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1. 发明授权

US08669233B2 Combination of compounds for treating or preventing skin diseases 有权
标题翻译：用于治疗或预防皮肤疾病的化合物的组合
公开(公告)号：US08669233B2
公开(公告)日：2014-03-11
申请号：US13201762
申请日：2010-02-16
申请人： André Jomard , Laurent Fredon , Olivier Roye
发明人： André Jomard , Laurent Fredon , Olivier Roye
IPC分类号： A61K31/70
CPC分类号： A61K31/498 , A61K9/0014 , A61K31/4164 , A61K31/7048 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/44 , A61K2300/00
摘要： A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay is described.
摘要翻译：描述了用于治疗皮肤疾病，特别是红斑痤疮和眼酒渣酒的化合物的组合。还描述了除虫菌素家族的化合物或米比霉素家族与α-1或α-2肾上腺素能受体激动剂家族的化合物的组合。此外，试剂盒形式的产品包括：（a）含有阿维菌素家族或米尔霉素家族的化合物的第一种组合物，和（b）不同于第一种组合物的第二种组合物，作为用作治疗和/或预防皮肤疾病，特别是红斑痤疮和酒渣酒的药物的组合产品，其中所述第一和第二组合物可以同时施用，分别描述或延迟时间。

2. 发明申请

US20120323006A1 NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS 有权
标题翻译：新型苯并噻二唑化合物，其合成方法及其在医药中的用途如同化妆品
公开(公告)号：US20120323006A1
公开(公告)日：2012-12-20
申请号：US13381234
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlene Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlene Schuppli
IPC分类号： C07D295/26 , C07D471/04 , C07D413/12 , C07D401/12 , C07D403/12
CPC分类号： C07D215/14 , A61K31/4965 , A61K31/497 , A61K31/551 , C07D209/10 , C07D209/12 , C07D209/20 , C07D209/24 , C07D209/26 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/68 , C07D261/20 , C07D295/15 , C07D295/26 , C07D471/04 , Y02A50/411
摘要： Benzenesulfonamide compounds having a structure of formula (I) are described. Also described, are methods for synthesizing the compounds and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.
摘要翻译：描述具有式（I）结构的苯磺酰胺化合物。还描述了用于合成化合物的方法及其在人或兽医学药物组合物和化妆品组合物中的用途。

3. 发明授权

US08772478B2 Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics 失效
标题翻译：苯磺酰胺化合物，其合成方法及其在医药以及化妆品中的应用
公开(公告)号：US08772478B2
公开(公告)日：2014-07-08
申请号：US13381237
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Pascale Mauvais , Olivier Roye , Marlène Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Pascale Mauvais , Olivier Roye , Marlène Schuppli
IPC分类号： C07D401/02 , C07D417/02 , C07D207/46 , C07D211/02 , C07D223/12 , C07D265/32
CPC分类号： C07D295/15 , C07D401/12
摘要： Benzenesulfonamide compounds having a structure of the following general formula (I) are described. Also described, are methods for synthesizing the compounds, and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.
摘要翻译：描述具有以下通式（I）的结构的苯磺酰胺化合物。还描述了用于合成化合物的方法及其在人或兽医学药物组合物和化妆品组合物中的用途。

4. 发明申请

US20120116072A1 NOVEL BENZENESULFONAMIDE COMPOUNDS, METHOD FOR SYNTHESIZING SAME, AND USE THEREOF IN MEDICINE AS WELL AS IN COSMETICS 失效
标题翻译：新型苯并噻二唑化合物，其合成方法及其在医药中的用途如同化妆品
公开(公告)号：US20120116072A1
公开(公告)日：2012-05-10
申请号：US13381237
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Pascale Mauvais , Olivier Roye , Marlene Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Pascale Mauvais , Olivier Roye , Marlene Schuppli
IPC分类号： C07D401/02 , C07D417/02 , C07D207/46 , C07D471/02 , C07D211/22 , C07D223/12 , C07D265/32
CPC分类号： C07D295/15 , C07D401/12
摘要： Benzenesulfonamide compounds having a structure of the following general formula (I) are described. Also described, are methods for synthesizing the compounds, and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.
摘要翻译：描述具有以下通式（I）的结构的苯磺酰胺化合物。还描述了用于合成化合物的方法及其用于人或兽医学药物组合物和化妆品组合物中的用途。

5. 发明申请

US20120035123A1 COMBINATION OF COMPOUNDS FOR TREATING OR PREVENTING SKIN DISEASES 有权
标题翻译：用于治疗或预防皮肤疾病的化合物的组合
公开(公告)号：US20120035123A1
公开(公告)日：2012-02-09
申请号：US13201762
申请日：2010-02-16
申请人： André Jomard , Laurent Fredon , Olivier Roye
发明人： André Jomard , Laurent Fredon , Olivier Roye
IPC分类号： A61K31/7048 , A61K31/4174 , A61P17/00 , A61K31/498
CPC分类号： A61K31/498 , A61K9/0014 , A61K31/4164 , A61K31/7048 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/44 , A61K2300/00
摘要： A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay is described.
摘要翻译：描述了用于治疗皮肤疾病，特别是红斑痤疮和眼酒渣酒的化合物的组合。还描述了除虫菌素家族的化合物或米比霉素家族与α-1或α-2肾上腺素能受体激动剂家族的化合物的组合。此外，试剂盒形式的产品包括：（a）含有阿维菌素家族或米尔霉素家族的化合物的第一种组合物，和（b）不同于第一种组合物的第二种组合物，作为用作治疗和/或预防皮肤疾病，特别是红斑痤疮和酒渣酒的药物的组合产品，其中所述第一和第二组合物可以同时施用，分别描述或延迟时间。

6. 发明授权

US07872026B2 Ligand activators of the RAR receptors and pharmaceutical/cosmetic applications thereof 有权
标题翻译： RAR受体的配体活化剂及其药物/化妆品应用
公开(公告)号：US07872026B2
公开(公告)日：2011-01-18
申请号：US11448782
申请日：2006-06-08
申请人： Thibaud Biadatti , Olivier Roye
发明人： Thibaud Biadatti , Olivier Roye
IPC分类号： A61K31/445 , A61K31/44 , C07D213/62 , A61K31/135 , C07C62/00 , C07D307/02 , A61K31/34 , C07D333/38 , A61K31/38
CPC分类号： C07D213/79 , C07C217/18 , C07C219/14 , C07C233/18 , C07C235/20 , C07C235/42 , C07C323/62 , C07C2602/10 , C07D213/80 , C07D295/088 , C07D295/192 , C07D307/68 , C07D333/38
摘要： Novel ligand compounds having the structural formula (I): in which: Ar is a radical selected from among the radical of formulae (a) to (c) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, or, alternatively, into cosmetic compositions.
摘要翻译：具有结构式（I）的新型配体化合物：其中：Ar是选自下式（a）至（c）的基团的基团：配制成适合于在人或兽医学中施用的药物组合物，或者，进入化妆品组合物。

7. 发明授权

US08420632B2 Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics 有权
公开(公告)号：US08420632B2
公开(公告)日：2013-04-16
申请号：US13381234
申请日：2010-06-28
申请人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlène Schuppli
发明人： Laurence Clary , Sandrine Chambon , Laurent Chantalat , Carine Rosignoli , Olivier Roye , Jean-Claude Pascal , Marlène Schuppli
IPC分类号： A61K31/551 , A61K31/4965 , A61K31/497 , C07D295/26 , C07D471/04 , C07D413/12 , C07D401/12 , C07D403/12
CPC分类号： C07D215/14 , A61K31/4965 , A61K31/497 , A61K31/551 , C07D209/10 , C07D209/12 , C07D209/20 , C07D209/24 , C07D209/26 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/68 , C07D261/20 , C07D295/15 , C07D295/26 , C07D471/04 , Y02A50/411
摘要： Benzenesulfonamide compounds having a structure of formula (I) are described. Also described, are methods for synthesizing the compounds and to the use thereof in pharmaceutical compositions for human or veterinary medicine and in cosmetic compositions.

8. 发明申请

US20070021473A1 Novel ligand activators of the RAR receptors and pharmaceutical/cosmetic applications thereof 有权
标题翻译： RAR受体的新型配体活化剂及其药物/化妆品应用
公开(公告)号：US20070021473A1
公开(公告)日：2007-01-25
申请号：US11448782
申请日：2006-06-08
申请人： Thibaud Biadatti , Olivier Roye
发明人： Thibaud Biadatti , Olivier Roye
IPC分类号： A61K31/455 , A61K31/401 , A61K31/381 , A61K31/34 , A61K31/195
CPC分类号： C07D213/79 , C07C217/18 , C07C219/14 , C07C233/18 , C07C235/20 , C07C235/42 , C07C323/62 , C07C2602/10 , C07D213/80 , C07D295/088 , C07D295/192 , C07D307/68 , C07D333/38
摘要： Novel ligand compounds having the structural formula (I): in which: Ar is a radical selected from among the radical of formulae (a) to (c) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, or, alternatively, into cosmetic compositions.
摘要翻译：具有结构式（I）的新型配体化合物：其中：Ar是选自下式（a）至（c）的基团的基团：配制成适合于在人或兽医学中施用的药物组合物，或者，进入化妆品组合物。

9. 发明申请

US20060009426A1 Pharmaceutical compositions comprising calcitriol and a clobetasol propionate 审中-公开
标题翻译：包含骨化三醇和丙酸氯倍他索的药物组合物
公开(公告)号：US20060009426A1
公开(公告)日：2006-01-12
申请号：US11154706
申请日：2005-06-17
申请人： Andre Jomard , Olivier Roye
发明人： Andre Jomard , Olivier Roye
IPC分类号： A61K31/59 , A61K31/573
CPC分类号： A61K45/06 , A61K31/573 , A61K31/575 , A61K31/59 , A61K31/593 , A61K2300/00
摘要： Topically applicable pharmaceutical gel, cream, lotion, solution or ointment compositions contain synergistically effective amounts of a) calcitriol and b) clobetasol propionate, formulated into a topically applicable, pharmaceutically acceptable medium therefor, and are useful for the treatment of such dermatological afflictions or conditions as psoriasis, atopic dermatitis, contact dermatitis and seborrhoeic dermatitis.
摘要翻译：局部适用的药物凝胶，霜剂，洗剂，溶液或软膏组合物含有协同有效量的a）骨化三醇和b）配制成局部适用的药学上可接受的介质的丙酸氯倍他索，并且可用于治疗这种皮肤病的病症或病症如牛皮癣，特应性皮炎，接触性皮炎和脂溢性皮炎。

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