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1. 发明申请

WO2005100303A1 INDENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：茚衍生物及其制备方法
公开(公告)号：WO2005100303A1
公开(公告)日：2005-10-27
申请号：PCT/KR2005/001066
申请日：2005-04-13
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , JEIL PHARM. CO., LTD. , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CJ CORP. , CHEON, Hyae Gyeong , YOO, Sung-Eun , KIM, Sung Soo , YANG, Sung-Don , KIM, Kwang-Rok , RHEE, Sang Dal , AHN, Jin Hee , KANG, Seung Kyu , JUNG, Won Hoon , PARK, Sung Dae , KIM, Nam Gee , LEE, Jang Hyuk , HUH, Sun Chul , LEE, Jae Mok , SONG, Seog Beom , KWON, Soon Ji , KIM, Jong Hoon , LEE, Jeong-Hyung , KIM, Seung Jun
发明人： CHEON, Hyae Gyeong , YOO, Sung-Eun , KIM, Sung Soo , YANG, Sung-Don , KIM, Kwang-Rok , RHEE, Sang Dal , AHN, Jin Hee , KANG, Seung Kyu , JUNG, Won Hoon , PARK, Sung Dae , KIM, Nam Gee , LEE, Jang Hyuk , HUH, Sun Chul , LEE, Jae Mok , SONG, Seog Beom , KWON, Soon Ji , KIM, Jong Hoon , LEE, Jeong-Hyung , KIM, Seung Jun
IPC分类号： C07C251/44
CPC分类号： C07D213/30 , C07C291/02 , C07C309/66 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D213/53 , C07D233/64 , C07D277/24 , C07D295/088 , C07D295/185 , C07D307/54 , C07D317/60 , C07D317/70 , C07D333/24 , C07D333/28 , C07D417/12
摘要： The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
摘要翻译：本发明式（I）的茚衍生物能够选择性地调节过氧化物酶体增殖物激活受体（PPAR）的活性，引起无副作用，因此它们可用于治疗和预防由PPARs调节的疾病，即代谢综合征如糖尿病，肥胖症，动脉硬化，高脂血症，高胰岛素血症和高血压，炎性疾病如骨质疏松症，肝硬化和哮喘以及癌症。

2. 发明申请

WO1998025916A1 NOVEL BENZOPYRAN DERIVATIVES 审中-公开
标题翻译：新的BENZOPYRAN衍生物
公开(公告)号：WO1998025916A1
公开(公告)日：1998-06-18
申请号：PCT/KR1997000265
申请日：1997-12-13
申请人： C & C RESEARCH LABORATORIES , JO, Jae, Chon , PARK, Sung, Dae , LIM, Hyun, Suk , KIM, Ju, Su , KIM, Sung, Jin , MORIKAWA, Kazumi , KANBE, Yoshitake , NISHIMOTO, Masahiro , KIM, Myung-Hwa
发明人： C & C RESEARCH LABORATORIES
IPC分类号： C07D311/30
CPC分类号： C07D335/06 , C07D311/38 , C07D311/58
摘要： The present invention relates to a novel benzopyran derivative having anti-estrogenic activity. More specifically, the present invention relates to a novel benzopyran derivative represented by formula (I) and pharmaceutically acceptable salt thereof, in which ----- represents a single bond or a double bond; R1 and R2 independently of one another represent hydrogen, hydroxy or OR group, wherein R represents acyl or alkyl; R3 represents hydrogen, lower alkyl or halogeno lower alkyl, provided that when ----- represents a double bond, R3 is not present; R4 represents hydrogen or lower alkyl; A represents a group of formula (a), (b), (c) or (d); R5, R6 and R7 independently of one another represent hydrogen, alkyl, halogenoalkyl, alkenyl or halogenoalkenyl, or R6 and R7 together with nitrogen atom to which they are bound can form a 4- to 8-membered heterocyclic ring which can be substituted with R5; X represents O, S or NR8, wherein R8 represents hydrogen or lower alkyl; m denotes an integer of 2 to 15; n denotes an integer of 0 to 2; and p denotes an integer of 0 to 4, and to a process for preparation thereof and a pharmaceutical composition having anti-estrogenic activity which contains the compound (I) as an active component.
摘要翻译：本发明涉及具有抗雌激素活性的新型苯并吡喃衍生物。更具体地说，本发明涉及式（I）表示的新的苯并吡喃衍生物及其药学上可接受的盐，其中代表单键或双键; R 1和R 2彼此独立地表示氢，羟基或OR基，其中R表示酰基或烷基; R 3表示氢，低级烷基或卤代低级烷基，条件是当o-表示双键时，R 3不存在; R4代表氢或低级烷基; A表示式（a），（b），（c）或（d）的基团; R 5，R 6和R 7彼此独立地表示氢，烷基，卤代烷基，烯基或卤代烯基，或者R 6和R 7与它们所连接的氮原子一起可以形成可被R 5取代的4至8元杂环 ; X表示O，S或NR8，其中R8表示氢或低级烷基; m表示2〜15的整数， n表示0〜2的整数，和p表示0〜4的整数，以及其制备方法和含有化合物（I）作为活性成分的具有抗雌激素活性的药物组合物。

3. 发明申请

WO2012081911A3 SALIVA PURIFYING METHOD 审中-公开
标题翻译： SALIVA净化方法
公开(公告)号：WO2012081911A3
公开(公告)日：2012-09-07
申请号：PCT/KR2011009639
申请日：2011-12-14
申请人： PERFECT KOREA CO LTD , PARK SUNG-DAE
发明人： PARK SUNG-DAE
IPC分类号： G01N33/74 , G01N33/53 , G01N33/534
CPC分类号： G01N33/74 , G01N1/4044
摘要： The present invention relates to a method which denatures proteins contained in the saliva by suddenly varying a temperature and pH, to thereby purify the saliva. Particularly, the method of the present invention has higher accuracy compared to conventional saliva pre-treatment methods, and thus enables very small amount of hormone in the saliva to be detected, and is therefore very useful. That is, the method of the present invention may be valuably used in a pre-treatment process for a variety of analyses which use saliva as a sample.
摘要翻译：本发明涉及一种通过突然改变温度和pH来变性唾液中的蛋白质从而净化唾液的方法。特别地，与常规唾液预处理方法相比，本发明的方法具有更高的精度，因此能够检测唾液中的少量激素，因此非常有用。也就是说，本发明的方法可以在使用唾液作为样品的各种分析的预处理过程中有价值地使用。

4. 发明申请

WO2005042577A1 DDR2 PROTEIN WITH ACTIVATED KINASE ACTIVITY AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：具有活性激酶活性的DDR2蛋白及其制备方法
公开(公告)号：WO2005042577A1
公开(公告)日：2005-05-12
申请号：PCT/KR2004/002784
申请日：2004-11-01
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , JEIL PHARMACEUTICAL. CO., LTD. , YANG, Beom-Seok , PARK, Sung-Dae
发明人： YANG, Beom-Seok , PARK, Sung-Dae
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/35 , C12N9/1205
摘要： The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase activity by inducing phosphorylations of tyrosines by a co-expression with Src or Src related proteins in host cells, or by H2O2 processing of host cells, or a site directed mutation modifying at least one of tyrosines to other amino acid; and a use thereof as a target material in developing medical drugs for treating a disease caused by an excessively activated DDR2 autophosphorylation and tyrosine kinase activity.
摘要翻译：本发明涉及含有增加的自磷酸化和酪氨酸激酶活性的修饰的DDR（盘带蛋白结构域受体）2胞质酪氨酸激酶结构域的蛋白质; 通过与宿主细胞中的Src或Src相关蛋白的共表达，或通过H 2 O 2处理，通过诱导酪氨酸的磷酸化，具有增加的自磷酸化和酪氨酸激酶活性的DDR2胞质酪氨酸激酶结构域的蛋白质的制备方法宿主细胞或将至少一种酪氨酸修饰至其它氨基酸的位点定向突变; 以及其用作开发用于治疗由过度活化的DDR2自磷酸化和酪氨酸激酶活性引起的疾病的药物的目标材料。

5. 发明申请

WO2005100297A1 INDENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译： INDENE衍生物及其制备方法
公开(公告)号：WO2005100297A1
公开(公告)日：2005-10-27
申请号：PCT/KR2005/001051
申请日：2005-04-12
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , JEIL PHARM. CO., LTD. , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CJ CORP. , CHEON, Hyae Gyeong , YOO, Sung-Eun , KIM, Sung Soo , YANG, Sung-Don , KIM, Kwang-Rok , RHEE, Sang Dal , AHN, Jin Hee , KANG, Seung Kyu , JUNG, Won Hoon , PARK, Sung Dae , KIM, Nam Gee , KIM, Sun Mee , MO, Kil Woong , LEE, Jae Mok , KANG, Hye Jung , LEE, Koun Ho , KIM, Jong Hoon , LEE, Jeong-Hyung , KIM, Seung Jun
发明人： CHEON, Hyae Gyeong , YOO, Sung-Eun , KIM, Sung Soo , YANG, Sung-Don , KIM, Kwang-Rok , RHEE, Sang Dal , AHN, Jin Hee , KANG, Seung Kyu , JUNG, Won Hoon , PARK, Sung Dae , KIM, Nam Gee , KIM, Sun Mee , MO, Kil Woong , LEE, Jae Mok , KANG, Hye Jung , LEE, Koun Ho , KIM, Jong Hoon , LEE, Jeong-Hyung , KIM, Seung Jun
IPC分类号： C07C69/753
CPC分类号： C07D295/088 , C07C65/26 , C07C69/757 , C07C229/50 , C07C233/52 , C07C255/47 , C07C2601/14 , C07C2602/08 , C07D295/155
摘要： The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
摘要翻译：式（I）的本发明的茚衍生物能够选择性调节过氧化物酶体增殖物激活受体（PPAR）的活性，不引起副作用，因此它们可用于治疗和预防由PPARs调节的病症，糖尿病，肥胖，动脉硬化，高脂血症，高胰岛素血症和高血压等代谢综合征，骨质疏松症，肝硬化和哮喘等炎性疾病和癌症。

6. 发明申请

WO2005092896A1 COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN 审中-公开
标题翻译：用于抑制DDR2蛋白的酪氨酸激酶活性的化合物
公开(公告)号：WO2005092896A1
公开(公告)日：2005-10-06
申请号：PCT/KR2005/000019
申请日：2005-01-05
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , JEIL PHARMACEUTICAL CO., LTD. , YANG, Beom-Seok , YANG, Kyung-Mi , KIM, Hae-Jong , PARK, In-Sung , PARK, Sung-Dae , LEE, Jang-Hyuk , KWON, Hyuk-Man , WOO, Byoung-Young
发明人： YANG, Beom-Seok , YANG, Kyung-Mi , KIM, Hae-Jong , PARK, In-Sung , PARK, Sung-Dae , LEE, Jang-Hyuk , KWON, Hyuk-Man , WOO, Byoung-Young
IPC分类号： C07D491/048
CPC分类号： C07D491/04
摘要： A new furopyrimidine compound, their pharmaceutically acceptable salt, and a tyrosine kinase activity inhibitor. The furopyrimidine compound is a compound defined by chemical formula 1, 2, 3 or 4, on their precursor, and can exist as a form of free base or in an acid-addition salt. Since the furopyrimidine compound has an effect of inhibiting activity of DDR2 tyrosine kinase, it can be used in treating illnesses caused by the DDR2 tyrosine kinase activity such as hepatocirrhosis, rheumatoid arthritis or cancer.
摘要翻译：新的呋喃嘧啶化合物，其药学上可接受的盐和酪氨酸激酶活性抑制剂。呋喃嘧啶化合物是化学式1,2,3或4所定义的化合物，它们的前体可以作为游离碱形式或在酸加成盐中存在。由于呋喃嘧啶化合物具有抑制DDR2酪氨酸激酶活性的作用，因此可用于治疗由DDR2酪氨酸激酶活性引起的疾病，如肝硬化，类风湿性关节炎或癌症。

7. 发明申请

WO1996005174A1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC 审中-公开
标题翻译：新型氨基衍生物，其生产方法及其作为反应性的用途
公开(公告)号：WO1996005174A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001134
申请日：1995-06-07
申请人： C & C RESEARCH LABS. , CHUNG, You, Sup , PARK, Sung, Dae , KWON, Lae, Sung , SHIN, Hong, Sub , TANABE, Shigeru
发明人： C & C RESEARCH LABS.
IPC分类号： C07D207/09
CPC分类号： C07D401/06 , C07D401/12
摘要： A novel amine derivative represented by general formula (I) and a salt thereof, both being useful as an antiarrhythmic, wherein (a) represents (b) or (c); A represents -NR8-(CH2)a-(5- or 6-membered nitrogenous heterocycle)- or a 6-membered nitrogenous heterocycle, wherein R8 represents lower alkyl or hydroxylated lower alkyl, and a represents 0 or 1; D represents -(CH2)m-, -(CH2)m-O-, -CO- or -SO2-; R1 and R2 represent each independently hydrogen, halogen, lower alkoxy or lower alkylsulfonylamino; R3 represents lower alkyl; R4, R5, R6 and R7 represent each independently hydrogen or lower alkylsulfonylamino; R represents nitro or lower alkylsulfonylamino; X represents hydrogen or halogen; and m and n represent each an integer of 0 to 3.
摘要翻译：一种由通式（I）表示的新型胺衍生物及其盐，均可用作抗心律失常药，其中（a）代表（b）或（c）; A表示-NR 8 - （CH 2）a - （5-或6-元含氮杂环） - 或6-元含氮杂环，其中R8表示低级烷基或羟基化低级烷基，a表示0或1; D表示 - （CH 2）m - ， - （CH 2）m -O-，-CO-或-SO 2 - ; R 1和R 2各自独立地表示氢，卤素，低级烷氧基或低级烷基磺酰基氨基; R3表示低级烷基; R4，R5，R6和R7各自独立地表示氢或低级烷基磺酰基氨基; R表示硝基或低级烷基磺酰基氨基; X表示氢或卤素; m和n表示0〜3的整数。

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