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1. 发明公开

EP0138165A2 Load-bearing mantle for bearing structures 失效
标题翻译： TragwerkantelfürTragkonstruktionen。
公开(公告)号：EP0138165A2
公开(公告)日：1985-04-24
申请号：EP84111908.4
申请日：1984-10-04
申请人： Szalai, Kálmán , Lepuschán, Béla , Pusztai, Lajos , Csák, Béla , Nédli, Péter
发明人： Szalai, Kálmán , Lepuschán, Béla , Pusztai, Lajos , Csák, Béla , Nédli, Péter
IPC分类号： E04C3/34 , E04C3/36
CPC分类号： E04C3/36
摘要： The invention relates to a load-bearing mantle surface to bearing structures, in particular to columns, which can be characterized in that a simple or multi-layer glasscloth having been impregnated with an adhesive and wound on a crade made of paper or any other suitable material with a diameter being larger, than the diameter of the column or in case of a prismatic cross-section larger, than the longest edge thereof, is wound onto the column. Between the mantle surface and the glasscloth a granular material, e.g. sand, gravel or split is filled. On the lower end and the upper end of the column a complementary glasscloth is wound - eventually directly on the column - and optionally a splicing muff can be wound at the splicing points of the glasscloth having been wound onto the column.
摘要翻译：本发明涉及一种承载地基表面与承载结构，特别是塔的特征，其特征在于，已经用粘合剂浸渍并缠绕在由纸或其它任何合适的材料制成的碎片上的简单或多层玻璃布直径大于柱的直径的材料或在其最长边缘较大的棱柱形横截面的情况下被卷绕到柱上。在地幔表面和玻璃布之间，颗粒状材料，例如沙子，砾石或裂缝被填满。在柱的下端和上端，互补的玻璃布被卷绕 - 最终直接在柱上 - 并且任选地，拼接的套筒可以在已经被卷绕到柱上的玻璃织物的接合点上被卷绕。

2. 发明公开

EP0138165A3 Load-bearing mantle surface for bearing structures 失效
标题翻译：承载结构的负载轴承手表表面
公开(公告)号：EP0138165A3
公开(公告)日：1986-04-30
申请号：EP84111908
申请日：1984-10-04
申请人： Szalai, Kßlmßn , Lepuschßn, Béla , Pusztai, Lajos , Csßk, Béla , Nédli, Péter
发明人： Szalai, Kßlmßn
IPC分类号： F16C03/00
CPC分类号： E04C3/36
摘要： The invention relates to a load-bearing mantle surface to bearing structures, in particular to columns, which can be characterized in that a simple or multi-layer glasscloth having been impregnated with an adhesive and wound on a crade made of paper or any other suitable material with a diameter being larger, than the diameter of the column or in case of a prismatic cross-section larger, than the longest edge thereof, is wound onto the column. Between the mantle surface and the glasscloth a granular material, e.g. sand, gravel or split is filled. On the lower end and the upper end of the column a complementary glasscloth is wound - eventually directly on the column - and optionally a splicing muff can be wound at the splicing points of the glasscloth having been wound onto the column.

3. 发明申请

WO2007030611A2 A CALCULATED INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER RELATED GENES 审中-公开
标题翻译：雌激素受体（ER）和ER相关基因的基因表达的计算指标
公开(公告)号：WO2007030611A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/034846
申请日：2006-09-11
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , SYMMANS, W., Fraser , HATZIS, Christos , ANDERSON, Keith , PUSZTAI, Lajos
发明人： SYMMANS, W., Fraser , HATZIS, Christos , ANDERSON, Keith , PUSZTAI, Lajos
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/6842 , G01N33/743 , G01N2333/723 , G01N2800/52 , G06F19/18 , G06F19/20
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.
摘要翻译：本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。本发明的一个或多个基因可用作标志物（或替代标记物），以鉴定可能被该试剂或一类试剂例如激素或内分泌治疗成功治疗的肿瘤。

4. 发明申请

WO2012078793A3 METHODS AND COMPOSITIONS RELATED TO TAZAROTENE-INDUCED GENE 1 (TIG1) 审中-公开
标题翻译：与TAZAROTENE诱导的基因1（TIG1）有关的方法和组合物
公开(公告)号：WO2012078793A3
公开(公告)日：2012-11-01
申请号：PCT/US2011063798
申请日：2011-12-07
申请人： UNIV TEXAS , UENO NAOTO I , WANG XIAOPING , PUSZTAI LAJOS
发明人： UENO NAOTO I , WANG XIAOPING , PUSZTAI LAJOS
IPC分类号： G01N33/68 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57415 , C12N15/1138 , C12Q1/6809 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N2800/52 , G01N2800/56 , C12N2310/14 , C12N2310/531
摘要： Certain embodiments of the invention are directed to the measurement of TIGl levels in a tumor and characterization of the tumor. For example, elevated TIGl levels can be used to determine the aggressiveness of a cancer, such as to determine if a patient has inflammatory breast cancer. Methods for treating cancer by inhibiting TIGl activity are also provided.
摘要翻译：本发明的某些实施方案涉及肿瘤中TIG1水平的测量和肿瘤的表征。例如，升高的TIG1水平可以用于确定癌症的侵袭性，例如以确定患者是否患有炎性乳腺癌。还提供了通过抑制TIG1活性来治疗癌症的方法。

5. 发明申请

WO2012078793A2 METHODS AND COMPOSITIONS RELATED TO TAZAROTENE-INDUCED GENE 1 (TIG1) 审中-公开
标题翻译：与TAZAROTENE诱导的基因1（TIG1）相关的方法和组合物
公开(公告)号：WO2012078793A2
公开(公告)日：2012-06-14
申请号：PCT/US2011/063798
申请日：2011-12-07
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , UENO, Naoto, I. , WANG, Xiaoping , PUSZTAI, Lajos
发明人： UENO, Naoto, I. , WANG, Xiaoping , PUSZTAI, Lajos
IPC分类号： G01N33/68 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57415 , C12N15/1138 , C12Q1/6809 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N2800/52 , G01N2800/56 , C12N2310/14 , C12N2310/531
摘要： Certain embodiments of the invention are directed to the measurement of TIGl levels in a tumor and characterization of the tumor. For example, elevated TIGl levels can be used to determine the aggressiveness of a cancer, such as to determine if a patient has inflammatory breast cancer. Methods for treating cancer by inhibiting TIGl activity are also provided.
摘要翻译：本发明的某些实施方案涉及肿瘤中TIG1水平的测量和肿瘤的表征。例如，可以使用升高的TIG1水平来确定癌症的侵袭性，例如确定患者是否患有炎性乳腺癌。还提供了通过抑制TIG1活性来治疗癌症的方法。

6. 发明申请

WO2007120806A2 METHOD OF MEASURING RESIDUAL CANCER AND PREDICTING PATIENT SURVIVAL 审中-公开
标题翻译：测量残留癌症和预测患者生存的方法
公开(公告)号：WO2007120806A2
公开(公告)日：2007-10-25
申请号：PCT/US2007009096
申请日：2007-04-13
申请人： NUVERA BIOSCIENCES , UNIV TEXAS , HATZIS CHRISTOS , SYMMANS FRASER W , PUSZTAI LAJOS
发明人： HATZIS CHRISTOS , SYMMANS FRASER W , PUSZTAI LAJOS
IPC分类号： G01N33/50
CPC分类号： G01N33/57484 , G01N33/574 , G01N33/57415
摘要： Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.
摘要翻译：公开了一种通过根据切除标本中所述肿瘤的原发肿瘤床的二维直径确定残留癌症负担指数来确定进行肿瘤治疗的患者的存活和复发的方法，原发性肿瘤床面积的比例包括侵袭性癌，包含转移性癌的局部淋巴结数目，区域性淋巴结中最大转移的直径; 和淋巴结大小的分数减少每个添加阳性淋巴结。

7. 发明申请

WO2009089521A2 PREDICTORS FOR EVALUATING RESPONSE TO CANCER THERAPY 审中-公开
标题翻译：评估癌症治疗反应的预测因素
公开(公告)号：WO2009089521A2
公开(公告)日：2009-07-16
申请号：PCT/US2009/030719
申请日：2009-01-12
申请人： NUVERA BIOSCIENCES, INC. , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , SYMMANS, W., Fraser , HATZIS, Christos , PUSZTAI, Lajos
发明人： SYMMANS, W., Fraser , HATZIS, Christos , PUSZTAI, Lajos
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N2800/52 , G01N2800/60 , G06F19/20 , G06F19/28
摘要： Embodiments of the invention include methods of evaluating a patient and determining the likelihood of a treatment outcome to one or four categories of residual cancer burden classification.
摘要翻译：本发明的实施方案包括评估患者并确定治疗结果对一种或四类残留癌症负担分类的可能性的方法。

8. 发明申请

WO2008073629A9 BIFUNCTIONAL PREDICTORS OF CANCER TREATMENT SENSITIVITY AND RESISTANCE 审中-公开
公开(公告)号：WO2008073629A9
公开(公告)日：2008-09-25
申请号：PCT/US2007083651
申请日：2007-11-05
申请人： UNIV TEXAS , NUVERA BIOSCIENCES INC , HATZIS CHRISTOS , SYMMANS FRASER W , PUSZTAI LAJOS
发明人： HATZIS CHRISTOS , SYMMANS FRASER W , PUSZTAI LAJOS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
摘要： The present invention provides the identification of genes that are expressed in tumors to indicate responsiveness or resistance to an agent or class of agents. More particularly, these genes show expression associated with responsiveness to one agent or class of agents is inversely related to expression in association with another class of agents. One or more of theses genes of the present invention can be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by the responsive agent as well as to identify tumors that should avoid treatment by the resistant agent.

9. 发明申请

WO2007120806A3 METHOD OF MEASURING RESIDUAL CANCER AND PREDICTING PATIENT SURVIVAL 审中-公开
公开(公告)号：WO2007120806A3
公开(公告)日：2007-10-25
申请号：PCT/US2007/009096
申请日：2007-04-13
申请人： NUVERA BIOSCIENCES , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , HATZIS, Christos , SYMMANS, Fraser, W. , PUSZTAI, Lajos
发明人： HATZIS, Christos , SYMMANS, Fraser, W. , PUSZTAI, Lajos
IPC分类号： G01N33/574
摘要： Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen, the proportion of the primary tumor bed area that contains invasive carcinoma, the number of regional lymph nodes containing metastatic carcinoma, the diameter of the largest metastasis in an regional lymph node; and the fractional reduction in lymph node size with each added positive lymph node.

10. 发明申请

WO2005118858A1 MULTIGENE PREDICTORS OF RESPONSE TO CHEMOTHERAPY 审中-公开
标题翻译：多基因治疗反应的预防因素
公开(公告)号：WO2005118858A1
公开(公告)日：2005-12-15
申请号：PCT/US2004/032547
申请日：2004-09-30
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , MILLENIUM PHARMACEUTICALS , PUSZTAI, Lajos , SYMMANS, Fraser, W. , HESS, Kenneth, R. , AYERS, Mark , STEC, James
发明人： PUSZTAI, Lajos , SYMMANS, Fraser, W. , HESS, Kenneth, R. , AYERS, Mark , STEC, James
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The present invention provides the identification of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose expression (either increased expression or decreased expression) correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention can be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent.
摘要翻译：本发明提供了在肿瘤中表达的对给定治疗剂有反应并且其表达（增加的表达或降低的表达）与对该治疗剂的反应性相关的基因的鉴定。本发明的一个或多个基因可用作标记物（或替代标记物）以鉴定可能被该试剂成功治疗的肿瘤。

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