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1. 发明授权

EP1599227B1 METHODS OF IMMUNOMODULATION IN ANIMALS 有权
标题翻译：方法可用于免疫调节在动物
公开(公告)号：EP1599227B1
公开(公告)日：2010-01-20
申请号：EP04714559.4
申请日：2004-02-25
申请人： The Lauridsen Group Inc. , Campbell, Joy M. , Strohbehn, Ronald E. , Weaver, Eric M. , Borg, Barton S. , Russell, Louis E. , Polo Pozo, Francisco Javier , Arthington, John D. , Quigley, III, James D.
发明人： CAMPBELL, Joy, M. , STROHBEHN, Ronald, E. , WEAVER, Eric, M. , BORG, Barton, S. , RUSSELL, Louis, E. , POLO POZO, Francisco Javier, Carretera Barcelona , ARTHINGTON, John, D. , QUIGLEY, James, D., III
IPC分类号： A61K39/395 , A61K39/40 , A61K35/14 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： A61K39/15 , A23K10/00 , A61K35/16 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C12N2720/12334 , C12N2770/10011 , C12N2770/10034
摘要： Methods and compositions are disclosed for the dietary modulation of the immune system and gut microbial response in animals. Applicant has identified that oral administration of a supplemental spray dried plasma purified from animal serum can modulate serum IgG levels for treatment in such things as diminished immune capacity, intestinal microbial balance, autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.

2. 发明公开

EP1599227A4 METHODS OF IMMUNOMODULATION IN ANIMALS 有权
标题翻译：方法可用于免疫调节在动物
公开(公告)号：EP1599227A4
公开(公告)日：2007-10-31
申请号：EP04714559
申请日：2004-02-25
申请人： LAURIDSON GROUP INC , CAMPBELL JOY M , STROHBEHN RONALD E , WEAVER ERIC M , BORG BARTON S , RUSSELL LOUIS E , POLO POZO FRANCISCO JAVIER , ARTHINGTON JOHN D , QUIGLEY III JAMES D
发明人： CAMPBELL JOY M , STROHBEHN RONALD E , WEAVER ERIC M , BORG BARTON S , RUSSELL LOUIS E , POLO POZO FRANCISCO JAVIER , ARTHINGTON JOHN D , QUIGLEY JAMES D III
IPC分类号： A61K35/12 , A61K35/14 , A61K35/16 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61K39/395 , A61K39/40 , A61P20060101 , A61P11/00 , A61P37/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K16/02 , C07K16/04 , C07K16/06 , C07K17/00 , C12N1/21
CPC分类号： A61K39/15 , A23K10/00 , A61K35/16 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C12N2720/12334 , C12N2770/10011 , C12N2770/10034
摘要： Methods and compositions are disclosed for the dietary modulation of the immune system and gut microbial response in animals. Applicant has identified that oral administration of a supplemental spray dried plasma purified from animal serum can modulate serum IgG levels for treatment in such things as diminished immune capacity, intestinal microbial balance, autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.

3. 发明公开

EP1599227A2 METHODS OF IMMUNOMODULATION IN ANIMALS 有权
标题翻译：方法可用于免疫调节在动物
公开(公告)号：EP1599227A2
公开(公告)日：2005-11-30
申请号：EP04714559.4
申请日：2004-02-25
申请人： The Lauridson Group Inc. , Campbell, Joy M. , Strohbehn, Ronald E. , Weaver, Eric M. , Borg, Barton S. , Russell, Louis E. , Polo Pozo, Francisco Javier , Arthington, John D. , Quigley, III, James D.
发明人： CAMPBELL, Joy, M. , STROHBEHN, Ronald, E. , WEAVER, Eric, M. , BORG, Barton, S. , RUSSELL, Louis, E. , POLO POZO, Francisco Javier,Carretera Barcelona , ARTHINGTON, John, D. , QUIGLEY, James, D., III
IPC分类号： A61K39/395 , A61K39/40 , A61K35/14 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： A61K39/15 , A23K10/00 , A61K35/16 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C12N2720/12334 , C12N2770/10011 , C12N2770/10034
摘要： Methods and compositions are disclosed for the dietary modulation of the immune system and gut microbial response in animals. Applicant has identified that oral administration of a supplemental spray dried plasma purified from animal serum can modulate serum IgG levels for treatment in such things as diminished immune capacity, intestinal microbial balance, autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.

4. 发明申请

WO2004019687A1 PICA DE DEGÜELLO Y UTILIZACIONES CORRESPONDIENTES 审中-公开
标题翻译：冷冻设备及其用途
公开(公告)号：WO2004019687A1
公开(公告)日：2004-03-11
申请号：PCT/ES2003/000356
申请日：2003-07-11
申请人： APC EUROPE S.A. , CASANELLAS MILÁ, Josep , MORAL HERRERA, Rafael, Jesús , POLO POZO, Francisco, Javier
发明人： CASANELLAS MILÁ, Josep , MORAL HERRERA, Rafael, Jesús , POLO POZO, Francisco, Javier
IPC分类号： A22B5/04
CPC分类号： A22B5/04
摘要： Pica de degüello y utilizaciones correspondientes. Pica de degüello apta para el sangrado de un animal suspendido verticalmente cabeza abajo, que comprende un recipiente de recogida (1) de sangre de un animal que es transportado por un dispositivo de arrastre y unos medios de transporte que soportan las patas anteriores del animal. Los medios de transporte se desplazan a la misma velocidad que el dispositivo de arrastre. Preferentemente comprende una baranda (23) paralela al recipiente de recogida (1) de sangre, y los medios de transporte tienen unos compartimentos (15) aptos para alojar cada uno de ellos una pata del animal. Preferentemente se utiliza para la recogida de sangre de ganado porcino, bovino y/o equino y que sea apta: consumo humano, consumo animal, preparación de productos farmacéuticos, preparación de productos veterinarios, fines médicos, y/o fines biotecnologicos.
摘要翻译：本发明涉及一种喉切割装置及其用途。本发明的装置可以用于将垂直悬挂的动物向下排出。所述装置包括容器（1），该容器用于从使用驱动装置输送的动物收集血液，以及支撑动物前肢的输送装置。上述输送装置以与驱动装置相同的速度移动。优选地，本发明包括平行于采血容器（1）设置的轨道（23），并且输送装置设置有各自用于容纳动物腿部的隔室（15）。本发明特别用于从猪，牛，绵羊和/或马的血液中收集适用于人类消费，动物消费，制备药物产品，制备兽医产品或用于医疗和/或生物技术目的的血液。

5. 发明申请

WO2003082678A1 PROCEDIMIENTO DE FABRICACIÓN DE UN PRODUCTO DERIVADO DE SANGRE ANIMAL EN POLVO EMPAQUETADO Y PRODUCTO Y UTILIZACIONES CORRESPONDIENTES 审中-公开
标题翻译：生产从包装粉末，产品和相关用途形式的动物血液中产生的产品的方法
公开(公告)号：WO2003082678A1
公开(公告)日：2003-10-09
申请号：PCT/ES2003/000129
申请日：2003-03-20
申请人： APC EUROPE S.A. , POLO POZO, Francisco, Javier , RÓDENAS NAVARRO, Jesús , RODRÍGUEZ CANEL, Carmen , SABORIDO GARCÍA, Neus
发明人： POLO POZO, Francisco, Javier , RÓDENAS NAVARRO, Jesús , RODRÍGUEZ CANEL, Carmen , SABORIDO GARCÍA, Neus
IPC分类号： B65B55/02
CPC分类号： A23B4/0056 , A23J1/06 , A23K10/24
摘要： El procedimiento comprende una etapa de empaquetado y una etapa de tratamiento térmico del producto empaquetado a una temperatura comprendida entre los 30°C y los 60°C durante un tiempo superior a las 24 horas. El producto derivado de sangre animal en polvo empaquetado está empaquetado en un envoltorio cuya permeabilidad al vapor de agua sea inferior a 3 g/m 2 /día. Preferentemente se utiliza el procedimiento para la reducción acelerada de la cantidad de microorganismos totales, para el incremento de la capacidad de retención de agua, y/o para la preparación de productos derivados de sangre animal aptos para el consumo humano y animal. Preferentemente se utiliza un material laminar cuya permeabilidad al vapor de agua sea inferior a 3 g/m 2 /día para la fabricación de envoltorios para productos derivados de sangre animal en polvo.
摘要翻译：本发明涉及以包装粉末，产品和相应用途的形式生产源自动物血液的产品的方法。本发明的方法包括包装步骤和包装产品在30℃至60℃的温度下热处理长达24小时的步骤。填充粉末形式的动物血源产品填充在水蒸汽透过度小于3g / m 2 /天的套管中。优选地，所述方法用于以加速的方式减少总微生物的量，以增加保水能力和/或制备适于人和动物消费的动物血液衍生产品。此外，为了制造粉末形式的动物血源产品的肠衣，优选使用具有小于3g / m 2 /天的水蒸气渗透性的层状材料。

6. 发明申请

WO02078741A3 METHODS AND COMPOSITIONS FOR MODULATING THE IMMUNE SYSTEM OF ANIMALS 审中-公开
标题翻译：用于调节动物免疫系统的方法和组合物
公开(公告)号：WO02078741A3
公开(公告)日：2003-05-01
申请号：PCT/US0202752
申请日：2002-01-29
申请人： LAURIDSEN GROUP INC , CAMPBELL JOY M , STROHBEHN RONALD E , WEAVER ERIC M , BORG BARTON S , RUSSELL LOUIS E , POLO POZO FRANCISCO JAVIER , ARTHINGTON JOHN D , QUIGLEY JAMES D III
发明人： CAMPBELL JOY M , STROHBEHN RONALD E , WEAVER ERIC M , BORG BARTON S , RUSSELL LOUIS E , POLO POZO FRANCISCO JAVIER , ARTHINGTON JOHN D , QUIGLEY JAMES D III
IPC分类号： A61K35/14 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61P11/00 , A61P37/00 , C07K16/02 , C07K16/04 , C07K16/06 , A61K39/395 , A61K39/00
CPC分类号： C07K14/005 , A23K10/20 , A23K10/24 , A23K50/30 , A23K50/75 , A61K35/16 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , A61K2039/55516 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C07K2317/77 , C12N2720/12322 , C12N2720/12334 , C12N2770/10022 , C12N2770/10034
摘要： Methods and compositions are disclosed for modulating the immune system of animals. Applicant has identified that oral administration of immunoglobulins purified from animal blood can modulate serum IgG, TNF- alpha or other nonspecific immunity components' levels for treatment of immune dysfunction disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译：公开了调节动物免疫系统的方法和组合物。申请人已经确定，从动物血液中纯化的免疫球蛋白的口服给药可以调节血清IgG，TNF-α或其他非特异性免疫组分的治疗免疫功能障碍水平，增强疫苗接种方案，改善动物体内的总体健康和体重增加，包括人类。

7. 发明申请

WO2002078742A2 METHODS AND COMPOSITIONS FOR TREATMENT OF IMMUNE DYSFUNCTION DISORDERS 审中-公开
标题翻译：用于治疗免疫功能障碍的方法和组合物
公开(公告)号：WO2002078742A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/002753
申请日：2002-01-29
申请人： THE LAURIDSEN GROUP, INCORPORATED , CAMPBELL, Joy, M. , STROHBEHN, Ronald, E. , WEAVER, ERIC, M. , BORG, Barton, S. , RUSSELL, Louis, E. , POLO POZO, Francisco, Javier , ARTHINGTON, John, D. , QUIGLEY, James, D., III
发明人： CAMPBELL, Joy, M. , STROHBEHN, Ronald, E. , WEAVER, ERIC, M. , BORG, Barton, S. , RUSSELL, Louis, E. , POLO POZO, Francisco, Javier , ARTHINGTON, John, D. , QUIGLEY, James, D., III
IPC分类号： A61K39/395
CPC分类号： A61K39/395 , A61K35/16 , A61K35/20 , A61K39/12 , A61K39/15 , A61K39/39 , A61K2039/505 , A61K2039/542 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C07K2317/77 , C12N2720/12334 , C12N2770/10034
摘要： Methods and compositions are disclosed for modulating the immune system of animals. Applicant has identified that oral administration of immunoglobulin or plasma fractions purified from animal serum can modulate serum IgG and/or TNF-Δ levels for treatment of autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译：公开了调节动物免疫系统的方法和组合物。申请人已经确定，从动物血清中纯化的免疫球蛋白或血浆级分的口服给药可以调节血清IgG和/或TNF-Δ水平，以治疗自身免疫性疾病，增强疫苗接种方案，以及提高包括人在内的动物的整体健康和体重增加。

8. 发明申请

WO2013004865A3 FOOD SUPPLEMENT, METHOD FOR INCREASING THE BACTERIAL MASS IN THE RUMEN OF A RUMINANT AND FOOD PREPARATION AND CORRESPONDING USES 审中-公开
标题翻译：食品补充，增加发酵剂和食品制备和相关用途的酵母中的细菌的方法
公开(公告)号：WO2013004865A3
公开(公告)日：2013-05-10
申请号：PCT/ES2012000188
申请日：2012-07-06
申请人： APC EUROP S A , POLO POZO FRANCISCO JAVIER , RODRIGUEZ CANEL CARMEN , BACH ARIZA ALEJANDRO , ARIS GIRALT ANNA
发明人： POLO POZO FRANCISCO JAVIER , RODRIGUEZ CANEL CARMEN , BACH ARIZA ALEJANDRO , ARIS GIRALT ANNA
IPC分类号： A23J1/06 , A23J3/32 , A23J3/34 , A23K1/04 , A23K1/16 , A23K1/18 , A23L1/305
CPC分类号： C07K14/805 , A23J1/06 , A23J3/32 , A23J3/34 , A23K10/14 , A23K10/24 , A23K20/142 , A23K20/147 , A23K50/10 , A23K50/20 , A23L33/18 , A61K38/42
摘要： The invention relates to a food supplement, a method for increasing the bacterial mass in the rumen of a ruminant and a food preparation and corresponding uses. The food supplement comprises hydrolysed proteins that have a degree of hydrolysis above 28% and/or contain more than 23 mg of alpha-amino nitrogen per gram of protein and/or contain more than 10% of free amino acids. The hydrolysed proteins are animal proteins, preferably haemoglobin. The supplement is administered orally, included in a food preparation, in liquid, concentrated or dehydrated form. The supplement forms the basis of a method for increasing the bacterial mass in the rumen of a ruminant, in which a supplement containing hydrolysed proteins in accordance with the invention is added to the diet of the ruminant.
摘要翻译：本发明涉及食品补充剂，增加反刍动物和食物制剂的瘤胃中的细菌质量的方法和相应的用途。食品补充剂包含水解蛋白质，其水解度高于28％，和/或含有超过23mg的α-氨基氮/克蛋白质和/或含有超过10％的游离氨基酸。水解蛋白质是动物蛋白质，优选血红蛋白。补充剂口服给药，包括在食品制剂中，液体，浓缩或脱水形式。该补充物形成了增加反刍动物瘤胃中的细菌质量的方法的基础，其中将含有根据本发明的水解蛋白质的补充剂添加到反刍动物的饮食中。

9. 发明申请

WO2004075988A2 METHODS OF IMMUNOMODULATION IN ANIMALS 审中-公开
标题翻译：动物免疫调节方法
公开(公告)号：WO2004075988A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005499
申请日：2004-02-25
申请人： THE LAURIDSON GROUP INC. , CAMPBELL, Joy, M. , STROHBEHN, Ronald, E. , WEAVER, Eric, M. , BORG, Barton, S. , RUSSELL, Louis, E. , POLO POZO, Francisco Javier , ARTHINGTON, John, D. , QUIGLEY, James, D., III
发明人： CAMPBELL, Joy, M. , STROHBEHN, Ronald, E. , WEAVER, Eric, M. , BORG, Barton, S. , RUSSELL, Louis, E. , POLO POZO, Francisco Javier , ARTHINGTON, John, D. , QUIGLEY, James, D., III
IPC分类号： A61P
CPC分类号： A61K39/15 , A23K10/00 , A61K35/16 , A61K39/12 , A61K39/39 , A61K2039/505 , A61K2039/542 , A61K2039/552 , C07K16/02 , C07K16/04 , C07K16/06 , C07K16/065 , C12N2720/12334 , C12N2770/10011 , C12N2770/10034
摘要： Methods and compositions are disclosed for the dietary modulation of the immune system and gut microbial response in animals. Applicant has identified that oral administration of a supplemental spray dried plasma purified from animal serum can modulate serum IgG levels for treatment in such things as diminished immune capacity, intestinal microbial balance, autoimmune disorders, potentiation of vaccination protocols, and improvement of overall health and weight gain in animals, including humans.
摘要翻译：公开了用于免疫系统的饮食调节和动物肠内微生物反应的方法和组合物。申请人已经确定，从动物血清中纯化的补充喷雾干燥血浆的口服给药可以调节血清IgG水平以进行治疗，例如免疫能力降低，肠微生物平衡，自身免疫疾病，增强疫苗接种方案以及提高整体健康和体重在动物，包括人类的增益。

10. 发明申请

WO2013004865A8 FOOD SUPPLEMENT, METHOD FOR INCREASING THE BACTERIAL MASS IN THE RUMEN OF A RUMINANT AND FOOD PREPARATION AND CORRESPONDING USES 审中-公开
标题翻译：食物补充剂，提高转化体瘤细菌质量的方法和食物制备及相应用途
公开(公告)号：WO2013004865A8
公开(公告)日：2013-07-18
申请号：PCT/ES2012000188
申请日：2012-07-06
申请人： APC EUROP S A , POLO POZO FRANCISCO JAVIER , RODRIGUEZ CANEL CARMEN , BACH ARIZA ALEJANDRO , ARIS GIRALT ANNA
发明人： POLO POZO FRANCISCO JAVIER , RODRIGUEZ CANEL CARMEN , BACH ARIZA ALEJANDRO , ARIS GIRALT ANNA
IPC分类号： A23J1/06 , A23J3/32 , A23J3/34 , A23K1/04 , A23K1/16 , A23K1/18 , A23L1/305
CPC分类号： C07K14/805 , A23J1/06 , A23J3/32 , A23J3/34 , A23K10/14 , A23K10/24 , A23K20/142 , A23K20/147 , A23K50/10 , A23K50/20 , A23L33/18 , A61K38/42
摘要： The invention relates to a food supplement, a method for increasing the bacterial mass in the rumen of a ruminant and a food preparation and corresponding uses. The food supplement comprises hydrolysed proteins that have a degree of hydrolysis above 28% and/or contain more than 23 mg of alpha-amino nitrogen per gram of protein and/or contain more than 10% of free amino acids. The hydrolysed proteins are animal proteins, preferably haemoglobin. The supplement is administered orally, included in a food preparation, in liquid, concentrated or dehydrated form. The supplement forms the basis of a method for increasing the bacterial mass in the rumen of a ruminant, in which a supplement containing hydrolysed proteins in accordance with the invention is added to the diet of the ruminant.
摘要翻译：本发明涉及一种食物补充剂，一种增加反刍动物瘤胃中细菌量的方法和一种食物制剂以及相应的用途。该食品补充剂包含水解蛋白质，其水解度高于28％和/或每克蛋白质含有超过23mg的α-氨基氮和/或含有超过10％的游离氨基酸。水解蛋白质是动物蛋白质，优选血红蛋白。该补充剂以包含在食物制剂中的液体，浓缩或脱水形式口服施用。该补充剂形成增加反刍动物瘤胃中细菌量的方法的基础，其中将含有根据本发明的水解蛋白质的补充物添加到反刍动物的食物中。

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