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1. 发明申请

WO1998025966A1 USE OF POLYPEPTIDES FOR TREATING THROMBOCYTOPENIA 审中-公开
标题翻译：多肽用于治疗血小板减少使用
公开(公告)号：WO1998025966A1
公开(公告)日：1998-06-18
申请号：PCT/EP1997006881
申请日：1997-12-10
申请人： BOEHRINGER MANNHEIM GMBH , OPITZ, Hans-Georg , SCHMITT, Joachim , FORSSMANN, Wolf-Georg , SCHULZ-KNAPPE, Peter
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C07K14/52
CPC分类号： C07K14/523 , A61K38/00
摘要： The invention relates to the use of polypeptides from the MIPs class (macrophage inflammatory proteins) for treating illnesses which are concomitant with a pathological change in blood platelet formation, in particular for treating thrombocytopenia.
摘要翻译：本发明涉及使用多肽的从类MIPS（巨噬细胞炎性蛋白）用于治疗与血小板形成病变相关的疾病的治疗，并且尤其是用于治疗血小板减少症。

2. 发明申请

WO1997022613A1 PHOSPHOLIPID DERIVATIVES OF PHOSPHONO-CARBOXYLIC ACIDS, THE PRODUCTION OF SAID DERIVATIVES AND THE USE OF SAID DERIVATIVES AS ANTIVIRAL MEDICAMENTS 审中-公开
标题翻译：膦他们的生产磷脂衍生物及其作为抗病毒药物
公开(公告)号：WO1997022613A1
公开(公告)日：1997-06-26
申请号：PCT/EP1996005647
申请日：1996-12-16
申请人： BOEHRINGER MANNHEIM GMBH , ZILCH, Harald , HERRMANN, Dieter , OPITZ, Hans-Georg , ZIMMERMANN, Gerd
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C07F09/40
CPC分类号： C07F9/4065 , C07F9/4006 , C07F9/4075
摘要： The present invention relates to: novel lipid derivatives of phosphono-carboxylic acids of general formula (I), the symbols of which are explained in the description; the tautomers and prodrugs of said derivatives and salts of inorganic and organic bases; as well as methods of producing said derivatives and medicaments containing them.
摘要翻译：本发明涉及的（I）通式的膦酰基羧酸，其中符号的意义在说明书中进行说明，它们的互变异构体和它们的前药和的无机和有机碱的盐的新的脂质衍生物，以及它们的制备方法以及这些化合物含有它们的药物组合物。

3. 发明申请

WO1996015234A2 LIPID-SPLITTING ENZYME 审中-公开
标题翻译：脂质裂解酶
公开(公告)号：WO1996015234A2
公开(公告)日：1996-05-23
申请号：PCT/EP1995004414
申请日：1995-11-09
申请人： BOEHRINGER MANNHEIM GMBH , HERRMANN, Dieter , OPITZ, Hans-Georg , ZILCH, Harald
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C12N09/16
CPC分类号： A61K31/7052 , C07H19/10 , C07H19/20 , C12N9/16 , C12Q1/44
摘要： A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates of this enzyme to prepare medicaments that contain these substrates as pharmaceutical active substance. These medicaments are useful to direct pharmacologically active substances to target cells and to enrich target cells with said substances. Also disclosed are in-vitro research systems containing this enzyme used to detect other substrates of this enzyme.
摘要翻译：本发明是一种先前描述的膜结合酶，其可从血液中的白细胞或单核细胞/巨噬细胞的细胞膜级分中分离。本发明还涉及使用这种酶用于药物的制备的基板，其特征在于，含有这些基板作为药物活性成分的药物。所述药物组合物适合于在相应的靶细胞的药理学活性物质靶向递送和积累。本发明提供了进一步包含此酶用于检测这种酶的其它底物的体外测定系统。

4. 发明申请

WO2008052722A2 USE OF RIBAVIRIN-CONJUGATES AS AN ANTI-VIRAL DRUG 审中-公开
标题翻译：将RIBAVIRIN-CONJUGATES用作抗病毒药物
公开(公告)号：WO2008052722A2
公开(公告)日：2008-05-08
申请号：PCT/EP2007/009354
申请日：2007-10-29
申请人： HEIDELBERG PHARMA AG , OPITZ, Hans-Georg , MÜLLER, Christoph , BRASPENNING, Joris
发明人： OPITZ, Hans-Georg , MÜLLER, Christoph , BRASPENNING, Joris
IPC分类号： C07H19/056 , A61K31/7042 , A61K31/7084
CPC分类号： C07H19/056 , A61K31/7024 , A61K31/7042 , A61K31/7084 , A61K47/542 , A61K47/543 , A61K47/544 , A61K47/549 , A61K47/55
摘要： The invention refers to ribavirin-nucleotide conjugates which are a substrate for nucleotide pyrophosphatases/phosphodiesterases for the treatment of viral diseases, preventing specifically ribavirin induced haemolysis of erythrocytes.
摘要翻译：本发明涉及利巴韦林 - 核苷酸缀合物，其是用于治疗病毒性疾病的核苷酸焦磷酸酶/磷酸二酯酶的底物，特异性地预防利巴韦林诱导的红细胞溶血。

5. 发明申请

WO2006042662A1 PARENTERALE DARREICHUNGSFORMEN VON IMEXON SOWIE VERFAHREN ZU DEREN HERSTELLUNG 审中-公开
标题翻译：注射剂型用于生产伊美克和方法形式
公开(公告)号：WO2006042662A1
公开(公告)日：2006-04-27
申请号：PCT/EP2005/010913
申请日：2005-10-11
申请人： HEIDELBERG PHARMA GMBH , OPITZ, Hans-Georg , WOOG, Heinrich, J. , GRUBER, Werner
发明人： OPITZ, Hans-Georg , WOOG, Heinrich, J. , GRUBER, Werner
IPC分类号： A61K31/505 , A61K9/19
CPC分类号： A61K31/505 , A61K9/0019 , A61K9/19 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/40
摘要： Die Erfindung betrifft gut intravenös verträgliche Imexon-Injektionspräperationen und Verfahren zu deren Herstellung sowie lagerstabile Imexon-Lyophilisate zur Herstellung der Injektionspräparationen.
摘要翻译：本发明涉及一种井伊美克Injektionspräperationen和它们的制备方法和伊美克用于制备注射剂的储存稳定的冻干产物的方法静脉内可接受的。

6. 发明申请

WO9722368A3 COVALENT LIPID-PHOSPHONO-CARBOXYLIC ACID CONJUGATES AND APPLICATION THEREOF AS ANTIVIRAL MEDICAMENTS 审中-公开
标题翻译：共价脂磷酸 - 羧酸 - 羧酸结合物及其作为抗病毒药物的应用
公开(公告)号：WO9722368A3
公开(公告)日：1997-10-23
申请号：PCT/EP9605648
申请日：1996-12-16
申请人： BOEHRINGER MANNHEIM GMBH , ZILCH HARALD , HERRMANN DIETER , OPITZ HANS GEORG , ZIMMERMANN GERD , VOSS EDGAR
发明人： ZILCH HARALD , HERRMANN DIETER , OPITZ HANS-GEORG , ZIMMERMANN GERD , VOSS EDGAR
IPC分类号： A61K31/00 , A61K31/66 , A61K31/662 , A61K47/48 , A61P31/00 , A61P31/12 , C07F9/40
CPC分类号： C07F9/4065 , C07F9/4006 , Y10S514/885
摘要： The present invention relates to: novel lipid derivatives of phosphono-carboxylic acids of general formula (I), the symbols of which are explained in the description; the tautomers and their physiologically acceptable salts of inorganic and organic bases; as well as methods of producing said derivatives and medicaments containing them.

7. 发明申请

WO1997022368A2 COVALENT LIPID-PHOSPHONO-CARBOXYLIC ACID CONJUGATES AND APPLICATION THEREOF AS ANTIVIRAL MEDICAMENTS 审中-公开
标题翻译：共价脂膦结合物及其作为抗病毒药物
公开(公告)号：WO1997022368A2
公开(公告)日：1997-06-26
申请号：PCT/EP1996005648
申请日：1996-12-16
申请人： BOEHRINGER MANNHEIM GMBH , ZILCH, Harald , HERRMANN, Dieter , OPITZ, Hans-Georg , ZIMMERMANN, Gerd , VOSS, Edgar
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： A61K97/48
CPC分类号： C07F9/4065 , C07F9/4006 , Y10S514/885
摘要： The present invention relates to: novel lipid derivatives of phosphono-carboxylic acids of general formula (I), the symbols of which are explained in the description; the tautomers and their physiologically acceptable salts of inorganic and organic bases; as well as methods of producing said derivatives and medicaments containing them.
摘要翻译：本发明涉及的（I）通式的膦酰基羧酸，其中符号的意义在说明书中进行说明，它们的互变异构体和它们的无机和有机碱的生理学上可接受的盐的新的脂质衍生物，以及它们的制备方法以及这些化合物含有它们的药物组合物。

8. 发明申请

WO1997014410A1 LIPID ALCOHOLS AS NEW IMMUNOSUPPRESSIVE AND ANTIVIRAL DRUGS 审中-公开
标题翻译：脂醇作为新型免疫和抗病毒药ARNEIMITTEL
公开(公告)号：WO1997014410A1
公开(公告)日：1997-04-24
申请号：PCT/EP1996004438
申请日：1996-10-11
申请人： BOEHRINGER MANNHEIM GMBH , ZILCH, Harald , HERRMANN, Dieter , OPITZ, Hans-Georg
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： A61K31/08
CPC分类号： C07C323/25 , A61K31/08 , A61K31/10 , C07C317/18
摘要： The present invention relates to new immunosuppressive and antiviral drugs based on lipid alcohols of the general formulas (I) and (II), in which R is a straight or branched, saturated or unsaturated alkyl chain with 1-30 carbon atoms which can optionally be substituted once or repeatedly by halogen, or by one of the following groups: C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkoxy-carbonyl, carboxy, C1-C6-alkylsulfinyl or C1-C6-alkylsulfonyl; R is a straight or branched, saturated or unsaturated alkyl chain with 1-20 carbon atoms which can optionally be substituted once or repeatedly by halogen, or by one of the following groups: C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkoxy-carbonyl or C1-C6-alkylsulfonyl; X is a valency bond, oxicarbonyl, carbonyloxy, amido carbonyl, carbonyl amido, oxygen, sulphur, the sulfinyl group or the sulfonyl group; Y is a valency bond, oxicarbonyl, carbonyloxy, amido carbonyl, carbonyl amido, oxygen, sulphur, the sulfinyl group or the sulfonyl group; and n may be an integer of from 1 to 5. The invention also relates to the tautomers of said drugs, and combinations with other active substances, which combinations contain these compounds.
摘要翻译：本发明涉及新的免疫抑制和抗病毒Arzeimittel使用式（I）和（II），其中R <1>是具有1-30个碳原子，其是任选地单的直链或支链的，饱和或不饱和烷基链的通式脂质醇或，C1-C6烷氧基 - 羰基，羧基，C1-C6烷基亚磺酰基或C1-C6烷基磺酰基可被取代被卤素多次，C1-C6烷氧基，C1-C6-烷基巯，R < 2>是氢，直链或支链，饱和或不饱和的烷基链具有1-20个碳原子，其任选地被卤素，C1-C6烷氧基，C1-C6-烷基巯基，C1-C6烷氧羰基或C1取代一次或多次的 C6烷基磺酰基X基团可以被取代，表示一个价键，Oxicarbonyl，羰氧基，amidocarbonyl，carbonylamido，氧，硫，亚磺酰基或磺酰基，Y是价键，Oxicarbonyl，羰氧基，amidocarbonyl，Carbonylam IDO，表示氧，硫，亚磺酰基或磺酰基，n具有从1至5的整数值可以构成包括，以及它们的互变异构体和含有这些化合物与其它药剂的组合。

9. 发明申请

WO2008052722A3 USE OF RIBAVIRIN-CONJUGATES AS AN ANTI-VIRAL DRUG 审中-公开
标题翻译：将RIBAVIRIN-CONJUGATES用作抗病毒药物
公开(公告)号：WO2008052722A3
公开(公告)日：2008-10-16
申请号：PCT/EP2007009354
申请日：2007-10-29
申请人： HEIDELBERG PHARMA AG , OPITZ HANS-GEORG , MUELLER CHRISTOPH , BRASPENNING JORIS
发明人： OPITZ HANS-GEORG , MUELLER CHRISTOPH , BRASPENNING JORIS
IPC分类号： C07H19/056 , A61K31/7042 , A61K31/7084
CPC分类号： C07H19/056 , A61K31/7024 , A61K31/7042 , A61K31/7084 , A61K47/542 , A61K47/543 , A61K47/544 , A61K47/549 , A61K47/55
摘要： The invention refers to ribavirin -nucleotide conjugates which are a substrate for nucleotide pyrophosphatases/phosphodiesterases for the treatment of viral diseases, preventing specifically ribavirin induced haemolysis of erythrocytes. These conjugates have the following structure (I). Ribavirin nucleotide conjugates of formula I which are substrates for nucleotide-pyrophosphatases/phosphodiesterases for a use as a medicament (structure (I)) wherein n is 1 to 2 and R is chosen among another ribavirin molecule, a sugar rest S, selected from the groups consisting of ribose, glucose or galactose, an amino acid residue AA, selected from the group consisting of residues of natural amino acids, and a lipid residue L, selected from the groups consisting of glycerol derivatives, as well as their stereoisomeric forms and pharmacological acceptable salts, for the preparation of a medicament for the treatment of viral infections preventing ribavirin induced haemolysis of erythrocytes.
摘要翻译：本发明涉及作为用于治疗病毒性疾病的核苷酸焦磷酸酶/磷酸二酯酶的底物的利巴韦林 - 核苷酸缀合物，特异性地预防利巴韦林诱导的红细胞溶血。这些缀合物具有以下结构（I）。作为用作药物（结构（I））的核苷酸 - 焦磷酸酶/磷酸二酯酶的底物的式I的利巴韦林核苷酸缀合物，其中n为1至2，R选自另一种利巴韦林分子，其中选自由核糖，葡萄糖或半乳糖组成的组，选自天然氨基酸残基的氨基酸残基AA和选自甘油衍生物的脂质残基L，以及其立体异构形式和药理学用于制备用于治疗病毒感染以防止利巴韦林诱导的红细胞溶血的药物。

10. 发明申请

WO1998007036A1 PROCESS FOR DETERMINING THE STATUS OF AN ORGANISM BY PEPTIDE MEASUREMENT 审中-公开
标题翻译：方法测定有机质的状态中通过测定肽
公开(公告)号：WO1998007036A1
公开(公告)日：1998-02-19
申请号：PCT/EP1997004396
申请日：1997-08-13
申请人： FORSSMANN, Wolf-Georg , SCHULZ-KNAPPE, Peter , SCHRADER, Michael , OPITZ, Hans-Georg
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6842 , G01N33/6893 , Y10T436/24 , Y10T436/25375 , Y10T436/255
摘要： A process is disclosed for determining the status of an organism by measuring peptides in a sample of the organism which contains high-molecular and low-molecular peptides and acts as an indicator of the organism status. Low-molecular peptides are directly sensed and characterised, and are then correlated with a reference.
摘要翻译：直接检测，一种用于通过从含有高和低分子量肽，所述生物体的样品的肽的测定检测生物体的状态，作为对生物体的状态的指示器，具有低分子量的肽的方法和表征，并与参考相关联。

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