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1. 发明申请

WO2012172398A1 AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
标题翻译：用于超临界血液治疗的装置
公开(公告)号：WO2012172398A1
公开(公告)日：2012-12-20
申请号：PCT/IB2012/000534
申请日：2012-03-20
申请人： GAMBRO LUNDIA AB , FONTANAZZI, Francesco , SURACE, Alessandro , PAOLINI, Francesco
发明人： FONTANAZZI, Francesco , SURACE, Alessandro , PAOLINI, Francesco
IPC分类号： A61M1/16
CPC分类号： A61M1/3639 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/341 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3393 , A61M2205/502 , A61M2205/52
摘要： An apparatus (1) for extracorporeal blood treatment is described, comprising a treatment unit (2), an extracorporeal blood circuit (8), an infusion line (9, 9a, 9b) of a replacement fluid, a dialysis line connected in inlet to the second chamber (4), and a fluid evacuation line (10). The apparatus further comprises sensors for determining a first parameter relating to a patient's blood volume (BV%) a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (Q INF ). Lastly, the apparatus comprises a control unit for performing a control procedure comprising receiving, from the sensors, the measured values of the above-cited parameters and calculating, on the basis of the measured values and the prescription values of the variation in blood volume (BV% target ), the weight loss (WL target )> the plasma conductivity or sodium concentration(C target , Na target) , the infusion volume (V INFtarget ), control values to be imposed during a time interval following the control instant.
摘要翻译：描述了一种用于体外血液处理的装置（1），包括处理单元（2），体外血液回路（8），替换流体的输注管线（9,9a，9b），透析线路连接到入口至第二室（4）和排液管（10）。该装置还包括用于确定与患者血液体积（BV％）相关的第一参数的传感器，涉及超滤流率（UFR）或患者体重减轻率（WLR）的第二参数，第三参数（Cd，Na ）涉及与透析线和/或输注线交叉的液体的电导率或浓度，以及与输注流量（QINF）有关的第四参数。最后，该装置包括用于执行控制程序的控制单元，包括从传感器接收上述参数的测量值，并根据测量值和血量变化的处方值 BV％目标），体重减轻（WLtarget）>等离子体导电率或钠浓度（Ctarget，Natarget），输注体积（VINFtarget），在控制时刻之后的时间间隔内施加的控制值。

2. 发明申请

WO2010004400A2 AN EXTRACORPOREAL BLOOD TREATMENT APPARATUS 审中-公开
标题翻译：一种体外血液处理装置
公开(公告)号：WO2010004400A2
公开(公告)日：2010-01-14
申请号：PCT/IB2009006162
申请日：2009-07-03
申请人： GAMBRO LUNDIA AB , PAOLINI FRANCESCO , GRANDI FABIO , FONTANAZZI FRANCESCO
发明人： PAOLINI FRANCESCO , GRANDI FABIO , FONTANAZZI FRANCESCO
IPC分类号： A61M1/16
CPC分类号： A61M1/16 , A61M1/1601 , A61M1/1613 , A61M1/1647 , A61M1/361
摘要： An extracorporeal blood treatment apparatus comprises a sensor (10) for emitting a signal indicating a change of hematic volume of an individual (7) subjected to a treatment and a weight loss system for actuating the individual's weight loss. A control unit (20) receives an effective weight value of the individual and a desired weight loss value and from these values determines a desired value of a change in hematic volume at end of treatment. The weight loss system is controlled on a basis of the hematic volume change signal and the desired value of the hematic volume change. The apparatus enables automatic control of a dialysis operation while preventing some complications arising from hypotension.
摘要翻译：一种体外血液处理装置，包括传感器（10），用于发出指示受到治疗的个体（7）的血容量变化的信号以及用于致动个体体重减轻的体重减轻系统。控制单元（20）接收个体的有效体重值和期望的体重减轻值，并且从这些值确定治疗结束时血液体积变化的期望值。根据血容量变化信号和血容量变化的期望值来控制体重减轻系统。该设备能够自动控制透析操作，同时防止由低血压引起的一些并发症。

3. 发明申请

WO2005074861A1 A FLUID BAG, USE OF ONE OR MORE FLUID BAGS AND A SYSTEM INCLUDING ONE OR MORE FLUID BAGS 审中-公开
标题翻译：流体袋，使用一个或多个流体袋和包括一个或多个流体袋的系统
公开(公告)号：WO2005074861A1
公开(公告)日：2005-08-18
申请号：PCT/SE2005/000173
申请日：2005-02-10
申请人： GAMBRO LUNDIA AB , HAGERMARK, Michaela , PAOLINI, Francesco
发明人： HAGERMARK, Michaela , PAOLINI, Francesco
IPC分类号： A61J1/10
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/14 , A61J1/2024 , A61J1/2027 , A61M1/1656 , A61M1/1668 , A61M1/167 , A61M1/287 , A61M1/3455 , A61M1/3465 , A61M2209/082
摘要： The invention concerns a fluid bag (10) that contains either a dialysis fluid for hemodialysis or a replacement fluid for replacing ultra-filtrate that is withdrawn from a patient or a fluid that is a rest product from a process of hemodialysis or the like. The fluid bag (10) has a first main sheet (14) and a second main sheet (16) located opposite to the first main sheet (14). The fluid bag (10) has a size such that it contains at least a certain quantity q ml of fluid when it is completely filled with fluid. The fluid bag (10) is arranged such that the distance between said first (14) and second (16) sheets never exceeds a certain value v mm, wherein: q ≥ 2000, and v ≤ 2q/100. The invention also concerns a use of one or more such fluid bags (10) as well as a system including one or more such fluid bags (10).
摘要翻译：本发明涉及一种流体袋（10），其包含用于血液透析的透析液或用于替换从患者抽出的超滤液的替代液体或从血液透析过程等作为静止产物的流体。流体袋（10）具有与第一主片（14）相对的第一主片（14）和第二主片（16）。流体袋（10）具有使其在完全充满流体时至少包含一定量的qml流体的尺寸。流体袋（10）布置成使得所述第一（14）和第二（16）片材之间的距离永远不超过一定值v mm，其中：q> = 2000，v <= 2q / 100。本发明还涉及使用一个或多个这样的流体袋（10）以及包括一个或多个这种流体袋（10）的系统。

4. 发明申请

WO1993000938A1 METHOD AND MEANS FOR DIALYSIS 审中-公开
标题翻译： DIALYSIS的方法和手段
公开(公告)号：WO1993000938A1
公开(公告)日：1993-01-21
申请号：PCT/EP1992001498
申请日：1992-07-03
申请人： HOSPAL LTD , ROSSI, Marco , PAOLINI, Francesco
发明人： HOSPAL LTD
IPC分类号： A61M01/16
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1611 , A61M1/1613 , A61M1/361 , A61M1/3612 , A61M2205/52 , G05B13/042
摘要： Means (1) for dialysis comprising a dialysis unit (11) which receives inputs of programmable machine parameters (U &cir& NOt ), a group of sensors (12) for measuring the patient parameters (Y &cir& NOt ) which have to be monitored, and a control unit (13) of the adaptive type which causes these patient parameters to vary in a predetermined desired way (YD) is described. The desired changes are specified by the operator at the start of the session and can be modified during its course via a system-operator interface (14) which allows the operator to monitor the system completely. The control unit (13) is based on a mathematical model of the patient-dialysis unit system (5), for which the inputs are the machine parameters (U &cir& NOt ) and whose outputs are the patient parameters (Y &cir& NOt ) and it consists of an estimator (31) which estimates the parameters (K &cir& NOt ) in the model and a controller (32) which determines the vector (U &cir& NOt ) of the machine parameters which have to be passed to the dialysis unit (11) on the basis of the desired patient parameters (YD), the actual patient parameters (Y &cir& NOt ) and estimated patient parameters (K &cir& NOt ).
摘要翻译：用于透析的装置（1）包括接收可编程机器参数（U＆cir＆NOt）的输入的透析单元（11），用于测量必须被监视的患者参数（Y＆Cir＆NOt）的一组传感器（12），以及描述使得这些患者参数以预定的期望方式（YD）变化的自适应型的控制单元（13）。所需的更改由操作员在会话开始时指定，并且可以在其过程期间通过系统操作员界面（14）进行修改，这允许操作者完全监视系统。控制单元（13）基于患者 - 透析单元系统（5）的数学模型，其输入是机器参数（U＆Cir＆NOt），其输出是患者参数（Y＆Cir＆NOt），并且其包括估计模型中的参数（K＆cir＆NOt）的估计器（31）和确定必须传递到透析单元（11）的机器参数的向量（U＆cir＆NOt）的控制器（32）根据期望的患者参数（YD），实际患者参数（Y＆Cir＆NOt）和估计的患者参数（K＆cir＆NOt）。

5. 发明申请

WO2003055544A1 NON-INVASIVE DEVICE FOR MEASURING BLOOD TEMPERATURE IN A CIRCUIT FOR THE EXTRACORPOREAL CIRCULATION OF BLOOD, AND EQUIPMENT PROVIDED WITH THIS DEVICE 审中-公开
标题翻译：用于测量血液提取物循环的电路中的血液温度的非入侵装置以及用该装置提供的设备
公开(公告)号：WO2003055544A1
公开(公告)日：2003-07-10
申请号：PCT/IB2002/005572
申请日：2002-12-20
申请人： GAMBRO LUNDIA AB , FONTANAZZI, Francesco , PAOLINI, Francesco , ZACCARELLI, Massimo , DE CICCO, Giorgio , DELNEVO, Annalisa
发明人： FONTANAZZI, Francesco , PAOLINI, Francesco , ZACCARELLI, Massimo , DE CICCO, Giorgio , DELNEVO, Annalisa
IPC分类号： A61M1/16
CPC分类号： G01J5/04 , A61M1/367 , A61M2205/3368 , G01J5/0037 , G01J5/061 , G01J5/12 , G01K1/143 , G01K11/006
摘要： A non-invasive device (16) for measuring blood temperature in a circuit for the extracorporeal circulation of blood includes a line (20) in which blood taken from a patient flows (P), and a temperature sensor (19), connected to the said line (20) and provided with a device (21) for measuring the intensity of an electromagnetic radiation. The measuring device (21) faces a connecting portion or window (37) of the line (20) which is permeable by electromagnetic radiation in a first wave band (B S ), and generates a first signal (V B ), correlated with the electromagnetic radiation in the first band (B S ) and therefore, with the temperature of the blood flowing in the line (20).
摘要翻译：一种用于测量血液体外循环的血液循环中的血液温度的非侵入性装置（16）包括从患者流出的血液（P）的线（20）和连接到患者的温度传感器（19）所述线（20）并且设置有用于测量电磁辐射的强度的装置（21）。测量装置（21）面对线路（20）的连接部分或窗口（37），其在第一波段（BS）中可被电磁辐射渗透，并产生与电磁辐射相关的第一信号（VB）在第一条带（BS）中，因此血液在线（20）中流动的温度。

6. 发明申请

WO2003002174A1 METHOD AND DEVICE FOR DETECTING THE DETACHMENT OF THE VENOUS NEEDLE FROM A PATIENT DURING DIALYSIS 审中-公开
标题翻译：用于在透析期间检测患者的静脉针脱离的方法和装置
公开(公告)号：WO2003002174A1
公开(公告)日：2003-01-09
申请号：PCT/IB2002/002354
申请日：2002-06-24
申请人： GAMBRO LUNDIA AB , LODI, Carlo, Alberto , PAOLINI, Francesco , FAVA, Massimo
发明人： LODI, Carlo, Alberto , PAOLINI, Francesco , FAVA, Massimo
IPC分类号： A61M1/36
CPC分类号： A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/367 , A61M5/16831 , A61M2039/1005 , A61M2205/13 , A61M2205/3331
摘要： A method of detecting the detachment of the venous needle (13) from a patient (P) during an extracorporal blood treatment in a dialysis machine (1) having an extracorporal blood circuit (2) provided with an arterial branch (8) and a venous branch (10) comprises the measurement of the arterial presure (Pa) in the arterial branch (8) and the venous pressure (PV) in the venous branch (10), and the determination of whether or not decreases of the arterial pressures (Pa) and pressures (PV) are occuring during the dialysis treatment in normal conditions.
摘要翻译：一种检测在具有体外血液循环（2）的透析机（1）中的体外血液处理期间从患者（P）分离静脉针（13）的方法，所述体外血液回路（2）具有动脉分支（8）和静脉分支（10）包括测量动脉分支（8）中的动脉压（Pa）和静脉分支（10）中的静脉压（PV），以及确定是否减少动脉压（Pa ）和压力（PV）在正常情况下在透析治疗期间发生。

7. 发明申请

WO2012127298A1 AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
标题翻译：用于超临界血液治疗的装置
公开(公告)号：WO2012127298A1
公开(公告)日：2012-09-27
申请号：PCT/IB2012/000537
申请日：2012-03-20
申请人： GAMBRO LUNDIA AB , FONTANAZZI, Francesco , SURACE, Alessandro , PAOLINI, Francesco
发明人： FONTANAZZI, Francesco , SURACE, Alessandro , PAOLINI, Francesco
IPC分类号： A61M1/16
CPC分类号： A61M1/34 , A61M1/1605 , A61M1/1611 , A61M1/3403 , A61M1/3406 , A61M1/341 , A61M1/3413 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3462 , A61M1/3465 , A61M2205/3334
摘要： An apparatus (1 ) for extracorporeal blood treatment is described, comprising a treatment unit (2), an extracorporeal blood circuit (8), an infusion line (9, 9a, 9b) of a replacement fluid, a dialysis line connected in inlet to the second chamber (4), and a fluid evacuation line (10). The apparatus further comprises sensors for determining a first parameter relating to a patient's blood volume (BV%) a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (Q INF )- Lastly, the apparatus comprises a control unit for performing a control procedure (50) for regulating a variation in blood volume (BV%) and a setting sequence (200) for imposing a transmembrane pressure (TMP) to values which enable maximising the convective exchanges.
摘要翻译：描述了一种用于体外血液处理的装置（1），包括处理单元（2），体外血液回路（8），替换流体的输注管线（9,9a，9b），透析线路连接到入口至第二室（4）和排液管（10）。该装置还包括用于确定与患者血液体积（BV％）相关的第一参数的传感器，涉及超滤流率（UFR）或患者体重减轻率（WLR）的第二参数，第三参数（Cd，Na ）涉及与透析线和/或输注线交叉的液体的电导率或浓度，以及与输注流量（QINF）有关的第四参数。最后，该装置包括用于执行控制过程的控制单元（50 ），用于调节血容量变化（BV％）和用于施加跨膜压力（TMP）的设定顺序（200）到能够最大化对流交换的值。

8. 发明申请

WO2006123197A1 AN APPARATUS FOR CONTROLLING BLOOD FLOW IN AN EXTRACORPOREAL CIRCUIT. 审中-公开
标题翻译：用于控制离子电路中血液流动的装置。
公开(公告)号：WO2006123197A1
公开(公告)日：2006-11-23
申请号：PCT/IB2005/001347
申请日：2005-05-18
申请人： GAMBRO LUNDIA AB , PAOLINI, Francesco , LODI, Carlo, Alberto , FONTANAZZI, Francesco
发明人： PAOLINI, Francesco , LODI, Carlo, Alberto , FONTANAZZI, Francesco
IPC分类号： F04B49/06 , A61M1/10
CPC分类号： A61M1/1086 , A61M1/1006 , A61M1/1039 , A61M1/3655 , A61M2205/3334
摘要： The apparatus for blood flow control in an extracorporeal circuit comprises: a user interface for setting a desired blood flow value (q bREAL ) and a datum relating to the vascular access, a memory for recording a plurality of mathematical relations having mathematical expressions relating to the vascular access organ to be used, and a control unit. The control unit identifies the vascular access, selects, from among the plurality of mathematical relations present in the memory, a relation which corresponds to the vascular access identified, and calculates, as a mathematical function of the set value for the desired flow (q bREAL ), a value at which to set the angular velocity of the pump associated to the extracorporeal circuit and/or a theoretical value of the arterial pressure upstream of the pump.
摘要翻译：用于体外循环血流控制的装置包括：用于设置所需血流值（qLBALAL）的用户界面和与血管通路有关的数据;存储器，用于记录多个数学具有与要使用的血管通路器官有关的数学表达式的关系，以及控制单元。控制单元识别血管通路，从存储器中存在的多个数学关系中选择与识别的血管通路相对应的关系，并计算出所需流量的设定值的数学函数（q < SUB> bREAL ），用于设定与体外循环相关的泵的角速度和/或泵的上游的动脉压的理论值的值。

9. 发明申请

WO2002102441A1 METHOD AND DEVICE FOR SENSING THE DETACHMENT OF THE VENOUS NEEDLE FROM A PATIENT DURING DIALYSIS 审中-公开
标题翻译：用于在透析期间感染患者的静脉针的方法和装置
公开(公告)号：WO2002102441A1
公开(公告)日：2002-12-27
申请号：PCT/IB2002/001954
申请日：2002-05-30
申请人： GAMBRO LUNDIA AB , LODI, Carlo, Alberto , PAOLINI, Francesco , CANINI, Enrico
发明人： LODI, Carlo, Alberto , PAOLINI, Francesco , CANINI, Enrico
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3669 , A61M5/16831 , A61M2039/1005 , A61M2205/12
摘要： A method of sensing the detachment of the venous needle (13) from a patient (P) during an extracorporeal blood treatment in a dialysis machine (1) having an extracorporeal blood circuit (2), in which an electric current is made to flow along a closed-loop path (P1) of an electrical circuit (37) formed by an electrical line (21, 22, 23) external to the extracorporeal circuit (2), a portion of extracorporeal circuit (2) directly connected to the venous needle (13), and the patient (P); a signal correlated with the electric current along the electrical line (21, 22, 23) is detected; and the signal is compared with a threshold value by means of a control unit (15).
摘要翻译：一种在具有体外血液循环（2）的透析机（1）中感测在体外血液处理期间从患者（P）脱离静脉针（13）的方法，其中使电流流动由体外回路（2）外部的电线（21,22,23）形成的电路（37）的闭环路径（P1），直接连接到静脉针的体外回路（2）的一部分（13）和患者（P）; 检测与沿着电线（21,22,23）的电流相关的信号; 并且通过控制单元（15）将信号与阈值进行比较。

10. 发明申请

WO2012085644A1 METHOD AND SYSTEM FOR DETECTING OR VERIFYING A BLOOD CIRCUIT CONNECTED TO AN EXTRACORPOREAL BLOOD TREATMENT CONSOLE 审中-公开
标题翻译：用于检测或验证连接到外部血液治疗控制台的血液回路的方法和系统
公开(公告)号：WO2012085644A1
公开(公告)日：2012-06-28
申请号：PCT/IB2011/003103
申请日：2011-12-21
申请人： GAMBRO LUNDIA AB , PAOLINI, Francesco , ROVATTI, Paolo
发明人： PAOLINI, Francesco , ROVATTI, Paolo
IPC分类号： A61M1/16
CPC分类号： G01B13/00 , A61M1/16 , A61M1/34 , A61M1/36 , A61M1/3607 , A61M1/3609 , A61M1/3621 , A61M1/3627 , A61M1/3632 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M2205/123 , A61M2205/3331 , A61M2205/3365 , A61M2205/3379 , A61M2205/50 , A61M2205/502 , A61M2205/60 , A61M2205/6018 , A61M2205/70
摘要： A method to determine a type of blood circuit attached to an extracorporeal blood treatment console including: pumping a liquid through a blood passage of the blood circuit, sensing a first pressure in: the blood passage while the passage is closed and pumping stopped, pumping an additional amount of the liquid into the blood passage while the blood passage is and remains closed and thereafter sensing a second pressure, and determine a dimensional characteristic of a fluid passage in the blood passage based on the additional amount of the liquid and the second pressure.
摘要翻译：一种确定附着在体外血液处理控制台上的血液回路类型的方法，包括：将液体泵送通过血液循环的血液通道，感测到第一压力：血液通道在通道关闭并泵送停止时，泵送另外量的液体进入血液通道，同时血液通道保持关闭，此后感测第二压力，并且基于液体的附加量和第二压力确定血液通道中的流体通道的尺寸特性。

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