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1. 发明申请

WO2008104923A3 CONTINUOUS GRANULATING AND DRYING APPARATUS INCLUDING MEASUREMENT UNITS AND METHOD OF CONTINUOUS GRANULATION AND DRYING 审中-公开
标题翻译：连续的造粒和干燥装置，包括测量单位和连续造粒和干燥方法
公开(公告)号：WO2008104923A3
公开(公告)日：2009-05-28
申请号：PCT/IB2008050670
申请日：2008-02-25
申请人： COLLETTE NV , WALDRON MICHEL SIMON , PAGE TREVOR GORDON , VERMEIRE TOMAS
发明人： WALDRON MICHEL SIMON , PAGE TREVOR GORDON , VERMEIRE TOMAS
IPC分类号： B01J2/16 , B01J2/20
CPC分类号： B01J2/16 , B01J2/20
摘要： A continuous granulating and drying apparatus (1) comprises a granulator (2) and a dryer (3). Measurement of product and process parameters is carried out by means of measurement units (MUl, MU2, MU3) positioned at critical locations in the apparatus.
摘要翻译：连续造粒和干燥装置（1）包括造粒机（2）和干燥机（3）。产品和工艺参数的测量通过位于设备关键位置的测量单元（MU1，MU2，MU3）进行。

2. 发明申请

WO2010128359A1 TABLET PRODUCTION MODULE AND METHOD FOR CONTINUOUS PRODUCTION OF TABLETS 审中-公开
标题翻译：片剂生产模块和连续生产片剂的方法
公开(公告)号：WO2010128359A1
公开(公告)日：2010-11-11
申请号：PCT/IB2009/051885
申请日：2009-05-07
申请人： GEA Pharma Systems Limited , PAGE, Trevor Gordon , WALDRON, Michel Simon , BOECKX, Jurgen
发明人： PAGE, Trevor Gordon , WALDRON, Michel Simon
IPC分类号： A61J3/10
CPC分类号： A61J3/10 , B29B7/48 , B29B7/726 , B29B13/065 , B29C43/02 , B29C43/34 , B29C43/50 , B29C43/58 , B29C2043/5833 , B29K2105/0035 , B29K2105/251 , B30B11/005 , B30B15/308
摘要： The contained module (1) comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (41,46), and the outlet of 5 the tablet press (6) is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is 10 controlled in response to the parameters measured upstream of the tab- let press. The finished tablets are discharged at an outlet of the tablet press (6).
摘要翻译：包含的模块（1）包括用于活性药物成分（API）和赋形剂的入口。入口与至少一个混合单元（41,46）流体连通，并且压片机（6）的出口5与片剂的可释放出口端口流体连通。包含API和赋形剂的物料流在混合单元中混合。在操作期间，通过在压片机上游的一个或多个分析传感器测量材料流内容物的参数。压片机的速度响应于在标签压力机上游测量的参数而被控制10。成品片剂在压片机（6）的出口排出。

3. 发明申请

WO2006067546A1 FLUID BED APPARATUS MODULE AND METHOD OF CHANGING A FIRST MODULE FOR A SECOND MODULE IN A FLUID BED APPARATUS 审中-公开
标题翻译：流体设备装置和改变流体装置中第二模块的第一模块的方法
公开(公告)号：WO2006067546A1
公开(公告)日：2006-06-29
申请号：PCT/IB2004/004266
申请日：2004-12-23
申请人： COLLETTE NV , HANSEN, Ove, Emil , PAGE, Trevor, Gordon , WALDRON, Michel, Simon
发明人： HANSEN, Ove, Emil , PAGE, Trevor, Gordon , WALDRON, Michel, Simon
IPC分类号： B01J8/36 , B01J2/16 , F26B3/08
CPC分类号： B01J8/36 , B01J2/16 , B01J8/006 , B01J8/1809 , B01J8/34 , B01J8/44 , B01J2208/00061 , B01J2208/00548 , B01J2208/00557 , B01J2208/00699 , B01J2208/0084 , B01J2208/00884 , B01J2219/0002 , B01J2219/00024 , B01J2219/00029 , B01J2219/00031 , B01J2219/00033 , B01J2219/1943 , B01J2219/1944 , B01J2219/1946
摘要： A fluid bed apparatus module (1) comprises an outer wall enclosing a processing chamber (9) and has a lower flange connection (4) and an upper flange connection (5), the lower flange connection being adapted to connection with a flange connection (14) of a supply of fluidising gas, and the upper flange connection being adapted to connection with a flange connection (17) of a filter chamber (18) for gas discharge. At least one partition element (6) is arranged in the processing chamber, so that at least one elongated channel is formed in the processing chamber, thereby defining a plug-flow area, and at least one substantially continuous product inlet (10) and at least one substantially continuous product outlet (11) are arranged in the module. Furthermore, a method comprises changing a first module for a second module in a fluid bed apparatus.
摘要翻译：流化床装置模块（1）包括封闭处理室（9）并具有下法兰连接件（4）和上法兰连接件（5）的外壁，所述下法兰连接件适于与法兰连接 14），并且所述上凸缘连接件适于与用于气体排放的过滤室（18）的法兰连接（17）连接。至少一个分隔元件（6）布置在处理室中，使得在处理室中形成至少一个细长通道，由此限定插塞流动区域和至少一个基本连续的产品入口（10）在模块中布置有至少一个基本连续的产品出口（11）。此外，一种方法包括在流化床装置中改变用于第二模块的第一模块。

4. 发明申请

WO2006067544A1 FLUID BED APPARATUS AND METHOD OF OPERATING SUCH APPARATUS 审中-公开
标题翻译：流体床装置和操作这种装置的方法
公开(公告)号：WO2006067544A1
公开(公告)日：2006-06-29
申请号：PCT/IB2004/004263
申请日：2004-12-23
申请人： COLLETTE NV , PAGE, Trevor, Gordon , HANSEN, Ove, Emil , WALDRON, Michel, Simon
发明人： PAGE, Trevor, Gordon , HANSEN, Ove, Emil , WALDRON, Michel, Simon
IPC分类号： B01J8/00 , B01J8/26 , B01J8/24 , F26B3/08
CPC分类号： B01J8/003 , B01J8/0035 , B01J8/1872 , B01J8/26 , B01J2208/00752 , B01J2208/00761 , B01J2208/00814 , B01J2219/00011 , B01J2219/00029
摘要： A fluid bed apparatus (1), comprises at least two separate batch processing compartments (C3, C6) , each compartment having a product inlet and a product outlet, a bed plate (6) having inlet openings for a fluidising gas, and a gas outlet. The apparatus comprises a product supply conduit (22) located centrally in relation to the separate batch processing compartments and being adapted to selectively communicate with the product inlet of each separate batch processing compartment, respectively, and comprises a product discharge conduit (14) located centrally in relation to the separate batch processing compartments and being adapted to selectively communicate with the product outlet of each separate batch processing compartment, respectively.
摘要翻译：一种流化床装置（1），包括至少两个单独的分批处理隔室（C3，C6），每个隔室具有产品入口和产品出口，具有用于流化气体的入口的床板（6）和气体出口。该设备包括相对于分开的分批处理室位于中心的产品供应管道（22），并且适于分别选择性地与每个分开的批处理室的产品入口连通，并且包括位于中心的产品排放管道（14）相对于单独的批处理隔室并且适于分别选择性地与每个单独批处理室的产品出口通信。

5. 发明申请

WO2013005138A3 METHOD AND SYSTEM FOR CONTROLLING PROCESS PARAMETERS IN A PHARMACEUTICAL PRODUCT PROCESSING SYSTEM 审中-公开
公开(公告)号：WO2013005138A3
公开(公告)日：2013-01-10
申请号：PCT/IB2012/053245
申请日：2012-06-27
申请人： GEA PHARMA SYSTEMS LIMITED , PAGE, Trevor Gordon
发明人： PAGE, Trevor Gordon
IPC分类号： G06Q10/04 , G06Q50/04
摘要： The invention is a method for monitoring and/or controlling process parameters of a batch or continuous pharmaceutical production process in a pharmaceutical product processing system, such as a continuous feeder or a granulator, the method comprising the steps of providing a pharmaceutical product processing system (1), providing said pharmaceutical product processing system (1) with a control system (2), measuring a time domain signal obtained from said pharmaceutical product processing system (1), Fourier transforming said time domain signal to obtain a frequency domain signal, analyzing said frequency domain signal by means of said control system (2) to obtain frequency domain data indicative of variations in one or more of said process parameters, and evaluating said one or more process parameters based on said frequency domain data. Likewise the invention may relate to a pharmaceutical product processing system (1) adapted for carrying out such a method.

6. 发明申请

WO2007072262A3 MEASURING DEVICE COMPRISING A PROBE BODY ADAPTED FOR CONNECTION WITH A PROCESS VESSEL OR CONDUIT AND MEASURING METHOD 审中-公开
标题翻译：测量装置，包括适用于与过程船舶或管道连接的探头体和测量方法
公开(公告)号：WO2007072262A3
公开(公告)日：2007-10-18
申请号：PCT/IB2006054594
申请日：2006-12-05
申请人： AEROMATIC FIELDER AG , PAGE TREVOR GORDON
发明人： PAGE TREVOR GORDON
IPC分类号： G01N1/20 , G01D11/24 , G01K1/14 , G01L19/00 , G01N21/85 , G01N27/28
CPC分类号： G01N1/2035 , G01N22/00 , G01N27/283
摘要： A measuring device (1) comprises a probe body (4) adapted for connection with a process vessel or conduit, so that a process opening (6) of the probe body communicates with the interior of the process vessel or conduit. A front valve (7) is arranged between the process opening and a washing chamber (5) in the probe body, and a probe piston (3) is arranged displaceably in the probe body between a retracted position, in which the probe piston is located behind the front valve (7), inside the washing chamber (5), and an extended position, in which the probe piston extends through the front valve and communicates with the process opening. A back valve (9) is arranged between the front valve and the washing chamber, and an intermediate chamber (8) is arranged between the front valve and the back valve. In its retracted position, the probe piston is located behind the back valve.
摘要翻译：测量装置（1）包括适于与处理容器或管道连接的探针主体（4），使得探针主体的处理开口（6）与处理容器或导管的内部连通。一个前阀（7）设置在探针体内的处理开口和洗涤室（5）之间，探针活塞（3）可置于探头主体内，位于探针活塞位于的缩回位置在前阀（7）的后面，在洗涤室（5）内部，以及延伸位置，其中探针活塞延伸穿过前阀并与过程开口连通。后阀（9）设置在前阀和洗涤室之间，中间室（8）设置在前阀和后阀之间。在其缩回位置，探针活塞位于后阀后面。

7. 发明申请

WO2007072262A2 MEASURING DEVICE COMPRISING A PROBE BODY ADAPTED FOR CONNECTION WITH A PROCESS VESSEL OR CONDUIT AND MEASURING METHOD 审中-公开
标题翻译：测量装置，包括适于连接过程容器或导管的探针体和测量方法
公开(公告)号：WO2007072262A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054594
申请日：2006-12-05
申请人： AEROMATIC-FIELDER AG , PAGE, Trevor Gordon
发明人： PAGE, Trevor Gordon
CPC分类号： G01N1/2035 , G01N22/00 , G01N27/283
摘要： A measuring device (1) comprises a probe body (4) adapted for connection with a process vessel or conduit, so that a process opening (6) of the probe body communicates with the interior of the process vessel or conduit. A front valve (7) is arranged between the process opening and a washing chamber (5) in the probe body, and a probe piston (3) is arranged displaceably in the probe body between a retracted position, in which the probe piston is located behind the front valve (7), inside the washing chamber (5), and an extended position, in which the probe piston extends through the front valve and communicates with the process opening. A back valve (9) is arranged between the front valve and the washing chamber, and an intermediate chamber (8) is arranged between the front valve and the back valve. In its retracted position, the probe piston is located behind the back valve.
摘要翻译：测量装置（1）包括适于与处理容器或导管连接的探头主体（4），使得探头主体的处理开口（6）与处理器的内部连通容器或导管。在过程开口与探头体中的洗涤室（5）之间布置前阀（7），并且探头活塞（3）可移动地布置在探头本体中的探头活塞位于其中的缩回位置在前部阀门（7）后面，在洗涤室（5）内部以及延伸位置，其中探针活塞延伸通过前部阀门并与处理开口连通。前阀与洗涤室之间设置有后阀（9），前阀与后阀之间设有中间室（8）。在缩回位置，探针活塞位于后部阀后面。

8. 发明申请

WO2013005138A2 METHOD AND SYSTEM FOR CONTROLLING PROCESS PARAMETERS IN A PHARMACEUTICAL PRODUCT PROCESSING SYSTEM 审中-公开
标题翻译：用于控制药物产品加工系统中过程参数的方法和系统
公开(公告)号：WO2013005138A2
公开(公告)日：2013-01-10
申请号：PCT/IB2012053245
申请日：2012-06-27
申请人： GEA PHARMA SYSTEMS LTD , PAGE TREVOR GORDON
发明人： PAGE TREVOR GORDON
CPC分类号： G06Q10/04 , G06Q10/06 , G06Q50/04 , G06Q50/22 , Y02P90/30
摘要： The invention is a method for monitoring and/or controlling process parameters of a batch or continuous pharmaceutical production process in a pharmaceutical product processing system, such as a continuous feeder or a granulator, the method comprising the steps of providing a pharmaceutical product processing system (1), providing said pharmaceutical product processing system (1) with a control system (2), measuring a time domain signal obtained from said pharmaceutical product processing system (1), Fourier transforming said time domain signal to obtain a frequency domain signal, analyzing said frequency domain signal by means of said control system (2) to obtain frequency domain data indicative of variations in one or more of said process parameters, and evaluating said one or more process parameters based on said frequency domain data. Likewise the invention may relate to a pharmaceutical product processing system (1) adapted for carrying out such a method.
摘要翻译：本发明是用于监测和/或控制药物产品加工系统（例如连续进料器或造粒机）中的批次或连续药物生产过程的工艺参数的方法，所述方法包括以下步骤：提供药物产品加工系统 1），向所述药品处理系统（1）提供控制系统（2），测量从所述药品处理系统（1）获得的时域信号，傅里叶变换所述时域信号以获得频域信号，分析所述频域信号通过所述控制系统（2）获得，以获得指示所述过程参数中的一个或多个的变化的频域数据，并且基于所述频域数据来评估所述一个或多个处理参数。同样，本发明可以涉及适于实施这种方法的药物产品处理系统（1）。

9. 发明申请

WO2008104923A2 CONTINUOUS GRANULATING AND DRYING APPARATUS INCLUDING MEASUREMENT UNITS AND METHOD OF CONTINUOUS GRANULATION AND DRYING 审中-公开
标题翻译：连续的造粒和干燥装置，包括测量单位和连续造粒和干燥方法
公开(公告)号：WO2008104923A2
公开(公告)日：2008-09-04
申请号：PCT/IB2008/050670
申请日：2008-02-25
申请人： COLLETTE NV , WALDRON, Michel Simon , PAGE, Trevor Gordon , VERMEIRE, Tomas
发明人： WALDRON, Michel Simon , PAGE, Trevor Gordon , VERMEIRE, Tomas
IPC分类号： B01J2/16 , B01J2/20
CPC分类号： B01J2/16 , B01J2/20
摘要： A continuous granulating and drying apparatus (1) comprises a granulator (2) and a dryer (3). Measurement of product and process parameters is carried out by means of measurement units (MUl, MU2, MU3) positioned at critical locations in the apparatus.
摘要翻译：连续造粒和干燥装置（1）包括造粒机（2）和干燥机（3）。产品和工艺参数的测量通过位于设备关键位置的测量单元（MU1，MU2，MU3）进行。

10. 发明申请

WO2006111816A1 Continuous granulator and a method of continuous granulation of powder material 审中-公开
标题翻译：连续造粒机和粉末材料的连续造粒方法
公开(公告)号：WO2006111816A1
公开(公告)日：2006-10-26
申请号：PCT/IB2006/000899
申请日：2006-04-18
申请人： COLLETTE NV , HANSEN, Ove, Emil , PAGE, Trevor, Gordon , WALDRON, Michel, Simon
发明人： HANSEN, Ove, Emil , PAGE, Trevor, Gordon , WALDRON, Michel, Simon
IPC分类号： B01J2/10 , B01F7/18 , B01F7/16 , B01F7/04
CPC分类号： B01J2/10
摘要： A continuous granulator comprises a longitudinal granulation chamber having a first end with an inlet for powder material and a binder feed port and a second end with an outlet for granulated product. The granu¬ lation chamber comprises at least two parallel rotary shafts provided with granulating elements and forming an angle of from O to 70 degrees with the vertical. Each granulating element on a shaft comprises at least one lobe having limited extent in the circumferential direction of the shaft and interleaving with a lobe of a granulating element on another shaft. A plurality of such separate granulating elements are distributed from the inlet to the outlet, and successive granulating elements on a shaft are mutually angled.
摘要翻译：连续造粒机包括纵向造粒室，其具有第一端，其具有用于粉末材料的入口和粘合剂进料口，第二端具有用于造粒产品的出口。所述造粒室包括至少两个平行的旋转轴，所述至少两个平行的旋转轴设有成粒元件并与垂直方向形成O至70度的角度。轴上的每个造粒元件包括在轴的圆周方向上具有有限程度的至少一个凸角，并且与另一个轴上的造粒元件的凸角交错。多个这样的分离的造粒元件从入口分配到出口，并且轴上的连续造粒元件相互成角度。

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