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1. 发明专利

IL238571D0 Bruton's tyrosine kinase inhibitors 未知
公开(公告)号：IL238571D0
公开(公告)日：2015-06-30
申请号：IL23857115
申请日：2015-04-30
申请人： PFIZER , JOHN ROBERT SPRINGER , BALEKUDRU DEVADAS , DANNY JAMES GARLAND , MARGARET LANAHAN GRAPPERHAUS , SEUNGIL HAN , SUSAN LANDIS HOCKERMAN , ROBERT OWEN HUGHES , EDDINE SAIAH , MARK EDWARD SCHNUTE , SHAUN RAJ SELNESS , DANIEL PATRICK WALKER , ZHAO KUI WAN , LI XING , CHRISTOPH WOLFGANG ZAPF , MICHELLE ANN SCHMIDT
IPC分类号： C07K20060101
摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

2. 外观设计

USD552717S1 Pull out wand 有权
标题翻译：拉出魔杖
公开(公告)号：USD552717S1
公开(公告)日：2007-10-09
申请号：US29233433
申请日：2005-07-01
申请人： Jonathan Wood , Charles Molina , Scott Cline , Patrick Walker
设计人： Jonathan Wood , Charles Molina , Scott Cline , Patrick Walker

3. 发明授权

US07176198B2 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease 失效
标题翻译： 1H-吡唑和1H-吡咯 - 氮杂双环化合物用于治疗疾病
公开(公告)号：US07176198B2
公开(公告)日：2007-02-13
申请号：US10627140
申请日：2003-07-25
申请人： David W. Piotrowski , Eric Jon Jacobsen , Brad A. Acker , Daniel Patrick Walker , Donn G. Wishka , Vincent E. Groppi, Jr.
发明人： David W. Piotrowski , Eric Jon Jacobsen , Brad A. Acker , Daniel Patrick Walker , Donn G. Wishka , Vincent E. Groppi, Jr.
IPC分类号： A61K31/381 , A61K31/55 , A61K31/444 , C07D221/02 , C07D223/14
CPC分类号： C07D471/08 , C07D453/02
摘要： The invention provides compounds of Formula I: wherein Azabicyclo is where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved.
摘要翻译：本发明提供了式I的化合物：其中氮杂双环是变量具有本文所讨论的定义的位置。这些化合物可以是药物盐或组合物的形式，可以是纯对映体形式或外消旋混合物，并且可用于药物以治疗其中已知α7的疾病或病症。

4. 发明授权

US06919359B2 Azabicyclic-substituted-heteroaryl compounds for the treatment of disease 失效
标题翻译：用于治疗疾病的氮杂双环取代的杂芳基化合物
公开(公告)号：US06919359B2
公开(公告)日：2005-07-19
申请号：US10288863
申请日：2002-11-06
申请人： David W. Piotrowski , Jason K. Myers , Bruce N. Rogers , Eric Jon Jacobsen , Alice L. Bodnar , Vincent E. Groppi, Jr. , Daniel Patrick Walker , Brad A. Acker
发明人： David W. Piotrowski , Jason K. Myers , Bruce N. Rogers , Eric Jon Jacobsen , Alice L. Bodnar , Vincent E. Groppi, Jr. , Daniel Patrick Walker , Brad A. Acker
IPC分类号： A61K31/407 , A61K31/422 , A61K31/427 , A61K31/4439 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/44 , C07D409/04
CPC分类号： C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/08 , C07D487/08
摘要： The invention provides compounds of Formula I: Azabicyclo-N(R1)—C(═X)—W Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which α7 is known to be involved.
摘要翻译：本发明提供了式I的化合物：<β在线式描述=“在线式”末端=“铅”→氮杂双环-N（R 1 H）-C（-X） -W Formula I <？in-line-formula description =“In-line Formulas”end =“tail”？>这些化合物可以是药物盐或组合物，外消旋混合物或其纯对映异构体的形式。式I的化合物可用于已知其中涉及α7的药物中。

5. 发明授权

US06869946B2 Substituted azabicyclic moieties for the treatment of disease 失效
标题翻译：用于治疗疾病的取代的氮杂双环部分
公开(公告)号：US06869946B2
公开(公告)日：2005-03-22
申请号：US10124145
申请日：2002-04-17
申请人： Eric Jon Jacobsen , Daniel Patrick Walker , Jason K. Myers , David W. Piotrowski , Vincent E. Groppi, Jr.
发明人： Eric Jon Jacobsen , Daniel Patrick Walker , Jason K. Myers , David W. Piotrowski , Vincent E. Groppi, Jr.
IPC分类号： A61K31/407 , A61K31/4375 , A61K31/55 , A61P25/00 , A61P25/28 , C07D453/02 , C07D471/08 , C07D487/08 , A61K31/44
CPC分类号： C07D471/08 , C07D453/02 , C07D487/08
摘要： The invention provides compounds of Formula I: wherein m1 is 0 or 1; m2 is 1 or 2; R1 is —H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or phenyl; R2 is —H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or phenyl, provided that when m1 is 1 at least one of R1 and R2 is —H; or a pharmaceutically acceptable salt, pharmaceutical composition, a pure enantiomer or racemic mixture thereof. The invention also provides a method for treating a disease or condition in a mammal, wherein the α7 nicotinic acetylcholine receptor is implicated and for treating diseases where there is a sensory-gating deficit in a mammal comprising administering to a mammal a therapeutically effective amount of a compound of Formula I. These compounds may be in the form of pharmaceutical salts or compositions, and may be in pure enantiomeric form or may be racemic mixtures.
摘要翻译：本发明提供式I化合物：其中m 1为0或1; m 2为1或2; R 1为-H，烷基，卤代烷基，取代的烷基，环烷基或苯基; R 2为-H，烷基，卤代烷基，取代的烷基，环烷基或苯基，条件是当m 1为1时，R 1和R 2中的至少一个为-H; 或其药学上可接受的盐，药物组合物，纯对映体或外消旋混合物。本发明还提供了一种治疗哺乳动物疾病或病症的方法，其中所述α7烟碱乙酰胆碱受体涉及并用于治疗哺乳动物感觉门控缺陷的疾病，包括向哺乳动物施用治疗有效量的式I化合物。这些化合物可以是药物盐或组合物的形式，并且可以是纯对映体形式或可以是外消旋混合物。

6. 发明申请

US20050047806A1 Xerographic development system where a gap between a donor member and a photoreceptor is estimated 有权
公开(公告)号：US20050047806A1
公开(公告)日：2005-03-03
申请号：US10650861
申请日：2003-08-28
申请人： Song-Feng Mo , Wendy Apton , Stephen Randall , Patrick Walker
发明人： Song-Feng Mo , Wendy Apton , Stephen Randall , Patrick Walker
IPC分类号： G03G21/00 , G03G15/06 , G03G15/08 , G03G15/09
CPC分类号： G03G15/065 , G03G15/0806 , G03G15/0928
摘要： In a hybrid jumping (HJD) or hybrid scavengeless (HSD) development station used in xerography, a control system avoids arcing conditions in a gap between a donor member and an image receptor. In a set-up operation, a series of test patches are produced while incrementing the AC amplitude in the gap. A change in reflectivity of the patches as a function of the AC amplitude in the gap is measured and the actual width of the gap is thus estimated. An accurate estimate of the gap width can then be used in a control algorithm.

7. 发明授权

US06858613B2 Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease 失效
标题翻译：用于治疗疾病的融合的双环-N-桥 - 杂芳族甲酰胺
公开(公告)号：US06858613B2
公开(公告)日：2005-02-22
申请号：US10366855
申请日：2003-02-14
申请人： Bruce N. Rogers , David W. Piotrowski , Daniel Patrick Walker , Eric Jon Jacobsen , Brad A. Acker , Donn G. Wishka , Vincent E. Groppi, Jr.
发明人： Bruce N. Rogers , David W. Piotrowski , Daniel Patrick Walker , Eric Jon Jacobsen , Brad A. Acker , Donn G. Wishka , Vincent E. Groppi, Jr.
IPC分类号： A61K31/439 , A61K31/519 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/06 , C07D519/00 , A61K31/4985 , C07D453/02 , C07D471/04
CPC分类号： C07D519/00
摘要： The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat conditions or diseases in which α7 is known to be involved.
摘要翻译：本发明提供式I化合物：这些化合物可以是药物盐或组合物的形式，可以是纯对映异构体形式或外消旋混合物，并且可用于药物治疗已知其中涉及α7的病症或疾病。

8. 发明申请

US20140183155A1 CARBONATION BEVERAGE CAP 审中-公开
标题翻译：碳酸饮料盖
公开(公告)号：US20140183155A1
公开(公告)日：2014-07-03
申请号：US14146685
申请日：2014-01-02
申请人： Patrick Walker
发明人： Patrick Walker
IPC分类号： B65D41/04
CPC分类号： B01F3/04794
摘要： A carbonation beverage cap which has a generally cylindrical shaped bottle adapter having a top middle portion and a raised perimeter aperture disposed on the top middle portion of the bottle adapter. A threaded adapter is coupled to a top portion of the bottle adapter, the threaded adapter having a top centered aperture disposed on a top middle portion of the threaded adapter. A bottom nipple is disposed on a bottom portion of the carbonation beverage cap that a gas hose or a carbonation stone can be coupled to to disperse carbon dioxide gas or other carbonation into a first beverage contained in a beverage bottle.
摘要翻译：一种碳酸饮料盖，其具有大致圆柱形的瓶适配器，其具有设置在瓶适配器的顶部中间部分上的顶部中间部分和升高的周边孔。螺纹适配器联接到瓶适配器的顶部，螺纹适配器具有设置在螺纹适配器的顶部中间部分上的顶部居中的孔。底部奶嘴设置在碳酸饮料帽的底部，气体软管或碳化石可以联接以将二氧化碳气体或其它碳酸化分散到饮料瓶中的第一饮料中。

9. 发明申请

US20120026258A1 METHOD AND SYSTEM FOR DELIVERING SOLID-INK PELLETS 有权
标题翻译：用于递送固体颗粒的方法和系统
公开(公告)号：US20120026258A1
公开(公告)日：2012-02-02
申请号：US12848136
申请日：2010-07-31
申请人： ROGER LEIGHTON , DAVID LOMENZO , PATRICK WALKER , MICHAEL BRUNDIGE , WILLIAM H. WAYMAN
发明人： ROGER LEIGHTON , DAVID LOMENZO , PATRICK WALKER , MICHAEL BRUNDIGE , WILLIAM H. WAYMAN
IPC分类号： B41J2/175 , B67D7/06 , G03G15/08
CPC分类号： B41J2/17593 , B41J2/175 , G03G15/0879
摘要： The present disclosure provides systems and methods for supplying solid-ink pellets from a container to an image-forming device. The system includes a delivery tube within the container, with one or more openings to receive solid-ink pellets from the container. An agitating structure coupled to the delivery tube disturbs the solid ink pellets. The movement of the delivery tube moves the agitating structure, resulting in disturbing the solid-ink pellets and maintaining flowability of the pellets to the image-forming device.
摘要翻译：本公开提供了用于将固体墨水颗粒从容器供应到图像形成装置的系统和方法。该系统包括在容器内的输送管，具有一个或多个开口以从容器接收固体墨水颗粒。耦合到输送管的搅拌结构干扰固体油墨颗粒。输送管的移动使搅动结构移动，导致干燥固体墨水颗粒并保持颗粒到图像形成装置的流动性。

10. 外观设计

USD594934S1 Faucet assembly 有权
公开(公告)号：USD594934S1
公开(公告)日：2009-06-23
申请号：US29275652
申请日：2007-01-03
申请人： Vince Vu , Jonathan Wood , Charles Molina , Scott Cline , Patrick Walker
设计人： Vince Vu , Jonathan Wood , Charles Molina , Scott Cline , Patrick Walker

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