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1. 发明申请

WO2011090283A3 COMPOSITION CONTAINING INHIBITORS OF THE EXPRESSION OR ACTIVITY OF SH3RF2 FOR PREVENTING OR TREATING CANCER 审中-公开
标题翻译：含有SH3RF2表达或活性抑制剂的组合物用于预防或治疗癌症
公开(公告)号：WO2011090283A3
公开(公告)日：2011-12-01
申请号：PCT/KR2011000108
申请日：2011-01-07
申请人： KOREA RES INST OF BIOSCIENCE , PARK KYUNG CHAN , YEOM YOUNG IL , KIM TAE WOO , PARK ZEE-YONG , KANG YUN KYUNG , YANG SUK-JIN , CHOI BYUNG-JUNG , LEE DONG CHUL , SHON HYUN AHM , YOO HYANG-SOOK
发明人： PARK KYUNG CHAN , YEOM YOUNG IL , KIM TAE WOO , PARK ZEE-YONG , KANG YUN KYUNG , YANG SUK-JIN , CHOI BYUNG-JUNG , LEE DONG CHUL , SHON HYUN AHM , YOO HYANG-SOOK
IPC分类号： A61K31/7105 , A61K31/7088 , A61K39/395 , A61P35/00
CPC分类号： A61K31/7088 , A61K31/7105 , C12N15/113 , C12N2310/14
摘要： The present invention relates to a composition containing inhibitors of the expression or activity of SH3 domain containing ring finger 2 (SH3RF2) for the preventing or treating cancer. More specifically, since the SH3RF2 protein, the expression level of which is increased in various cancer tissues, binds to PAK4, which is a cancer-associated gene, to regulate an apoptosis inhibitory function of the PAK4 protein by ubiquitination activity in the RING domain of SH3RF2, cancer cells, in which the expression of SH3RF2 is inhibited, sensitively respond to the induction of apoptosis to facilitate apoptosis and reduce in vivo tumorigenicity, such that an inhibitor of the expression or activity of SHRF2 may be useful as a composition for the prevention or treatment of cancer.
摘要翻译：本发明涉及含有用于预防或治疗癌症的含SH3结构域的无名指2（SH3RF2）的表达或活性抑制剂的组合物。更具体地说，由于其表达水平在各种癌症组织中增加的SH3RF2蛋白与作为癌症相关基因的PAK4结合，通过泛素化活性调节PAK4蛋白的细胞凋亡抑制功能 SH3RF2，其中抑制SH3RF2表达的癌细胞对细胞凋亡的诱导敏感地响应以促进凋亡并降低体内致瘤性，使得SHRF2的表达或活性的抑制剂可用作预防组合物或治疗癌症。

2. 发明申请

WO2009126003A3 NOVEL PYRAZOLE AND BENZOXAZOLE-SUBSTITUTED PYRIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION PROCESS FOR SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF DISORDERS INVOLVING ABERRANT CELL PROLIFERATION 审中-公开
标题翻译：新型吡唑和苯并噻唑取代的吡啶衍生物或其药学上可接受的盐，其制备方法和用于预防和治疗涉及细胞增殖的疾病的药物组合物
公开(公告)号：WO2009126003A3
公开(公告)日：2010-02-04
申请号：PCT/KR2009001866
申请日：2009-04-10
申请人： KOREA RESERACH INST OF CHEMICA , KOREA RES INST OF BIOSCIENCE , KOREA INST SCI & TECH , KOH JONG SUNG , LEE JONG KOOK , CHO SUNG YUN , HAN SUN-YOUNG , LEE CHONG OCK , RYU JAE WOOK , PARK KYUNG CHAN , HAN DONG CHO , HA JAE DU , PARK SONG-KYU , JUNG HEE JUNG , KWON BYOUNG-MOG , YOO KYUNG HO , SIM TAEBO
发明人： KOH JONG SUNG , LEE JONG KOOK , CHO SUNG YUN , HAN SUN-YOUNG , LEE CHONG OCK , RYU JAE WOOK , PARK KYUNG CHAN , HAN DONG CHO , HA JAE DU , PARK SONG-KYU , JUNG HEE JUNG , KWON BYOUNG-MOG , YOO KYUNG HO , SIM TAEBO
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： The present invention relates to novel pyrazole and benzoxazole-substituted pyridine derivatives or pharmaceutically acceptable salts thereof, a preparation process for same, and a pharmaceutical composition for preventing and treating disorders involving aberrant cell proliferation containing the same as active ingredients. The present invention exhibits superior effects of inhibiting a wide variety of protein kinases, for example, c-Met, Ron, KDR, Lck, Flt1, Flt3, Tie2, TrkA, TrkB, b-Raf, Aurora-A and the like which are useful for treatment of disorders involving aberrant cell proliferation, and therefore can be valuably used for the prevention and treatment of disorders involving aberrant cell proliferation.
摘要翻译：本发明涉及新的吡唑和苯并恶唑取代的吡啶衍生物或其药学上可接受的盐，其制备方法以及用于预防和治疗包含与活性成分相同的异常细胞增殖的病症的药物组合物。本发明表现出抑制多种蛋白激酶例如c-Met，Ron，KDR，Lck，Flt1，Flt3，Tie2，TrkA，TrkB，b-Raf，Aurora-A等的优异效果，可用于治疗涉及异常细胞增殖的疾病，因此可以有价值地用于预防和治疗涉及异常细胞增殖的病症。

3. 发明申请

WO2004107332A1 HIGH-DENSITY RECORDING MEDIUM AND RECORDING AND/OR REPRODUCING DEVICE THEREFOR 审中-公开
标题翻译：高密度记录介质和记录和/或再现设备
公开(公告)号：WO2004107332A1
公开(公告)日：2004-12-09
申请号：PCT/KR2004/001321
申请日：2004-06-03
申请人： LG Electronics Inc. , KIM, Jin Yong , PARK, Kyung Chan
发明人： KIM, Jin Yong , PARK, Kyung Chan
IPC分类号： G11B7/24
CPC分类号： G11B23/0035 , G11B7/121
摘要： Disclosed herein are a high-density recording medium, such as a high-density optical disc and a recording and/or reproducing device therefor. At a transition area of the high-density optical disc allocated between a clamping area and an information area of the high-density optical disc is formed a step having a prescribed slope so that the high-density optical disc does not collide with an objective lens of an optical pickup provided in an optical disc device although the objective lens of the optical pickup is upwardly moved toward a recording layer of the high-density optical disc until it moves to the maximum working distance when the high-density optical disc, such as a Blu-ray disc, is improperly placed on a turntable provided in the optical disc device, e.g., when the high-density optical disc is placed upside down on the turntable. The thickness of the information area is smaller than that of the clamping area by the provision of the step at the transition area. Consequently, damage to the high-density optical disc or the objective lens due to a collision of the objective lens with the high-density optical disc is prevented, and fatal errors of a servo operation are effectively prevented. Furthermore, the cost of materials required to manufacture the high-density optical disc is reduced while stable clamping force is maintained, and safe insertion of the high-density optical disc into a slot-type optical disc drive is possible.
摘要翻译：这里公开了高密度记录介质，例如高密度光盘及其记录和/或再现装置。在分配在高密度光盘的夹持区域和信息区域之间的高密度光盘的过渡区域形成具有规定斜率的步骤，使得高密度光盘不与物镜碰撞设置在光盘装置中的光学拾取器，尽管当高密度光盘如高密度光盘移动到最大工作距离时，光学拾取器的物镜朝向高密度光盘的记录层向上移动，蓝光盘不适当地放置在设置在光盘装置中的转盘上，例如当高密度光盘被倒置放置在转台上时。通过在过渡区域提供步骤，信息区域的厚度小于夹紧区域的厚度。因此，防止了由于物镜与高密度光盘的碰撞而对高密度光盘或物镜造成的损坏，从而有效地防止了伺服操作的致命错误。此外，制造高密度光盘所需的材料的成本降低，同时保持稳定的夹持力，并且可以将高密度光盘安全插入槽式光盘驱动器。

4. 发明申请

WO2011071232A1 METHOD FOR DIAGNOSIS/PROGNOSIS OF CANCERS USING AN EPIGENETIC MARKER CONSISTING OF A SPECIFIC SINGLE CPG SITE IN TTP PROMOTER AND TREATMENT OF CANCERS BY REGULATING ITS EPIGENETIC STATUS 审中-公开
标题翻译：使用包含特定单个CPG位点的特异性标志物在TTP促进剂中诊断/预防癌症的方法和通过调节其治疗状态治疗癌症
公开(公告)号：WO2011071232A1
公开(公告)日：2011-06-16
申请号：PCT/KR2010/006113
申请日：2010-09-08
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , YEOM, Young Il , SOHN, Bo Hwa , PARK, In Young , LEE, Jung Ju , JANG, Yejin , YANG, Suk-jin , PARK, Kyung Chan , YOO, Hyang-sook , CHOI, Jong Young
发明人： YEOM, Young Il , SOHN, Bo Hwa , PARK, In Young , LEE, Jung Ju , JANG, Yejin , YANG, Suk-jin , PARK, Kyung Chan , YOO, Hyang-sook , CHOI, Jong Young
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/531 , C12Q1/6886 , C12Q2600/154
摘要： The present invention relates to a method for the diagnosis and prognosis of cancers using an epigenetic marker consisting of a specific single CpG site in TTP (Tristetraprolin) promoter and treatment of cancers by regulating its epigenetic status. Particularly, the present invention relates to a method for the diagnosis and prognosis of liver cancer by measuring specific methylation of C, the 32 nd residue of the nucleic acid sequence represented by SEQ. ID. NO. 41, and a method for treatment of cancer by regulating the same. The present invention can be effectively used for the diagnosis and/or treatment of liver cancer characterized by TTP down-regulation and methylation of C, the 32 nd residue of the nucleic acid sequence represented by SEQ. ID. NO. 41. The present invention can be further applied for the diagnosis and treatment of other cancers or inflammatory diseases that are characterized by TTP down-regulation and methylation of C, the 32 nd residue of the nucleic acid sequence represented by SEQ. ID. NO. 41.
摘要翻译：本发明涉及一种使用由TTP（Tristetraprolin）启动子中的特定单个CpG位点组成的表观遗传标记和通过调节其表观遗传学状态来治疗癌症的癌症诊断和预后的方法。特别地，本发明涉及通过测定由SEQ ID NO：1表示的核酸序列的第32位的C的特异性甲基化来诊断和预测肝癌的方法。 ID。没有。 41，以及通过调节癌症治疗癌症的方法。本发明可以有效地用于诊断和/或治疗特征为TTP下调和甲基化的肝癌，即SEQ ID NO：1所示的核酸序列的第32个残基。 ID。没有。 41.本发明可以进一步应用于以TTP下调和甲基化为特征的其他癌症或炎性疾病的诊断和治疗，C为SEQ ID NO：1所示核酸序列的第32位残基。 ID。没有。 41。

5. 发明申请

WO2009126003A9 NOVEL PYRAZOLE AND BENZOXAZOLE-SUBSTITUTED PYRIDINE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION PROCESS FOR SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF DISORDERS INVOLVING ABERRANT CELL PROLIFERATION 审中-公开
标题翻译：新型吡唑和苯并唑取代的吡啶衍生物或其药学上可接受的盐，其制备方法和药物组合物用于预防和治疗涉及异常细胞增殖的病症
公开(公告)号：WO2009126003A9
公开(公告)日：2009-12-10
申请号：PCT/KR2009001866
申请日：2009-04-10
申请人： KOREA RESERACH INST OF CHEMICA , KOREA RES INST OF BIOSCIENCE , KOREA INST SCI & TECH , KOH JONG SUNG , LEE JONG KOOK , CHO SUNG YUN , HAN SUN-YOUNG , LEE CHONG OCK , RYU JAE WOOK , PARK KYUNG CHAN , HAN DONG CHO , HA JAE DU , PARK SONG-KYU , JUNG HEE JUNG , KWON BYOUNG-MOG , YOO KYUNG HO , SIM TAEBO
发明人： KOH JONG SUNG , LEE JONG KOOK , CHO SUNG YUN , HAN SUN-YOUNG , LEE CHONG OCK , RYU JAE WOOK , PARK KYUNG CHAN , HAN DONG CHO , HA JAE DU , PARK SONG-KYU , JUNG HEE JUNG , KWON BYOUNG-MOG , YOO KYUNG HO , SIM TAEBO
IPC分类号： C07D413/14
CPC分类号： C07D413/14
摘要： The present invention relates to novel pyrazole and benzoxazole-substituted pyridine derivatives or pharmaceutically acceptable salts thereof, a preparation process for same, and a pharmaceutical composition for preventing and treating disorders involving aberrant cell proliferation containing the same as active ingredients. The present invention exhibits superior effects of inhibiting a wide variety of protein kinases, for example, c-Met, Ron, KDR, Lck, Flt1, Flt3, Tie2, TrkA, TrkB, b-Raf, Aurora-A and the like which are useful for treatment of disorders involving aberrant cell proliferation, and therefore can be valuably used for the prevention and treatment of disorders involving aberrant cell proliferation.
摘要翻译：本发明涉及新的吡唑和苯并恶唑取代的吡啶衍生物或其药学上可接受的盐，其制备方法，以及用于预防和治疗包含异常细胞增殖的疾病的药物组合物作为活性成分。本发明展示了抑制多种蛋白激酶的优越效果，例如c-Met，Ron，KDR，Lck，Flt1，Flt3，Tie2，TrkA，TrkB，b-Raf，Aurora-A等用于治疗涉及异常细胞增殖的疾病，因此可以有价值地用于预防和治疗涉及异常细胞增殖的疾病。

6. 发明申请

WO2006049452A1 MULTI-LAYER DISC 审中-公开
标题翻译：多层盘
公开(公告)号：WO2006049452A1
公开(公告)日：2006-05-11
申请号：PCT/KR2005/003712
申请日：2005-11-04
申请人： LG Electronics Inc. , KIM, Jin Yong , PARK, Kyung Chan
发明人： KIM, Jin Yong , PARK, Kyung Chan
IPC分类号： G11B7/24
CPC分类号： G11B7/24038 , G11B7/26
摘要： A multi-layer disc is disclosed which includes a plurality of recording layers, as in a dual layer blu-ray disc. In the multi- layer disc, the tolerance of a transparent substrate thickness from a surface of a cover layer to each recording layer is set to be different from those of transparent substrate thicknesses to other recording layers within a range in which no degradation in the characteristics of recording and reproduction signals for each recording layer occurs. Accordingly, it is possible to more efficiently manufacture multi -layer discs, to achieve an improvement in the manufacturing yield of multi-layer discs, and to achieve a reduction in the manufacturing costs of multi-layer discs.
摘要翻译：公开了一种多层盘，其包括多个记录层，如在双层蓝光盘中。在多层盘中，将透明基板厚度从覆盖层的表面到每个记录层的公差设置为与其它记录层的透明基板厚度的不同在于其特性不劣化的范围内发生每个记录层的记录和再现信号。因此，可以更有效地制造多层盘，实现多层盘的制造成品率的提高，实现多层盘的制造成本的降低。

7. 发明申请

WO2005027128A8 DISC CARTRIDGE 审中-公开
标题翻译：盘盒
公开(公告)号：WO2005027128A8
公开(公告)日：2005-06-23
申请号：PCT/KR2004002333
申请日：2004-09-14
申请人： LG ELECTRONICS INC , KIM JIN YONG , PARK KYUNG CHAN , LIM HYUNG JUN , EOM IN SEOP , KIM JI DUK
发明人： KIM JIN YONG , PARK KYUNG CHAN , LIM HYUNG JUN , EOM IN SEOP , KIM JI DUK
IPC分类号： G06F1/16 , G11B23/03
CPC分类号： G11B23/0308 , G11B23/0317
摘要： A disc cartridge is provided. The disc cartridge includes: a lower housing (100a, 100b, 100c, 100d) having a window (101a, 101b, 101c, 101d) for allowing a recorder or reader to access to a read-out surface (15) of a disc (10); and an upper housing (200a, 200b, 200c, 200d) coupled to the lower housing to ejectably receive the disc between the lower housing and the upper housing, and having at least a portion rotatable up and down with respect to one side of the lower housing until the disc can be ejected.
摘要翻译：提供了一个光盘盒。盘盒包括：具有用于允许记录器或读取器访问盘的读出表面（15）的窗口（101a，101b，101c，101d）的下壳体（100a，100b，100c，100d） 10）; 以及联接到所述下壳体的上壳体（200a，200b，200c，200d），以在所述下壳体和所述上壳体之间可弹性地容纳所述盘，并且具有至少一部分可相对于所述下壳体的一侧上下移动外壳，直到光盘可以弹出。

8. 发明申请

WO2005027129A1 DISC CARTRIDGE 审中-公开
标题翻译：盘盒
公开(公告)号：WO2005027129A1
公开(公告)日：2005-03-24
申请号：PCT/KR2004/002334
申请日：2004-09-14
申请人： LG ELECTRONICS INC. , KIM, Jin, Yong , PARK, Kyung, Chan , LIM, Hyung, Jun , EOM, In, Seop , KIM, Ji, Duk
发明人： KIM, Jin, Yong , PARK, Kyung, Chan , LIM, Hyung, Jun , EOM, In, Seop , KIM, Ji, Duk
IPC分类号： G11B23/03
CPC分类号： G11B23/0317 , G11B23/0308
摘要： The present invention discloses a disc cartridge for easy mounting/dismounting of a disc (10) to/from the disc cartridge. The present invention provides a disc cartridge including a lower housing (100a, 100b, 100c, 100d, or 100e) having a window (101a, 101b, 101c, 101d, or 101e0 for a recorder or a reader to access to a read-out surface of the disc (10), and an upper housing (200a, 200b, 200c, 200d, or 200e) secured to the lower housing (100a, 100b, 100c, 100d, or 100e) for holding the disc (10) between the lower housing (100a, 100b, 100c, 100d, or 100e) and the upper housing (200a, 200b, 200c, 200d, or 200e) such that the disc (10) can be taken out therefrom, the upper housing (200a, 200b, 200c, 200d, or 200e) having at least a portion configured movable for securing a space for taking out the disc (10) therethrough.
摘要翻译：本发明公开了一种用于容易地将盘（10）安装/从盘盒卸载的盘盒。本发明提供一种盘盒，其包括具有窗口（101a，101b，101c，101d或101e0，用于记录器或读取器）的下壳体（100a，100b，100c，100d或100e）以及固定到下壳体（100a，100b，100c，100d或100e）的上壳体（200a，200b，200c，200d或200e），用于将盘（10）保持在所述盘下壳体（100a，100b，100c，100d或100e）和上壳体（200a，200b，200c，200d或200e），使得盘（10）能够从其中取出，上壳体（200a，200b），200c，200d或200e），其具有至少一部分，所述至少一部分可移动以固定用于从其中取出所述盘（10）的空间。

9. 发明申请

WO2005027128A1 DISC CARTRIDGE 审中-公开
标题翻译： DISC碳粉盒
公开(公告)号：WO2005027128A1
公开(公告)日：2005-03-24
申请号：PCT/KR2004/002333
申请日：2004-09-14
申请人： LG ELECTRONICS INC. , KIM, Jin, Yong , PARK, Kyung, Chan , LIM, Hyung, Jun , EOM, In, Seop , KIM, Ji, Duk
发明人： KIM, Jin, Yong , PARK, Kyung, Chan , LIM, Hyung, Jun , EOM, In, Seop , KIM, Ji, Duk
IPC分类号： G11B23/03
CPC分类号： G11B23/0308 , G11B23/0317
摘要： A disc cartridge is provided. The disc cartridge includes: a lower housing (100a, 100b, 100c, 100d) having a window (101a, 101b, 101c, 101d) for allowing a recorder or reader to access to a read-out surface (15) of a disc (10); and an upper housing (200a, 200b, 200c, 200d) coupled to the lower housing to ejectably receive the disc between the lower housing and the upper housing, and having at least a portion rotatable up and down with respect to one side of the lower housing until the disc can be ejected.
摘要翻译：
提供光盘盒。盘盒包括：具有窗口（101a，101b，101c，101d）的下壳体（100a，100b，100c，100d），用于允许记录器或读取器访问盘的读出表面（15） 10）; 以及联接到下壳体的上壳体（200a，200b，200c，200d），以可弹出地接收位于下壳体和上壳体之间的盘，并且至少一部分相对于下部的一侧可上下转动直到光盘可以弹出为止。

10. 发明申请

WO2004025634A1 HIGH-DENSITY DISK RECORDING MEDIUM AND A DRIVING METHOD THEREOF 审中-公开
标题翻译：高密度磁盘记录介质及其驱动方法
公开(公告)号：WO2004025634A1
公开(公告)日：2004-03-25
申请号：PCT/KR2003/001859
申请日：2003-09-09
申请人： LG ELECTRONICS INC. , KIM, Jin Yong , PARK, Kyung Chan
发明人： KIM, Jin Yong , PARK, Kyung Chan
IPC分类号： G11B7/085
CPC分类号： G11B7/0945 , G11B7/00736 , G11B7/08511
摘要： The present invention relates to a disk driving method to prevent collision of an optical pickup's objective lens with a high-density disk such as a blu-ray disk in the event that the disk is placed upside down in a disk device. In the present invention, a focusing operation for a lead-in area of the disk is conducted first when it is placed. While focusing operation is conducted a first signal produced by a reflected beam from the surface of the disk is detected. If a second signal produced by a reflected beam from a recording layer of the disk is not detected within a preset time after the first signal is detected, the focusing operation is stopped immediately to prevent collision of an optical pickup's objective lens with a high-density disk.
摘要翻译：盘驱动方法技术领域本发明涉及一种盘驱动方法，用于在盘被倒置放置在盘装置中的情况下防止光学拾取器物镜与蓝光盘等高密度盘的碰撞。在本发明中，当放置盘时，首先进行对盘的导入区域的聚焦操作。当进行聚焦操作时，检测由来自盘表面的反射光束产生的第一信号。如果在检测到第一信号之后的预设时间内没有检测到来自盘的记录层的反射光束产生的第二信号，则立即停止聚焦操作，以防止光学拾取器的物镜与高密度磁盘。

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