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1. 发明申请

WO2008051432A2 PATTERNING OF IONOTROPIC POLYMERS 审中-公开
标题翻译：离子聚合物的构图
公开(公告)号：WO2008051432A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022219
申请日：2007-10-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LAHAV, Michal , WINKLEMAN, Adam , NAROVLYANSKY, Max , PEREZ-CASTILLEJOS, Raquel , WEISS, Emily, A. , RODRIGUEZ, Leonard, N. J. , WHITESIDES, George, M.
发明人： LAHAV, Michal , WINKLEMAN, Adam , NAROVLYANSKY, Max , PEREZ-CASTILLEJOS, Raquel , WEISS, Emily, A. , RODRIGUEZ, Leonard, N. J. , WHITESIDES, George, M.
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag + , Ca 2+ , Pd 2+ , Al 3+ , La 3+ , and Ti 4+ ) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以通过使交联剂溶液（例如，金属阳离子如Ag 2+，Ca 2+，Pd 2+， 2+，3+，3+，3+，和3++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 与溶液接触。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

2. 发明申请

WO2009006409A2 DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 审中-公开
标题翻译：基于密度的方法分离材料，监测固体支撑反应和测量小液体体积和固体密度
公开(公告)号：WO2009006409A2
公开(公告)日：2009-01-08
申请号：PCT/US2008068797
申请日：2008-06-30
申请人： HARVARD COLLEGE , PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
发明人： PHILLIPS SCOTT T , WHITESIDES GEORGE M , MIRICA KATHERINE A , CARRILHO EMANUEL , MARTINEZ ANDRES W , SHEVKOPLYAS SERGEY S , SNYDER PHILLIP W , PEREZ-CASTILLEJOS RAQUEL , GUPTA MALANCHA , WINKLEMAN ADAM , GUDIKSEN KATHERINE L
IPC分类号： G01N33/53
CPC分类号： G01N33/5434 , B01L3/502761 , B01L3/502776 , B01L3/50825 , B01L2200/0652 , B01L2300/045 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , G01N33/54333 , G01R33/1269
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.
摘要翻译：描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。

3. 发明申请

WO2009061392A1 FORMING GEL STRUCTURES USING MICROFLUIDIC CHANNELS 审中-公开
标题翻译：使用微流通道形成凝胶结构
公开(公告)号：WO2009061392A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/012445
申请日：2008-11-04
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WONG, Amy, P. , PEREZ-CASTILLEJOS, Raquel , LOVE, J., Christopher , WHITESIDES, George, M.
发明人： WONG, Amy, P. , PEREZ-CASTILLEJOS, Raquel , LOVE, J., Christopher , WHITESIDES, George, M.
IPC分类号： B01L3/00 , C12M3/00
CPC分类号： C12N5/0062 , B01L3/502707 , B01L2200/0636 , B01L2200/0647 , B01L2300/069 , C12M23/16 , C12M25/14 , C12N2533/90 , C12N2535/10
摘要： Articles and methods for forming structures in microfluidic channels are provided. Methods described herein may include the use of spatially-defined flows of fluid within microchannels to form portions of gel (e.g., gel structures) inside the microchannels. The gel structures may be formed by flowing, e.g., laminarly, one or more streams of fluid in a microfluidic channel, at least one of the streams including a gel precursor. The stream(s) of gel precursor can be polymerized to form one or more gel structures by various methods such as by application of heat. Advantageously, the dimensions of the gel structures may be varied, for example, by applying different flow rates to the fluid streams, choosing different viscosities of the fluids, and/or by varying the dimensions of the microchannel. Using such methods, different configurations of gel structures in microfluidic channels can be formed. Gel structures having different components encapsulated therein may also be formed. Articles and methods described herein may involve, in some embodiments, i) culturing cells within or on surfaces of the gel portions, ii) patterning different types of cells on or in adjacent gel structures, and/or iii) applying gradients of soluble factors across the cell-containing gel portions. Such structures may be used for studying intercellular communication between cells cultured within biologically-derived, 3-D matrices of microscopic size.
摘要翻译：提供了在微流体通道中形成结构的制品和方法。本文描述的方法可以包括在微通道内使用空间限定的流体流，以在微通道内部形成凝胶（例如，凝胶结构）的部分。凝胶结构可以通过在微流体通道中流动（例如，层流）一种或多种流体流而形成，至少一种流包括凝胶前体。凝胶前体的流可以通过各种方法例如通过加热来聚合以形成一种或多种凝胶结构。有利地，凝胶结构的尺寸可以例如通过对流体流施加不同的流速，选择不同的流体粘度和/或通过改变微通道的尺寸来改变。使用这种方法，可以形成微流体通道中凝胶结构的不同构型。也可以形成具有封装在其中的不同组分的凝胶结构。在一些实施方案中，文章和方法可能涉及i）在凝胶部分内或表面上培养细胞，ii）在相邻凝胶结构上或相邻凝胶结构中构图不同类型的细胞，和/或iii）将可溶性因子的梯度跨越含有细胞的凝胶部分。这种结构可用于研究在微观尺寸的生物衍生的3-D基质内培养的细胞之间的细胞间通信。

4. 发明申请

WO2008051432A3 PATTERNING OF IONIC POLYMERS 审中-公开
标题翻译：离子聚合物的构图
公开(公告)号：WO2008051432A3
公开(公告)日：2009-04-09
申请号：PCT/US2007022219
申请日：2007-10-18
申请人： HARVARD COLLEGE , LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
发明人： LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与解决方案。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

5. 发明申请

WO2009006409A3 DENSITY-BASED METHODS FOR SEPARATION OF MATERIALS, MONITORING OF SOLID SUPPORTED REACTIONS AND MEASURING DENSITIES OF SMALL LIQUID VOLUMES AND SOLIDS 审中-公开
公开(公告)号：WO2009006409A3
公开(公告)日：2009-01-08
申请号：PCT/US2008/068797
申请日：2008-06-30
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , PHILLIPS, Scott, T. , WHITESIDES, George, M. , MIRICA, Katherine, A. , CARRILHO, Emanuel , MARTINEZ, Andres, W. , SHEVKOPLYAS, Sergey, S. , SNYDER, Phillip, W. , PEREZ-CASTILLEJOS, Raquel , GUPTA, Malancha , WINKLEMAN, Adam , GUDIKSEN, Katherine, L.
发明人： PHILLIPS, Scott, T. , WHITESIDES, George, M. , MIRICA, Katherine, A. , CARRILHO, Emanuel , MARTINEZ, Andres, W. , SHEVKOPLYAS, Sergey, S. , SNYDER, Phillip, W. , PEREZ-CASTILLEJOS, Raquel , GUPTA, Malancha , WINKLEMAN, Adam , GUDIKSEN, Katherine, L.
IPC分类号： B01D35/06
摘要： The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.

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