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1. 发明公开

EP0218188A1 An apparatus and method for reading the results of agglutination tests 失效
标题翻译： Vorrichtung und Verfahrenfürdie Auswertung der Ergebnisse von Agglutinationstests。
公开(公告)号：EP0218188A1
公开(公告)日：1987-04-15
申请号：EP86113536.6
申请日：1986-10-01
申请人： Orion Corporation Ltd
发明人： Niskanen, Aimo Juhani , Kahma, Kauko Ilmari , Vainio, Atte Olavi , Lekkala, Jukka Olavi , Joki, Harri Juhani
IPC分类号： G01N21/82 , G01N33/546
CPC分类号： G01N21/82 , G01N33/54313 , G01N33/554
摘要： Described is an apparatus which can be used for the carrying out of agglutination tests. The apparatus is used as a base for the reaction in place of the traditional base plate, after which the apparatus is used for estimation of the test result in place of or in addition to the traditional visual observation.
摘要翻译：描述了可用于进行凝集试验的装置。该装置用作反应的基础代替传统的基板，之后该装置用于估计测试结果以代替传统的目视观察或除了传统的目视观察。

2. 发明公开

EP0175326A2 Diagnostic-test specimen-preparation vial 失效
标题翻译：医疗器械检测仪器。
公开(公告)号：EP0175326A2
公开(公告)日：1986-03-26
申请号：EP85111691.3
申请日：1985-09-16
申请人： Orion Corporation Ltd
发明人： Novgrad, Cliff , Häivä, Antti Veli-Mies , Niskanen, Aimo Juhani , Wallenius, Kaija Orvokki , Väänänen, Terttu Sinikka , West, Cheryl Karin
IPC分类号： B01L3/00 , A61B10/00 , G01N1/28 , G01N33/48
CPC分类号： A61B10/02 , A61B10/0038 , B01L3/508 , G01N2001/028
摘要： A specimen-preparation vial for collecting and preparing a specimen of fecal matter or other clinical specimen for a diagnostic test includes a sample-dilution container (20) and a specimen-collection/dispenser top (50). The sample dilution container (20) is shaped to contain a liquid in an interior volume. The container (20) has an opening (34) dimensioned to receive the specimen and a sidewall which is yieldable upon manual squeezing. The specimen-collection/dispenser top (50) includes a cap housing (110) which is connectable to the specimen-dilution container (20) for closing the opening (34) of the container (20). A specimen-collection tool (130) is connected to the cap housing (110) and projects from the cap housing (110) so that the tool (130) extends into the interior volume of the specimen-dilution container (20) when the cap housing (110) closes the opening (34) of the container (20). The specimen-collection/dispenser top (50) also includes a dispenser tip connected to the cap housing (110). The dispenser tip (112) has a channel passing through it which communicates with the interior volume of the sample-dilution container (20) when the cap housing (110) closes the opening (34) of the container (20). An end of the channel defines a filtrate-discharge orifice. A dispenser-tip closure is provided for closing the filtrate-discharge orifice of the channel passing through the dispenser tip (112). A microfiltration filter is located in the cap housing (110) in a liauid oath extendina from the interior volume of the sample-dilution container (20) to the filtrate-discharge orifice of the dispenser tip (112) so that liquid flowing from the interior volume of the container to the filtrate-discharge orifice passes through the microfiltration filter. The microfiltration filter has pores passing through it of dimensions effective to permit virus particle to pass through the pores and to block the passage of particles significantly larger than virus particles.
摘要翻译：用于收集和制备用于诊断测试的粪便物质或其他临床标本的样本的标本制备小瓶包括样品稀释容器（20）和样本收集/分配器顶部（50）。样品稀释容器（20）成形为在内部容积中容纳液体。容器（20）具有开口（34），该开口（34）的尺寸被设计成容纳样本和侧壁，所述侧壁在手动挤压时是可屈服的。样本收集/分配器顶部（50）包括可连接到样本 - 稀释容器（20）的盖壳体（110），用于封闭容器（20）的开口（34）。标本收集工具（130）连接到盖壳体（110）并且从盖壳体（110）突出，使得当盖子（130）延伸到样品 - 稀释容器（20）的内部容积中时，壳体（110）关闭容器（20）的开口（34）。样本收集/分配器顶部（50）还包括连接到盖壳体（110）的分配器尖端。当帽壳体（110）关闭容器（20）的开口（34）时，分配器尖端（112）具有通过该通道的通道，其与样品 - 稀释容器（20）的内部容积连通。通道的一端限定了滤液 - 排放口。提供分配器顶端封闭件用于封闭通过分配器尖端（112）的通道的滤液 - 排出孔。微滤过滤器以从样品稀释容器（20）的内部容积延伸到分配器末端（112）的滤液 - 排出孔的液体通道位于盖壳体（110）中，使得从容器到滤液排出孔的内部容积通过微滤过滤器。微滤过滤器具有穿过其的孔，其尺寸有效地允许病毒颗粒通过孔并阻止明显大于病毒颗粒的颗粒的通过。

3. 发明公开

EP0229355A3 Apparatus and method for carrying out photometric assays 失效
标题翻译：装置和方法进行光学测定
公开(公告)号：EP0229355A3
公开(公告)日：1988-01-07
申请号：EP86117641
申请日：1986-12-18
申请人： Orion Corporation Ltd
发明人： Vainio, Atte Olavi , Niskanen, Aimo Juhani , Kahma, Kauko Ilmari , Joki, Harri Kalevi , Poramo, Risto A.A. , Lekkala, Jukka Olavi,
IPC分类号： G01N21/59
CPC分类号： G01N21/82 , G01N21/59 , G01N2201/0616
摘要： The invention consists of an apparatus which can be used for the measurement of changes in light intensity in the liquid phase. A characteristic of the apparatus is that it does not include its own light source, but instead the apparatus utilizes ambient illumination. The apparatus can be used instead of a photometer for quantitative, semi-quantitative or qualitative chemical, immunochemical or enzymatic assays and also for other analyses in which change in the intensity of light passing through a liquid phase is recorded between different measurements or alternatively the change is monitored continuously as a function of time. The change in light intensity may result eg. from changes in the size or number of light-absorbing or light-scattering particles in the liquid. The apparatus is inexpensive and can easily be transported. The apparatus also includes the necessary controls, display, A/D-converter or comparator, processing unit, timer and power source. The power source may be eg. a solar cell or a small battery.
摘要翻译：本发明由可用于测量液相光强变化的装置组成。该装置的特征在于它不包括其自身的光源，而是设备利用环境照明。可以使用该装置代替用于定量，半定量或定性化学，免疫化学或酶学测定的光度计，并且还可以用于在不同测量之间记录通过液相的光的强度变化的其他分析，或者替代地，改变作为时间的函数被连续地监视。光强的变化可能会导致例如。来自液体中的光吸收或光散射颗粒的尺寸或数量的变化。该设备便宜并且可以容易地运输。该装置还包括必要的控制，显示，A / D转换器或比较器，处理单元，定时器和电源。电源可以是例如。太阳能电池或小电池。

4. 发明公开

EP0175326A3 Diagnostic-test specimen-preparation vial 失效
标题翻译：诊断样本制备VIAL
公开(公告)号：EP0175326A3
公开(公告)日：1987-12-02
申请号：EP85111691
申请日：1985-09-16
申请人： Orion Corporation Ltd
发明人： Novgrad, Cliff , Häivä, Antti Veli-Mies , Niskanen, Aimo Juhani , Wallenius, Kaija Orvokki , Väänänen, Terttu Sinikka , West, Cheryl Karin
IPC分类号： B01L03/00 , A61B10/00 , G01N01/28 , G01N33/48
CPC分类号： A61B10/02 , A61B10/0038 , B01L3/508 , G01N2001/028
摘要： A specimen-preparation vial for collecting and preparing a specimen of fecal matter or other clinical specimen for a diagnostic test includes a sample-dilution container (20) and a specimen-collection/dispenser top (50). The sample dilution container (20) is shaped to contain a liquid in an interior volume. The container (20) has an opening (34) dimensioned to receive the specimen and a sidewall which is yieldable upon manual squeezing. The specimen-collection/dispenser top (50) includes a cap housing (110) which is connectable to the specimen-dilution container (20) for closing the opening (34) of the container (20). A specimen-collection tool (130) is connected to the cap housing (110) and projects from the cap housing (110) so that the tool (130) extends into the interior volume of the specimen-dilution container (20) when the cap housing (110) closes the opening (34) of the container (20). The specimen-collection/dispenser top (50) also includes a dispenser tip connected to the cap housing (110). The dispenser tip (112) has a channel passing through it which communicates with the interior volume of the sample-dilution container (20) when the cap housing (110) closes the opening (34) of the container (20). An end of the channel defines a filtrate-discharge orifice. A dispenser-tip closure is provided for closing the filtrate-discharge orifice of the channel passing through the dispenser tip (112). A microfiltration filter is located in the cap housing (110) in a liauid oath extendina from the interior volume of the sample-dilution container (20) to the filtrate-discharge orifice of the dispenser tip (112) so that liquid flowing from the interior volume of the container to the filtrate-discharge orifice passes through the microfiltration filter. The microfiltration filter has pores passing through it of dimensions effective to permit virus particle to pass through the pores and to block the passage of particles significantly larger than virus particles.

5. 发明公开

EP0229355A2 Apparatus and method for carrying out photometric assays 失效
标题翻译： Vorrichtung und Verfahren zurDurchführungvon photometrischen Untersuchungen。
公开(公告)号：EP0229355A2
公开(公告)日：1987-07-22
申请号：EP86117641.0
申请日：1986-12-18
申请人： Orion Corporation Ltd
发明人： Vainio, Atte Olavi , Niskanen, Aimo Juhani , Kahma, Kauko Ilmari , Joki, Harri Kalevi , Poramo, Risto A.A. , Lekkala, Jukka Olavi,
IPC分类号： G01N21/82 , G01N21/59
CPC分类号： G01N21/82 , G01N21/59 , G01N2201/0616
摘要： The invention consists of an apparatus which can be used for the measurement of changes in light intensity in the liquid phase. A characteristic of the apparatus is that it does not include its own light source, but instead the apparatus utilizes ambient illumination. The apparatus can be used instead of a photometer for quantitative, semi-quantitative or qualitative chemical, immunochemical or enzymatic assays and also for other analyses in which change in the intensity of light passing through a liquid phase is recorded between different measurements or alternatively the change is monitored continuously as a function of time. The change in light intensity may result eg. from changes in the size or number of light-absorbing or light-scattering particles in the liquid. The apparatus is inexpensive and can easily be transported. The apparatus also includes the necessary controls, display, A/D-converter or comparator, processing unit, timer and power source. The power source may be eg. a solar cell or a small battery.
摘要翻译：本发明由可用于测量液相光强变化的装置组成。该装置的特征在于它不包括其自身的光源，而是设备利用环境照明。可以使用该装置代替用于定量，半定量或定性化学，免疫化学或酶学测定的光度计，并且还可以用于在不同测量之间记录通过液相的光的强度变化的其他分析，或者替代地，改变作为时间的函数被连续地监视。光强的变化可能会导致例如。来自液体中的光吸收或光散射颗粒的尺寸或数量的变化。该设备便宜并且可以容易地运输。该装置还包括必要的控制，显示，A / D转换器或比较器，处理单元，定时器和电源。电源可以是例如。太阳能电池或小电池。

6. 发明公开

EP0228666A2 Peptide substrates and method for the quantitative assay of endotoxin 失效
标题翻译：内肽酶和维生素B定量。
公开(公告)号：EP0228666A2
公开(公告)日：1987-07-15
申请号：EP86117642.8
申请日：1986-12-18
申请人： Orion Corporation Ltd
发明人： Lundström, Erkki Matias , Rantama, Annikka Helena , Raussi, Jaana Heleni
IPC分类号： G01N33/579 , C07K5/04 , C07K7/04 , C07K15/00
CPC分类号： C07K14/00 , G01N33/579
摘要： The subject matter of the invention is a peptide-based compound for utilization in the assay of endotoxin in samples by an LAL-type analysis method. The structure of the compound has the form:
X - A1 - A2 - A3 - B - R
in which X is hydrogen or a protective aromatic hydrocarbon or acyl group; A1 is a peptide chain consisting of 0-100 amino acids; A2 is glycine; A3 is arginine; B is an amide mixture and R is a molecule which, after its liberation in the LAL-type analysis, can be identified by diazotizing its liberated amine group and allowing it to react with a compound with which it combines to form a visibly coloured final product.
摘要翻译：本发明的主题是通过LAL型分析方法在样品中的内毒素测定中使用的基于肽的化合物。该化合物的结构具有其中X为氢或保护性芳族烃或酰基的X-A1-A2-A3-B-R; A1是由0-100个氨基酸组成的肽链; A2是甘氨酸; A3是精氨酸; B是酰胺混合物，R是在LAL型分析中释放后可以通过对其释放的胺基进行重氮化并使其与其组合的化合物反应以形成可见的最终产物而被鉴定的分子。

7. 发明公开

EP0098557A3 Preparation for the diagnosis of chlamydial infections and for the production of chlamydial group-specific antibodies 失效
标题翻译：诊断CHLAMYDIAL感染和生产CHLAMYDIAL组特异性抗体的准备
公开(公告)号：EP0098557A3
公开(公告)日：1984-04-04
申请号：EP83106453
申请日：1983-07-01
申请人： Orion Corporation, Ltd.
发明人： Mäkelä, Pirjo Helena , Leinonen, Maija Kaarina , Nurminen-Kalliokoski, Marjatta Hellevi , Saikku, Pekka Auvo Ilmari
IPC分类号： G01N33/54
CPC分类号： G01N33/56927 , G01N2333/295 , G01N2400/50 , Y10S435/879 , Y10S436/811 , Y10S436/823
摘要： Described are preparations to be used for diagnosis of chlamydial infections comprising a lipopolysaccharide of chemotype Re isolated from Re mutants of gram-negative bacteria, such as Salmonella minnesota, Salmonella typhimurium, Escherichia coli or Proteus mirabilis strains und cross-reacting with chlamydial glycolipids (group antigen). The preparations can be used for the detection of chlamydial infections, for example by serological or immunological methods such as the countercurrentimmuno-electrophoresis, passive haemaggluti- nation, HIG, EIA, FIA or RIA. The preparations can also be used for the production of chlamydial group-specific antibodies.

8. 发明公开

EP0228666A3 Peptide substrates and method for the quantitative assay of endotoxin 失效
标题翻译：肽基质和内毒素定量测定方法
公开(公告)号：EP0228666A3
公开(公告)日：1987-12-23
申请号：EP86117642
申请日：1986-12-18
申请人： Orion Corporation Ltd
发明人： Lundström, Erkki Matias , Rantama, Annikka Helena , Raussi, Jaana Heleni
IPC分类号： G01N33/579 , C07K05/04 , C07K07/04 , C07K15/00
CPC分类号： C07K14/00 , G01N33/579
摘要： The subject matter of the invention is a peptide-based compound for utilization in the assay of endotoxin in samples by an LAL-type analysis method. The structure of the compound has the form:
X - A1 - A2 - A3 - B - R
in which X is hydrogen or a protective aromatic hydrocarbon or acyl group; A1 is a peptide chain consisting of 0-100 amino acids; A2 is glycine; A3 is arginine; B is an amide mixture and R is a molecule which, after its liberation in the LAL-type analysis, can be identified by diazotizing its liberated amine group and allowing it to react with a compound with which it combines to form a visibly coloured final product.

9. 发明公开

EP0203443A3 An apparatus for the carrying out of chemical analyses 失效
标题翻译：用于化学分析的装置
公开(公告)号：EP0203443A3
公开(公告)日：1987-09-02
申请号：EP86106474
申请日：1986-05-13
申请人： Orion Corporation Ltd
发明人： Niskanen, Aimo Juhani , Kahma, Kauko Ilmari
IPC分类号： G01N33/53 , G01N33/569 , G01N33/74
CPC分类号： G01N33/54366 , G01N33/5304 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/807 , Y10S436/809 , Y10S436/81
摘要： The invention comprises an apparatus for the carrying out of chemical, particulary immunochemical analyses in non-laboratory environments. The apparatus comprises a test base containing small wells (7), into which are introduced all the reagents necessary for the carrying out of the reaction in question. The wells (7) are covered with an impervious foil layer which can easily be pierced with the sharp, reactive end of the testing stick included in the apparatus.

10. 发明公开

EP0203443A2 Test kit for the carrying out of chemical analyses 失效
标题翻译：检测试剂盒进行化学分析。
公开(公告)号：EP0203443A2
公开(公告)日：1986-12-03
申请号：EP86106474.9
申请日：1986-05-13
申请人： Orion Corporation Ltd
发明人： Niskanen, Aimo Juhani , Kahma, Kauko Ilmari
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , G01N33/5304 , Y10S435/81 , Y10S435/97 , Y10S435/975 , Y10S436/807 , Y10S436/809 , Y10S436/81
摘要： The invention comprises an apparatus for the carrying out of chemical, particulary immunochemical analyses in non-laboratory environments. The apparatus comprises a test base containing small wells (7), into which are introduced all the reagents necessary for the carrying out of the reaction in question. The wells (7) are covered with an impervious foil layer which can easily be pierced with the sharp, reactive end of the testing stick included in the apparatus.

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