRY, Sara , KOHANSKI, Michael , ADAPPA, Nithin, D. , PALMER, James, N. , TAN, Li, Hui
IPC分类号： A61K31/49 , A61K31/167 , A61K31/17 , A61K31/341 , A61K31/26 , A61K31/513 , A61K9/00 , A61P31/14 , C12Q1/18
摘要： The invention provides methods and compositions for assaying infectivity of viruses and potential treatments of such viruses in the upper respiratory tract using an air- liquid interface model with nasal epithelium cells; and treatment of viral infections of the upper respiratory tract by treating with bitter taste receptor agonists that stimulate NO production and/or antimicrobial protein production.

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