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1. 发明申请

WO2011032277A1 QUINAZOLINONE DERIVATIVES AS VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：喹唑啉酮衍生物作为病毒聚合酶抑制剂
公开(公告)号：WO2011032277A1
公开(公告)日：2011-03-24
申请号：PCT/CA2010/001443
申请日：2010-09-16
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , STAMMERS, Timothy , BARBEAU, Xavier , BEAULIEU, Pierre , BERTRAND-LAPERLE, Megan , BROCHU, Christian , EDWARDS, Paul, J. , FORGIONE, Pasquale , GODBOUT, Cédrickx , HUCKE, Oliver , JOLY, Marc-André , LANDRY, Serge , LEPAGE, Olivier , NAUD, Julie , PESANT, Marc , POIRIER, Martin , POIRIER, Maude , THAVONEKHAM, Bounkham
发明人： STAMMERS, Timothy , BARBEAU, Xavier , BEAULIEU, Pierre , BERTRAND-LAPERLE, Megan , BROCHU, Christian , EDWARDS, Paul, J. , FORGIONE, Pasquale , GODBOUT, Cédrickx , HUCKE, Oliver , JOLY, Marc-André , LANDRY, Serge , LEPAGE, Olivier , NAUD, Julie , PESANT, Marc , POIRIER, Martin , POIRIER, Maude , THAVONEKHAM, Bounkham
IPC分类号： C07D401/12 , A61K31/517 , A61K31/14 , C07C211/29 , C07C233/13 , C07C237/44 , C07C251/48 , C07C255/58 , C07D213/74 , C07D239/42 , C07D239/88 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07F5/02
CPC分类号： C07D401/12 , A61K31/14 , A61K31/517 , C07C211/29 , C07C233/11 , C07C237/44 , C07C251/48 , C07C255/58 , C07C255/59 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07F5/025
摘要： Compounds of formula I: (I) wherein X, R 2 , R 3 , R 5 and R 6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译：式I化合物（其中X，R 2，R 3，R 5和R 6在本文中定义）可用作丙型肝炎病毒NS5B聚合酶的抑制剂。

2. 发明申请

WO2005080388A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2005080388A1
公开(公告)日：2005-09-01
申请号：PCT/CA2005/000208
申请日：2005-02-18
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , BOEHRINGER INGELHEIM PHARMA GmbH & CO KG , TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
发明人： TSANTRIZOS, Youla, S. , CHABOT, Catherine , BEAULIEU, Pierre , BROCHU, Christian , POIRIER, Martin , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham , RANCOURT, Jean
IPC分类号： C07D417/14
CPC分类号： C07D487/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： An enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein either A or B is nitrogen and the other B or A is C, and the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a salt or ester thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particularly those viral polymerases within the Flaviviridae family, more particularly to HCV polymerase.
摘要翻译：由式（I）表示的化合物的对映体，非对映异构体或互变异构体：其中A或B为氮，另一个B或A为C，基团R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8，R 9和R 10如本文所定义，或其盐或酯作为病毒聚合酶抑制剂。该化合物用作RNA依赖性RNA聚合酶的抑制剂，特别是黄病毒科中的那些病毒聚合酶，更特别地涉及HCV聚合酶。

3. 发明申请

WO03010141A3 HEPATITIS C VIRUS POLYMERASE INHIBITORS WITH A HETEROBICYCLIC STRUCTURE 审中-公开
标题翻译：具有异构结构的丙型肝炎病毒聚合酶抑制剂
公开(公告)号：WO03010141A3
公开(公告)日：2003-05-30
申请号：PCT/CA0201128
申请日：2002-07-18
申请人： BOEHRINGER INGELHEIM CA LTD , BEAULIEU PIERRE LOUIS , FAZAL GULREZ , GOULET SYLVIE , KUKOLJ GEORGE , POIRIER MARTIN , TSANTRIZOS YOULA S , JOLICOEUR ERIC , GILLARD JAMES , POUPART MARC-ANDRE , RANCOURT JEAN
发明人： BEAULIEU PIERRE LOUIS , FAZAL GULREZ , GOULET SYLVIE , KUKOLJ GEORGE , POIRIER MARTIN , TSANTRIZOS YOULA S , JOLICOEUR ERIC , GILLARD JAMES , POUPART MARC-ANDRE , RANCOURT JEAN
IPC分类号： A61K31/13 , A61K31/381 , A61K31/404 , A61K31/405 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/7052 , A61K38/21 , A61K45/00 , A61P31/12 , A61P31/14 , A61P37/02 , A61P43/00 , C07D20060101 , C07D209/08 , C07D209/14 , C07D209/20 , C07D209/30 , C07D209/42 , C07D333/62 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/02 , C07D471/04 , C07D491/02 , C07D498/02 , C07H19/056 , C07D403/12
CPC分类号： C07D333/62 , C07D209/08 , C07D209/30 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, NR , or CR , wherein R is defined herein; represents either a single or a double bond;R is selected from: H, halogen, R , OR , SR , COOR ,SO2N(R )2, N(R )2, , CON(R )2,NR C(O)R or NR C(O)NR wherein R and each R is defined herein; B is NR or CR , with the proviso that one of A or B is either CR or CR , wherein R is defined herein; K is N or CR , wherein R is defined herein; L is N or CR , wherein R has the same definition as R ; M is N or CR , wherein R has the same definition as R ; Y is O or S; Z is N(R )R or OR , wherein R is H or alkyl or NR R wherein R and R are defined herein; and R is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het;or R is wherein R and R and Q are as defined herein; Y is O or S; R is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl, aryl, Het, (C1-6)alkyl-aryl or (C1-6)alkyl-Het, all of which optionally substituted with R ; or R is covalently bonded to either of R or R to form a 5- or 6-membered heterocycle; a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.
摘要翻译：由式I表示的化合物的异构体，对映异构体，非对映异构体或互变异构体：其中：A是O，S，NR 1或CR 1，其中R 1在本文中定义; 表示单键或双键; R 2选自：H，卤素，R 21，OR 21，SR 21，COOR 21，SO 2 N（R 22）2， N（R 22）2，CON（R 22）2，NR 22 C（O）R 22或NR 22 C（O）NR 22其中R 21和每个R 22在本文中定义; B是NR 3或CR 3，条件是A或B中的一个是CR 1或CR 3，其中R 3在本文中定义; K是N或CR 4，其中R 4在本文中定义; L是N或CR 5，其中R 5具有与R 4相同的定义; M是N或CR 7，其中R 7具有与R 4相同的定义; Y 1是O或S; Z是N（R 6a）R 6或OR 6，其中R 6a是H或烷基或NR 61 R 62，其中R 61和R 62定义在本文中 ; 且R 6为H，烷基，环烷基，烯基，Het，烷基 - 芳基，烷基-Het;或R 6为其中R 7和R 8和Q如本文所定义; Y 2为O或S; R 9是H，（C 1-6烷基），（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基，芳基，Het，（C 1-6）烷基 - 芳基或（C 1 -6）烷基-Het，它们全部被R 90取代; 或R 9与R 7或R 8中的任一个共价键合以形成5-或6-元杂环; 其盐或其衍生物，作为HCV NS5B聚合酶的抑制剂。

4. 发明申请

WO2009076747A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2009076747A1
公开(公告)日：2009-06-25
申请号：PCT/CA2008/002107
申请日：2008-12-03
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , BEAULIEU, Pierre, L. , FORGIONE, Pasquale , GAGNON, Alexandre , GODBOUT, Cedrickx , JOLY, Marc-André , LLINAS-BRUNET, Montse , NAUD, Julie , POIRIER, Martin , RANCOURT, Jean
发明人： BEAULIEU, Pierre, L. , FORGIONE, Pasquale , GAGNON, Alexandre , GODBOUT, Cedrickx , JOLY, Marc-André , LLINAS-BRUNET, Montse , NAUD, Julie , POIRIER, Martin , RANCOURT, Jean
IPC分类号： C07D213/643 , A61K31/395 , A61K31/44 , A61P31/12 , A61P31/18 , C07D211/38 , C07D213/54 , C07D239/26 , C07D249/04 , C07D277/24 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D401/14 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/04
CPC分类号： A61K31/444 , A61K31/5377 , C07D211/38 , C07D213/643 , C07D213/69 , C07D213/81 , C07D215/227 , C07D217/24 , C07D239/34 , C07D239/38 , C07D239/47 , C07D239/52 , C07D249/04 , C07D277/24 , C07D307/20 , C07D333/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Compounds of formula I: wherein X, R 2 , R 3 , R 3a , R 3b ,R 5 and R 6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译：式I化合物：其中X，R2，R3，R3a，R3b，R5和R6如本文所定义，可用作丙型肝炎病毒NS5B聚合酶的抑制剂。

5. 发明申请

WO2003007945A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2003007945A1
公开(公告)日：2003-01-30
申请号：PCT/CA2002/001129
申请日：2002-07-18
申请人： BOEHRINGER INGELHEIM (CANADA) LTD. , BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S.
发明人： BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S.
IPC分类号： A61K31/4184
CPC分类号： C07D401/04 , C07D235/18 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04
摘要： An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula (I): wherein R 1 is selected from: H, haloalkyl, (C 1-6 )alkyl, (C 2-6 )alkenyl, (C 3-7 )cycloalkyl, (C 2-6 )alkynyl, (C 5-7 )cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C 1-6 )alkyl, (C 3-7 )cycloalkyl, (C 6-10 )bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR 5 , wherein R 5 is H, halogen, haloalkyl, (C 1-6 )alkyl, (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl; X is N or CR 5 ; D is N or CR 5 ; each of Y 1 and Y 2 is independently O or S; Z is O, N, or NR z wherein R z is H, (C 1-6 )alkyl, (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl; R 3 and R 4 are each independently H, (C 1-6 )alkyl, first (C 3-7 )cycloalkyl, 6- or 10-membered aryl, Het (C 1-6 )alkyl-6- or 10-membered aryl, (C 1-6 )alkyl-Het; or each R 3 and R 4 are independently covalently bonded together to form second (C 3-7 )cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R 3 or R 4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R 7 is H, (C 1-6 alkyl), (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl; or R 7 is covalently bonded to either of R 3 or R 4 to form a heterocycle; A is (C 1-6 ) alkyl-CONHR 8 wherein R 8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.
摘要翻译：由式（I）表示的化合物的异构体，对映异构体，非对映异构体或互变异构体：其中R 1选自：H，卤代烷基，（C 1-6）烷基，（C 2-6）烯基，（C 3 -C 6） 7）环烷基，（C 2-6）炔基，（C 5-7）环烯基，6或10元芳基，Het全部被取代; R 2选自（C 1-6）烷基，（C 3-7）环烷基，（C 6-10）双环烷基，6-或10-元芳基，或任选取代的Het; B是N或CR 5，其中R 5是H，卤素，卤代烷基，（C 1-6）烷基，（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基; X为N或CR <5>; D为N或CR 5; Y1和Y2各自独立地为O或S; Z是O，N或NR z，其中R z是H，（C 1-6）烷基，（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基; R 3和R 4各自独立地为H，（C 1-6）烷基，第一（C 3-7）环烷基，6-或10-元芳基，Het（C 1-6）烷基-6-或10- （C 1-6）烷基-Het; 或每个R 3和R 4独立地共价键合在一起形成全部任意取代的第二（C 3-7）环烷基或杂环; 或当Z为N时，R 3或R 4独立地与其共价键合形成含氮杂环; R 7是H，（C 1-6烷基），（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基; 或R 7共价键合到R 3或R 4中的任一个以形成杂环; A是（C 1-6）烷基-CONHR 8，其中R 8是6-元或10元芳基，或Het; 或A是6-或10-元芳基，或Het表示芳基或Het任选被取代; 或其盐或衍生物; 这些化合物是HCV NS5B聚合酶的有效抑制剂。

6. 发明申请

WO2009018657A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2009018657A1
公开(公告)日：2009-02-12
申请号：PCT/CA2008/001412
申请日：2008-07-31
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BEAULIEU, Pierre, L. , EDWARDS, Paul, J. , POIRIER, Martin , RACOURT, Jean , STAMMERS, Timothy, A.
发明人： BEAULIEU, Pierre, L. , EDWARDS, Paul, J. , POIRIER, Martin , RACOURT, Jean , STAMMERS, Timothy, A.
IPC分类号： C07D401/12 , A61K31/13 , A61K31/381 , A61K31/44 , A61K31/4427 , A61K31/7056 , A61P31/14 , C07D231/14 , C07D277/56 , C07D333/28 , C07D401/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： C07D333/38 , C07D213/81 , C07D231/14 , C07D277/56 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula I: wherein X, R 2 , R 3 , R 5 and R 6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译：式I化合物：其中X，R 2，R 3，R 5和R 6在本文中定义，可用作丙型肝炎病毒NS5B聚合酶的抑制剂。

7. 发明申请

WO2009018656A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2009018656A1
公开(公告)日：2009-02-12
申请号：PCT/CA2008/001411
申请日：2008-07-31
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , BEAULIEU, Pierre, L. , FORGIONE, Pasquale , GAGNON, Alexandre , GODBOUT, Cédrickx , NAUD, Julie , POIRIER, Martin , RACOURT, Jean , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham
发明人： BEAULIEU, Pierre, L. , FORGIONE, Pasquale , GAGNON, Alexandre , GODBOUT, Cédrickx , NAUD, Julie , POIRIER, Martin , RACOURT, Jean , STAMMERS, Timothy, A. , THAVONEKHAM, Bounkham
IPC分类号： C07D401/06 , A61K31/13 , A61K31/395 , A61K31/7056 , A61P31/14 , C07D213/04 , C07D213/63 , C07D213/643 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00
CPC分类号： C07D233/60 , C07D211/38 , C07D213/16 , C07D213/643 , C07D213/65 , C07D213/74 , C07D217/24 , C07D231/12 , C07D231/56 , C07D235/12 , C07D237/20 , C07D239/42 , C07D241/20 , C07D249/06 , C07D249/08 , C07D251/22 , C07D257/06 , C07D261/14 , C07D275/03 , C07D277/24 , C07D277/42 , C07D295/088 , C07D307/20 , C07D309/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C07D487/04
摘要： Compound of Formula I: wherein, R 2 , R 5 and R 6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase
摘要翻译：式I化合物：其中，R2，R5和R6如本文所定义，可用作丙型肝炎病毒NS5B聚合酶的抑制剂

8. 发明申请

WO2003010141A2 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2003010141A2
公开(公告)日：2003-02-06
申请号：PCT/CA2002/001128
申请日：2002-07-18
申请人： BOEHRINGER INGELHEIM (CANADA) LTD. , BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S. , JOLICOEUR, Eric , GILLARD, James , POUPART, Marc-André , RANCOURT, Jean
发明人： BEAULIEU, Pierre, Louis , FAZAL, Gulrez , GOULET, Sylvie , KUKOLJ, George , POIRIER, Martin , TSANTRIZOS, Youla, S. , JOLICOEUR, Eric , GILLARD, James , POUPART, Marc-André , RANCOURT, Jean
IPC分类号： C07D209/00
CPC分类号： C07D333/62 , C07D209/08 , C07D209/30 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, NR 1 , or CR 1 , wherein R 1 is defined herein; represents either a single or a double bond;R 2 is selected from: H, halogen, R 21 , OR 21 , SR 21 , COOR 21 ,SO 2 N(R 22 ) 2 , N(R 22 ) 2 , , CON(R 22 ) 2 ,NR 22 C(O)R 22 or NR 22 C(O)NR 22 wherein R 21 and each R 22 is defined herein; B is NR 3 or CR 3 , with the proviso that one of A or B is either CR 1 or CR 3 , wherein R 3 is defined herein; K is N or CR 4 , wherein R 4 is defined herein; L is N or CR 5 , wherein R 5 has the same definition as R 4 ; M is N or CR 7 , wherein R 7 has the same definition as R 4 ; Y 1 is O or S; Z is N(R 6a )R 6 or OR 6 , wherein R 6a is H or alkyl or NR 61 R 62 wherein R 61 and R 62 are defined herein; and R 6 is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het;or R 6 is wherein R 7 and R 8 and Q are as defined herein; Y 2 is O or S; R 9 is H, (C 1-6 alkyl), (C 3-7 )cycloalkyl or (C 1-6 )alkyl-(C 3-7 )cycloalkyl, aryl, Het, (C 1-6 )alkyl-aryl or (C 1-6 )alkyl-Het, all of which optionally substituted with R 90 ; or R 9 is covalently bonded to either of R 7 or R 8 to form a 5- or 6-membered heterocycle; a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.
摘要翻译：由式I表示的化合物的异构体，对映异构体，非对映异构体或互变异构体：其中：A是O，S，NR 1或CR 1，其中R 1在本文中定义; 表示单键或双键; R 2选自：H，卤素，R 21，OR 21，SR 21，COOR 21，SO 2 N（R 22）2， N（R 22）2，CON（R 22）2，NR 22 C（O）R 22或NR 22 C（O）NR 22其中R 21和每个R 22在本文中定义; B是NR 3或CR 3，条件是A或B中的一个是CR 1或CR 3，其中R 3在本文中定义; K是N或CR 4，其中R 4在本文中定义; L是N或CR 5，其中R 5具有与R 4相同的定义; M是N或CR 7，其中R 7具有与R 4相同的定义; Y 1是O或S; Z是N（R 6a）R 6或OR 6，其中R 6a是H或烷基或NR 61 R 62，其中R 61和R 62定义在本文中 ; 且R 6为H，烷基，环烷基，烯基，Het，烷基 - 芳基，烷基-Het;或R 6为其中R 7和R 8和Q如本文所定义; Y 2为O或S; R 9是H，（C 1-6烷基），（C 3-7）环烷基或（C 1-6）烷基 - （C 3-7）环烷基，芳基，Het，（C 1-6）烷基 - 芳基或（C 1 -6）烷基-Het，它们全部被R 90取代; 或R 9与R 7或R 8中的任一个共价键合以形成5-或6-元杂环; 其盐或其衍生物，作为HCV NS5B聚合酶的抑制剂。

9. 发明申请

WO2008019477A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2008019477A1
公开(公告)日：2008-02-21
申请号：PCT/CA2007/001363
申请日：2007-08-06
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH , BOEHRINGER INGELHEIM PHARMA GMBH & CO KG , BEAULIEU, Pierre, L , COULOMBE, René , FAZAL, Gulrez , GOULET, Sylvie , POIRIER, Martin , RANCOURT, Jean , STAMMERS, Timothy , THAVONEKHAM, Bounkham
发明人： BEAULIEU, Pierre, L , COULOMBE, René , FAZAL, Gulrez , GOULET, Sylvie , POIRIER, Martin , RANCOURT, Jean , STAMMERS, Timothy , THAVONEKHAM, Bounkham
IPC分类号： C07D213/62 , A61K31/351 , A61K31/381 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4439 , A61K31/497 , A61K31/5377 , A61P31/14 , C07D231/18 , C07D235/12 , C07D309/12 , C07D333/32 , C07D401/06 , C07D401/12 , C07D413/04 , C07D413/06 , C07D417/06
CPC分类号： C07D213/68 , C07D213/70 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/85 , C07D213/89 , C07D215/227 , C07D217/24 , C07D231/18 , C07D235/08 , C07D235/12 , C07D237/14 , C07D239/34 , C07D239/56 , C07D241/20 , C07D241/24 , C07D307/20 , C07D309/12 , C07D333/32 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04
摘要： Compounds of formula (I) : wherein X, R 2 , R 3 , R 5 and R 6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
摘要翻译：式（I）化合物：其中X，R 2，R 3，R 5和R 6是可用作丙型肝炎病毒NS5B聚合酶的抑制剂。

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