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1. 发明申请

WO2007139744A2 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF BUPRENORPHINE WITH MINIMAL INITIAL BURST 审中-公开
标题翻译：用最小初始爆炸物持续释放布可宁的可植入聚合物
公开(公告)号：WO2007139744A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012046
申请日：2007-05-18
申请人： TITAN PHARMACEUTICALS, INC. , PATEL, Rajesh, A. , BUCALO, Louis, R.
发明人： PATEL, Rajesh, A. , BUCALO, Louis, R.
IPC分类号： A61K9/06
CPC分类号： A61K9/0024 , A61K9/1682
摘要： The present invention provides compositions, methods, and kits for treatment of pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time, and exhibits minimal initial burst upon subcutaneous implantation. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine. Devices of the invention are washed with ethanol for greater than 30 minutes prior to subcutaneous implantation or have release characteristics of a device that has been washed with ethanol for greater than 30 minutes, such as a low peak to steady state plasma level ratio.
摘要翻译：本发明提供用于治疗疼痛的组合物，方法和试剂盒。本发明提供了一种生物相容性非可矫治的聚合物装置，其通过线性释放动力学连续释放丁丙诺啡以延长时间，并且在皮下植入时表现出最小的初始爆发。丁丙诺啡通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用丁丙诺非连续治疗的个体。在皮下植入之前，本发明的装置用乙醇洗涤超过30分钟，或者已经用乙醇洗涤超过30分钟的装置（例如低峰值 - 稳态血浆水平比）的释放特性。

2. 发明申请

WO2004110400A3 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF NALMEFENE 审中-公开
标题翻译：用于持续释放纳米酮的可植入聚合物
公开(公告)号：WO2004110400A3
公开(公告)日：2005-02-17
申请号：PCT/US2004016944
申请日：2004-05-27
申请人： TITAN PHARMACEUTICALS INC , PATEL RAJESH A , BUCALO LOUIS R , COSTANTINI LAUREN
发明人： PATEL RAJESH A , BUCALO LOUIS R , COSTANTINI LAUREN
IPC分类号： A61K9/00 , A61K9/20 , A61K9/26 , A61K9/32 , A61K31/485 , A61P25/32 , A61P25/34
CPC分类号： A61K9/0024 , A61K9/2027 , A61K9/2086 , A61K31/485
摘要： The present invention provides compositions, methods, and kits for administration of nalmefene for treatment of alcoholism, nicotine dependence, or another condition for which treatment with nalmefene is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases nalmefene continuously with generally linear release kinetics for extended periods of time. Nalmefene is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with nalmefene.
摘要翻译：本发明提供了用于治疗酒精中毒，尼古丁依赖性的纳美芬的组合物，方法和试剂盒，或者其中用纳夫芬处理治疗有益的另一种病症。本发明提供了一种生物相容的非可溶性聚合物装置，其通过长时间的连续释放动力学连续释放纳美芬。纳美芬通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用纳美芬连续治疗的个体。

3. 发明申请

WO2004110400A2 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF NALMEFENE 审中-公开
标题翻译：用于持续释放纳米酮的可植入聚合物
公开(公告)号：WO2004110400A2
公开(公告)日：2004-12-23
申请号：PCT/US2004/016944
申请日：2004-05-27
申请人： TITAN PHARMACEUTICALS, INC. , PATEL, Rajesh, A. , BUCALO, Louis, R. , COSTANTINI, Lauren
发明人： PATEL, Rajesh, A. , BUCALO, Louis, R. , COSTANTINI, Lauren
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61K9/2027 , A61K9/2086 , A61K31/485
摘要： The present invention provides compositions, methods, and kits for administration of nalmefene for treatment of alcoholism, nicotine dependence, or another condition for which treatment with nalmefene is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases nalmefene continuously with generally linear release kinetics for extended periods of time. Nalmefene is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with nalmefene.
摘要翻译：本发明提供了用于治疗酒精中毒，尼古丁依赖性的纳美芬的组合物，方法和试剂盒，或者其中用纳夫芬处理治疗有益的另一种病症。本发明提供了一种生物相容的非可溶性聚合物装置，其通过长时间的连续释放动力学连续释放纳美芬。纳美芬通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用纳美芬连续治疗的个体。

4. 发明申请

WO2004089375A1 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF DOPAMINE AGONIST 审中-公开
标题翻译：用于持续释放多巴胺激动剂的可植入聚合物
公开(公告)号：WO2004089375A1
公开(公告)日：2004-10-21
申请号：PCT/US2004/010270
申请日：2004-03-31
申请人： TITAN PHARMACEUTICALS, INC. , PATEL, Rajesh, A. , BUCALO, Louis, R. , COSTANTINI, Lauren , KLEPPNER, Sofie
发明人： PATEL, Rajesh, A. , BUCALO, Louis, R. , COSTANTINI, Lauren , KLEPPNER, Sofie
IPC分类号： A61K31/485
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/146 , A61K9/1635 , A61K31/198 , A61K31/381 , A61K31/4045 , A61K31/428 , A61K31/48 , A61K31/485 , A61L31/048 , A61L31/10 , A61L31/125 , A61L31/146 , A61L2300/20 , A61L2300/40 , A61L2300/41 , A61L2300/602 , A61L2300/606 , A61L2300/62 , A61L2420/04 , C08L31/04
摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist
摘要翻译：本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体

5. 发明申请

WO2011116132A1 HETEROGENEOUS IMPLANTABLE DEVICES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的异质可植入装置
公开(公告)号：WO2011116132A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028727
申请日：2011-03-16
申请人： TITAN PHARMACEUTICALS, INC. , PATEL, Rajesh, A. , BHONSLE, Sunil, R.
发明人： PATEL, Rajesh, A. , BHONSLE, Sunil, R.
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61K9/2086 , A61K9/2886 , A61K31/198 , A61K31/4045 , A61K31/485 , A61K45/06 , A61K47/32
摘要： The present invention comprises compositions, methods and kits for delivering drugs. The invention provides an implantable device for delivery of a pharmaceutical substance to a patient, comprising a core comprising a core polymeric material optionally containing a core pharmaceutical substance, surrounded by a first layer comprising a first-layer pharmaceutical substance and a first-layer polymeric material, optionally surrounded by one or more additional layers comprising an additional pharmaceutical substance and an additional polymeric material, where the core, first, and optional additional polymeric materials may be the same or different, and where the optional core pharmaceutical substance, first-layer pharmaceutical substance, and optional additional pharmaceutical substances are the same or different. Implantation of the device allows a controlled release of drug for an extended period of time. The device may be implanted subcutaneously in an individual in need of continuous treatment with a drug.
摘要翻译：本发明包括用于递送药物的组合物，方法和试剂盒。本发明提供了一种用于将药物物质递送到患者的可植入装置，其包括芯，其包含任选地含有核心药物物质的核心聚合物材料，被包含第一层药物物质的第一层和第一层聚合物材料，任选被包含另外的药物物质和另外的聚合物材料的一个或多个另外的层包围，其中芯，第一和任选的另外的聚合物材料可以相同或不同，并且其中任选的核心药物物质，第一层药物物质和任选的另外的药物相同或不同。装置的植入允许药物长时间控制释放。该装置可以皮下植入需要用药物连续治疗的个体中。

6. 发明申请

WO2003101358A1 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF BUPRENORPHINE 审中-公开
标题翻译：可持续使用的布可宁释放聚合物的方法
公开(公告)号：WO2003101358A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/017401
申请日：2003-06-02
申请人： TITAN PHARMACEUTICALS, INC. , PATEL, Rajesh, A. , BUCALO, Louis, R.
发明人： PATEL, Rajesh, A. , BUCALO, Louis, R.
IPC分类号： A61F13/00
CPC分类号： A61K9/0024 , A61K31/4748 , A61K31/485 , A61K47/32 , A61L31/048 , A61L31/125 , A61L31/16
摘要： The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
摘要翻译：本发明提供了用于治疗阿片成瘾和疼痛的组合物，方法和试剂盒。本发明提供了一种生物相容性非必需的聚合物装置，其通过线性释放动力学持续释放丁丙诺啡以延长时间。丁丙诺啡通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用丁丙诺非连续治疗的个体。

7. 发明申请

WO2007139744A3 IMPLANTABLE POLYMERIC DEVICE FOR SUSTAINED RELEASE OF BUPRENORPHINE WITH MINIMAL INITIAL BURST 审中-公开
标题翻译：用最小初始爆炸物持续释放布可宁的可植入聚合物
公开(公告)号：WO2007139744A3
公开(公告)日：2008-11-06
申请号：PCT/US2007012046
申请日：2007-05-18
申请人： TITAN PHARMACEUTICALS INC , PATEL RAJESH A , BUCALO LOUIS R
发明人： PATEL RAJESH A , BUCALO LOUIS R
IPC分类号： A61K9/06
CPC分类号： A61K9/0024 , A61K9/1682
摘要： The present invention provides compositions, methods, and kits for treatment of pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time, and exhibits minimal initial burst upon subcutaneous implantation. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine. Devices of the invention are washed with ethanol for greater than 30 minutes prior to subcutaneous implantation or have release characteristics of a device that has been washed with ethanol for greater than 30 minutes, such as a low peak to steady state plasma level ratio.
摘要翻译：本发明提供用于治疗疼痛的组合物，方法和试剂盒。本发明提供了一种生物相容的非可溶性聚合物装置，其通过延长的时间段以大致线性释放动力学连续释放丁丙诺啡，并且在皮下植入时显示出最小的初始爆发。丁丙诺啡通过孔被释放，孔通过其被封装在其中的聚合物基质的表面。该装置可以皮下给予需要用丁丙诺非连续治疗的个体。本发明的装置在皮下植入之前用乙醇洗涤超过30分钟，或者已经用乙醇洗涤超过30分钟的装置的释放特性，例如低峰 - 稳态血浆水平比。

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