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1. 发明申请

WO2010094020A1 SPECTROSCOPIC CHEMICAL COMPOUND IDENTIFICATION 审中-公开
标题翻译：光谱化学化合物鉴定
公开(公告)号：WO2010094020A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/024261
申请日：2010-02-16
申请人： OPTOPO, INC. D/B/A CENTICE CORPORATION , POTULURI, Prasant , BRADY, David J.
发明人： POTULURI, Prasant , BRADY, David J.
IPC分类号： G01J3/28 , G01J3/44
CPC分类号： G01N21/31 , G01N21/65 , G01N21/9508 , G01N33/15 , G01N2021/651 , G01N2201/0221
摘要： A spectroscopic chemical compound identification system includes a container, a memory, a spectrometer, and a processor. The container receives unknown chemical compound. The memory stores a plurality of spectral signatures corresponding to known chemical compounds. The spectrometer measures a spectral signature of the unknown chemical compound through the container. The processor is connected to the memory and the spectrometer, performs a comparison of the spectral signature with at least one of the plurality of spectral signatures, and determines the identity of the unknown chemical compound from the comparison. The system can be housed in a portable handheld housing. A chemical compound can include a pharmaceutical or controlled substance. The system can be also be used to determine if a pharmaceutical or controlled substance is present within an unknown mixture of chemical compounds.
摘要翻译：光谱化学化合物识别系统包括容器，存储器，光谱仪和处理器。容器收到未知的化合物。存储器存储对应于已知化合物的多个光谱特征。光谱仪通过容器测量未知化合物的光谱特征。处理器连接到存储器和光谱仪，执行光谱特征与多个光谱特征中的至少一个的比较，并从比较中确定未知化合物的身份。该系统可以安装在便携式手持式外壳中。化合物可以包括药物或受控物质。该系统还可以用于确定未知的化合物混合物中是否存在药物或受控物质。

2. 发明申请

WO2008073931A3 PHARMACEUTICAL VERIFICATION NETWORK 审中-公开
公开(公告)号：WO2008073931A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/087062
申请日：2007-12-11
申请人： OPTOPO, INC. D/B/A CENTICE CORPORATION , POTULURI, Prasant , BRADY, David J. , FULLER, Michael
发明人： POTULURI, Prasant , BRADY, David J. , FULLER, Michael
IPC分类号： G06Q10/00
摘要： A system communicates pharmaceutical verification information between a server and a node using a network. The node includes a pharmaceutical identification and verification system. The verification information includes a known spectral signature of a known pharmaceutical and a corresponding known pharmaceutical name and dosage strength of the known pharmaceutical. The server stores the verification information in a server database. The node receives the verification information from the server, stores the verification information in the client database, reads a pharmaceutical name and dosage strength from a container enclosing a pharmaceutical, obtains a detected spectral signature for the pharmaceutical, and compares the detected spectral signature to the at least one known spectral signature. The pharmaceutical identification and verification system includes a static multimodal multiplex spectrometer. The verification information can also include a spectral signature of a known container.

3. 发明申请

WO2007047004A3 RAPID PHARMACEUTICAL IDENTIFICATION AND VERIFICATION SYSTEM 审中-公开
标题翻译：快速的药物鉴定和验证系统
公开(公告)号：WO2007047004A3
公开(公告)日：2007-07-26
申请号：PCT/US2006036612
申请日：2006-09-20
申请人： OPTOPO INC D B A CENTICE CORP , POTULURI PRASANT , BRADY DAVID J , SULLIVAN MICHAEL E , KAYE STEPHEN T , FULLER MICHAEL
发明人： POTULURI PRASANT , BRADY DAVID J , SULLIVAN MICHAEL E , KAYE STEPHEN T , FULLER MICHAEL
IPC分类号： G01J3/00
CPC分类号： G01J3/44 , B07C5/344 , G01J3/02 , G01J3/0264 , G01J3/28 , G01J3/2846 , G01J2003/4424 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N21/65 , G01N21/9508 , G01N2021/3595 , G01N2021/651 , G01N2201/129
摘要： A prescription verification system includes a database that contains a plurality of spectral signatures corresponding to identified pharmaceuticals. A multimodal multiplex sampling (MMS) spectrometer obtains a spectra of a pharmaceutical to be identified and verified. The pharmaceutical can be inside or out of a vial. The prescription verification system includes algorithms for matching spectra of pharmaceuticals to be verified obtaining using the MMS spectrometer to spectral signatures contained in the database corresponding to identified pharmaceuticals. The prescription verification system further includes algorithms for identifying such pharmaceuticals to be verified.
摘要翻译：处方验证系统包括包含与所鉴定的药物对应的多个光谱特征的数据库。多模式多重采样（MMS）光谱仪获得待鉴定和验证的药物的光谱。药物可以在瓶子的内部或外部。处方验证系统包括用于使用MMS光谱仪将待验证的药物的光谱匹配的光谱与包含在与所鉴定的药物相对应的数据库中的光谱特征的算法。处方验证系统还包括用于鉴定要验证的这样的药物的算法。

4. 发明申请

WO2008073931A2 PHARMACEUTICAL VERIFICATION NETWORK 审中-公开
标题翻译：药学验证网络
公开(公告)号：WO2008073931A2
公开(公告)日：2008-06-19
申请号：PCT/US2007087062
申请日：2007-12-11
申请人： OPTOPO INC D B A CENTICE CORP , POTULURI PRASANT , BRADY DAVID J , FULLER MICHAEL
发明人： POTULURI PRASANT , BRADY DAVID J , FULLER MICHAEL
IPC分类号： G06F17/30 , G06F17/40 , G06Q10/00 , G06Q50/00
CPC分类号： G06F19/3462 , G06Q50/22 , G06Q50/24
摘要： A system communicates pharmaceutical verification information between a server and a node using a network. The node includes a pharmaceutical identification and verification system. The verification information includes a known spectral signature of a known pharmaceutical and a corresponding known pharmaceutical name and dosage strength of the known pharmaceutical. The server stores the verification information in a server database. The node receives the verification information from the server, stores the verification information in the client database, reads a pharmaceutical name and dosage strength from a container enclosing a pharmaceutical, obtains a detected spectral signature for the pharmaceutical, and compares the detected spectral signature to the at least one known spectral signature. The pharmaceutical identification and verification system includes a static multimodal multiplex spectrometer. The verification information can also include a spectral signature of a known container.
摘要翻译：系统使用网络在服务器和节点之间传送药品验证信息。该节点包括药物识别和验证系统。验证信息包括已知药物的已知光谱特征和已知药物的相应的已知药物名称和剂量强度。服务器将验证信息存储在服务器数据库中。节点从服务器接收验证信息，将验证信息存储在客户端数据库中，从包含药品的容器读取药品名称和剂量强度，获得检测到的药品光谱特征，并将检测到的光谱特征与至少一个已知的光谱特征。药物鉴定和验证系统包括静态多模式多重光谱仪。验证信息还可以包括已知容器的光谱签名。

5. 发明申请

WO2007047004A2 RAPID PHARMACEUTICAL IDENTIFICATION AND VERIFICATION SYSTEM 审中-公开
标题翻译：快速的药物识别和验证系统
公开(公告)号：WO2007047004A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/036612
申请日：2006-09-20
申请人： OPTOPO INC. D/B/A CENTICE CORPORATION , POTULURI, Prasant , BRADY, David, J. , SULLIVAN, Michael, E. , KAYE, Stephen, T. , FULLER, Michael
发明人： POTULURI, Prasant , BRADY, David, J. , SULLIVAN, Michael, E. , KAYE, Stephen, T. , FULLER, Michael
IPC分类号： G01J3/04 , G01J3/28
CPC分类号： G01J3/44 , B07C5/344 , G01J3/02 , G01J3/0264 , G01J3/28 , G01J3/2846 , G01J2003/4424 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N21/65 , G01N21/9508 , G01N2021/3595 , G01N2021/651 , G01N2201/129
摘要： A prescription verification system includes a database that contains a plurality of spectral signatures corresponding to identified pharmaceuticals. A multimodal multiplex sampling (MMS) spectrometer obtains a spectra of a pharmaceutical to be identified and verified. The pharmaceutical can be inside or out of a vial. The prescription verification system includes algorithms for matching spectra of pharmaceuticals to be verified obtaining using the MMS spectrometer to spectral signatures contained in the database corresponding to identified pharmaceuticals. The prescription verification system further includes algorithms for identifying such pharmaceuticals to be verified.
摘要翻译：处方验证系统包括含有与识别的药物相对应的多个光谱特征的数据库。多模式多重采样（MMS）光谱仪获得待识别和验证的药物的光谱。药物可以在瓶内或瓶外。处方验证系统包括用于将使用MMS光谱仪获得的待验证药物的光谱与包含在数据库中对应于所识别的药物的光谱标记进行匹配的算法。处方验证系统还包括用于识别待验证药物的算法。

6. 发明申请

WO2008063681A9 SPATIALLY PATTERNED SUBSTRATES FOR CHEMICAL AND BIOLOGICAL SENSING 审中-公开
标题翻译：用于化学和生物传感的空间图案化的基质
公开(公告)号：WO2008063681A9
公开(公告)日：2009-07-16
申请号：PCT/US2007061705
申请日：2007-02-06
申请人： OPTOPO INC D B A CENTICE CORP , BRADY DAVID , SULLIVAN MICHAEL , POTULURI PRASANT
发明人： BRADY DAVID , SULLIVAN MICHAEL , POTULURI PRASANT
IPC分类号： G01J3/44 , G01J3/00 , G01J3/443
CPC分类号： G01N21/658 , G01N21/31 , G01N21/554 , G01N21/6452 , G01N21/648 , G01N2021/317 , G01N2021/6417 , G01N2201/06113 , G01N2201/062
摘要： A system and method are provided for imaging a test substrate having a test surface that is configured to enable spectroscopic detection of one or more chemical or biological species, wherein the test surface includes a testing site disposed thereon according to a predetermined spatial pattern. The test substrate is provided in an image plane or a Fourier Transform plane of the sensor. The invention provides high throughput and high spectral resolution.
摘要翻译：提供了一种用于对具有测试表面的测试基底成像的系统和方法，所述测试基底被配置成能够对一种或多种化学或生物物质进行光谱检测，其中所述测试表面包括根据预定空间图案布置在其上的测试位点。测试基板设置在传感器的图像平面或傅立叶变换平面中。本发明提供了高通量和高光谱分辨率。

7. 发明申请

WO2008064278A2 A METHOD AND APPARATUS FOR RECONSTRUCTING OPTICAL SPECTRA IN A STATIC MULTIMODE MULTIPLEX SPECTROMETER 审中-公开
标题翻译：用于重建静态多模式光谱仪中的光学光谱的方法和装置
公开(公告)号：WO2008064278A2
公开(公告)日：2008-05-29
申请号：PCT/US2007085323
申请日：2007-11-21
申请人： OPTOPO INC DBA CENTICE CORP , POTULURI PRASANT , GHOFRANI MEHRAN , CULL EVAN , STRANZL JOHN
发明人： POTULURI PRASANT , GHOFRANI MEHRAN , CULL EVAN , STRANZL JOHN
IPC分类号： G06K9/03
CPC分类号： G01J3/2803 , G01J3/02 , G01J3/021 , G01J3/0229
摘要： The static MMS spectral reconstruction process is optimized using algorithmic methods. Because the static MMS encodes spectral information across the detector plane in a highly non-local way, optical errors have a non-local effect on the reconstruction which introduces noise and errors at regions throughout the spectral range. Mathematical signal processing techniques are used to condition and de-convolve the spectral image to compensate for non-ideal system behavior. Spectral signal-to-noise and accuracy are both improved, while the inherent resolution and etendue advantages of the static MMS technique are retained.
摘要翻译：静态MMS频谱重建过程使用算法进行优化。因为静态MMS以高度非局部的方式在检测器平面上编码光谱信息，所以光学误差对重建产生非局部效应，其在整个光谱范围内的区域引入噪声和误差。数学信号处理技术用于调节和去卷积光谱图像以补偿非理想系统行为。光谱信噪比和精度都得到了改善，同时保留了静态MMS技术的固有分辨率和延迟优势。

8. 发明申请

WO2008063681A2 SPATIALLY PATTERNED SUBSTRATES FOR CHEMICAL AND BIOLOGICAL SENSING 审中-公开
标题翻译：用于化学和生物传感的空间图案
公开(公告)号：WO2008063681A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/061705
申请日：2007-02-06
申请人： OPTOPO, INC. D/B/A CENTICE CORPORATION , BRADY, David , SULLIVAN, Michael , POTULURI, Prasant
发明人： BRADY, David , SULLIVAN, Michael , POTULURI, Prasant
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01N21/658 , G01N21/31 , G01N21/554 , G01N21/6452 , G01N21/648 , G01N2021/317 , G01N2021/6417 , G01N2201/06113 , G01N2201/062
摘要： A system and method are provided for imaging a test substrate having a test surface that is configured to enable spectroscopic detection of one or more chemical or biological species, wherein the test surface includes a testing site disposed thereon according to a predetermined spatial pattern. The test substrate is provided in an image plane or a Fourier Transform plane of the sensor. The invention provides high throughput and high spectral resolution.
摘要翻译：提供了一种系统和方法，用于对具有被配置为使得能够对一种或多种化学或生物物种进行光谱检测的测试表面的测试基底成像，其中所述测试表面包括根据预定空间图案设置在其上的测试位置。测试基板设置在传感器的图像平面或傅里叶变换平面中。本发明提供高通量和高光谱分辨率。

9. 发明公开

EP2316013A1 SPECTRAL SIGNATURE EXTRACTION FOR DRUG VERIFICATION AND IDENTIFICATION 审中-公开
标题翻译： FOR REVIEW光谱特征提取及药物的鉴定
公开(公告)号：EP2316013A1
公开(公告)日：2011-05-04
申请号：EP09811997.7
申请日：2009-08-25
申请人： Optopo Inc. D/B/A Centice Corporation , Potuluri, Prasant , Xue, Ya , Qi, Yuting
发明人： POTULURI, Prasant , XUE, Ya , QI, Yuting
IPC分类号： G01N21/65
CPC分类号： G06Q50/22 , G06F19/00 , G06F19/3456
摘要： Systems and methods perform signature extraction from an acquired spectrum of a pharmaceutical. An acquired spectrum of the pharmaceutical is measured using a spectrometer. The acquired spectrum is obtained from the spectrometer using a processor. A system-response function of the spectrometer is removed from the acquired spectrum using the processor. An intensity of the acquired spectrum is normalized to a predetermined scale using the processor. Fluorescence is removed from the acquired spectrum using the processor. Finally, an extracted signature of the pharmaceutical is obtained from the remainder of the acquired spectrum using the processor. If the acquired spectrum of the pharmaceutical is measured by the spectrometer through a container holding the pharmaceutical, a spectrum of the container is removed from the remainder of the acquired spectrum to produce the extracted signature of the pharmaceutical using the processor.

10. 发明申请

WO2012012428A3 SYSTEMS AND METHODS FOR IDENTIFYING A DISCONTINUITY IN THE BOUNDARY OF AN OBJECT IN AN IMAGE 审中-公开
公开(公告)号：WO2012012428A3
公开(公告)日：2012-01-26
申请号：PCT/US2011/044538
申请日：2011-07-19
申请人： OPTOPO, INC. D/B/A CENTICE CORPORATION , CHAPMAN, Kenneth Wayne , POTULURI, Prasant
发明人： CHAPMAN, Kenneth Wayne , POTULURI, Prasant
IPC分类号： A61J3/00 , G01N21/00 , G01N33/15 , B65B1/30
摘要： Machine vision is used to identify a discontinuity in the boundary of an object in an image. An image of one or more objects is captured. One or more skeletons of the one or more objects are calculated. One or more boundaries of the one or more objects are calculated. A plurality of radial lines is extended from a spine point of a skeleton to the one or more boundaries. Each radial line intersects a boundary at a radial endpoint producing a plurality of radial endpoints. For each radial endpoint an expected radial endpoint is calculated based on two or more neighboring radial endpoints. If the difference between the radial endpoint and its expected radial endpoint exceeds a threshold, a radial line including the radial endpoint is identified as a discontinuity in a boundary of an object.

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