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1. 发明专利

IL195198D0 BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C 未知
公开(公告)号：IL195198D0
公开(公告)日：2009-08-03
申请号：IL19519808
申请日：2008-11-10
申请人： ARROW THERAPEUTICS LTD , THOMAS ALEXANDER JAMES FLOYD , LUMLEY JAMES , SALTER JAMES IAIN , CARTER MALCOLM CLIVE , MATHEWS NEIL , PILKINGTON CHRISTOPHER JOHN , FRASER IAN JOHN
摘要： Compounds of formula (I) are found to be active against HCV. wherein: R 1 is a moiety -A 1 -L 1 -A 1 ', -A 1 -L 1 -A 1 '-A 1 " or -A 1 -L 1 -A 1 '-Y 1 -A 1 "; A and B are the same or different and each represent a direct bond or a -CO- NR'-, -NR'-CO-, -NR'-CO-NR"-, -NR'-S(O) 2 -, -S(O) 2 -NR'- or -NR'- moiety, wherein R' and R" are the same or different and each represent hydrogen or C 1 -C 4 alkyl; R 2 and R 3 are the same or different and each represent C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, halogen, hydroxy, thio, -NR'R", -SO 2 -R'", -NR'-COR'" or -CO 2 R'", wherein R' and R" are the same or different and represent hydrogen or C 1 -C 4 alkyl and R'" represents C 1 -C 4 alkyl; n and m are the same or different and each represent 0, 1 or 2; R 4 is a C 1 -C 6 alkyl or C 1 -C 6 haloalkyl group or a moiety -A 4 , -A 4 -A 4 ', -L 4 -A 4 , -A 4 -L 4 -A 4 ', -A 4 -Het 4 -L 4 -Het 4 '-L 4 ' or -L 4 -Het 4 -L 4 ', - each A 1 , A 4 , A 1 ', A 1 " and A 4 ' are the same or different and represent a phenyl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl or C 3 -C 6 carbocyclyl moiety; each L 1 and L 4 is the same or different and represents a C 1 -C 4 alkylene or a C 1 -C 4 hydroxyalkylene group; - Y 1 represents -CO-NR'-, -CO-( C 1 -C 4 alkylene)-, -CO-( C 1 -C 4 alkylene)-NR'-, -NR'-CO-, -CO-, -O-CO- or -CO-O-, wherein R' is hydrogen or C 1 -C 4 alkyl; L 4 ' represents hydrogen or a C 1 -C 4 alkyl group; Het 4 and Het 4 ' are the same or different and represent -O-, -S- or -NR'-, wherein R' is hydrogen or a C 1 -C 4 alkyl group; the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R 1 and R 4 being unsubstituted or substituted by (a) a single unsubstituted substituent selected from -CO 2 R', -SO 2 NR"R', -S(O) 2 -R', -CONR"R", -COR'", -CO-CO-OR''', -CO-( C 1 -C 4 alkylene)-OR", -CO-( C 1 -C 4 alkylene)-NR"R", -CO-( C 1 -C 4 alkylene)-NR"-CO-R''', -CO- (C 1 -C 4 alkylene)-CO-NR"R", -CO-( C 1 -C 4 alkylene)-SO 2 -R'", -CO-( C 1 -C 4 alkylene)-O- (C 1 -C 4 alkylene)-OR", -CO-( C 1 -C 4 alkylene)-O-( C 1 -C 4 alkylene)-NR"R", -CO-( C 1 -C 4 alkylene)-NR"-( C 1 -C 4 alkylene)-OR", -CO-( C 1 -C 4 alkylene)-NR"-( C 1 -C 4 alkylene)- NR"R", -SO 2 -( C 1 -C 4 alkylene)-OR", -NR"-SO 2 -R'", -( C 1 -C 4 alkylene)-CO-( C 1 -C 4 alkylene)-CO

2. 发明专利

IL190636D0 QUINAZOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE THEREOF IN THE MANUFACTURE OF MEDICAMENTS USEFUL FOR TREATING OR PREVENTING FLAVIVIRIDAE INFECTION 未知
公开(公告)号：IL190636D0
公开(公告)日：2008-11-03
申请号：IL19063608
申请日：2008-04-06
申请人： ARROW THERAPEUTICS LTD , THOMAS ALEXANDER JAMES FLOYD , MATHEWS NEIL , PILKINGTON CHRISTOPHER JOHN , DENNISON HELENA , SPENCER KEITH CHARLES , BARNES MICHAEL CHRISTOPHER , CHANA SURINDER SINGH , JENNENS LYN
IPC分类号： C07D20100101 , C07D239/94
摘要： Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses (Ia), wherein R 1 and R 2 are the same or different and represent hydrogen, halogen, -L-O-R 3 , -L-O-L-A or -L-O-L'-A', wherein each L is the same or different and represents a direct bond or a C 1 -C 4 alkylene group; L' represents a direct bond or a C 2 -C 4 alkylene group; R 3 represents hydrogen, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl; A represents a 5- to 10-membered heterocyclyl group; and A' represents a C 6 -C 1 aryl group; wherein at least one of R 1 and R 2 is -L-O-R 3 , -L-O-L-A or -L-O-L'-A'.

3. 发明专利

IL191928D0 TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS 未知
公开(公告)号：IL191928D0
公开(公告)日：2008-12-29
申请号：IL19192808
申请日：2008-06-03
申请人： ARROW THERAPEUTICS LTD , THOMAS ALEXANDER JAMES FLOYD , MATHEWS NEIL , PILKINGTON CHRISTOPHER JOHN , SPENCER KEITH CHARLES , CHANA SURINDER SINGH , JENNENS LYN , TIBERGHIEN NATHALIE , FRASER IAN JOHN
IPC分类号： C07D20100101
摘要： A quinazoline derivative of formula (I), or a pharmaceutically acceptable salt thereof: formula (I) for use in treatment of prevention of a flaviviridae infection.

4. 发明专利

IL189694D0 BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C 未知
公开(公告)号：IL189694D0
公开(公告)日：2008-06-05
申请号：IL18969408
申请日：2008-02-21
申请人： ARROW THERAPEUTICS LTD , WHEELHOUSE CHRISTOPHER JAMES , THOMAS ALEXANDER JAMES FLOYD , BUSHNELL DAVID JOHN , LUMLEY JAMES , SALTER JAMES IAIN , CARTER MALCOLM CLIVE , MATHEWS NEIL , PILKINGTON CHRISTOPHER JOHN , ANGELL RICHARD MARTYN
IPC分类号： C07D20100101
摘要： Use of a compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of Hepatitis C wherein the variables are described herein.

5. 发明申请

WO2007042782A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2007042782A1
公开(公告)日：2007-04-19
申请号：PCT/GB2006/003746
申请日：2006-10-09
申请人： ARROW THERAPEUTICS LIMITED , MATHEWS, Neil , THOMAS, Alexander, James, Floyd , SPENCER, Keith, Charles , DENNISON, Helena , BARNES, Michael, Christopher , CHANA, Surinder, Singh , JENNENS, Lyn , PILKINGTON, Christopher, John
发明人： MATHEWS, Neil , THOMAS, Alexander, James, Floyd , SPENCER, Keith, Charles , DENNISON, Helena , BARNES, Michael, Christopher , CHANA, Surinder, Singh , JENNENS, Lyn , PILKINGTON, Christopher, John
IPC分类号： C07D239/94 , A61K31/517 , A61P31/14
CPC分类号： C07D239/94
摘要： Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses (Ia), wherein R 1 and R 2 are the same or different and represent hydrogen, halogen, -L-O-R 3 , -L-O-L-A or -L-O-L´-A´, wherein each L is the same or different and represents a direct bond or a C 1 -C 4 alkylene group; L´ represents a direct bond or a C 2 -C 4 alkylene group; R 3 represents hydrogen, C 1 -C 4 alkyl or C 1 -C 4 haloalkyl; A represents a 5- to 10-membered heterocyclyl group; and A´ represents a C 6 -C 1 aryl group; wherein at least one of R 1 and R 2 is -L-O-R 3 , -L-O-L-A or -L-O-L´-A´.
摘要翻译：发现式（Ia）的化合物在抑制黄病毒科病毒（Ia）的复制中是有活性的，其中R 1和R 2相同或不同并且表示氢，卤素，-LOR 3，-LOLA或-LOL'-A'，其中每个L相同或不同，表示直接键或C 1 -C 3烷基，亚烷基; L代表直接键或C 2 -C 4亚烷基; R 3表示氢，C 1 -C 4烷基或C 1 -C 4烷基或C 1 -C 4 - 卤代烷基; A表示5至10元杂环基; 和A'表示C 6 -C 12芳基; 其中R 1和R 2中的至少一个为-L-O-R 3，-L-O-L-A或-L-O-L'-A'。

6. 发明申请

WO2007031791A1 BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C 审中-公开
公开(公告)号：WO2007031791A1
公开(公告)日：2007-03-22
申请号：PCT/GB2006/003469
申请日：2006-09-18
申请人： ARROW THERAPEUTICS LIMITED , WHEELHOUSE, Christopher, James , THOMAS, Alexander, James, Floyd , BUSHNELL, David, John , LUMLEY, James , SALTER, James, Iain , CARTER, Malcolm, Clive , MATHEWS, Neil , PILKINGTON, Christopher, John , ANGELL, Richard, Martyn
发明人： WHEELHOUSE, Christopher, James , THOMAS, Alexander, James, Floyd , BUSHNELL, David, John , LUMLEY, James , SALTER, James, Iain , CARTER, Malcolm, Clive , MATHEWS, Neil , PILKINGTON, Christopher, John , ANGELL, Richard, Martyn
IPC分类号： C07D205/04 , C07D213/75 , C07D233/54 , C07D237/28 , C07D279/12 , C07D295/12 , C07D295/22 , C07D307/38 , C07D333/20 , C07D417/12 , A61K31/395 , A61K31/4433 , A61K31/381 , A61P31/12
CPC分类号： C07D213/75 , C07D205/04 , C07D233/64 , C07D237/28 , C07D279/12 , C07D295/135 , C07D295/26 , C07D307/38 , C07D333/20 , C07D417/12
摘要： A compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein: R 1 is a C 1 -C 6 alkyl group or a moiety -A 1 , -L 1 -A 1 , -A 1 -A 1 ′, -L 1 -A 1 -A 1 ′, -A 1 -L 1 -A 1 ′, -A 1 -Y 1 -A 1 ′, -A 1 -Het 1 -A 1 ′, -L 1 -A 1 -Y 1 -A 1 ′, -L 1 -A 1 -Het 1 -A 1 ′, -L 1 -Het 1 -A 1 , -L 1 -Y 1 -A 1 , -L 1 -Y 1 -Het 1 -A 1 , -L 1 -Het 1 -Y 1 -A 1 , -L 1 -Y 1 -Het 1 -L 1 ′, -A 1 -Y 1 -Het 1 -A 1 ′, -A 1 -Het 1 -Y 1 -A 1 ′, -A 1 -Het 1 -L 1 -A 1 ′, -A 1 -L 1 -Het 1 -A 1 ′ or -L 1 -Het 1 -L 1 ′; - A and B are the same or different and each represent a direct bond or a -CO- NR′-, -NR′-CO-, -NR′-CO 2 -, -CO-, -NR′-CO-NR′′-, -NR′-S(O) 2 -, -S(O) 2 -NR′-, -SO 2 -, -NR′-, -NR′-CO-CO-, -CO-O-, -O-CO-, -(C 1 -C 2 alkylene)-NR′- or -(C 1 -C 2 hydroxyalkylene)-NR′ - moiety, wherein R′ and R′′ are the same or different and each represent hydrogen or C 1 -C 4 alkyl; - R 2 and R 3 are the same or different and each represent C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy or halogen; n and m are the same or different and each represent 0 or 1 ; R 4 is a C 1 -C 6 alkyl group or a moiety -A 4 , -L 4 -A 4 , -A 4 -A 4 ′, -L 4 -A 4 -A 4 ′ , -A 4 -L 4 -A 4 ′, -A 4 -Y 4 -A 4 ′, -A 4 -Het 4 -A 4 ′, -L 4 -A 4 -Y 4 -A 4 ′, -L 4 -A 4 -Het 4 -A 4 ′, -L 4 -Het 4 -A 4 , -L 4 -Y 4 -A 4 , -L 4 -Y 4 -Het 4 -A 4 , -L 4 -Het 4 -Y 4 -A 4 , -L 4 -Y 4 -Het 4 -L 4 ′, -A 4 -Y 4 -Het 4 -A 4 ′, -A 4 -Het 4 -Y 4 -A 4 ′, -A 4 -Het 4 -L 4 -A 4 ′, -A 4 -L 4 -Het 4 -A 4 ′ or -L 4 -Het 4 -L 4 ′, each A 1 , A 4 , A 1 ′ and A 4 ′ are the same or different and represent a phenyl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl or C 3 -C 8 carbocyclyl moiety; each L 1 and L 4 is the same or different and represents a C 1 -C 4 alkylene or a C 1 -C 4 hydroxyalkylene group; each Y 1 and Y 4 is the same or different and represents -CO-, -SO- or -S(O) 2 -; each L 1 ′ and L 4 ′ is the same or different and represents hydrogen or a C 1 -C 4 alkyl group; and each Het 1 and Het 4 is the same or different and represents -O-, -S- or -NR′-, wherein R′ is hydrogen or a C 1 -C 4 alkyl group, the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R 1 and R 4 being optionally fused to a phenyl, 5- to 10- membered heteroaryl or 5- to 10- membered heterocyclyl ring; and the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R 1 and R 4 being unsubstituted or substituted by (a) a single unsubstituted substituent selected from -(C 1 -C 4 alkyl)-X 1 , -CO 2 R′, -SO 2 NR′R′′, -S(O) 2 -R′, -CONR′R′′, -NR′-CO-R′′′, -NR′-S(O) 2 -R′′′, -CO-NR′-(C 1 -C 4 alkyl)-NR′R′′ and -CO-O-(C 1 -C 4 alkyl)-NR′R′′ and/or (b) 1, 2 or 3 unsubstituted substituents selected from -(C 1 -C 4 alkyl)-X 2 , halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, C 1 -C 4 hydroxyalkyl, hydroxy, cyano, nitro and -NR′R′′, wherein X 1 is -CO 2 R′, -SO 2 -R′, -NR′-CO 2 -R′′, -NR′-S(O) 2 -R′′′, -CONR′R′′ or -SO 2 -NR′R′′, each X 2 is the same or different and is cyano, nitro or -NR′R′′, each R′ and R′′ is the same or different and represents hydrogen or C 1 -C 4 alkyl and each R′′′ is the same or different and represents C 1 -C 4 alkyl.

7. 发明申请

WO2010103306A1 BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS ANTIVARAL AGENTS 审中-公开
标题翻译：苯并咪唑衍生物及其作为拮抗剂的用途
公开(公告)号：WO2010103306A1
公开(公告)日：2010-09-16
申请号：PCT/GB2010/050394
申请日：2010-03-09
申请人： ASTRAZENECA UK LIMITED , ARROW THERAPEUTICS LIMITED , BLADE, Helen , CARRON, Elisa, Ann , JACKSON, Heather, Marie , LUMLEY, James, Andrew , PILKINGTON, Christopher, John , TOMKINSON, Gary, Peter , THOMAS, Alexander, James, Floyd , WARNE, Justin
发明人： BLADE, Helen , CARRON, Elisa, Ann , JACKSON, Heather, Marie , LUMLEY, James, Andrew , PILKINGTON, Christopher, John , TOMKINSON, Gary, Peter , THOMAS, Alexander, James, Floyd , WARNE, Justin
IPC分类号： C07D403/06 , C07D471/04 , A61K31/517 , A61K31/519 , A61P31/14
CPC分类号： C07D403/06 , C07D471/04
摘要： The invention provides compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are as defined in the specification, and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory syncytial virus (RSV).
摘要翻译：本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本说明书中所定义，以及其旋光异构体，外消旋体和互变异构体，其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。该化合物可用于治疗呼吸道合胞病毒（RSV）。

8. 发明申请

WO2007080401A8 TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS 审中-公开
标题翻译：用作抗病毒剂的三唑烷基吡啶衍生物
公开(公告)号：WO2007080401A8
公开(公告)日：2008-07-24
申请号：PCT/GB2007000065
申请日：2007-01-11
申请人： ARROW THERAPEUTICS LTD , MATHEWS NEIL , THOMAS ALEXANDER JAMES FLOYD , SPENCER KEITH CHARLES , TIBERGHIEN NATHALIE , PILKINGTON CHRISTOPHER JOHN , JENNENS LYN , CHANA SURINDER , FRASER IAN JOHN
发明人： MATHEWS NEIL , THOMAS ALEXANDER JAMES FLOYD , SPENCER KEITH CHARLES , TIBERGHIEN NATHALIE , PILKINGTON CHRISTOPHER JOHN , JENNENS LYN , CHANA SURINDER , FRASER IAN JOHN
IPC分类号： C07D401/14 , A61K31/505 , A61P31/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： A quinazoline derivative of formula (I), or a pharmaceutically acceptable salt thereof: formula (I) for use in treatment of prevention of a flaviviridae infection.
摘要翻译：式（I）的喹唑啉衍生物或其药学上可接受的盐：用于治疗预防黄病毒科感染的式（I）。

9. 发明申请

WO2007138242A1 BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C 审中-公开
标题翻译：联苯衍生物及其在治疗乙型肝炎中的应用C
公开(公告)号：WO2007138242A1
公开(公告)日：2007-12-06
申请号：PCT/GB2007/001024
申请日：2007-03-21
申请人： ARROW THERAPEUTICS LIMITED , LUMLEY, James , SALTER, James, Iain , CARTER, Malcolm, Clive , MATHEWS, Neil , PILKINGTON, Christopher, John , THOMAS, Alexander, James, Floyd , FRASER, Ian
发明人： LUMLEY, James , SALTER, James, Iain , CARTER, Malcolm, Clive , MATHEWS, Neil , PILKINGTON, Christopher, John , THOMAS, Alexander, James, Floyd , FRASER, Ian
IPC分类号： C07D205/04 , C07D213/75 , C07D233/54 , C07D237/28 , C07D279/12 , C07D295/12 , C07D295/22 , C07D307/38 , C07D333/20 , C07D417/12 , A61K31/395 , A61K31/4433 , A61K31/381 , A61P31/12
CPC分类号： C07D205/04 , C07D213/75 , C07D233/54 , C07D237/28 , C07D279/12 , C07D295/22 , C07D307/38 , C07D333/20 , C07D417/12
摘要： Compounds of formula (I) are found to be active against HCV. wherein: R 1 is a moiety -A 1 -L 1 -A 1 ', -A 1 -L 1 -A 1 '-A 1 " or -A 1 -L 1 -A 1 '-Y 1 -A 1 "; A and B are the same or different and each represent a direct bond or a -CO- NR'-, -NR'-CO-, -NR'-CO-NR"-, -NR'-S(O) 2 -, -S(O) 2 -NR'- or -NR'- moiety, wherein R' and R" are the same or different and each represent hydrogen or C 1 -C 4 alkyl; R 2 and R 3 are the same or different and each represent C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 haloalkyl, C 1 -C 4 haloalkoxy, halogen, hydroxy, thio, -NR'R", -SO 2 -R'", -NR'-COR'" or -CO 2 R'", wherein R' and R" are the same or different and represent hydrogen or C 1 -C 4 alkyl and R'" represents C 1 -C 4 alkyl; n and m are the same or different and each represent 0, 1 or 2; R 4 is a C 1 -C 6 alkyl or C 1 -C 6 haloalkyl group or a moiety -A 4 , -A 4 -A 4 ', -L 4 -A 4 , -A 4 -L 4 -A 4 ', -A 4 -Het 4 -L 4 -Het 4 '-L 4 ' or -L 4 -Het 4 -L 4 ', - each A 1 , A 4 , A 1 ', A 1 " and A 4 ' are the same or different and represent a phenyl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl or C 3 -C 6 carbocyclyl moiety; each L 1 and L 4 is the same or different and represents a C 1 -C 4 alkylene or a C 1 -C 4 hydroxyalkylene group; - Y 1 represents -CO-NR'-, -CO-( C 1 -C 4 alkylene)-, -CO-( C 1 -C 4 alkylene)-NR'-, -NR'-CO-, -CO-, -O-CO- or -CO-O-, wherein R' is hydrogen or C 1 -C 4 alkyl; L 4 ' represents hydrogen or a C 1 -C 4 alkyl group; Het 4 and Het 4 ' are the same or different and represent -O-, -S- or -NR'-, wherein R' is hydrogen or a C 1 -C 4 alkyl group; the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R 1 and R 4 being unsubstituted or substituted by (a) a single unsubstituted substituent selected from -CO 2 R', -SO 2 NR"R', -S(O) 2 -R', -CONR"R", -COR'", -CO-CO-OR''', -CO-( C 1 -C 4 alkylene)-OR", -CO-( C 1 -C 4 alkylene)-NR"R", -CO-( C 1 -C 4 alkylene)-NR"-CO-R''', -CO- (C 1 -C 4 alkylene)-CO-NR"R", -CO-( C 1 -C 4 alkylene)-SO 2 -R'", -CO-( C 1 -C 4 alkylene)-O- (C 1 -C 4 alkylene)-OR", -CO-( C 1 -C 4 alkylene)-O-( C 1 -C 4 alkylene)-NR"R", -CO-( C 1 -C 4 alkylene)-NR"-( C 1 -C 4 alkylene)-OR", -CO-( C 1 -C 4 alkylene)-NR"-( C 1 -C 4 alkylene)- NR"R", -SO 2 -( C 1 -C 4 alkylene)-OR", -NR"-SO 2 -R'", -( C 1 -C 4 alkylene)-CO-( C 1 -C 4 alkylene)-CO
摘要翻译：发现式（I）化合物对HCV具有活性。其中：R 1是部分-A 1-SUB 1-SUB 1，-A _{1 1 1 1 1 →_{1 -A _{1 ' - ý_{1 -A _{1 “; A和B相同或不同，各自表示直接键或-CO-NR'-，-NR'-CO-，-NR'-CO-NR“ - ， - NR'-S（O）其中R'和R“相同或不同，各自表示氢或C 1 -C 6烷基， C 1 -C 4烷基; R 2和R 3相同或不同，各自表示C 1 -C 4烷基，C 1 -C 4烷基， C 1 -C 4烷基，C 1 -C 4烷基硫基，C 1 -C 4烷基，C 1 -C 4烷基，C 1 -C 4烷基， C 4卤代烷基，C 1 -C 4卤代烷氧基，卤素，羟基，硫代，-NR'R“，-SO 2 R''，“NR'-COR”或-CO 2 R“，其中R'和R”相同或不同，表示氢或C C 1 -C 4烷基，R 1'表示C 1 -C 4烷基; n和m相同或不同，各自表示0,1或2; R 4是C 1 -C 6烷基或C 1 -C 6烷基或C 1 -C 6 - >卤代烷基或部分-A 4 - ， - 4 - 4 - ， - 4 - ， - 4 - A 4 - ， - 4 - 4 - 4 - - - - - - - - - - - - - - - - - - - 4 4 4 4 4 4 4个 - 4个 - 4个 - 4个， - 每个A 1，A 4，A “1”，“A 1”和“A 4”相同或不同，表示苯基，5至10元杂芳基，5 至10元杂环基或C 3 -C 6碳环基部分;每个L 1和L 4是相同或不同，表示C 1 -C 4亚烷基或C 1 -C 4 - 羟基亚烷基 ; -Y 1表示-CO-NR'-，-CO-（C 1 -C 4亚烷基） - ， - （ - C 1 -C 4 - 亚烷基）-NR' - ， - NR'-CO - ， - CO - ， - O-CO-或-CO-O-，其中 R'是氢或C 1 -C 4 B>烷基; L 4表示氢或C 1 -C 4烷基; Het 4和Het 4相同或不同，表示-O - ， - S-或-NR'-，其中R'是氢或C _{1个-C 4烷基; R 1和R 4中的苯基，杂芳基，杂环基和碳环基部分是未取代的或被（a）单个未取代的取代基选自-CO 2， R“，-SO 2 NR”R“，-S（O）2 -R'，-CONR”R“，-COR'”， - CO-CO-OR“，-CO-（C 1 -C 4亚烷基）-OR”， - CO-（C 1 H 2） -C≡S亚烷基）-NR“R”，-CO-（C 1 -C 4亚烷基）-NR“-CO- -CO-（C 1 -C 4亚烷基）-CO-NR“R”， - CO-（C 1 -C 4） C 1 -C 4亚烷基）-SO 2 R“，-CO-（C 1 -C 4 - 亚烷基）亚烷基）-O-（C 1 -C 4亚烷基）-OR“， - CO-（C 1 -C 3 - 4个亚烷基）-O-（C 1 -C 4亚烷基）-NR“R”， - CO-（C 1}}}}}}

10. 发明申请

WO2007080401A1 TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS 审中-公开
标题翻译：用作抗病毒剂的三唑烷基吡啶衍生物
公开(公告)号：WO2007080401A1
公开(公告)日：2007-07-19
申请号：PCT/GB2007/000065
申请日：2007-01-11
申请人： ARROW THERAPEUTICS LIMITED , MATHEWS, Neil , THOMAS, Alexander, James, Floyd , SPENCER, Keith, Charles , TIBERGHIEN, Nathalie , PILKINGTON, Christopher, John , JENNENS, Lyn , CHANA, Surinder , FRASER, Ian, John
发明人： MATHEWS, Neil , THOMAS, Alexander, James, Floyd , SPENCER, Keith, Charles , TIBERGHIEN, Nathalie , PILKINGTON, Christopher, John , JENNENS, Lyn , CHANA, Surinder , FRASER, Ian, John
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , A61K31/505 , A61P31/14
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： A quinazoline derivative of formula (I), or a pharmaceutically acceptable salt thereof: formula (I) for use in treatment of prevention of a flaviviridae infection.
摘要翻译：式（I）的喹唑啉衍生物或其药学上可接受的盐：用于治疗预防黄病毒科感染的式（I）。

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