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1. 发明申请

WO2012168680A8 PHARMACEUTICAL PREPARATION COMPRISING RECOMBINANT FSH 审中-公开
公开(公告)号：WO2012168680A8
公开(公告)日：2012-12-13
申请号：PCT/GB2012/000491
申请日：2012-06-06
申请人： FERRING B.V. , COTTINGHAM, Ian , PLAKSIN, Daniel , SANDSTROM, Bjorn, Rikard, Lorentz
发明人： COTTINGHAM, Ian , PLAKSIN, Daniel , SANDSTROM, Bjorn, Rikard, Lorentz
IPC分类号： A61K38/24 , C07K14/59
摘要： Preparations including FSH, for example recombinant FSH, wherein 17% to 23% of the sialyated glycan structures are tetra-sialylated glycan structures.

2. 发明申请

WO2005010153A3 ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2005010153A3
公开(公告)日：2005-02-03
申请号：PCT/US2004/021002
申请日：2004-06-30
申请人： BIO-TECHNOLOGY GENERAL (ISRAEL) LTD. , PLAKSIN, Daniel , LEVANON, Avigdor , SZANTON, Esther , HAGAY, Yocheved , BEN-LEVY, Rachel , NISGAV, Yael , SZRAJBER, Tali , KANFI, Yariv
发明人： PLAKSIN, Daniel , LEVANON, Avigdor , SZANTON, Esther , HAGAY, Yocheved , BEN-LEVY, Rachel , NISGAV, Yael , SZRAJBER, Tali , KANFI, Yariv
IPC分类号： A61K38/00 , A61K38/12 , A61K38/04 , C07K1/00 , C07K16/00 , C12P21/08
摘要： The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.

3. 发明申请

WO2002059264A2 SPECIFIC HUMAN ANTIBODIES FOR SELECTIVE CANCER THERAPY 审中-公开
标题翻译：特定人体抗体选择性癌症治疗
公开(公告)号：WO2002059264A2
公开(公告)日：2002-08-01
申请号：PCT/US2001/049440
申请日：2001-12-31
申请人： BIO-TECHNOLOGY GENERAL CORP. , HAGAI, Yocheved , LAZAROVITS, Janette , GUY, Rachel , LIPSCHITZ, Orly , SZANTON, Esther , LEVANON, Avigdor , PLAKSIN, Daniel , PERETZ, Tuvia
发明人： HAGAI, Yocheved , LAZAROVITS, Janette , GUY, Rachel , LIPSCHITZ, Orly , SZANTON, Esther , LEVANON, Avigdor , PLAKSIN, Daniel , PERETZ, Tuvia
IPC分类号： C12N
CPC分类号： C07K14/472 , A61K38/00
摘要： The present invention is directed to a peptide or polypeptide comprising an Fv molecule, a construct thereof, a fragment of either, or a construct of a fragment having enhanced binding characteristics so as to bind selectively and/or specifically to a target cell in favor of other cells, wherein the binding selectivity or specificity is primarily determined by a first hypervariable region, and wherein the Fv is a scFv or a dsFv, and optionally having one or more tags. The enhanced binding is directed to a substantially exposed and/or over-expressed binding site on or in a target comprising a cell in favor of other cells on or in which the binding site is not substantially available and/or expressed. The invention is further directed to a method for isolating such peptides and polypeptides from a phage display library and to the nucleic acid molecules encoding them. The invention provides for a pharmaceutical composition comprising the peptide or polypeptide and kits for diagnosis and treatment of disease, specifically cancer, most specifically acute myeloid leukemia.
摘要翻译：本发明涉及一种肽或多肽，其包含Fv分子，其构建体，或具有增强的结合特性的片段的构建体或具有结合选择性和/或特异性靶向靶细胞的片段的构建体，有利于其它细胞，其中结合选择性或特异性主要由第一高变区确定，并且其中Fv是scFv或dsFv，并且可选地具有一个或多个标签。增强的结合涉及在靶上或靶上的基本暴露和/或过度表达的结合位点，其包含有利于结合位点基本上不可用和/或表达的其它细胞的细胞。本发明还涉及从噬菌体展示文库和编码它们的核酸分子分离这些肽和多肽的方法。本发明提供包含肽或多肽的药物组合物和用于诊断和治疗疾病，特别是癌症，尤其是急性骨髓性白血病的试剂盒。

4. 发明申请

WO2009063307A2 INFLAMMATORY ACTIVITY DETECTION METHOD USING IL-6 审中-公开
标题翻译：使用IL-6的炎症活动检测方法
公开(公告)号：WO2009063307A2
公开(公告)日：2009-05-22
申请号：PCT/IB2008/003063
申请日：2008-11-14
申请人： BIO-TECHNOLOGY GENERAL (ISRAEL) LTD. , PLAKSIN, Daniel
发明人： PLAKSIN, Daniel
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N2333/5412
摘要： Inflammatory activity contaminating a medical device or biologic agent can greatly affect both its safety and its efficacy. Disclosed are methods of detecting inflammatory activity in a test sample by administering the test sample to an animal and detecting the level of a pro-inflammatory cytokine or other cell-derived mediator of inflammation. Elevated levels of pro-inflammatory cytokines such as IL-1, IL-6, TNF-α, or IFN-γ, or of other cell-derived mediators of inflammation such as lysosome granules, histamine, IL-8, leukotriene B4, nitric oxide, or prostaglandin E 2 (PGE 2 ), indicate that the test sample has inflammatory activity. The inflammatory activity may be due to any pro-inflammatory factor, such as a bacterial endotoxin (e.g., a lipopolysaccharide) or a non-endotoxin pyrogen (e.g., a Streptococcal mucopeptide).
摘要翻译：污染医疗器械或生物制剂的炎症活性可能会严重影响其安全性和疗效。公开了通过将测试样品给予动物并检测促炎细胞因子或其他细胞衍生的炎症介质的水平来检测测试样品中的炎症活性的方法。促炎细胞因子如IL-1，IL-6，TNF-α或IFN-γ或其它细胞衍生的炎症介质如溶酶体颗粒，组胺，IL-8，白三烯B4，一氧化氮氧化物或前列腺素E 2（PGE 2），表明测试样品具有炎性活性。炎性活性可能是由于任何促炎因子如细菌内毒素（例如脂多糖）或非内毒素热原（例如链球菌糖肽）引起的。

5. 发明申请

WO2009063307A8 INFLAMMATORY ACTIVITY DETECTION METHOD USING IL-6 审中-公开
标题翻译：使用IL-6的炎症活动检测方法
公开(公告)号：WO2009063307A8
公开(公告)日：2009-09-17
申请号：PCT/IB2008003063
申请日：2008-11-14
申请人： BIO TECHNOLOGY GENERAL ISRAEL , PLAKSIN DANIEL
发明人： PLAKSIN DANIEL
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N2333/5412
摘要： Inflammatory activity contaminating a medical device or biologic agent can greatly affect both its safety and its efficacy. Disclosed are methods of detecting inflammatory activity in a test sample by administering the test sample to an animal and detecting the level of a pro-inflammatory cytokine or other cell-derived mediator of inflammation. Elevated levels of pro-inflammatory cytokines such as IL-1, IL-6, TNF-a, or IFN-?, or of other cell-derived mediators of inflammation such as lysosome granules, histamine, IL-8, leukotriene B4, nitric oxide, or prostaglandin E2 (PGE2), indicate that the test sample has inflammatory activity. The inflammatory activity may be due to any pro-inflammatory factor, such as a bacterial endotoxin (e.g., a lipopolysaccharide) or a non-endotoxin pyrogen (e.g., a Streptococcal mucopeptide).
摘要翻译：污染医疗器械或生物制剂的炎症活动可能会严重影响其安全性和疗效。公开了通过将测试样品给予动物并检测促炎细胞因子或其他细胞衍生的炎症介质的水平来检测测试样品中的炎症活性的方法。促炎细胞因子如IL-1，IL-6，TNF-α或IFN-γ或其他细胞衍生的炎症介质如溶酶体颗粒，组胺，IL-8，白三烯B4，一氧化氮氧化物或前列腺素E2（PGE2）表明测试样品具有炎性活性。炎性活性可能是由于任何促炎因子如细菌内毒素（例如脂多糖）或非内毒素热原（例如链球菌粘肽）造成的。

6. 发明申请

WO2005005455A3 SPECIFIC HUMAN ANTIBODIES 审中-公开
标题翻译：特异性人体抗体
公开(公告)号：WO2005005455A3
公开(公告)日：2006-02-16
申请号：PCT/US2004021099
申请日：2004-06-30
申请人： BIO TECHNOLOGY GENERAL ISRAEL , LEVANON AVIGDOR , VOGEL TIKVA , PLAKSIN DANIEL , PERETZ TUVIA , AMIT BOAZ , COOPERMAN LENA , HAGAY YOCHEVED , SZANTON ESTHER , KANFI YARIV , BEN-LEVY RACHEL , SZRAJBER TALI
发明人： LEVANON AVIGDOR , VOGEL TIKVA , PLAKSIN DANIEL , PERETZ TUVIA , AMIT BOAZ , COOPERMAN LENA , HAGAY YOCHEVED , SZANTON ESTHER , KANFI YARIV , BEN-LEVY RACHEL , SZRAJBER TALI
IPC分类号： A61K47/48 , C07K16/06 , C07K16/28 , C07K16/36 , C07K16/44 , A61K39/395
CPC分类号： C07K16/36 , A61K47/6809 , A61K47/6849 , C07K16/2896 , C07K16/44 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2319/00
摘要： The present invention provides antibodies that bind an epitope of PSGL-1 comprising the motif D-X-Y-D, wherein X represents any amino acid or the covalent linkage between D and Y, and Y is sulfated, which antibody can be complexed with one or more copies of an agent. The antibodies of the invention can be used in a method of inducing antibody-dependent cell cytotoxicity and/or stimulating natural killer (NK) cells or T cells. In addition, by administering these antibodies to a patient in need thereof, a method of inducing cell death is provided. A method of preventing infection by a virus (e.g., HIV) by administering to a patient in need thereof an antibody of the present invention is also provided. The present invention also provides a method of introducing an agent into a cell that expresses sulfated PSGL-1 by coupling or complexing an agent to an antibody of the present invention and administering the complex to the cell. Finally, the present invention provides methods of diagnosis, prognosis and staging using the present antibodies.
摘要翻译：本发明提供了结合包含基序DXYD的PSGL-1的表位的抗体，其中X表示任何氨基酸或D和Y之间的共价键，Y被硫酸化，该抗体可以与一个或多个拷贝的剂。本发明的抗体可用于诱导抗体依赖性细胞毒性和/或刺激天然杀伤（NK）细胞或T细胞的方法。另外，通过向有需要的患者施用这些抗体，提供诱导细胞死亡的方法。还提供了通过向有需要的患者施用本发明的抗体来预防病毒感染（例如HIV）的方法。本发明还提供了通过将试剂偶联或络合到本发明的抗体并将该复合物给予细胞而将试剂引入到表达硫酸化PSGL-1的细胞中的方法。最后，本发明提供使用本发明的抗体进行诊断，预后和分期的方法。

7. 发明申请

WO2011042688A1 PHARMACEUTICAL PREPARATION COMPRISING RECOMBINANT HCG 审中-公开
标题翻译：包含重组HCG的药物制剂
公开(公告)号：WO2011042688A1
公开(公告)日：2011-04-14
申请号：PCT/GB2010/001854
申请日：2010-10-04
申请人： FERRING INTERNATIONAL CENTER SA , COTTINGHAM, Ian , PLAKSIN, Daniel , WHITE, Richard, Boyd
发明人： COTTINGHAM, Ian , PLAKSIN, Daniel , WHITE, Richard, Boyd
IPC分类号： C07K14/59 , A61K38/24
CPC分类号： C07K14/575 , A61K38/16 , C07K14/59 , C12P21/005
摘要： Preparations including recombinant hCG (r hCG).
摘要翻译：制剂包括重组hCG（r hCG）。

8. 发明申请

WO2009063307A3 INFLAMMATORY ACTIVITY DETECTION METHOD USING IL-6 审中-公开
标题翻译：使用IL-6的炎症活性检测方法
公开(公告)号：WO2009063307A3
公开(公告)日：2009-11-05
申请号：PCT/IB2008003063
申请日：2008-11-14
申请人： BIO TECHNOLOGY GENERAL ISRAEL , PLAKSIN DANIEL
发明人： PLAKSIN DANIEL
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N2333/5412
摘要： Inflammatory activity contaminating a medical device or biologic agent can greatly affect both its safety and its efficacy. Disclosed are methods of detecting inflammatory activity in a test sample by administering the test sample to an animal and detecting the level of a pro-inflammatory cytokine or other cell-derived mediator of inflammation. Elevated levels of pro-inflammatory cytokines such as IL-1, IL-6, TNF-a, or IFN-?, or of other cell-derived mediators of inflammation such as lysosome granules, histamine, IL-8, leukotriene B4, nitric oxide, or prostaglandin E2 (PGE2), indicate that the test sample has inflammatory activity. The inflammatory activity may be due to any pro-inflammatory factor, such as a bacterial endotoxin (e.g., a lipopolysaccharide) or a non-endotoxin pyrogen (e.g., a Streptococcal mucopeptide).
摘要翻译：污染医疗器械或生物制剂的炎症活动可能会极大地影响其安全性及其功效。公开了通过向动物施用测试样品并检测促炎细胞因子或其他细胞来源的炎症介质的水平来检测测试样品中的炎症活性的方法。炎症细胞因子如IL-1，IL-6，TNF-α或IFN-γ或其它细胞来源的炎症介质如溶酶体颗粒，组胺，IL-8，白三烯B4，硝酸氧化物或前列腺素E2（PGE2），表明测试样品具有炎症活性。炎症活性可能是由于任何促炎因子，例如细菌内毒素（例如脂多糖）或非内毒素热原（例如链球菌粘肽）。

9. 发明申请

WO2005010153A2 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗体及其用途
公开(公告)号：WO2005010153A2
公开(公告)日：2005-02-03
申请号：PCT/US2004021002
申请日：2004-06-30
申请人： SAVIENT PHARMACEUTICALS INC , PLAKSIN DANIEL , LEVANON AVIGDOR , SZANTON ESTHER , HAGAY YOCHEVED , BEN-LEVY RACHEL , NISGAV YAEL , SZRAJBER TALI , KANFI YARIV
发明人： PLAKSIN DANIEL , LEVANON AVIGDOR , SZANTON ESTHER , HAGAY YOCHEVED , BEN-LEVY RACHEL , NISGAV YAEL , SZRAJBER TALI , KANFI YARIV
IPC分类号： C07K16/00 , C07K16/28 , C12N
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/005 , C07K16/2896 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2319/00
摘要： The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.
摘要翻译：本发明提供了结合癌细胞的抗体或其片段，并且在生理现象如细胞转移和转移中是重要的。还提供了使用其抗体片段的治疗和诊断方法和组合物。根据本发明的方法和组合物可用于靶向治疗剂以及用于诸如癌症（包括肿瘤生长和转移，白血病，自身免疫疾病和炎症性疾病）的疾病的诊断，预后，分期和治疗。还提供了具有用于互补结合的不同抗原结合结构域的免疫球蛋白结合结构域的文库，其中文库仅在重链CDR3中具有多样性。

10. 发明申请

WO2012131306A8 PHARMACEUTICAL PREPARATION 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2012131306A8
公开(公告)日：2013-10-24
申请号：PCT/GB2012000291
申请日：2012-03-29
申请人： FERRING BV , COTTINGHAM IAN , PLAKSIN DANIEL , AHARANOV JENNY
发明人： COTTINGHAM IAN , PLAKSIN DANIEL , AHARANOV JENNY
IPC分类号： A61K47/48 , A61P15/08
CPC分类号： A61K47/48215 , A61K47/60
摘要： Preparations including poly (ethylene glycol) modified recombinant hCG (r hCG).
摘要翻译：制备包括聚（乙二醇）修饰的重组hCG（r hCG）。

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