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1. 发明公开

EP2074145A2 HUMANIZED ANTIBODY AGAINST AMYLOID BETA 有权转让
标题翻译：人源化抗AMYLOID BETA抗体
公开(公告)号：EP2074145A2
公开(公告)日：2009-07-01
申请号：EP07867188.0
申请日：2007-10-02
申请人： AC Immune S.A. , Genentech, Inc. , Pfeifer, Andrea , Pihlgren, Maria , Muhs, Andreas , Watts, Ryan
发明人： PFEIFER, Andrea , PIHLGREN, Maria , MUHS, Andreas , WATTS, Ryan
IPC分类号： C07K16/18
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N33/6896
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of j3-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid- like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译：本发明涉及用于治疗和诊断用于治疗由淀粉状蛋白或淀粉状蛋白样蛋白引起或与其相关的疾病和病症的方法和组合物，所述疾病和病症包括淀粉状蛋白病，与淀粉状蛋白相关的一组病症和异常例如阿尔茨海默氏病。本发明提供了新颖的方法和组合物，其包含具有特异性识别和结合来自多种β淀粉样蛋白的特异性表位的能力的高度特异性和高效的抗体。通过本发明的教导实现的抗体对于治疗由淀粉状蛋白或淀粉样蛋白样蛋白引起的或与淀粉样蛋白样蛋白有关的疾病和病症特别有用，所述蛋白包括淀粉样变性，与淀粉状蛋白斑形成相关的一组疾病和病症，包括继发性淀粉样变性和年龄相关的淀粉样变性病，包括但不限于神经疾病如阿尔茨海默氏病（AD）。

2. 发明申请

WO2010106127A3 METHOD FOR THERAPEUTIC USE 审中-公开
标题翻译：治疗方法
公开(公告)号：WO2010106127A3
公开(公告)日：2011-03-31
申请号：PCT/EP2010053519
申请日：2010-03-18
申请人： AC IMMUNE SA , PFEIFER ANDREA , MUHS ANDREAS , PIHLGREN MARIA
发明人： PFEIFER ANDREA , MUHS ANDREAS , PIHLGREN MARIA
IPC分类号： C07K14/47 , A61K39/00 , A61P25/28
CPC分类号： C07K14/4711 , A61K39/0007 , A61K2039/55555 , A61K2039/6018
摘要： The present invention is related to methods for the therapeutic use in the treatment of diseases and disorders where T-helper independent antibody responses are beneficial. In particular, the present invention relates to a method wherein these diseases and disorders above are treated in immunocompromised or autoimmune diseased animals or humans. Even more particular the present invention relates to the treatment of Alzheimer's disease in immunocompromised or autoimmune diseased animals or humans or where inflammatory reactions need to be specifically avoided.
摘要翻译：本发明涉及治疗用于治疗T辅助者独立抗体应答有益的疾病和病症的方法。特别地，本发明涉及一种方法，其中在免疫受损或自身免疫疾病的动物或人中治疗上述这些疾病和病症。更具体地，本发明涉及在免疫受损或自身免疫疾病的动物或人中治疗阿尔茨海默病，或者需要特别避免炎症反应。

3. 发明申请

WO2010115843A3 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2010115843A3
公开(公告)日：2010-12-02
申请号：PCT/EP2010054418
申请日：2010-04-01
申请人： AC IMMUNE SA , LEUVEN K U RES & DEV , PFEIFER ANDREA , MUHS ANDREAS , VAN LEUVEN FRED , PIHLGREN MARIA
发明人： PFEIFER ANDREA , MUHS ANDREAS , VAN LEUVEN FRED , PIHLGREN MARIA
IPC分类号： A61K39/00 , C07K14/47 , C07K16/18 , G01N33/53
CPC分类号： C07K16/18 , A61K39/0005 , A61K2039/505 , A61K2039/6087 , C07K14/4711 , C07K2317/24 , G01N33/53 , G01N33/6896 , G01N2333/47 , G01N2800/2821 , G01N2800/52
摘要： The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical composition comprising an antigenic peptide, particularly an antigenic phospho-peptide mimicking a major pathological phospho-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease.
摘要翻译：本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结相关的疾病和病症的方法和药物组合物。具体而言，本发明涉及包含抗原肽，特别是模拟蛋白质tau的主要病理磷酸表位的抗原性磷酸肽的药物组合物，用于治疗和诊断用于治疗包括阿尔茨海默氏病的tau蛋白病。

4. 发明申请

WO2009048539A2 MONOCLONAL ANTIBODY 审中-公开
标题翻译：单克隆抗体
公开(公告)号：WO2009048539A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/011493
申请日：2008-10-03
申请人： GENENTECH, INC. , AC IMMUNE S.A , PIHLGREN, Maria , PFEIFER, Andrea , MUHS, Andreas , WATTS, Ryan
发明人： PFEIFER, Andrea , MUHS, Andreas , WATTS, Ryan
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies that specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies of the present invention are particularly useful for the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system, particularly those ocular diseases associated with amyloid-beta-related pathological abnormalities/changes in the tissues of the visual system.
摘要翻译：本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其特异性识别并结合来自β-淀粉样蛋白质范围的特异性表位。本发明的抗体特别可用于治疗与视觉系统的组织中的病理学异常/变化相关的眼部疾病，特别是与视觉上的淀粉样蛋白-β相关的病理学异常/组织中的变化相关的眼部疾病系统。

5. 发明申请

WO2010115843A2 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2010115843A2
公开(公告)日：2010-10-14
申请号：PCT/EP2010/054418
申请日：2010-04-01
申请人： AC Immune S.A. , K. U. Leuven Research & Development , PFEIFER, Andrea , MUHS, Andreas , VAN LEUVEN, Fred , PIHLGREN, Maria
发明人： PFEIFER, Andrea , MUHS, Andreas , VAN LEUVEN, Fred , PIHLGREN, Maria
IPC分类号： A61K39/00 , C07K14/47 , C07K16/18 , G01N33/53
CPC分类号： C07K16/18 , A61K39/0005 , A61K2039/505 , A61K2039/6087 , C07K14/4711 , C07K2317/24 , G01N33/53 , G01N33/6896 , G01N2333/47 , G01N2800/2821 , G01N2800/52
摘要： The present invention is related to methods and pharmaceutical compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to pharmaceutical composition comprising an antigenic peptide, particularly an antigenic phospho-peptide mimicking a major pathological phospho-epitope of protein tau, for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease.
摘要翻译：本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的药物组合物。特别地，本发明涉及药物组合物，其包含抗原肽，特别是模拟蛋白质tau的主要病理学磷酸化表位的抗原性磷酸肽，用于治疗和诊断用于治疗包括阿尔茨海默氏病的tau蛋白病。

6. 发明申请

WO2009048538A2 HUMANIZED ANTIBODY 审中-公开
标题翻译：人类抗体
公开(公告)号：WO2009048538A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/011492
申请日：2008-10-03
申请人： GENENTECH, INC. , AC IMMUNE S.A , PIHLGREN, Maria , PFEIFER, Andrea , MUHS, Andreas , WATTS, Ryan
发明人： PFEIFER, Andrea , MUHS, Andreas , WATTS, Ryan
IPC分类号： C07K14/43
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies that specifically recognize and bind to specific epitopes from a range of ?-amyloid proteins. The antibodies of the present invention are particularly useful for the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system, particularly associated with amyloid-beta-related pathological abnormalities/changes in the tissues of the visual system.
摘要翻译：本发明提供包含高度特异性和高效抗体的新型方法和组合物，其特异性识别并结合来自β-淀粉样蛋白质范围的特异性表位。本发明的抗体特别可用于治疗与视觉系统的组织中的病理学异常/变化相关的眼部疾病，特别是与视觉系统的组织中淀粉样蛋白-β相关的病理学异常/变化相关。

7. 发明申请

WO2008156622A1 HUMANIZED ANTIBODIES TO AMYLOID BETA 审中-公开
标题翻译：人体抗体对AMYLOID BETA
公开(公告)号：WO2008156622A1
公开(公告)日：2008-12-24
申请号：PCT/US2008007318
申请日：2008-06-12
申请人： AC IMMUNE SA , GENENTECH INC , PFEIFER ANDREA , PIHLGREN MARIA , MUHS ANDREAS , WATTS RYAN
发明人： PFEIFER ANDREA , PIHLGREN MARIA , MUHS ANDREAS , WATTS RYAN
IPC分类号： A61K39/395 , A61P25/28 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present application is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
摘要翻译：本申请涉及嵌合和人源化抗体以及用于治疗和诊断用途的方法和组合物，用于治疗淀粉样变性，一类与阿尔茨海默病等淀粉样蛋白相关的疾病和异常。

8. 发明申请

WO2012045882A2 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2012045882A2
公开(公告)日：2012-04-12
申请号：PCT/EP2011/067604
申请日：2011-10-07
申请人： AC IMMUNE S.A. , K. U. LEUVEN RESEARCH & DEVELOPMENT , PFEIFER, Andrea , MUHS, Andreas , VAN LEUVEN, Fred , PIHLGREN, Maria , ADOLFSSON, Oskar
发明人： PFEIFER, Andrea , MUHS, Andreas , VAN LEUVEN, Fred , PIHLGREN, Maria , ADOLFSSON, Oskar
IPC分类号： C07K16/18 , G01N33/68 , A61K39/00
CPC分类号： C07K16/18 , A61K39/0005 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
摘要翻译：本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的方法和组合物。特别地，本发明涉及特异性识别和结合磷酸化病理蛋白质tau-构象异构体的抗体以及涉及治疗和诊断用于治疗包括阿尔茨海默病（AD）在内的tau蛋白病的治疗和诊断用途的所述抗体的方法和组合物。

9. 发明申请

WO2008060364A3 HUMANI ZED ANTIBODY AGAINST AMYLOID BETA 审中-公开
标题翻译：人类抗体抗体对AMYLOID BETA
公开(公告)号：WO2008060364A3
公开(公告)日：2009-02-19
申请号：PCT/US2007021134
申请日：2007-10-02
申请人： AC IMMUNE SA , GENENTECH INC , PFEIFER ANDREA , PIHLGREN MARIA , MUHS ANDREAS , WATTS RYAN
发明人： PFEIFER ANDREA , PIHLGREN MARIA , MUHS ANDREAS , WATTS RYAN
IPC分类号： C07K16/18 , A61P25/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of j3-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid- like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译：本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组病症和异常，例如阿尔茨海默氏病。本发明提供包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列j3-淀粉样蛋白质的特异性表位的能力。通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或类淀粉样蛋白引起的疾病和病症，包括淀粉样变性，与淀粉样蛋白斑形成有关的一组疾病和病症，包括继发性淀粉样变性和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

10. 发明专利

SG185277A1 HUMANIZED ANTIBODY 未知
公开(公告)号：SG185277A1
公开(公告)日：2012-11-29
申请号：SG2012074142
申请日：2008-10-03
申请人： GENENTECH INC , AC IMMUNE SA , PIHLGREN MARIA
发明人： PFEIFER ANDREA , MUHS ANDREAS , WATTS RYAN , PIHLGREN MARIA
摘要： The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies that specifically recognize and bind to specific epitopes from a range of ß-amyloid proteins. The antibodies of the present invention are particularly useful for the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system, particularly associated with amyloid-beta-related pathological abnormalities/changes in the tissues of the visual system.No Suitable Figure

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