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1. 发明申请

WO2010094074A1 PHARMACEUTICAL PREPARATION AND DELIVERY SYSTEM 审中-公开
标题翻译：药物制备和输送系统
公开(公告)号：WO2010094074A1
公开(公告)日：2010-08-26
申请号：PCT/AU2010/000186
申请日：2010-02-19
申请人： PALMAYA PTY LTD , O'NEIL, Alexander George Brian
发明人： O'NEIL, Alexander George Brian
IPC分类号： A61K31/5517 , A61K31/437 , A61K31/4745 , A61P25/22
CPC分类号： A61K31/437 , A61K31/4745 , A61K31/5517
摘要： The present invention relates to unique delivery systems and the use of an imidazobenzodiazepine derivative, such as flumazenil either alone or in combination with other receptor antagonists in the treatment of disease or medical disorders.
摘要翻译：本发明涉及独特的递送系统以及咪唑并二氮杂衍生物如氟马西酰单独使用或与其它受体拮抗剂组合用于治疗疾病或医学疾病的用途。

2. 发明授权

US11090428B2 Syringe infusion devices and systems for delivery of active agents 有权
公开(公告)号：US11090428B2
公开(公告)日：2021-08-17
申请号：US15511690
申请日：2015-09-17
申请人： PALMAYA PTY LTD.
发明人： Alexander George Brian O'Neil , Boon Yew Yeo
IPC分类号： A61M5/145 , A61M5/168 , A61M5/142 , A61M5/14
摘要： A pump device (10) operable with a syringe (11) having a barrel (12) and a plunger (13). The pump device (10) is operable to cause relative movement between the syringe plunger (13) and the syringe barrel (12) for discharging fluid from the syringe (11). The pump device (10) comprises a portion (31) adapted to engage the syringe barrel (12), and a drive mechanism for moving the syringe plunger (13) relative to the syringe barrel (12) to discharge fluid from the syringe (11). The drive mechanism comprises an actuator (45) adapted to engage the syringe plunger (13) and a power mechanism (61) for moving the actuator (45) to effect movement of the syringe plunger (13) relative to the syringe barrel (12). The pump device (10) thus provides a syringe driving means. There is also provided an infusion system comprising a syringe driving means, the syringe driving means comprising the pump device (10). Further, there is provided an infusion system comprising a syringe driving means operable to maintain a constant pressure within a syringe and tubing with viscosity corrections for various antibiotic concentrations.

3. 发明申请

US20160089379A1 TREATMENT OF NEUROLOGICAL AND OTHER DISORDERS 审中-公开
标题翻译：治疗神经病和其他疾病
公开(公告)号：US20160089379A1
公开(公告)日：2016-03-31
申请号：US14891836
申请日：2014-05-20
申请人： Alexander George Brian O'NEIL , PALMAYA PTY LTD
发明人： Alexander George Brian O'Neil
IPC分类号： A61K31/5517 , A61K31/485 , A61K31/5513
CPC分类号： A61K31/5517 , A61K9/2081 , A61K9/2853 , A61K31/485 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： Methods and implants for treating neurological, muscular and other cells having an electrical potential, with an infusion of antagonists or inverse agonists (such as flumazenil for the benzodiazepine receptor, or naltrexone for the opiate receptor or other antagonist for other receptor) at rates that are so low that only a small percentage of receptors have the antagonist effect at any one time.
摘要翻译：用于治疗神经系统，肌肉和其他具有电位的细胞的方法和植入物，其输入拮抗剂或反向激动剂（例如苯并二氮杂受体的氟马西汀或鸦片剂受体的纳曲酮或其它受体的其他拮抗剂）以很低，只有一小部分受体在任何时候都具有拮抗作用。

4. 发明申请

US20210369951A1 SYRINGE INFUSION DEVICES AND SYSTEMS FOR DELIVERY OF ACTIVE AGENTS 有权
公开(公告)号：US20210369951A1
公开(公告)日：2021-12-02
申请号：US17400865
申请日：2021-08-12
申请人： PALMAYA PTY LTD.
发明人： Alexander George Brian O'NEIL , Boon Yew YEO
IPC分类号： A61M5/145 , A61M5/168
摘要： A pump device (10) operable with a syringe (11) having a barrel (12) and a plunger (13). The pump device (10) is operable to cause relative movement between the syringe plunger (13) and the syringe barrel (12) for discharging fluid from the syringe (11). The pump device (10) comprises a portion (31) adapted to engage the syringe barrel (12), and a drive mechanism for moving the syringe plunger (13) relative to the syringe barrel (12) to discharge fluid from the syringe (11). The drive mechanism comprises an actuator (45) adapted to engage the syringe plunger (13) and a power mechanism (61) for moving the actuator (45) to effect movement of the syringe plunger (13) relative to the syringe barrel (12). The pump device (10) thus provides a syringe driving means. There is also provided an infusion system comprising a syringe driving means, the syringe driving means comprising the pump device (10). Further, there is provided an infusion system comprising a syringe driving means operable to maintain a constant pressure within a syringe and tubing with viscosity corrections for various antibiotic concentrations.

5. 发明申请

US20210205595A1 FLUID COUPLING 有权
公开(公告)号：US20210205595A1
公开(公告)日：2021-07-08
申请号：US17059542
申请日：2019-05-30
申请人： PALMAYA PTY LTD.
发明人： Alexander George Brian O'NEIL
IPC分类号： A61M39/10
摘要： A fluid coupling (10) comprising several intravenous fluid delivery tubes (11) and a connector (15). The connector (15) is configured for attachment to an intravenous cannula or needle. The connector (15) comprises a body (20) having a first end portion (21) and a second end portion (22). The first end portion (21) comprises a plurality of sockets (23), each socket being adapted to receive an end section of a respective fluid delivery tube (11). The second end portion (22) comprises a nozzle (31) having an end face (33), wherein there is a plurality of interior flow paths (41) within the nozzle. Each flow path (41) opens onto the end of the nozzle (31) and communicates with a respective one of the sockets (23), whereby fluid delivered by each tube (11) is transported along the respective flow path (41) to the end of the nozzle (31) and the intravenous cannula or needle attached thereto. Each tube (11) has an end section thereof sealingly received in a respective socket (23).

6. 发明申请

US20220152044A1 TREATMENT OF INFLAMMATORY DISEASES OF THE CENTRAL NERVOUS SYSTEM 有权
公开(公告)号：US20220152044A1
公开(公告)日：2022-05-19
申请号：US17593249
申请日：2020-03-16
申请人： PALMAYA PTY LTD
发明人： Alexander George Brian O'NEIL
IPC分类号： A61K31/5517 , A61K31/485 , A61K9/00
摘要： The present invention relates to the use of flumazenil for the treatment of inflammatory conditions of the central nervous system, such as migraine, headache and multiple sclerosis, anxiety, PTSD, psychosis, depression, and cessation of addictive behaviours. The active may be administered in the form of an implant. The present invention also relates to the use of flumazenil, naltrexone, and optionally buprenorphine in order to reduce symptoms associated with withdrawal of drugs of dependence or addictive behaviours.

7. 发明申请

US20170246381A1 SYRINGE INFUSION DEVICES AND SYSTEMS FOR DELIVERY OF ACTIVE AGENTS 审中-公开
公开(公告)号：US20170246381A1
公开(公告)日：2017-08-31
申请号：US15511690
申请日：2015-09-17
申请人： PALMAYA PTY LTD.
发明人： Alexander George Brian O'Neil
IPC分类号： A61M5/145 , A61M5/168
CPC分类号： A61M5/1454 , A61M5/141 , A61M5/14244 , A61M5/14546 , A61M5/1456 , A61M5/1458 , A61M5/16813 , A61M5/16881 , A61M2005/1405 , A61M2205/70 , A61M2205/7536 , A61M2209/088
摘要： A pump device (10) operable with a syringe (11) having a barrel (12) and a plunger (13). The pump device (10) is operable to cause relative movement between the syringe plunger (13) and the syringe barrel (12) for discharging fluid from the syringe (11). The pump device (10) comprises a portion (31) adapted to engage the syringe barrel (12), and a drive mechanism for moving the syringe plunger (13) relative to the syringe barrel (12) to discharge fluid from the syringe (11). The drive mechanism comprises an actuator (45) adapted to engage the syringe plunger (13) and a power mechanism (61) for moving the actuator (45) to effect movement of the syringe plunger (13) relative to the syringe barrel (12). The pump device (10) thus provides a syringe driving means. There is also provided an infusion system comprising a syringe driving means, the syringe driving means comprising the pump device (10). Further, there is provided an infusion system comprising a syringe driving means operable to maintain a constant pressure within a syringe and tubing with viscosity corrections for various antibiotic concentrations.

8. 发明申请

US20160256472A1 COMPOSITIONS AND METHODS OF ADMINISTERING SAME 审中-公开
标题翻译：组合物和管理方法
公开(公告)号：US20160256472A1
公开(公告)日：2016-09-08
申请号：US15028146
申请日：2014-10-14
申请人： PALMAYA PTY LTD
发明人： Alexander George Brian O'Neil
IPC分类号： A61K31/5517 , A61K31/138 , A61K31/4168 , A61K31/485
CPC分类号： A61K31/5517 , A61K9/0043 , A61K31/137 , A61K31/138 , A61K31/4168 , A61K31/485 , A61K2300/00
摘要： A composition comprising two or more active agents in a micro-dose amount, such as a micro-dose of naltrexone in combination with a micro-dose of flumazenil, in the treatment of craving or anxiety resulting in rapid settling of the craving for substance use, smoking or an obsessional behaviour, preferably within minutes of administration of the composition.
摘要翻译：包含两种或多种微量剂量活性剂的组合物，例如与微量剂量的氟马西尼联用的微量纳曲酮，用于治疗渴望或焦虑，导致快速沉降物质使用的渴望，吸烟或强迫行为，优选在施用组合物的几分钟内。

9. 发明申请

WO2016040990A1 SYRINGE INFUSION DEVICES AND SYSTEMS FOR DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：用于递送活性剂的注射装置和系统
公开(公告)号：WO2016040990A1
公开(公告)日：2016-03-24
申请号：PCT/AU2015/000572
申请日：2015-09-17
申请人： PALMAYA PTY LTD
发明人： O'NEIL, Alexander George Brian
IPC分类号： A61M5/145
CPC分类号： A61M5/1454 , A61M5/141 , A61M5/14244 , A61M5/14546 , A61M5/1456 , A61M5/1458 , A61M5/16813 , A61M5/16881 , A61M2005/1405 , A61M2205/70 , A61M2205/7536 , A61M2209/088
摘要： A pump device (10) operable with a syringe (11) having a barrel (12) and a plunger (13). The pump device (10) is operable to cause relative movement between the syringe plunger (13) and the syringe barrel (12) for discharging fluid from the syringe (11). The pump device (10) comprises a portion (31) adapted to engage the syringe barrel (12), and a drive mechanism for moving the syringe plunger (13) relative to the syringe barrel (12) to discharge fluid from the syringe (11). The drive mechanism comprises an actuator (45) adapted to engage the syringe plunger (13) and a power mechanism (61) for moving the actuator (45) to effect movement of the syringe plunger (13) relative to the syringe barrel (12). The pump device (10) thus provides a syringe driving means. There is also provided an infusion system comprising a syringe driving means, the syringe driving means comprising the pump device (10). Further, there is provided an infusion system comprising a syringe driving means operable to maintain a constant pressure within a syringe and tubing with viscosity corrections for various antibiotic concentrations.
摘要翻译：泵装置（10）可与具有筒体（12）和柱塞（13）的注射器（11）一起操作。泵装置（10）可操作以引起注射器柱塞（13）和注射器筒（12）之间的相对运动，用于从注射器（11）排出流体。泵装置（10）包括适于接合注射器筒（12）的部分（31）和用于相对于注射器筒（12）移动注射器柱塞（13）以从注射器（11）排出流体的驱动机构）。驱动机构包括适于接合针筒柱塞（13）的致动器（45）和用于移动致动器（45）以实现针筒柱塞（13）相对于注射器筒（12）的运动的动力机构（61）。因此，泵装置（10）提供注射器驱动装置。还提供了包括注射器驱动装置的注射系统，所述注射器驱动装置包括泵装置（10）。此外，提供了一种输注系统，其包括注射器驱动装置，其可操作以保持注射器内的恒定压力和具有针对各种抗生素浓度的粘度校正的管道。

10. 发明申请

WO2015054730A1 COMPOSITIONS AND METHODS OF ADMINISTERING SAME 审中-公开
标题翻译：组合物和管理方法
公开(公告)号：WO2015054730A1
公开(公告)日：2015-04-23
申请号：PCT/AU2014/000978
申请日：2014-10-14
申请人： PALMAYA PTY LTD
发明人： O'NEIL, Alexander George Bria
IPC分类号： A61K31/5517 , A61K31/485 , A61K31/4168 , A61K31/137 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36
CPC分类号： A61K31/5517 , A61K9/0043 , A61K31/137 , A61K31/138 , A61K31/4168 , A61K31/485 , A61K2300/00
摘要： A composition comprising two or more active agents in a micro-dose amount, such as a micro- dose of naltrexone in combination with a micro-dose of flumazenil, in the treatment of craving or anxiety resulting in rapid settling of the craving for substance use, smoking or an obsessional behaviour, preferably within minutes of administration of the composition.
摘要翻译：包含微量剂量的两种或更多种活性剂的组合物，例如与微量剂量的氟马西尼联用的微量纳曲酮，用于治疗渴望或焦虑，导致物质使用的渴望快速沉降，吸烟或强迫行为，优选在施用组合物的几分钟内。

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