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1. 发明申请

US20060159752A1 Extended release matrix tablets 审中-公开
标题翻译：延长释放矩阵片
公开(公告)号：US20060159752A1
公开(公告)日：2006-07-20
申请号：US10524461
申请日：2003-08-12
申请人： Girish Jain , Orn Anand , Ashok Rampal
发明人： Girish Jain , Orn Anand , Ashok Rampal
IPC分类号： A61K31/736 , A61K31/717 , A61K9/22
CPC分类号： A61K9/2027 , A61K9/205 , A61K9/2054
摘要： The present invention relates to extended release matrix tablets for oral administration that include a cationic polymer, a water-swellable polymer, and an alginic acid derivative to cause the release rate of the active ingredient of the tablets to be independent of pH and gastric residence time. The active pharmaceutical ingredient may be one or more of antibiotics, sympathomimetics, sympatholytic agents, cholinergic agents, antimuscarinics, gastro-intestinal drugs, gentio-urinary smooth muscle relaxants, cardiac drugs, anticonvulsants, tranquilizers and sedatives, and in particular may be an antibiotic, such as cefaclor, or may be a sympatholytic agent, such as carvedilol.
摘要翻译：本发明涉及用于口服给药的延长释放基质片剂，其包括阳离子聚合物，水溶胀性聚合物和藻酸衍生物，以使片剂的活性成分的释放速率与pH和胃停留时间无关。活性药物成分可以是抗生素，拟交感神经，交感神经药，胆碱能药，抗毒蕈碱，胃肠药，龙胆平喘肌松弛剂，心脏药物，抗惊厥药，镇静剂和镇静剂中的一种或多种，特别是抗生素，例如头孢克洛，或者可以是交替溶解剂，例如卡维地洛。

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