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1. 发明申请

WO2012078177A1 DEVICES FOR CLEARING BLOCKAGES IN IN-SITU ARTIFICIAL LUMENS 审中-公开
标题翻译：用于在现场人造红眼中清除屏障的装置
公开(公告)号：WO2012078177A1
公开(公告)日：2012-06-14
申请号：PCT/US2010/061900
申请日：2010-12-22
申请人： ACTUATED MEDICAL, INC. , BAGWELL, Roger B. , FRANKHOUSER, Paul L. , MULVIHILL, Maureen L. , CRESPO, Josue R. , PARK, Brian M. , MALLEN, Dana B. , MEZA, Gabriela Hernandez , DEMERS, Debora L.
发明人： BAGWELL, Roger B. , FRANKHOUSER, Paul L. , MULVIHILL, Maureen L. , CRESPO, Josue R. , PARK, Brian M. , MALLEN, Dana B. , MEZA, Gabriela Hernandez , DEMERS, Debora L.
IPC分类号： A61M25/00 , A61J15/00 , B08B9/00 , E03F9/00 , A61B1/00
CPC分类号： A61M1/0078 , A61B1/018 , A61B90/70 , A61B2090/701 , A61J15/00 , A61J15/0026 , A61M25/00 , A61M2025/0019 , B08B9/027 , B08B9/0436 , Y10T137/6055 , Y10T137/789
摘要： Devices and methods for the effective clearing of artificial tubes ( 39 ), especially in- situ clearing of artificial tubes in a living being are covered in this disclosure. The devices and methods provide an elongated clearing member ( 26 ) having a first end that is coupled to a driving mechanism ( 1 ) and having a second working end that is subjected to repetitive motion for clearing blockages within the artificial tube. The elongated clearing member includes either a fixed or an adjustable element ( 22 ) that selectively defines the portion of the elongated clearing member that is insertable within the artificial tube. The proximal end of the clearing member is releasably secured to the driving mechanism and the driving mechanisms may comprise a wide variety of repetitive motion drivers such as voice coil motors, piezoelectric actuators, pneumatic actuators, DC motors, etc. These devices/methods may comprise a free-standing console for hands -free operation or may comprise hand-held versions.
摘要翻译：有效清除人造管（39）的设备和方法，特别是生活中人造管的原位清除在本公开中被覆盖。装置和方法提供了细长的清理构件（26），其具有联接到驱动机构（1）的第一端，并具有经受重复运动的第二工作端，以清除人造管内的堵塞。细长的清理构件包括固定或可调元件（22），其可选择性地限定可插入人造管内的细长清理构件的部分。清洁构件的近端可释放地固定到驱动机构，并且驱动机构可以包括各种各样的重复运动驱动器，例如音圈马达，压电致动器，气动执行器，DC马达等。这些装置/方法可以包括一个独立的控制台，用于免提操作，或者可以包括手持版本。

2. 发明申请

WO2009099805A3 PHACO-EMULSIFICATION HANDPIECE 审中-公开
公开(公告)号：WO2009099805A3
公开(公告)日：2009-10-22
申请号：PCT/US2009032137
申请日：2009-01-27
申请人： PIEZO RESONANCE INNOVATIONS IN , BOOTH DAVID E , MULVIHILL MAUREEN L , PARK BRIAN M , BAGWELL ROGER B
发明人： BOOTH DAVID E , MULVIHILL MAUREEN L , PARK BRIAN M , BAGWELL ROGER B
IPC分类号： A61B18/08 , A61B8/00
CPC分类号： A61F9/00745
摘要： A handpiece for ultrasonic surgical applications includes a member for cutting, fragmenting, emulsifying, or grasping and at least one flextensional transducer for driving the member. The flextensional transducer includes a piezoelectric material and a flexible structure coupled to the piezoelectric material that amplifies the generated piezoelectric displacement of the piezoelectric material.
摘要翻译：用于超声手术应用的手持件包括用于切割，碎裂，乳化或抓握的构件以及用于驱动构件的至少一个弯张换能器。弯曲换能器包括压电材料和耦合到压电材料的柔性结构，其放大压电材料的产生的压电位移。

3. 发明申请

WO2009102944A3 TRANSDERMAL MICRO-PATCH 审中-公开
标题翻译：超薄微孔
公开(公告)号：WO2009102944A3
公开(公告)日：2009-10-15
申请号：PCT/US2009034038
申请日：2009-02-13
申请人： PIEZO RESONANCE INNOVATIONS IN , MULVIHILL MAUREEN L , PARK BRIAN M , KNOWLES GARETH
发明人： MULVIHILL MAUREEN L , PARK BRIAN M , KNOWLES GARETH
IPC分类号： A61N7/00 , A61F13/02 , A61K9/70
CPC分类号： A61M37/0092 , A61K9/703 , A61N7/00
摘要： A transdermal micro -patch (1) for use with living tissue (19) is provided. The micro -patch (1) includes a first membrane (9), a reservoir (3), a micro -pump (4), flextensional transducers (2), a microelectronics circuit (5), and an optional sensor (27). The first membrane (9) is permeable to allow the passage of fluid (1 8) in either a unidirectional or bidirectional fashion. The reservoir (3) is a container -like element capable of storing a fluid (19) removed from or communicated into the tissue (19). The micro -pump (4) facilitates transport of the fluid (1 8) between the reservoir (3) and first membrane (9). The flextensional transducers (2) generate ultrasonic waves (15) which are separately communicated into the tissue (19) to transport fluid (18) between the first membrane (9) and tissue (19). Ultrasonic waves (15) could interact to enhance the performance of the micro-patch (1). The microelectronics circuit (5) controls both flextensional transducers (2) and the micro -pump (4). The sensor (27) could be embedded within the micro -patch (1) to monitor temperature, pressure, or flow rate so as to avoid damage or irritation to the tissue (19).
摘要翻译：提供了一种用于生物体组织（19）的透皮微型贴片（1）。微型配件（1）包括第一膜（9），储存器（3），微泵（4），弯曲换能器（2），微电子电路（5）和可选的传感器（27）。第一膜（9）是可渗透的以允许流体（108）以单向或双向方式通过。储存器（3）是能够存储从组织（19）中移出或连通到其中的流体（19）的容器状元件。微泵（4）有利于储存器（3）和第一膜（9）之间的流体（108）的输送。屈曲换能器（2）产生分离地连通到组织（19）中以在第一膜（9）和组织（19）之间输送流体（18）的超声波（15）。超声波（15）可以相互作用以增强微贴片的性能（1）。微电子电路（5）控制两个弯曲传感器（2）和微型泵（4）。传感器（27）可以嵌入在微型配件（1）内以监测温度，压力或流速，以避免对组织（19）的损伤或刺激。

4. 发明申请

WO2009102944A2 TRANSDERMAL MICRO-PATCH 审中-公开
公开(公告)号：WO2009102944A2
公开(公告)日：2009-08-20
申请号：PCT/US2009/034038
申请日：2009-02-13
申请人： PIEZO RESONANCE INNOVATIONS, INC. , MULVIHILL, Maureen, L. , PARK, Brian, M. , KNOWLES, Gareth
发明人： MULVIHILL, Maureen, L. , PARK, Brian, M. , KNOWLES, Gareth
IPC分类号： A61N7/00 , A61K9/70 , A61F13/02
CPC分类号： A61M37/0092 , A61K9/703 , A61N7/00
摘要： A transdermal micro -patch (1) for use with living tissue (19) is provided. The micro -patch (1) includes a first membrane (9), a reservoir (3), a micro -pump (4), flextensional transducers (2), a microelectronics circuit (5), and an optional sensor (27). The first membrane (9) is permeable to allow the passage of fluid (1 8) in either a unidirectional or bidirectional fashion. The reservoir (3) is a container -like element capable of storing a fluid (19) removed from or communicated into the tissue (19). The micro -pump (4) facilitates transport of the fluid (1 8) between the reservoir (3) and first membrane (9). The flextensional transducers (2) generate ultrasonic waves (15) which are separately communicated into the tissue (19) to transport fluid (18) between the first membrane (9) and tissue (19). Ultrasonic waves (15) could interact to enhance the performance of the micro-patch (1). The microelectronics circuit (5) controls both flextensional transducers (2) and the micro -pump (4). The sensor (27) could be embedded within the micro -patch (1) to monitor temperature, pressure, or flow rate so as to avoid damage or irritation to the tissue (19).
摘要翻译：提供了用于活组织（19）的透皮微量贴剂（1）。微调（1）包括第一薄膜（9），储液器（3），微型泵（4），弯曲换能器（2），微电子电路（5）和可选传感器（27）。第一膜（9）是可渗透的以允许流体（18）以单向或双向方式通过。储存器（3）是能够储存从组织（19）移除或连通到组织（19）中的流体（19）的容器状元件。微型泵（4）便于流体（18）在贮存器（3）和第一膜（9）之间的运输。弯张换能器（2）产生分别连通到组织（19）中以在第一膜（9）和组织（19）之间输送流体（18）的超声波（15）。超声波（15）可以相互作用以增强微贴片（1）的性能。微电子电路（5）控制弯曲换能器（2）和微型泵（4）。传感器（27）可以嵌入微型面板（1）内以监测温度，压力或流速，从而避免损伤或刺激组织（19）。

5. 发明申请

WO2012109621A1 MEDICAL TOOL WITH ELECTROMECHANICAL CONTROL AND FEEDBACK 审中-公开
标题翻译：医疗工具与机电控制和反馈
公开(公告)号：WO2012109621A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/024762
申请日：2012-02-10
申请人： ACTUATED MEDICAL, INC. , FRANKHOUSER, Paul L. , MULVIHILL, Maureen L. , BAGWELL, Roger B. , CLEMENT, Ryan S. , HERNANDEZ MESA, Gabriela , SHEEHAN, Ryan M. , PARK, Brian M.
发明人： FRANKHOUSER, Paul L. , MULVIHILL, Maureen L. , BAGWELL, Roger B. , CLEMENT, Ryan S. , HERNANDEZ MESA, Gabriela , SHEEHAN, Ryan M. , PARK, Brian M.
IPC分类号： A61B17/32
CPC分类号： A61B17/3476 , A61B10/025 , A61B17/320068 , A61B17/3401 , A61B17/3415 , A61B90/06 , A61B2017/00026 , A61B2017/0003 , A61B2017/00039 , A61B2017/00115 , A61B2017/00123 , A61B2017/00477 , A61B2017/3409 , A61B2090/064 , A61M5/3287 , A61M5/46 , A61M19/00 , A61M25/0662 , A61M2025/0166 , A61M2205/0294 , A61M2205/332
摘要： A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, a feedback system monitors electromechanical properties of a control signal of the device and automatically modifies control based thereon, e.g., electrical power to the reciprocating actuator is automatically terminated.
摘要翻译：一种医疗装置，用于减少使用各种往复运动致动器渗透生物组织所需的力。往复式致动器以较小的力驱动诸如针的穿透构件穿过组织，同时装置检测穿透构件通过组织的通道。当穿透构件通过组织时，反馈系统监测装置的控制信号的机电特性并且基于此自动修改控制，例如，自动终止往复式致动器的电功率。

6. 发明申请

WO2010031004A3 MEDICAL TOOL FOR REDUCED PENETRATION FORCE WITH FEEDBACK MEANS 审中-公开
公开(公告)号：WO2010031004A3
公开(公告)日：2010-06-24
申请号：PCT/US2009056864
申请日：2009-09-14
申请人： PIEZO RESONANCE INNOVATIONS IN , FRANKHOUSER PAUL L , MULVIHILL MAUREEN L , PARK BRIAN M
发明人： FRANKHOUSER PAUL L , MULVIHILL MAUREEN L , PARK BRIAN M
IPC分类号： A61M5/48 , A61B10/02 , A61M5/20 , A61M5/315
CPC分类号： A61B10/025 , A61B10/0283 , A61B17/320068 , A61B17/3401 , A61B2010/0003 , A61B2018/00196
摘要： A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators, including piezoelectric, voice coil, solenoids, pneumatics or fluidics. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, electrical power to the reciprocating actuator is automatically terminated. One exemplary method for detecting this passage is via a fluid-containing syringe that is coupled to a channel within the penetrating member. Once the penetrating member tip has passed through the living tissue, the fluid within the syringe no longer experiences any pressure and a plunger within the syringe displaces indicating passage of the penetrating member tip. This motion can provide direct tactile feedback to an operator of the medical device or can automatically open a switch providing electrical power to the medical device. Alternatively, a pressure transducer can also monitor the pressure within the penetrating member channel and automatically activate the switch to cut off the electrical power.

7. 发明申请

WO2010045158A2 TOOL FOR INCISING TISSUE 审中-公开
标题翻译：用于焚烧组织的工具
公开(公告)号：WO2010045158A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/060387
申请日：2009-10-12
申请人： PIEZO RESONANCE INNOVATIONS, INC. , MULVIHILL, Maureen, L. , PARK, Brian, M. , CRESPO, Josue, R.
发明人： MULVIHILL, Maureen, L. , PARK, Brian, M. , CRESPO, Josue, R.
IPC分类号： A61B17/32
CPC分类号： A61B17/3211 , A61B17/32093 , A61B2017/0003 , A61B2017/00039 , A61B2017/00119 , A61B2017/00123 , A61B2017/00398 , A61B2017/00402
摘要： A medical device for reducing the force necessary to penetrate tissue by reciprocating a cutting member in a direction that is parallel to the tissue and using a feedback system to indicate when different layers of tissue are being encountered. Although a variety of driving mechanisms can be used to generate the reciprocating motion, the preferred method is via the use of piezoelectric elements, such as flextensional transducers, amplified piezoelectric actuators, along with a bender bar, and voice coil motor motors. The feedback system utilizes any number of acoustic properties, such as controller impedance, phase lag, conductivity, or resistivity density variable. A vibrating reference member is passed through various tissues and the change in acoustic property is associated with the tissue. A look-up table can be developed that can be used by the feedback system to automatically alert the medical operator (e.g., visual, audible, tactile or display) that a different tissue is being encountered. A power shut-off can be provided as another alternative when a different tissue is encountered.
摘要翻译：一种医疗装置，用于通过使切割构件在平行于组织的方向上往复运动来减小穿透组织所需的力，并且使用反馈系统来指示何时遇到不同层组织。尽管可以使用各种驱动机构来产生往复运动，但是优选的方法是通过使用压电元件，诸如弯曲换能器，放大的压电致动器，以及弯曲杆和音圈马达马达。反馈系统利用任何数量的声学特性，例如控制器阻抗，相位滞后，电导率或电阻率密度可变。振动参考构件穿过各种组织并且声学特性的变化与组织相关联。可以开发查找表，其可以由反馈系统使用以自动提醒医疗操作员（例如视觉，听觉，触觉或显示器）正在遇到不同的组织。当遇到不同的组织时，可以提供断电作为另一种选择。

8. 发明申请

WO2010031004A2 MEDICAL TOOL FOR REDUCED PENETRATION FORCE WITH FEEDBACK MEANS 审中-公开
标题翻译：医疗工具减少穿透力与反馈手段
公开(公告)号：WO2010031004A2
公开(公告)日：2010-03-18
申请号：PCT/US2009056864
申请日：2009-09-14
申请人： PIEZO RESONANCE INNOVATIONS IN , FRANKHOUSER PAUL L , MULVIHILL MAUREEN L , PARK BRIAN M
发明人： FRANKHOUSER PAUL L , MULVIHILL MAUREEN L , PARK BRIAN M
IPC分类号： A61M5/48 , A61B10/02 , A61M5/20 , A61M5/315
CPC分类号： A61B10/025 , A61B10/0283 , A61B17/320068 , A61B17/3401 , A61B2010/0003 , A61B2018/00196
摘要： A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators, including piezoelectric, voice coil, solenoids, pneumatics or fluidics. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, electrical power to the reciprocating actuator is automatically terminated. One exemplary method for detecting this passage is via a fluid-containing syringe that is coupled to a channel within the penetrating member. Once the penetrating member tip has passed through the living tissue, the fluid within the syringe no longer experiences any pressure and a plunger within the syringe displaces indicating passage of the penetrating member tip. This motion can provide direct tactile feedback to an operator of the medical device or can automatically open a switch providing electrical power to the medical device. Alternatively, a pressure transducer can also monitor the pressure within the penetrating member channel and automatically activate the switch to cut off the electrical power.
摘要翻译：一种医疗装置，用于使用各种往复运动致动器（包括压电，音圈，螺线管，气动或流体）来减少穿透活体组织所需的力。往复式致动器以较小的力驱动诸如针的穿透构件穿过组织，同时装置检测穿透构件通过组织的通道。当穿透构件穿过组织时，往复式致动器的电力自动终止。用于检测该通道的一个示例性方法是经由含有流体的注射器连接到穿透构件内的通道。一旦穿透构件尖端已经穿过活组织，注射器内的流体不再经历任何压力，并且注射器内的柱塞移动穿透构件尖端的指示通道。该运动可以向医疗装置的操作者提供直接的触觉反馈，或者可以自动打开向医疗装置提供电力的开关。或者，压力传感器还可以监视穿透构件通道内的压力并自动启动开关以切断电力。

9. 发明申请

WO2010045158A3 TOOL FOR INCISING TISSUE 审中-公开
标题翻译：投入组织工具
公开(公告)号：WO2010045158A3
公开(公告)日：2010-07-15
申请号：PCT/US2009060387
申请日：2009-10-12
申请人： PIEZO RESONANCE INNOVATIONS IN , MULVIHILL MAUREEN L , PARK BRIAN M , CRESPO JOSUE R
发明人： MULVIHILL MAUREEN L , PARK BRIAN M , CRESPO JOSUE R
IPC分类号： A61B17/32
CPC分类号： A61B17/3211 , A61B17/32093 , A61B2017/0003 , A61B2017/00039 , A61B2017/00119 , A61B2017/00123 , A61B2017/00398 , A61B2017/00402
摘要： A medical device for reducing the force necessary to penetrate tissue by reciprocating a cutting member in a direction that is parallel to the tissue and using a feedback system to indicate when different layers of tissue are being encountered. Although a variety of driving mechanisms can be used to generate the reciprocating motion, the preferred method is via the use of piezoelectric elements, such as flextensional transducers, amplified piezoelectric actuators, along with a bender bar, and voice coil motor motors. The feedback system utilizes any number of acoustic properties, such as controller impedance, phase lag, conductivity, or resistivity density variable. A vibrating reference member is passed through various tissues and the change in acoustic property is associated with the tissue. A look-up table can be developed that can be used by the feedback system to automatically alert the medical operator (e.g., visual, audible, tactile or display) that a different tissue is being encountered. A power shut-off can be provided as another alternative when a different tissue is encountered.
摘要翻译：一种医疗装置，用于通过使切割构件沿与组织平行的方向往复运动来减少穿透组织所需的力，并且使用反馈系统来指示何时遇到不同组织的层。虽然可以使用各种驱动机构来产生往复运动，但是优选的方法是通过使用压电元件，例如弯曲换能器，放大的压电致动器，以及弯曲杆和音圈马达马达。反馈系统使用任何数量的声学特性，例如控制器阻抗，相位滞后，电导率或电阻率密度变量。振动参考构件通过各种组织，并且声学特性的变化与组织相关联。可以开发可以由反馈系统使用的查找表来自动警告医疗操作者（例如，视觉，听觉，触觉或显示）正在遇到不同组织。当遇到不同的组织时，可以提供电源切断作为另一种选择。

10. 发明申请

WO2010031004A9 MEDICAL TOOL FOR REDUCED PENETRATION FORCE WITH FEEDBACK MEANS 审中-公开
公开(公告)号：WO2010031004A9
公开(公告)日：2010-03-18
申请号：PCT/US2009/056864
申请日：2009-09-14
申请人： PIEZO RESONANCE INNOVATIONS, INC. , FRANKHOUSER, Paul L. , MULVIHILL, Maureen L. , PARK, Brian M.
发明人： FRANKHOUSER, Paul L. , MULVIHILL, Maureen L. , PARK, Brian M.
IPC分类号： A61M5/48 , A61M5/20 , A61M5/315 , A61B10/02
摘要： A medical device for reducing the force necessary to penetrate living being tissue using a variety of reciprocating motion actuators, including piezoelectric, voice coil, solenoids, pneumatics or fluidics. The reciprocating actuator drives a penetrating member, such as a needle, through the tissue at a reduced force while the device detects the passage of the penetrating member through the tissue. Upon passage of the penetrating member through the tissue, electrical power to the reciprocating actuator is automatically terminated. One exemplary method for detecting this passage is via a fluid-containing syringe that is coupled to a channel within the penetrating member. Once the penetrating member tip has passed through the living tissue, the fluid within the syringe no longer experiences any pressure and a plunger within the syringe displaces indicating passage of the penetrating member tip. This motion can provide direct tactile feedback to an operator of the medical device or can automatically open a switch providing electrical power to the medical device. Alternatively, a pressure transducer can also monitor the pressure within the penetrating member channel and automatically activate the switch to cut off the electrical power.

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