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1. 发明申请

WO2012035462A1 MAGNETIC SYSTEM FOR PARTICLE ATTRACTION IN A PLURALITY OF CHAMBERS 审中-公开
标题翻译：用于在多个气泡中吸附粒子的磁系统
公开(公告)号：WO2012035462A1
公开(公告)日：2012-03-22
申请号：PCT/IB2011/053863
申请日：2011-09-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OVSYANKO, Mikhail, Mikhaylovich
发明人： OVSYANKO, Mikhail, Mikhaylovich
IPC分类号： G01N35/00 , G01N33/543 , B03C1/28
CPC分类号： G01N33/54333 , G01N21/55 , G01N33/54373 , G01N35/0098 , G01N2201/061 , H01F7/064
摘要： The invention relates to a magnetic sample-processing device, particularly a sensor device (100), that comprises two electromagnets (110, 120) for generating a magnetic field (B) in a first and a second sample chamber (SC1, SC2) located adjacent to each other in an x-direction. The poles of the electromagnets are disposed below the first and the second sample chamber (SC1, SC2), respectively, next to each other in a perpendicular y-direction. Moreover, the electromagnets are individually controlled by a control unit (130). In a preferred embodiment, the distance between the electromagnets (110, 120) in x-direction is so large that magnetic cross talk can be neglected. In another embodiment, said distance is close, and the electromagnets are operated in a synchronized way.
摘要翻译：本发明涉及一种磁性样品处理装置，特别是传感器装置（100），其包括用于在第一和第二样品室（SC1，SC2）中产生磁场（B）的两个电磁体（110,120）在x方向上彼此相邻。电磁体的磁极分别在第一和第二样本室（SC1，SC2）的下方沿垂直的y方向彼此相邻配置。此外，电磁体由控制单元（130）分别控制。在优选实施例中，电磁体（110,120）在x方向上的距离是如此之大以至于可以忽略磁串扰。在另一个实施例中，所述距离是接近的，并且电磁体以同步的方式操作。

2. 发明申请

WO2012073182A1 A SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES 审中-公开
标题翻译：一种用于磁力驱动颗粒的传感器装置
公开(公告)号：WO2012073182A1
公开(公告)日：2012-06-07
申请号：PCT/IB2011/055341
申请日：2011-11-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
发明人： DITTMER, Wendy, Uyen , OVSYANKO, Mikhail, Mikhaylovich , EVERS, Toon, Hendrik , NIEUWENHUIS, Jeroen, Hans , VAN ZON, Joannes, Baptist, Adrianus, Dionisius
IPC分类号： G01N33/53 , G01N21/27 , G01N21/55
CPC分类号： G01N33/54373 , G01N21/274 , G01N21/552 , G01N27/72 , G01N27/745 , G01N27/825 , G01N33/54326 , G01N35/0098
摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an "auxiliary parameter" is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).
摘要翻译：本发明涉及一种传感器装置（100）和用于在具有接触表面（11））的样品室（2）中检测磁性颗粒（1）的方法。传感器装置（100）包括用于检测目标区域（TR）中和/或接触表面上的至少一个参考区域中的磁性颗粒（1）的传感器单元（120,130）。此外，它包括用于产生磁场的磁场发生器（140），该磁场将磁性颗粒引导到接触表面。在这些组件的帮助下，确定与磁性颗粒（1）和/或它们的运动相关的“辅助参数”，而与磁性颗粒和接触表面之间的目标区域中发生的结合过程无关。辅助参数可以例如与在磁场和目标区域（TR）的影响下由磁性颗粒（1）达到的位置之间的失配程度相关。评估结果可用于验证和/或校正在目标区域（TR）中获得的测量结果。

3. 发明申请

WO2011161499A1 DETECTION OF MAGNETIC PARTICLES AND THEIR CLUSTERING 审中-公开
标题翻译：检测磁性颗粒及其聚集
公开(公告)号：WO2011161499A1
公开(公告)日：2011-12-29
申请号：PCT/IB2010/055495
申请日：2010-11-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Joannes Baptist Adrianus Dionisius , OVSYANKO, Mikhail Mikhaylovich , EVERS, Toon Hendrik , SIJBERS, Mara Johanna Jacoba
发明人： VAN ZON, Joannes Baptist Adrianus Dionisius , OVSYANKO, Mikhail Mikhaylovich , EVERS, Toon Hendrik , SIJBERS, Mara Johanna Jacoba
IPC分类号： H01F1/00 , H01F1/44
CPC分类号： G01N27/72 , B01L3/502761 , B82Y25/00 , G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1276 , H01F1/0036
摘要： The invention relates to a method and associated apparatuses (100) for the detection of magnetic particles (MP) in a sample chamber (111). The method comprises the determination of a "particle-parameter" that is related to the amount of magnetic particles (MP) in a first detection region (P, C), the determination of a "cluster-parameter" that is related to the degree of clustering of magnetic particles (MP) in a second detection region (P, C), and the evaluation of the particle-parameter based on the cluster-parameter. Various apparatuses are disclosed that can be applied in said method. In one apparatus (100), a magnetic field (B) is generated in the sample chamber (111) in such a way that it has different inclinations in a first and second field region (P, C) and/or that it is oblique to the binding surface (112) in at least one field region. Magnetic particles (MP) are then detected in said first and second field region and/or in said at least one field region before and after a permanent switch-off of the inclined magnetic field. The resulting detection signals are related to each other to determine a cluster-parameter. In other embodiments, a cluster- parameter may be determined from light transmission measurements during the application of a magnetic field that is switched on and off.
摘要翻译：本发明涉及一种用于检测样品室（111）中的磁性颗粒（MP）的方法和相关装置（100）。该方法包括确定与第一检测区域（P，C）中的磁性粒子（MP）的量相关的“粒子参数”，确定与该程度相关的“聚类参数” 在第二检测区域（P，C）中的磁性粒子（MP）的聚类，以及基于聚类参数的粒子参数的评估。公开了可以应用于所述方法的各种装置。在一个装置（100）中，在样品室（111）中产生磁场（B），使得其在第一和第二场区域（P，C）中具有不同的倾斜度和/或倾斜到达至少一个场区域中的结合表面（112）。然后在永久关闭倾斜磁场之前和之后，在所述第一和第二场区和/或所述至少一个场区中检测磁性颗粒（MP）。所得到的检测信号彼此相关，以确定簇参数。在其他实施例中，可以在施加接通和关断的磁场期间的光透射测量来确定簇参数。

4. 发明申请

WO2011036634A1 A BIOSENSOR SYSTEM FOR SINGLE PARTICLE DETECTION 审中-公开
标题翻译：一种用于单粒子检测的生物传感器系统
公开(公告)号：WO2011036634A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054292
申请日：2010-09-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
发明人： SCHLEIPEN, Johannes Joseph Hubertina Barbara , VAN ZON, Joannes Baptist Adrianus Dionisius , KLUNDER, Derk Jan Wilfred , EVERS, Toon Hendrik , KAHLMAN, Josephus Arnoldus Henricus Maria , VAN LIESHOUT, Ron Martinus Laurentius , OVSYANKO, Mikhail Mikhaylovich
IPC分类号： G01R33/12 , G01N21/55
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface,a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic subunits separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：本发明涉及一种用于检测颗粒的生物传感器系统，包括：生物传感器盒，包括传感器表面，在盒的一侧上的生物传感器磁体组件，用于产生在盒和感测器表面有效的磁场;第一生物传感器磁体组件，其包括由间隙分开的至少两个磁性子单元，第一光学检测系统，用于检测与磁体组件位于盒的同一侧的颗粒，而磁体组件设计成使得光学检测是通过磁体组件的间隙完成。

5. 发明申请

WO2012172503A1 PROCESSING OF BIOLOGICAL SAMPLE COMPONENTS 审中-公开
标题翻译：生物样品成分的处理
公开(公告)号：WO2012172503A1
公开(公告)日：2012-12-20
申请号：PCT/IB2012/053005
申请日：2012-06-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OVSYANKO, Mikhail, Mikhaylovich , VAN HEMERT, Freek , PRINS, Menno, Willem, Jose , VAN DE STOLPE, Anja , WIMBERGER-FRIEDL, Reinhold
发明人： OVSYANKO, Mikhail, Mikhaylovich , VAN HEMERT, Freek , PRINS, Menno, Willem, Jose , VAN DE STOLPE, Anja , WIMBERGER-FRIEDL, Reinhold
IPC分类号： B03C1/01 , B03C1/28 , G01N33/543
CPC分类号： G01N33/54333 , B03C1/01 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N33/57492 , Y10T436/255
摘要： The invention relates to means for processing a sample fluid containing different components, particularly magnetic particles (M) and targets (cells) (C+M) labeled with magnetic particles. A processing device(100) according to the invention comprises a container (110) with a first compartment (120) that can be filled with a sample fluid and that is separated from a second compartment (130) by a filtering element (140). The filtering element (140) allows the passage of only at least one selected component(M) of the sample. Moreover, an optical surface (150), for example a microscopy slide, is provided in one (120) of the compartments. Components (C+M) of the sample that are in this compartment (120) collect on the optical surface (150). The migration of sample components (M, C+M) is preferably assisted by magnetic fields (B1, B2).
摘要翻译：本发明涉及用于处理含有用磁性颗粒标记的不同组分，特别是磁性颗粒（M）和靶（细胞）（C + M）的样品流体的装置。根据本发明的处理装置（100）包括具有第一隔室（120）的容器（110），所述第一隔室可以填充有样品流体，并且通过过滤元件（140）与第二隔室（130）分离。过滤元件（140）允许只有样品的至少一个选定组分（M）通过。此外，在一个（120）隔室中提供光学表面（150），例如显微镜载玻片。在该隔室（120）中的样品的组分（C + M）聚集在光学表面（150）上。样品组分（M，C + M）的迁移优选由磁场（B1，B2）辅助。

6. 发明申请

WO2012069988A1 CARTRIDGE FOR EXAMINATIONS OF A SAMPLE 审中-公开
标题翻译：用于检验样品的盒子
公开(公告)号：WO2012069988A1
公开(公告)日：2012-05-31
申请号：PCT/IB2011/055228
申请日：2011-11-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OVSYANKO, Mikhail, Mikhaylovich
发明人： OVSYANKO, Mikhail, Mikhaylovich
IPC分类号： G01N21/55 , G01N21/64 , G01N33/543
CPC分类号： G01N21/552 , G01N21/648
摘要： The invention relates to a cartridge (10) and a sensor device (100) with which a sample can be examined in a detection region (12) of said cartridge (10). The cartridge (10) comprises at least one marker (13) that can be localized by the sensor device (100), and a tag element (14) in which information about the position of the detection region (12) relative to said marker (13) is stored. This information is read out by the sensor device (100) and used to make a desired examination correctly at the actual position of the detection region (12).
摘要翻译：本发明涉及一种盒（10）和传感器装置（100），通过该传感器装置可以在所述盒（10）的检测区域（12）中检查样品。盒（10）包括可由传感器装置（100）定位的至少一个标记（13）和标签元件（14），其中关于检测区域（12）相对于所述标记（12）的位置的信息 13）被存储。该信息由传感器装置（100）读出，用于在检测区域（12）的实际位置正确地进行所需检查。

7. 发明申请

WO2013008142A1 FILTER SUPPORT WITH A PHASE-CHANGING MEDIUM 审中-公开
标题翻译：过滤器支持与相位变化中
公开(公告)号：WO2013008142A1
公开(公告)日：2013-01-17
申请号：PCT/IB2012/053408
申请日：2012-07-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PRINS, Menno Willem Jose , OVSYANKO, Mikhail Mikhaylovich , VAN HEMERT, Freek , VAN DOORN, Arie Rombertus
发明人： PRINS, Menno Willem Jose , OVSYANKO, Mikhail Mikhaylovich , VAN HEMERT, Freek , VAN DOORN, Arie Rombertus
IPC分类号： G01N1/36 , G01N1/28 , G02B21/34 , G01N33/48
CPC分类号： G01N1/30 , G01N1/2813 , G01N1/36 , G01N33/48 , G01N33/569 , G02B21/34
摘要： The present invention relates to a method for processing isolated cells, in particular rare cells such as circulating tumor cells, to render them suitable for optical imaging, comprising the steps of (a) depositing filter material comprising captured cells on a phase-change medium; (b) melting said phase-change medium until the medium is spread out below said filter material; and (c) lowering the temperature of said phase-change medium until the medium solidifies, resulting in an optically flat filter comprising said cells at a fixed position. The method may additionally comprise an initial step of capturing a cell on a filter material. The phase-change medium, preferably paraffin wax, may comprise a porous, or mesh-like structure allowing the passage of a fluid through the medium. The phase-change medium may further be mounted on a carrier such as a glass carrier or a polymer material carrier. The present invention further relates to processed filter material comprising isolated cells suitable for optical imaging, which is obtainable by the method; the use of such filter material for diagnostic, histological, microbiological, biochemical, oncologic, or hematologic analysis, as well as a device for isolating cells or processing cells to render them suitable for optical imaging.
摘要翻译：本发明涉及一种用于处理分离的细胞，特别是稀有细胞例如循环肿瘤细胞以使其适合于光学成像的方法，包括以下步骤：（a）将包含捕获的细胞的过滤材料沉积在相变介质上; （b）熔化所述相变介质，直到介质在所述过滤材料之下展开; 和（c）降低所述相变介质的温度，直到介质凝固，得到包含所述电池在固定位置的光学平面滤光器。该方法可以另外包括在过滤材料上捕获细胞的初始步骤。相变介质，优选石蜡，可以包括允许流体通过介质的多孔或网状结构。相变介质还可以安装在诸如玻璃载体或聚合物材料载体的载体上。本发明还涉及包含可通过该方法获得的适于光学成像的分离的细胞的经处理过滤材料; 使用这种过滤材料进行诊断，组织学，微生物学，生物化学，肿瘤学或血液学分析，以及用于分离细胞或处理细胞以使其适合于光学成像的装置。

8. 发明申请

WO2012032476A1 A METHOD AND A DEVICE FOR ATTRACTING MAGNETIC PARTICLES TO A SURFACE 审中-公开
标题翻译：一种用于将磁性颗粒吸附到表面的方法和装置
公开(公告)号：WO2012032476A1
公开(公告)日：2012-03-15
申请号：PCT/IB2011/053910
申请日：2011-09-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OVSYANKO, Mikhail, Mikhaylovich
发明人： OVSYANKO, Mikhail, Mikhaylovich
IPC分类号： G01N27/74 , G01N21/55 , G01N33/543 , G01R33/12
CPC分类号： G01N27/745 , G01N21/552 , G01N33/54366 , G01N35/0098 , G01R33/1269
摘要： The invention relates to a method for attracting magnetic particles (1) to a contact surface (11) in an associated sensor device (100). The attraction of the magnetic particles is achieved by generating a pulsed magnetic field (B) according to an actuation protocol, wherein said protocol includes a "local attraction phase" during which the duty cycle of the pulsations is smaller than about 10%, preferably ranging between 2% and 5%. It turns out that these small duty cycles are advantageous in bringing magnetic particles (1) into actual contact with the contact surface (11).
摘要翻译：本发明涉及一种用于将磁性颗粒（1）吸附到相关传感器装置（100）中的接触表面（11）上的方法。通过根据致动协议生成脉冲磁场（B）来实现磁性颗粒的吸引力，其中所述协议包括“局部吸引相”，在该区域期间脉动的占空比小于约10％，优选范围在2％和5％之间。结果证明，这些小占空比有利于使磁性颗粒（1）与接触表面（11）实际接触。

9. 发明申请

WO2011021142A1 DETECTION OF DIFFERENT TARGET COMPONENTS BY CLUSTER FORMATION 审中-公开
标题翻译：通过集群形成检测不同的目标组件
公开(公告)号：WO2011021142A1
公开(公告)日：2011-02-24
申请号：PCT/IB2010/053690
申请日：2010-08-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , RANZONI, Andrea , OVSYANKO, Mikhail, Mikhaylovich , PRINS, Menno, Willem, Jose
发明人： RANZONI, Andrea , OVSYANKO, Mikhail, Mikhaylovich , PRINS, Menno, Willem, Jose
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N27/745 , G01N33/54306 , G01N33/54366
摘要： The invention relates to a method, a test kit, and an apparatus (100) for detecting a plurality of different species of target components (T1, T2) in a sample. This is achieved by using a plurality of classes of label particles (1, 2), wherein at least one of the label particles (1, 2) in each class is a magnetic particle, and wherein label particles (1, 2) from each class can bind to each other via the same class-specific species of target component. Clusters of label particles (1, 2) can then form in which binding to specific target components (T1, T2) is accompanied by characteristic properties, for example magnetic susceptibilities of the associated label particles (1, 2). The selective actuation of such clusters by a magnetic field (B) with at least one oscillating component and a variable field amplitude together with the detection of such selectively actuated clusters will hence allow to specifically detect the clusters. This provides information about the different target components (T1, T2) in the sample.
摘要翻译：本发明涉及用于检测样品中多种不同种类的目标成分（T1，T2）的方法，测试试剂盒和装置（100）。这通过使用多种类型的标签颗粒（1,2）来实现，其中每个类别中的标签颗粒（1,2）中的至少一个是磁性颗粒，并且其中来自每个的标签颗粒（1,2）类可以通过目标组件的相同类特定物种彼此结合。然后可以形成与特定靶组分（T1，T2）结合的标记颗粒（1,2）簇，其特征在于特征性质，例如相关标记颗粒（1,2）的磁化率。具有至少一个振荡分量和可变场振幅的磁场（B）对这种簇的选择性驱动与这种选择性致动的簇的检测一起将因此允许特定地检测簇。这提供了有关样本中不同目标组件（T1，T2）的信息。

10. 发明申请

WO2013001431A1 MULTIPLE EXAMINATIONS OF A SAMPLE 审中-公开
标题翻译：样品的多次检验
公开(公告)号：WO2013001431A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053182
申请日：2012-06-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NEIJZEN, Jacobus Hermanus Maria , DITTMER, Wendy Uyen , OVSYANKO, Mikhail Mikhaylovich
发明人： NEIJZEN, Jacobus Hermanus Maria , DITTMER, Wendy Uyen , OVSYANKO, Mikhail Mikhaylovich
IPC分类号： G01N21/55 , G01N33/543 , G01N21/03 , G01N21/31
CPC分类号： G01N21/59 , G01N21/0303 , G01N21/31 , G01N21/3151 , G01N21/552 , G01N33/54326 , G01N2021/0325 , G01N2021/1738 , G01N2021/1742 , G01N2201/024 , G01N2201/066
摘要： The invention relates to means for the examination of a sample, wherein a first input light beam (L1) is totally internally reflected at a detection surface of a sample chamber (111), while a second input light beam (L1') is transmitted through the sample chamber (111). The resulting first and second output light beams (L2, L2') are detected and can be evaluated with respect to frustrated total internal reflection and optical absorbance, respectively. Preferably, both output light beams (L2, L2') are detected by a single image sensor (155).
摘要翻译：本发明涉及一种用于检查样品的装置，其中第一输入光束（L1）在样品室（111）的检测表面处被全内反射，而第二输入光束（L1'）被透射样品室（111）。检测所得到的第一和第二输出光束（L2，L2'），并且可以分别对沮丧的全内反射和光吸收率进行评估。优选地，两个输出光束（L2，L2'）由单个图像传感器（155）检测。

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