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1. 发明专利

TW201834386A 用於結合杜赫放大器訊號與90度集總與分散式阻抗反相器的方法审中-公开
简体标题：用于结合杜赫放大器信号与90度集总与分佈式阻抗反相器的方法
公开(公告)号：TW201834386A
公开(公告)日：2018-09-16
申请号：TW107103816
申请日：2018-02-02
申请人：布伊斯吉拉德 , BOUISSE, GERARD , 亞利桑德安德魯 , ALEXANDER, ANDREW , 佩特森安德魯 , PATTERSON, ANDREW
发明人：布伊斯吉拉德 , BOUISSE, GERARD , 亞利桑德安德魯 , ALEXANDER, ANDREW , 佩特森安德魯 , PATTERSON, ANDREW
IPC分类号： H03F1/42 , H03F1/56
摘要：說明用於操作在千兆赫頻率下的經修改杜赫放大器的設備與方法。來自主放大器與峰化放大器的訊號的結合，發生在放大器輸出對負載的阻抗匹配之前。可在阻抗反相器中使用整合分散式電感器以結合訊號。可在製造期間內藉由圖案化選定阻抗元件的尺寸，以調諧放大器並允許放大器的功率縮放。
简体摘要：说明用于操作在千兆赫频率下的经修改杜赫放大器的设备与方法。来自主放大器与峰化放大器的信号的结合，发生在放大器输出对负载的阻抗匹配之前。可在阻抗反相器中使用集成分佈式电感器以结合信号。可在制造期间内借由图案化选定阻抗组件的尺寸，以调谐放大器并允许放大器的功率缩放。

2. 发明专利

TW201836262A 90度集總與分散式杜赫阻抗反相器审中-公开
简体标题： 90度集总与分佈式杜赫阻抗反相器
公开(公告)号：TW201836262A
公开(公告)日：2018-10-01
申请号：TW107103832
申请日：2018-02-02
申请人：布伊斯吉拉德 , BOUISSE, GERARD , 亞利桑德安德魯 , ALEXANDER, ANDREW , 佩特森安德魯 , PATTERSON, ANDREW
发明人：布伊斯吉拉德 , BOUISSE, GERARD , 亞利桑德安德魯 , ALEXANDER, ANDREW , 佩特森安德魯 , PATTERSON, ANDREW
IPC分类号： H03F1/02 , H03F1/56 , H03F3/21
摘要：說明用於操作在千兆赫頻率下的經修改杜赫放大器的設備與方法。來自主放大器與峰化放大器的訊號的結合，發生在放大器輸出對負載的阻抗匹配之前。可在阻抗反相器中使用整合分散式電感器以結合訊號。可在製造期間內藉由圖案化選定阻抗元件的尺寸，以調諧放大器並允許放大器的功率縮放。
简体摘要：说明用于操作在千兆赫频率下的经修改杜赫放大器的设备与方法。来自主放大器与峰化放大器的信号的结合，发生在放大器输出对负载的阻抗匹配之前。可在阻抗反相器中使用集成分佈式电感器以结合信号。可在制造期间内借由图案化选定阻抗组件的尺寸，以调谐放大器并允许放大器的功率缩放。

3. 发明专利

TW201832461A 90度集總與分散式杜赫阻抗反相器审中-公开
简体标题： 90度集总与分佈式杜赫阻抗反相器
公开(公告)号：TW201832461A
公开(公告)日：2018-09-01
申请号：TW107103822
申请日：2018-02-02
申请人：布伊斯吉拉德 , BOUISSE, GERARD , 亞利桑德安德魯 , ALEXANDER, ANDREW , 佩特森安德魯 , PATTERSON, ANDREW
发明人：布伊斯吉拉德 , BOUISSE, GERARD , 亞利桑德安德魯 , ALEXANDER, ANDREW , 佩特森安德魯 , PATTERSON, ANDREW
IPC分类号： H03F1/07
摘要：說明用於操作在千兆赫頻率下的經修改杜赫放大器的設備與方法。來自主放大器與峰化放大器的訊號的結合，發生在放大器輸出對負載的阻抗匹配之前。可在阻抗反相器中使用整合分散式電感器以結合訊號。可在製造期間內藉由圖案化選定阻抗元件的尺寸，以調諧放大器並允許放大器的功率縮放。
简体摘要：说明用于操作在千兆赫频率下的经修改杜赫放大器的设备与方法。来自主放大器与峰化放大器的信号的结合，发生在放大器输出对负载的阻抗匹配之前。可在阻抗反相器中使用集成分佈式电感器以结合信号。可在制造期间内借由图案化选定阻抗组件的尺寸，以调谐放大器并允许放大器的功率缩放。

4. 发明专利

CA2631371A1 COMPACT MANIFOLDED FAIL-SAFE HYDRAULIC CONTROL SYSTEM 未知
公开(公告)号：CA2631371A1
公开(公告)日：2009-04-30
申请号：CA2631371
申请日：2008-05-15
申请人： PATTERSON ANDREW JOHN
发明人： PATTERSON ANDREW JOHN
IPC分类号： F16K31/124 , F16K17/10 , F16K17/168 , F16K31/143 , F17D3/00 , F17D5/00
摘要： A manifolded fail-safe hydraulic control system provides fail-safe operation of a pipeline valve using no more than a total of 45 proprietary parts in the system. The system controls the operation of a spring return actuator, which in turn strokes the pipeline valve from the normal operating position to the fail-safe position, or from the fail-safe position to the normal operating position. The system enables the valve to automatically stroke to its fail-safe position without external power.

5. 发明专利

GB190610631A Improvements in Clock Controlled Apparatus for Checking Watchmen and the like 未知
公开(公告)号：GB190610631A
公开(公告)日：1906-11-15
申请号：GB190610631D
申请日：1906-05-07
申请人： PATTERSON ANDREW VINCENT
发明人： PATTERSON ANDREW VINCENT
摘要： 10,631. Patterson, A. V. May 7. Tell-tale clocks for checking watchmen &c. At predetermined times, the clock completes electric alarm circuits unless the watchman on his round operates other contacts in the circuits, means being provided for rendering a fixing of the contact by the watchmen ineffectual. The hour spindle of the clock carries two wheels C, C' which are loose upon it, are weighted so as to return to the same position when free, and have each a projecting pin for contacting in a given position with one of the depending arms E, E in the alarm bell circuit. Moving with the clock spindle but feathered to slide thereon is a clutch member D, which normally, when the electromagnet H is de-energized, is in gear with wheel C, but when this wheel has turned so far that its pin strikes the contact arm, the alarm circuit is completed and the electro-magnet therein attracts its armature to move the clutch momentarily into gear with the wheel C'. If, however, the distant contact in the circuit has previously been made by the watchman, the armature and clutch will move in the same way, and should this contact be held down, the pin on the wheel C' will also cause the bell to ring after a time. If the clock is to control a number of alarms, as many wheels C may be employed, or with a single wheel a circuit-determining dial G may be combined, whereby the movement of the hour-hand determines at any time which circuit shall be completed by a contact with the arm E.

6. 发明专利

CA89900A LEVEL AND PLUMB 未知
公开(公告)号：CA89900A
公开(公告)日：1904-11-08
申请号：CA89900D
申请日：1904-08-24
申请人： PATTERSON ANDREW J
发明人： PATTERSON ANDREW J

7. 发明专利

CA2535326C COMPACT MANIFOLDED FAIL-SAFE HYDRAULIC CONTROL SYSTEM 未知
公开(公告)号：CA2535326C
公开(公告)日：2009-10-06
申请号：CA2535326
申请日：2005-11-18
申请人： PATTERSON ANDREW JOHN
发明人： PATTERSON ANDREW JOHN
IPC分类号： F15B20/00 , F15B1/04 , F15B1/26 , F16K17/10 , F16K27/00 , F16K31/122 , F16K31/143
摘要： A manifolded fail-safe hydraulic control system provides fail-safe operation of a pipeline valve using no more than a total of 45 proprietary parts in the system. The system controls the operation of a spring return actuator, which in turn strokes the pipeline valve from the normal operating position to the fail-safe position, or from the fail-safe position to the normal operating position. The system enables the valve to automatically stroke to its fail-safe position without external power.

8. 发明专利

CA2535326A1 COMPACT MANIFOLDED FAIL SAFE HYDRAULIC CONTROL SYSTEM 未知
公开(公告)号：CA2535326A1
公开(公告)日：2007-05-18
申请号：CA2535326
申请日：2005-11-18
申请人： PATTERSON ANDREW JOHN
发明人： PATTERSON ANDREW JOHN
IPC分类号： F16K31/122 , F15B1/04 , F15B1/26 , F15B20/00 , F16K17/10 , F16K27/00 , F16K31/143
摘要： The compact manifolded hydraulic fail safe control system is used to control the operation of a spring return actuator which in turn strokes the pipeline valve from the normal operating position to the fail safe position, or from the fail safe position to the normal operating position. The 2-way dump valve opens to circulate the spring return actuator's cylinder volume t o the reservoir. The pipeline valve will automatically stroke to the required fail-safe position Without an external power source. Pipeline valves operated with quarterturn or linear type sprin g return actuators can be operated using the manifolded hydraulic fail safe control system. The 2-w ay dump valve is opened when the regulated signal pressure is removed. The manifolded hydraul ic fail safe control system incorporates a regulated signal pressure circuit and a pressu re circuit maintained at the actuator operating pressure. The regulated signal pressure to the 2-way dump valve is removed when pipeli ne pressure exceeds the 3-way pressure pilot's high or low set-point. Likewise the 2-way dump valve regulated signal pressure is removed when the 3-way S.C.A.D.A. valve receive s a signal. When the 2-way dump valve is opened the spring return actuator cylinder volume is circulated to the reservoir across the regulator (pressure regulated cylinder dump) or across a diffuser (high--pressure cylinder dump). High pressure and low-pressure relief valves are used to limit system pressu re upstream and downstream of the regulator. A low-pressure accumulator is provided to accommodate ambient temperature fluctuations. The hydraulic fail-safe control system can be reset, or "re-charged", by han d pumping in order to refill the spring return actuator cylinder volume and return the pipeline valve to it's normal operating position. The 2-way dump valve's lever is first rotated to the horizontal plane, from the vertical plane. Then the manual hand pump is cycled until the spring return actuator and pipeline valve have returned to their normal operating positions. Alternatively an electrically powered pump enclosed in the reservoir can also be used to reset the system. The system is reset when the 2-way dump valve's latch lever automatically repositions itself in the vertical plane and the line valve is in the normal operating position. When reset the system is able to monitor pipeline pressure and process conditions. The pipeline valve s' fail-safe valve position can be achieved manually by applying axial hand force to the 2-way dump valve lever. This hand force acts against 2-way dump valve internal pressure tomanually open the dump valve. All of the fail-safe hydraulic control system proprietary components are assembled and/or installed into a single pressurized manifold.

9. 发明申请

WO2015051044A3 NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE 审中-公开
标题翻译：用于RNA干扰的有机化合物的新形式
公开(公告)号：WO2015051044A3
公开(公告)日：2015-07-02
申请号：PCT/US2014058703
申请日：2014-10-01
申请人： NOVARTIS AG , BARYZA JEREMY LEE , BLOMMERS MARCEL , FERNANDEZ CESAR , GENO ERIN , GOSSERT ALVAR , GREENIDGE PAULETTE , HUESKEN DIETER , HUNZIKER JUERG , NATT FRANCIOS JEAN-CHARLES , PATNAIK ANUP , PATTERSON ANDREW , RONDEAU JEAN-MICHEL RENE , WEILER JAN , ZHU MEICHENG
发明人： BARYZA JEREMY LEE , BLOMMERS MARCEL , FERNANDEZ CESAR , GENO ERIN , GOSSERT ALVAR , GREENIDGE PAULETTE , HUESKEN DIETER , HUNZIKER JUERG , NATT FRANCIOS JEAN-CHARLES , PATNAIK ANUP , PATTERSON ANDREW , RONDEAU JEAN-MICHEL RENE , WEILER JAN , ZHU MEICHENG
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3515 , C12N2310/3521 , C12N2310/3525 , C12N2310/3533
摘要： The disclosure relates to compositions comprising a RNAi agent having a novel format. These RNAi agents comprise a sense and an anti-sense strand, each strand being an 18-mer and the strands together forming a blunt-ended duplex, wherein the 3' end of at least one strand terminates in a phosphate or modified internucleoside linker and further comprises, in 5' to 3' order: a spacer; a second phosphate or modified internucleoside linker; and a 3' end cap. In some embodiments, the 3' end of both the sense and anti-sense strand further comprise, in 5' to 3' order: a spacer; a second phosphate or modified internucleoside linker; and a 3' end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3' end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the first two base-pairing nucleotides on the 3' end of the sense and/or anti-sense strand are 2'-MOE. Optionally, the RNAi agent can be modified on one or both 5' end. Optionally, the sense strand can comprise a 5' end cap which reduces the amount of the RNA interference mediated by this strand. Optionally, the RNAi agent is attached to a ligand. This format can be used to devise RNAi agents to a variety of different targets and sequences. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.
摘要翻译：本公开涉及包含具有新颖形式的RNAi剂的组合物。这些RNAi剂包含有义链和反义链，每条链都是18聚体，并且链一起形成平头双链体，其中至少一条链的3'末端终止于磷酸盐或修饰的核苷间连接体并且进一步包括按照5'至3'的顺序：间隔物; 第二磷酸盐或修饰的核苷间连接体; 和3'端盖。在一些实施方案中，有义链和反义链两者的3'末端还以5'至3'的顺序包含：间隔子; 第二磷酸盐或修饰的核苷间连接体; 和3'端盖。两条链可以具有相同或不同的间隔区，磷酸盐或修饰的核苷间接头，和/或3'端帽。链可以是核糖核苷酸，或者任选地，一个或多个核苷酸可以被修饰或取代。任选地，至少一个核苷酸包含修饰的核苷间连接体。任选地，有义链和/或反义链的3'末端上的前两个碱基配对核苷酸是2'-MOE。任选地，RNAi剂可以在一个或两个5'末端被修饰。任选地，有义链可以包含5'端帽，其减少由该链介导的RNA干扰的量。任选地，RNAi剂附着于配体。该格式可用于将RNAi试剂设计为多种不同的靶标和序列。本公开还涉及制备这种组合物的方法，以及这些组合物的方法和用途，例如介导RNA干扰。

10. 发明申请

WO2015051135A2 ORGANIC COMPOSITIONS TO TREAT HEPCIDIN-RELATED DISEASES 审中-公开
标题翻译：有机组合物治疗与肝素相关的疾病
公开(公告)号：WO2015051135A2
公开(公告)日：2015-04-09
申请号：PCT/US2014/058851
申请日：2014-10-02
申请人： NOVARTIS AG , BARYZA, Jeremy Lee , BLOMMERS, Marcel , BORLAND, Todd , FERNANDEZ, Cesar , GEBUHR, Tom , GENO, Erin , GOSSERT, Alvar , GREENIDGE, Paulette , HUESKEN, Dieter , HUNZIKER, Juerg , NATT, Francois Jean-Charles , PATNAIK, Anup , PATTERSON, Andrew , RONDEAU, Jean-Michel Rene , SOLOMON, Jonathan , WEILER, Jan , ZHU, Meicheng
发明人： BARYZA, Jeremy Lee , BLOMMERS, Marcel , BORLAND, Todd , FERNANDEZ, Cesar , GEBUHR, Tom , GENO, Erin , GOSSERT, Alvar , GREENIDGE, Paulette , HUESKEN, Dieter , HUNZIKER, Juerg , NATT, Francois Jean-Charles , PATNAIK, Anup , PATTERSON, Andrew , RONDEAU, Jean-Michel Rene , SOLOMON, Jonathan , WEILER, Jan , ZHU, Meicheng
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/351 , C12N2320/51
摘要： The present disclosure relates to methods of treating Hepcidin-related diseases such as anemia, iron-deficient erythropoiesis, hypoferremia, impaired dietary iron uptake, iron sequestration, anemia of inflammation (AI) (sometimes designated anemia of chronic disease or ACD), atherosclerosis, diabetes, and multiple neurodegenerative disorders such as Alzheimers disease, Parkinsons disease and Friedrichs ataxia, heart failure, chronic kidney disease, cardiorenal-anemia syndrome, infection, blood loss, hemolysis, vitamin B12 or folate deficiency, hyperparathyroidism, hemoglobinopathies and malignancies, cancer, AIDS, surgery, runted growth, and hair loss, using a therapeutically effective amount of a RNAi agent to Hepcidin.
摘要翻译：本公开涉及治疗肝细胞因子相关疾病如贫血，缺铁性红细胞生成素，低铁血症，膳食铁吸收受损，铁螯合，炎症性贫血（AI）（有时称为慢性疾病或ACD的贫血），动脉粥样硬化，糖尿病和多种神经变性疾病如阿尔茨海默病，帕金森病和弗里德里希共济失调，心力衰竭，慢性肾脏疾病，心肾贫血综合征，感染，失血，溶血，维生素B12或叶酸缺乏，甲状旁腺功能亢进，血红蛋白病和恶性肿瘤，艾滋病，手术，发育不良和脱发，使用治疗有效量的RNAi剂对Hepcidin。

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