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1. 发明授权

US07281416B2 Method for surface tension measurement 失效
标题翻译：表面张力测量方法
公开(公告)号：US07281416B2
公开(公告)日：2007-10-16
申请号：US10527085
申请日：2003-09-15
申请人： Christoffer Johans , Pekka Suomalainen , Paavo Kinnunen
发明人： Christoffer Johans , Pekka Suomalainen , Paavo Kinnunen
IPC分类号： G01N13/00
CPC分类号： B01L3/5085 , B01L2300/0829 , B01L2300/0858 , B01L2300/165 , G01N13/02 , G01N2013/0291
摘要： The present invention is directed to a method for measuring the surface tension of a sample comprising providing a well plate, containing at least one well defined by well walls and an opening and forming a space for receiving the sample to be tested, bringing a probe in contact with the surface of the sample in the well, and measuring the force applied to the probe by the sample, characterized in that the walls of the well are inclined with respect to the plane defined by the opening of the well so that the cross section of the well is decreasing in the direction from the opening of the well towards the bottom of the same, so as provide a geometry resulting in a flat or convex shape of the meniscus of the sample when in the well and that at least the surface of the wall of the well facing the sample space comprises an antistatic material, and providing means for dissipating static electricity from the well. The invention also concerns a well plate for use in the method.
摘要翻译：本发明涉及一种用于测量样品的表面张力的方法，包括提供孔板，其包含由阱壁和开口限定的至少一个孔，并形成用于接收待测试样品的空间，使探针进入与样品的表面接触，并测量由样品施加到探针的力，其特征在于，井的壁相对于由孔的开口限定的平面倾斜，使得横截面在井的开口朝向其的底部的方向上的井的减少，从而提供在井中形成样品的弯月面的平坦或凸起形状的几何形状，并且至少在面向样品空间的井的壁包括抗静电材料，并提供用于从井中散发静电的装置。本发明还涉及用于该方法的孔板。

2. 发明申请

US20060288761A1 Method and device for forming a liquid-liquid interface, especially for surface tension measurement 失效
标题翻译：用于形成液 - 液界面的方法和装置，特别用于表面张力测量
公开(公告)号：US20060288761A1
公开(公告)日：2006-12-28
申请号：US11167252
申请日：2005-06-28
申请人： Paavo Kinnunen
发明人： Paavo Kinnunen
IPC分类号： G01N13/00
CPC分类号： G01N13/02 , B01L3/502 , B01L3/50853 , B01L2200/025 , B01L2300/045 , B01L2300/047 , B01L2400/065
摘要： The present invention is directed to a method and a device for forming an interface between a first and a second essentially immiscible liquid, especially for the measurement of the surface tension at said interface. According to the invention, a volume of the first liquid is added to a first well having a closed bottom, walls and an upper opening in a horizontal surface. A volume of the second liquid is added to a second well, e.g. in the form of a bore or a sleeve having an upper well opening and a lower well opening which lower well opening rests in a sealing relationship on the said horizontal surface, the said surface closing the lower opening, but in sliding engagement therewith. The lower opening of the second well is brought into alignment with the upper opening of the first well, thus depositing the volume of the second liquid on top of the surface of the volume of the first liquid, to form the desired liquid-liquid interface.
摘要翻译：本发明涉及用于在第一和第二基本上不混溶的液体之间形成界面的方法和装置，特别是用于测量所述界面处的表面张力。根据本发明，第一液体的体积被添加到在水平表面中具有封闭的底部，壁和上部开口的第一阱中。将第二液体的体积添加到第二孔中，例如，以孔或具有上井开口和下井井口的套筒的形式，下井井开口在所述水平表面上处于密封关系中，所述表面封闭下开口，但与其滑动接合。第二孔的下开口与第一孔的上开口对准，从而将第二液体的体积沉积在第一液体体积的表面上，形成所需的液 - 液界面。

3. 发明申请

US20100323451A1 METHOD OF PREDICTING PHOSPOLIPIDOSIS INDUCING PROPERTIES OF A SUBSTANCE 失效
标题翻译：预防物质诱导物质性质的方法
公开(公告)号：US20100323451A1
公开(公告)日：2010-12-23
申请号：US12517880
申请日：2007-12-04
申请人： Paavo Kinnunen , Juha-Matti Alakoskela
发明人： Paavo Kinnunen , Juha-Matti Alakoskela
IPC分类号： G01N33/92
CPC分类号： G01N33/92
摘要： The present invention is directed to a method for predicting the risk of a substance exhibiting phospholipidosis inducing properties, the method comprising adding the said substance to an anionic surfactant to form a mixture of said substance and said surfactant, and determining the effect of said substance on the critical micelle concentration (CMC) of the anionic surfactant by determining the CMC of the mixture, whereby a decrease in the CMC as compared to the CMC of the surfactant prior to the addition of the substance is indicative of a risk of said substance exhibiting phospholipidosis inducing properties.
摘要翻译：本发明涉及一种用于预测表现出磷脂诱发性质的物质的风险的方法，所述方法包括将所述物质加入到阴离子表面活性剂中以形成所述物质和所述表面活性剂的混合物，并确定所述物质对通过测定混合物的CMC，阴离子表面活性剂的临界胶束浓度（CMC），由此与添加物质之前的表面活性剂的CMC相比，CMC的降低表明所述物质显示出磷脂病的风险诱导性质。

4. 发明申请

US20130079493A1 Method for prepairing peptide inhibitors of a lipid-activated enzyme and peptides produced by same 审中-公开
标题翻译：脂质激活酶的肽抑制剂的制备方法和由其制备的肽
公开(公告)号：US20130079493A1
公开(公告)日：2013-03-28
申请号：US13701719
申请日：2011-06-03
申请人： Paavo Kinnunen
发明人： Paavo Kinnunen
IPC分类号： C07K7/06 , C07K7/08 , C07K19/00 , G06F19/16
CPC分类号： C07K7/06 , C07K7/08 , C07K19/00 , C12N9/18 , C12Q1/28 , C12Q1/34 , C12Q1/37 , C12Q1/44 , C12Y301/01004 , G01N33/573 , G01N2333/908 , G01N2333/916 , G01N2333/918 , G01N2500/04 , G16B15/00
摘要： The present invention is based on the discovery of a mechanism mediating the formation of amyloid-type aggregates of lipid-activated enzymes. The invention discloses a method for preparing inhibitors of said enzymes and provides peptide inhibitors having potential for therapeutic use. The method comprises the identification of aggregation-prone regions in the amino acid sequence of the enzyme by the use of a suitable computer algorithm and designing a peptide based on the found aggregation-prone region.
摘要翻译：本发明是基于介导脂质激活酶的淀粉样蛋白型聚集体的形成的机制的发现。本发明公开了一种制备所述酶的抑制剂并提供具有治疗用途潜力的肽抑制剂的方法。该方法包括通过使用合适的计算机算法来鉴定酶的氨基酸序列中的易聚集区域，并基于发现的聚集多发区域设计肽。

5. 发明申请

US20060123893A1 Method for surface tension measurement 失效
标题翻译：表面张力测量方法
公开(公告)号：US20060123893A1
公开(公告)日：2006-06-15
申请号：US10527085
申请日：2003-09-15
申请人： Christoffer Johans , Pekka Suomalainen , Paavo Kinnunen
发明人： Christoffer Johans , Pekka Suomalainen , Paavo Kinnunen
IPC分类号： G01N13/00
CPC分类号： B01L3/5085 , B01L2300/0829 , B01L2300/0858 , B01L2300/165 , G01N13/02 , G01N2013/0291
摘要： The present invention is directed to a method for measuring the surface tension of a sample comprising providing a well plate, containing at least one well defined by well walls and an opening and forming a space for receiving the sample to be tested, bringing a probe in contact with the surface of the sample in the well, and measuring the force applied to the probe by the sample, characterized in that the walls of the well are inclined with respect to the plane defined by the opening of the well so that the cross section of the well is decreasing in the direction from the opening of the well towards the bottom of the same, so as provide a geometry resulting in a flat or convex shape of the meniscus of the sample when in the well and that at least the surface of the wall of the well facing the sample space comprises an antistatic material, and providing means for dissipating static electricity from the well. The invention also concerns a well plate for use in the method.
摘要翻译：本发明涉及一种用于测量样品的表面张力的方法，包括提供孔板，其包含由阱壁和开口限定的至少一个孔，并形成用于接收待测试样品的空间，使探针进入与样品的表面接触，并测量由样品施加到探针的力，其特征在于，井的壁相对于由孔的开口限定的平面倾斜，使得横截面在井的开口朝向其的底部的方向上的井的减少，从而提供在井中形成样品的弯月面的平坦或凸起形状的几何形状，并且至少在面向样品空间的井的壁包括抗静电材料，并提供用于从井中散发静电的装置。本发明还涉及用于该方法的孔板。

6. 发明授权

US06845654B2 Method for measuring the surface tension of an aqueous solution 失效
标题翻译：测量水溶液表面张力的方法
公开(公告)号：US06845654B2
公开(公告)日：2005-01-25
申请号：US10416522
申请日：2002-01-09
申请人： Paavo Kinnunen , Tim Söderlund
发明人： Paavo Kinnunen , Tim Söderlund
IPC分类号： G01N5/04 , G01N13/02 , G01N33/15
CPC分类号： G01N13/02 , G01N5/04
摘要： The present invention is directed to a method for determining the surface activity properties of an amphiphilic substance, such as a drug, the method including a step wherein the surface tension of an aqueous solution of the said substance is measured at its air-water interface at a plurality of concentrations of said substance and determining the relationship between the surface tension and the concentration of the substance, and using the relationship so determined to predict the surface activity properties of the substance, according to which method, to the aqueous solution, a water soluble substance, which increases the surface tension of the aqueous solution is added in an amount to provide a concentration of 0.3 M up to the saturation concentration of the said substance in said solution.
摘要翻译：本发明涉及一种用于确定诸如药物的两亲物质的表面活性性质的方法，所述方法包括以下步骤：其中所述物质的水溶液的表面张力在其空气 - 水界面处多种浓度的所述物质，并确定表面张力与物质的浓度之间的关系，并且使用如此确定的关系来预测物质的表面活性，根据该方法，向水溶液中加入水添加提高水溶液的表面张力的可溶性物质的添加量，以提供0.3M浓度，直到所述溶液中所述物质的饱和浓度。

7. 发明申请

US20120271555A1 DEVICE FOR MEASURING TISSUE STIFFNESS 审中-公开
标题翻译：用于测量组织硬度的装置
公开(公告)号：US20120271555A1
公开(公告)日：2012-10-25
申请号：US13387302
申请日：2010-07-27
申请人： Ilya Levental , Paul Janmey , Paavo Kinnunen
发明人： Ilya Levental , Paul Janmey , Paavo Kinnunen
IPC分类号： G06F19/00 , G01L1/00
CPC分类号： A61B5/442 , A61B5/0057 , G01N3/42 , G01N2203/0278 , G01N2203/0286
摘要： This invention relates to measuring stiffness of a biological sample Specifically, the invention relates to a milliprobe indentation device that comprises a force probe and a micromanipulator and uses thereof for measuring stiffness of biological samples
摘要翻译：本发明涉及测量生物样品的刚度。具体而言，本发明涉及一种包括力探针和显微操纵器的毫针压痕装置，其用于测量生物样品的刚度

8. 发明授权

US07343784B2 Method and device for forming a liquid—liquid interface, especially for surface tension measurement 失效
标题翻译：用于形成液 - 液界面的方法和装置，特别用于表面张力测量
公开(公告)号：US07343784B2
公开(公告)日：2008-03-18
申请号：US11167252
申请日：2005-06-28
申请人： Paavo Kinnunen
发明人： Paavo Kinnunen
IPC分类号： G01N13/00
CPC分类号： G01N13/02 , B01L3/502 , B01L3/50853 , B01L2200/025 , B01L2300/045 , B01L2300/047 , B01L2400/065
摘要： The present invention is directed to a method and a device for forming an interface between a first and a second essentially immiscible liquid, especially for the measurement of the surface tension at said interface. According to the invention, a volume of the first liquid is added to a first well having a closed bottom, walls and an upper opening in a horizontal surface. A volume of the second liquid is added to a second well, e.g. in the form of a bore or a sleeve having an upper well opening and a lower well opening which lower well opening rests in a sealing relationship on the said horizontal surface, the said surface closing the lower opening, but in sliding engagement therewith. The lower opening of the second well is brought into alignment with the upper opening of the first well, thus depositing the volume of the second liquid on top of the surface of the volume of the first liquid, to form the desired liquid-liquid interface.
摘要翻译：本发明涉及用于在第一和第二基本上不混溶的液体之间形成界面的方法和装置，特别是用于测量所述界面处的表面张力。根据本发明，第一液体的体积被添加到在水平表面中具有封闭的底部，壁和上部开口的第一阱中。将第二液体的体积添加到第二孔中，例如，以孔或具有上井开口和下井井口的套筒的形式，下井井开口在所述水平表面上处于密封关系中，所述表面封闭下开口，但与其滑动接合。第二孔的下开口与第一孔的上开口对准，从而将第二液体的体积沉积在第一液体体积的表面上，形成所需的液 - 液界面。

9. 发明授权

US06619134B1 Measuring device for measuring small forces and displacements 失效
标题翻译：用于测量小力和位移的测量装置
公开(公告)号：US06619134B1
公开(公告)日：2003-09-16
申请号：US09831881
申请日：2001-07-16
申请人： Paavo Kinnunen , Veikko Mönkkönen
发明人： Paavo Kinnunen , Veikko Mönkkönen
IPC分类号： G01J546
CPC分类号： G01G3/125 , G01B11/16 , G01D5/34
摘要： The object of the invention is a measuring device for measuring small forces and displacements having in a body (1) of the device a detector means comprising a light source (4) and a position-sensitive detector (5), and a sensing means comprising a spring means (2) to be loaded by a force to be measured and a shading means (3) mounted to this spring means (2), which shading means moves under the influence of the force loading the spring means (2) in a light source (4) of the detector means, the beam being directed towards an active surface of the detector (5). It is characterizing for the invention that the detector means and the sensing means are arranged to a common clamp (8) arranged to the body (1) of the device.
摘要翻译：本发明的目的是一种测量装置，用于测量在装置的主体（1）中具有包括光源（4）和位置敏感检测器（5）的检测器装置的小力和位移，以及感测装置，包括安装在该弹簧装置（2）上的遮光装置（3），该遮光装置在加载弹簧装置（2）的力的影响下移动检测器装置的光源（4），光束被引向检测器（5）的有效表面。本发明的特征在于，检测器装置和感测装置布置到布置到装置的主体（1）上的公共夹具（8）上。

10. 发明授权

US3946286A Device for controlling the formation of frost on cooling radiators and the defrosting of the same 失效
标题翻译：用于控制冷却散热器上霜冻形成的装置及其除霜
公开(公告)号：US3946286A
公开(公告)日：1976-03-23
申请号：US519391
申请日：1974-10-30
申请人： Paavo Kinnunen , Viljo Lukkarinen
发明人： Paavo Kinnunen , Viljo Lukkarinen
IPC分类号： F25D21/00 , F25D21/02 , G01N21/46
CPC分类号： F25D21/002 , F25D21/02 , F25B2700/111
摘要： A device to be used e.g. in cooling radiators, for monitoring the formation of frost and for defrosting. Frost formed on the cooling radiator causes a change in the quantity of light received by a light receiver from a light transmitter, and when the quantity of light received by said light receiver reaches a predetermined value a unit controlled by the light receiver initiates the drfrosting which continues until all of the frost has molten.
摘要翻译：要使用的装置。在冷却散热器中，用于监测霜冻和解冻的形成。形成在冷却散热器上的冰霜导致光接收器从光发射器接收的光量的变化，并且当所述光接收器接收到的光量达到预定值时，由光接收器控制的单元启动除霜，其中继续，直到所有的霜都熔化。

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