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1. 发明申请

WO1996016612A1 TENDON AND LIGAMENT REPAIR SYSTEM 审中-公开
标题翻译： TENDON和LIGAMENT维修系统
公开(公告)号：WO1996016612A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015550
申请日：1995-12-04
申请人： OMEROS MEDICAL SYSTEMS, INC. , DEMOPULOS, Gregory, A. , YENCHO, Stephen, A. , HERRIN, David, A. , MCILVAINE, Neil, G. , NELSON, Michael, D. , SIGELMANN, Milton, R. , DE CASTRO, Jose, T., V. , SELECMAN, George , COLLINS, John , AZIZ, Imraan , BRESSNER, Gorm
发明人： OMEROS MEDICAL SYSTEMS, INC.
IPC分类号： A61F02/08
CPC分类号： A61F2/0811 , A61B17/1146 , A61F2002/0829 , A61F2002/0864 , A61F2002/087 , A61F2002/0888 , A61F2210/0085 , A61F2240/004
摘要： The damaged portion of an injured tendon or ligament (C) ("connective cord") is inserted into a thin, hollow sleeve (100, 110, 120, 130, 140, 160, 180, 200, 240, 260, 270, 300, 390, generically designated "S") and is connected to the sleeve (S) such that the cord-sleeve combination can immediately withstand normal tensile forces. The interconnection can be mechanical, such as by pins (22, 22', 148, 150, 164, 188, 190, 206, 206', 210, 226, 230, 238, 239, 266, 286, 308) extending through the sleeve (S) and cord (C). The sleeve (S) can be bioabsorbable over a sufficiently long period of time that the cord (C) is healed by the time the sleeve (S) is absorbed.
摘要翻译：损伤的腱或韧带（C）（“连接绳”）的受损部分被插入薄的中空的套管（100,110,120,130,140,160,180,2400,240,260,270,300 ，390，通称为“S”）并且连接到套筒（S），使得绳套组合可以立即承受正常的拉力。互连可以是机械的，例如通过引脚（22,22'，148,150,164,188,190,206,206'，210,226,230,238,239,266,286,308）的引脚套筒（S）和绳索（C）。套筒（S）可以在足够长的时间段内被生物吸收，使得当套筒（S）被吸收时，绳索（C）被愈合。

2. 发明申请

US20020028798A1 Irrigation solution and method for inhibition of pain and inflammation 审中-公开
标题翻译：灌注溶液和抑制疼痛和炎症的方法
公开(公告)号：US20020028798A1
公开(公告)日：2002-03-07
申请号：US09839633
申请日：2001-04-20
申请人： Omeros Medical Systems
发明人： Gregory A. Demopulos , Pamela Pierce-Palmer , Jeffrey M. Herz
IPC分类号： A61K031/4427 , A61K031/4439 , A61K031/55
CPC分类号： A61K31/18 , A61K9/08 , A61K31/00 , A61K31/352 , A61K31/4045 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/439 , A61K31/4406 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/465 , A61K31/48 , A61K31/498 , A61K31/506 , A61K31/538 , A61K31/55 , A61K31/675 , A61K38/1793 , A61K45/06 , A61K2300/00
摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one pharmacological agent selected from the group consisting of a mitogen-activated protein kinase (MAPK) inhibitor, an null2-receptor agonist, a neuronal nicotinic acetylcholine receptor agonist, a cyclooxygenase-2 (COX-2) inhibitor, a soluble receptor and mixtures thereof, and optionally additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.
摘要翻译：一种围手术期抑制来自一般外科手术（包括口腔/牙科手术）的伤口的各种疼痛和炎症过程的方法和解决方案。该溶液优选包含至少一种选自丝裂原活化蛋白激酶（MAPK）抑制剂，α2-受体激动剂，神经元烟碱乙酰胆碱受体激动剂，环氧合酶-2（COX-2）抑制剂，可溶性受体及其混合物，以及任选地在生理载体例如盐水或乳酸林格溶液中稀释浓度的另外多种疼痛和炎症抑制剂。在外科手术过程中连续冲洗伤口以解决疼痛的预防性作用，同时避免与口服，肌肉内，皮下或静脉内施用较大剂量的药剂相关的不良副作用。

3. 发明申请

WO1996019233A2 IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN, INFLAMMATION AND SPASM 审中-公开
标题翻译：灌溉解决方案和抑制疼痛，炎症和血脂的方法
公开(公告)号：WO1996019233A2
公开(公告)日：1996-06-27
申请号：PCT/US1995016028
申请日：1995-12-12
申请人： OMEROS MEDICAL SYSTEMS, INC. , DEMOPULOS, Gregory, A. , PIERCE, Pamela, Anne , HERZ, Jeffrey, M.
发明人： OMEROS MEDICAL SYSTEMS, INC.
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K9/0019 , A61K9/08 , A61K31/00 , A61K31/135 , A61K31/352 , A61K31/4045 , A61K31/407 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/4196 , A61K31/437 , A61K31/439 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/48 , A61K31/498 , A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5415 , A61K38/04 , A61K38/043 , A61K38/12 , A61K38/22 , A61K38/57 , A61K45/06 , Y10S977/904 , A61K2300/00
摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation and spasm processes at a wound. The solution includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents at dilute concentration in a physiologic base, such as saline or lactated Ringer's solution. Depending on the application, the pain and inflammation agents included in the solution may include: (1) serotonin receptor antagonists; (2) serotonin receptor agonists; (3) histamine receptor antagonists; (4) bradykinin receptor antagonists; (5) kallikrein inhibitors; (6) tachykinin receptor antagonists, including neurokinin1 and neurokinin2 receptor subtype antagonists; (7) calcitonin gene-related peptide (CGRP) receptor antagonists; (8) interleukin receptor antagonists; (9) inhibitors of enzymes active in the synthetic pathway for arachadonic acid metabolites, including (a) phospholipase inhibitors, including PLA2 isoform and PLC gamma isoform inhibitors, (b) cyclooxygenase inhibitors, and (c) lipooxygenase inhibitors; (10) prostanoid receptor antagonists including eicosanoid EP-1 and EP-2 receptor subtype antagonists and thromboxane receptor subtype antagonists; (11) leukotriene receptor antagonists including leukotriene B4 and D4 receptor subtype antagonists; (12) opioid receptor agonists, including mu-opiate, delta-opiate, and kappa-opiate receptor sybtype agonists; (13) purinoceptor agonists and antagonists including P2X receptor antagonists and P2Y receptor agonists; (14) adenosine triphosphate (ATP)-sensitive potassium channel openers; and (15) calcium channel antagonists. Suitable anti-inflammatory/anti-pain agents which also act as anti-spasm agents include serotonin receptor antagonists, tachykinin receptor antagonists, ATP-sensitive potassium channel openers and calcium channel antagonists. Other agents which may be utilized in the solution specifically for their anti-spasm properties including endothelin receptor antagonists and the nitric oxyde donors (enzyme activators). The solution is used to continuously irrigate a wound during an operative/interventional procedure for preemptive inhibition of pain and inflammation, as well as vascular and smooth muscle spasm, while avoiding undesirable side effects associated with oral, intramuscular or intravenous application of larger doses of the agents. The solution is useful for arthroscopic, intravascular and urologic procedures, as well as for application to burns, and intra- and postoperative application to surgical wounds.
摘要翻译：围手术期抑制伤口疼痛和炎症和痉挛过程的方法和解决方案。该溶液包括多种疼痛和炎症抑制剂以及在生理基质如盐水或乳酸林格溶液中稀释浓度的痉挛抑制剂。根据应用，包括在溶液中的疼痛和炎症剂可以包括：（1）5-羟色胺受体拮抗剂; （2）5-羟色胺受体激动剂; （3）组胺受体拮抗剂; （4）缓激肽受体拮抗剂; （5）激肽释放酶抑制剂; （6）速激肽受体拮抗剂，包括神经激肽1和神经激肽2受体亚型拮抗剂; （7）降钙素基因相关肽（CGRP）受体拮抗剂; （8）白介素受体拮抗剂; 包括（a）磷脂酶抑制剂，包括PLA2同种型和PLCγ同种型抑制剂，（b）环氧合酶抑制剂和（c）脂氧合酶抑制剂;（9）抑制活性于花生四烯酸代谢物合成途径的酶。（10）前列腺素受体拮抗剂，包括类二十烷酸EP-1和EP-2受体亚型拮抗剂和血栓烷受体亚型拮抗剂; （11）白细胞三烯受体拮抗剂，包括白细胞三烯B4和D4受体亚型拮抗剂; （12）阿片样物质受体激动剂，包括鸦片剂，δ-阿片剂和κ-阿片受体sybtype激动剂; （13）嘌呤受体激动剂和拮抗剂，包括P2X受体拮抗剂和P2Y受体激动剂; （14）三磷酸腺苷（ATP）敏感性钾通道开放剂; 和（15）钙通道拮抗剂。也用作抗痉挛剂的合适的抗炎/抗疼痛剂包括血清素受体拮抗剂，速激肽受体拮抗剂，ATP敏感的钾通道开放剂和钙通道拮抗剂。可以专门用于其抗痉挛性质的溶液中的其它试剂，包括内皮素受体拮抗剂和硝酸氧合物供体（酶活化剂）。该溶液用于在手术/介入手术期间连续冲洗伤口以预防性地抑制疼痛和炎症，以及血管和平滑肌痉挛，同时避免与口服，肌内或静脉内施用较大剂量的代理商。该解决方案可用于关节镜，血管内和泌尿系统手术，以及应用于烧伤，以及术中和术后应用于手术伤口。

4. 发明申请

US20030114355A1 Arthroscopic irrigation solution and method for inhibition of pain and inflammation 失效
标题翻译：关节镜灌洗液和抑制疼痛和炎症的方法
公开(公告)号：US20030114355A1
公开(公告)日：2003-06-19
申请号：US10195625
申请日：2002-07-12
申请人： Omeros Medical Systems, Inc.
发明人： Gregory A. Demopulos , Pamela A. Pierce , Jeffrey M. Herz
IPC分类号： A61K031/00 , A61K031/485
CPC分类号： A61K31/439 , A61K31/00 , A61K31/352 , A61K31/40 , A61K31/4045 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/435 , A61K31/4406 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/48 , A61K31/498 , A61K31/505 , A61K31/506 , A61K31/538 , A61K45/06 , Y10S977/738 , Y10S977/904 , Y10S977/916 , Y10S977/919
摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a null-opioid agonist.
摘要翻译：一种围手术期抑制来自一般外科手术（包括口腔/牙科手术）的伤口的各种疼痛和炎症过程的方法和解决方案。该溶液优选包括在生理载体例如盐水或乳酸林格氏溶液中以稀释浓度抑制的多种疼痛和炎症。在外科手术过程中连续冲洗伤口以解决疼痛的预防性作用，同时避免与口服，肌肉内，皮下或静脉内施用较大剂量的药剂相关的不良副作用。抑制疼痛和炎症的一个优选的解决方案包括5-羟色胺2拮抗剂，5-羟色胺3拮抗剂，组胺拮抗剂，5-羟色胺激动剂，环加氧酶抑制剂，神经激肽1拮抗剂，神经激肽2拮抗剂，嘌呤受体拮抗剂，ATP-敏感钾通道开放剂，钙通道拮抗剂，缓激肽1拮抗剂，缓激肽2拮抗剂和μ-阿片样物质激动剂。

5. 发明申请

US20010044616A1 Surgical irrigation solution and method for inhibition of pain and inflammation 有权
公开(公告)号：US20010044616A1
公开(公告)日：2001-11-22
申请号：US09837141
申请日：2001-04-17
申请人： Omeros Medical Systems, Inc.
发明人： Gregory A. Demopulos , Pamela A. Pierce , Jeffrey M. Herz
IPC分类号： A61K031/00
CPC分类号： A61K31/439 , A61K31/00 , A61K31/352 , A61K31/40 , A61K31/4045 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/435 , A61K31/4406 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/48 , A61K31/498 , A61K31/505 , A61K31/506 , A61K31/538 , A61K45/06 , Y10S977/738 , Y10S977/904 , Y10S977/916 , Y10S977/919
摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a null-opioid agonist.

6. 发明申请

US20030105126A1 Irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis 审中-公开
公开(公告)号：US20030105126A1
公开(公告)日：2003-06-05
申请号：US10180815
申请日：2002-06-25
申请人： Omeros Medical Systems, Inc.
发明人： Gregory A. Demopulos , Pamela Anne Pierce , Jeffrey M. Herz
IPC分类号： A61K031/46 , A61K031/24
CPC分类号： A61K45/06 , A61K31/00 , A61K31/352 , A61K31/4045 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/439 , A61K31/4406 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/48 , A61K31/498 , A61K31/506 , A61K31/538 , A61K38/00
摘要： A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.

7. 发明申请

US20020169477A1 Soft tissue repair system 有权
标题翻译：软组织修复系统
公开(公告)号：US20020169477A1
公开(公告)日：2002-11-14
申请号：US10114709
申请日：2002-04-02
申请人： Omeros Medical Systems, Inc.
发明人： Gregory A. Demopulos , Scott W. Reed , Alan B. Bachman , Frederick T. Karl , William J. Allen , Leland Ray Adams , G. Lawrence Thatcher
IPC分类号： A61B017/08
CPC分类号： A61B17/064 , A61B17/00491 , A61B2017/00004 , A61B2017/0646 , A61B2017/0647
摘要： A medical fastener (18), preferably bioabsorbable, is used for repairing torn soft tissue, particularly meniscal tissue (16). The fastener (18) can have an enlarged head (22) at the proximate end to engage meniscal tissue (16) adjacent to a tear (14), and a pointed distal tip (21) at the other end to ease insertion of the fastener (18) into the meniscus (16). The shank (20) of the fastener (18) bridges across the tear (14). Opposite ends of the shank (20) are secured in the meniscal tissue (16) by a medical adhesive, preferably bioabsorbable, and preferably at locations remote from the tear (14) so as not to interfere with healing of the tear (14). The fastener (18) can have a blind bore (24) opening through the head (22) of the fastener (18) and extending through the shank (20) to a location close to the tip (21) and generally radial holes (26) communicating between the bore (24) and the exterior of the shank (20). The medical adhesive can be injected through the bore (24) for passage outward through the holes (26).
摘要翻译：医疗紧固件（18），优选地是生物可吸收的，用于修复被撕毁的软组织，特别是半月板组织（16）。紧固件（18）可以在近端处具有扩大的头部（22），以与邻近泪液（14）的半月板组织（16）接合，并且在另一端处具有尖锐的远端尖端（21），以便于紧固件（18）进入弯月面（16）。紧固件（18）的柄（20）穿过泪液（14）。柄（20）的相对端通过医疗粘合剂固定在半月板组织（16）中，优选地是生物可吸收的，优选在远离泪液（14）的位置处，以便不干扰泪液（14）的愈合。紧固件（18）可以具有穿过紧固件（18）的头部（22）的盲孔（24），并且通过柄部（20）延伸到靠近尖端（21）的位置，并且大致为径向孔）连通孔（24）和柄（20）的外部。医用粘合剂可以通过孔（24）注入，以通过孔（26）向外通过。

8. 发明申请

WO1997021445A1 VASCULAR IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN, INFLAMMATION, SPASM AND RESTENOSIS 审中-公开
标题翻译：血管灌注解决方案和抑制疼痛，炎症，血管和保留的方法
公开(公告)号：WO1997021445A1
公开(公告)日：1997-06-19
申请号：PCT/US1996010954
申请日：1996-06-26
申请人： OMEROS MEDICAL SYSTEMS, INC. , DEMOPULOS, Gregory, A. , PIERCE, Pamela, Anne , HERZ, Jeffrey, M.
发明人： OMEROS MEDICAL SYSTEMS, INC.
IPC分类号： A61K38/08
CPC分类号： A61K31/4045 , A61K31/48 , A61K45/06
摘要： A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general vascular therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents. The solution is introduced luminally to continuously irrigate an arterial site during an operative/interventional or diagnostic procedure for preemptive inhibition of pain and inflammation, vascular and non-vascular smooth muscle spasm, and restenosis while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain, inflammation, vasospasm and restenosis includes a serotonin2 antagonist, a cyclooxygenase inhibitor, an endothelin antagonist, an ATP-sensitive K channel antagonist, a Ca channel antagonist, a nitric oxide donor, an anti-thrombin agent, a glycoprotein IIb/IIIa receptor blocker, a PKC inhibitor and a protein tyrosine kinase inhibitor.
摘要翻译：一种围手术期抑制由心血管或一般血管治疗和诊断程序产生的各种疼痛，炎症，痉挛和再狭窄过程的方法和解决方案。该溶液优选包括多种疼痛和炎症抑制剂和在生理载体例如盐水或乳酸林格氏溶液中稀释浓度的痉挛抑制剂。本发明用于心血管和一般血管手术的溶液的具体优选实施方案还包括抗再狭窄剂。在手术/介入或诊断程序期间，将溶液亮度引入以持续灌注动脉部位，用于先期性抑制疼痛和炎症，血管和非血管平滑肌痉挛以及再狭窄，同时避免与口服，肌内，皮下相关的不期望的副作用或静脉内施用较大剂量的药剂。抑制疼痛，炎症，血管痉挛和再狭窄的一种优选的解决方案包括5-羟色胺2拮抗剂，环氧合酶抑制剂，内皮素拮抗剂，ATP敏感性K +通道拮抗剂，Ca 2+通道拮抗剂，一氧化氮供体，抗凝血酶剂，糖蛋白IIb / IIIa受体阻断剂，PKC抑制剂和蛋白质酪氨酸激酶抑制剂。

9. 发明公开

EP0797416A1 TENDON AND LIGAMENT REPAIR SYSTEM 失效
标题翻译：修复系统STRINGS和磁带
公开(公告)号：EP0797416A1
公开(公告)日：1997-10-01
申请号：EP95943623.0
申请日：1995-12-04
申请人： OMEROS MEDICAL SYSTEMS, INC.
发明人： DEMOPULOS, Gregory, A. , YENCHO, Stephen, A. , HERRIN, David, A. , MCILVAINE, Neil, G. , NELSON, Michael, D. , SIGELMANN, Milton, R. , DE CASTRO, Jose, T., V. , SELECMAN, George , COLLINS, John , AZIZ, Imraan , BRESSNER, Gorm
IPC分类号： A61B17 , A61F2
CPC分类号： A61F2/0811 , A61B17/1146 , A61F2002/0829 , A61F2002/0864 , A61F2002/087 , A61F2002/0888 , A61F2210/0085 , A61F2240/004
摘要： The damaged portion of an injured tendon or ligament (C) ('connective cord') is inserted into a thin, hollow sleeve (100, 110, 120, 130, 140, 160, 180, 200, 240, 260, 270, 300, 390, generically designated 'S') and is connected to the sleeve (S) such that the cord-sleeve combination can immediately withstand normal tensile forces. The interconnection can be mechanical, such as by pins (22, 22', 148, 150, 164, 188, 190, 206, 206', 210, 226, 230, 238, 239, 266, 286, 308) extending through the sleeve (S) and cord (C). The sleeve (S) can be bioabsorbable over a sufficiently long period of time that the cord (C) is healed by the time the sleeve (S) is absorbed.

10. 发明公开

EP0799051A2 IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF PAIN, INFLAMMATION AND SPASM 失效
标题翻译： BESPÜLLUNGSLÖSUNG和他们的疼痛，炎症和痉挛围手术期抑制伤口使用
公开(公告)号：EP0799051A2
公开(公告)日：1997-10-08
申请号：EP95943396.0
申请日：1995-12-12
申请人： OMEROS MEDICAL SYSTEMS, INC
发明人： DEMOPULOS, Gregory, A. , PIERCE, Pamela, Anne , HERZ, Jeffrey, M.
IPC分类号： A61K9 , A61K31 , A61K38 , A61K45 , A61P17 , A61P29 , A61P41
CPC分类号： A61K38/08 , A61K9/0019 , A61K9/08 , A61K31/00 , A61K31/135 , A61K31/352 , A61K31/4045 , A61K31/407 , A61K31/4164 , A61K31/4168 , A61K31/4174 , A61K31/4196 , A61K31/437 , A61K31/439 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/48 , A61K31/498 , A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5415 , A61K38/04 , A61K38/043 , A61K38/12 , A61K38/22 , A61K38/57 , A61K45/06 , Y10S977/904 , A61K2300/00
摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation and spasm processes at a vascular structure during an intervascular procedure. The solution includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents in a physiologic base, such as saline or lactated Ringer's solution. Depending on the application, the pain and inflammation agents included in the solution may include: (1) serotonin receptor antagonists; (2) serotonin receptor agonists; (3) histamine receptor antagonists; (4) bradykinin receptor antagonists: (5) kallikrein inhibitors; (6) tachykinin receptor antagonists, including neurokinin1 and neurokinin2 receptor subtype antagonists; (7) calcitonin gene-related peptide (CGRP) receptor antagonists; (8) interleukin receptor antagonists; (9) inhibitors of enzymes active in the synthetic pathway for arachadonic acid metabolites, including (a) phospholipase inhibitors, including PLA2 isoform and PLC gamma isoform inhibitors, (b) cyclooxygenase inhibitors, and (c) lipooxygenase inhibitors; (10) prostanoid receptor antagonists including eicosanoid EP-1 and EP-2 receptor subtype antagonists and thromboxane receptor subtype antagonists; (11) leukotriene receptor antagonists including leukotriene B4 and D4 receptor subtype antagonists; (12) opioid receptor agonists, including mu-opiate, delta-opiate, and kappa-opiate receptor subtype agonists; (13) purinoceptor agonists and antagonists including P2X receptor antagonists and P2Y receptor agonists; (14) adenosine triphosphate (ATP) sensitive potassium channel openers; and (15) calcium channel antagonists. Suitable anti-inflammatory/anti-pain agents which also act as anti-spasm agents include serotonin receptor antagonists, tachykinin receptor antagonists, ATP-sensitive potassium channel openers and calcium channel antagonists. Other agents which may be utilized in the solution specifically for their anti-spasm properties including endothelin receptor antagonists and the nitric oxyde donors (enzyme activators). The solution is used to continuously irrigate a wound during an operative/interventional procedure for preemptive inhibition of pain and inflammation, as well as vascular and smooth muscle spasm, while avoiding undesirable side effects associated with oral, intramuscular or intravenous application of larger doses of the agents. The solution is useful for intravascular procedures.

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