专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2014085813A1 PROSTACYLIN COMPOSITIONS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：前列腺素组合物及其使用方法
公开(公告)号：WO2014085813A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072647
申请日：2013-12-02
申请人： INSMED INCORPORATED , LEIFER, Franziska , OMIATEK, Donna, M. , ONG, Jane , GUPTA, Renu , LI, Zhilli , PERKINS, Walter , MALININ, Vladimir
发明人： LEIFER, Franziska , OMIATEK, Donna, M. , ONG, Jane , GUPTA, Renu , LI, Zhilli , PERKINS, Walter , MALININ, Vladimir
IPC分类号： A61K9/14
CPC分类号： A61K31/5575 , A61K9/0075 , A61K9/0078 , A61K9/1272 , A61K9/5123 , A61K47/14 , A61K47/186 , A61K47/28
摘要： The present invention relates to pharmaceutical compositions comprising a prostacyclin, a cationic compound, and a surfactant. Particulate compositions, including liposomal, solid nanoparticulate prostacyclin compositions, including treprostinil formulations comprising cationic compound and the surfactant are also described. The present invention also relates to a system comprising the pharmaceutical composition and an inhalation device. Methods for treating pulmonary hypertension and portopulmonary hypertension with the compositions and systems described herein are also provided.
摘要翻译：本发明涉及包含前列环素，阳离子化合物和表面活性剂的药物组合物。还描述了包括脂质体，固体纳米微粒前列环素组合物的颗粒组合物，包括包含阳离子化合物和表面活性剂的曲前列环素制剂。本发明还涉及包含药物组合物和吸入装置的系统。还提供了用本文所述的组合物和系统治疗肺动脉高压和肺动脉高压的方法。

2. 发明申请

WO2003020913A3 ANOPHELES GAMBIAE ODORANT RECEPTORS AND GENES 审中-公开
公开(公告)号：WO2003020913A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/028315
申请日：2002-09-04
申请人： SENTIGEN CORP. , LEE, Kevin, J. , ONG, Jane , NGUYEN, Thuy-Ai, T. , KLOSS, Brian
发明人： LEE, Kevin, J. , ONG, Jane , NGUYEN, Thuy-Ai, T. , KLOSS, Brian
IPC分类号： C07K14/705 , C12N15/15 , G01N33/566 , C07K16/28
摘要： The present invention relates to Anopheles gambiae odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of Anopheles gambiae odorant receptor genes, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may be operatively linked to promoter sequences and transformed into host cells. Methods of production of an odorant receptor protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Antibodies to an odorant receptor protein, and derivatives and analogs thereof, are provided. Methods for identifying molecules that bind or modulate the activity of these odorant receptor genes are provided. Molecules found to bind or modulate the activity of odorant receptor genes may be formulated into pest control agents by providing a carrier. In a preferred embodiment, molecules that bind or modulate the activity of an odorant receptor gene from Anopheles gambiae but not others is desired. Methods to modify the insect behavior by modifying an odorant receptor are also provided.

3. 发明申请

WO2012012653A1 COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS 审中-公开
标题翻译：与MDM2和EFGR抑制剂组合治疗
公开(公告)号：WO2012012653A1
公开(公告)日：2012-01-26
申请号：PCT/US2011/044882
申请日：2011-07-21
申请人： ERRICO, Joseph P. , MUGRAGE, Benjamin , TURCHI, Ignatius , SILLS, Matthew , ONG, Jane , ALLOCCO, John , WINES, Pam , BASTOS, Margarita
发明人： ERRICO, Joseph P. , MUGRAGE, Benjamin , TURCHI, Ignatius , SILLS, Matthew , ONG, Jane , ALLOCCO, John , WINES, Pam , BASTOS, Margarita
IPC分类号： G01N33/574
CPC分类号： A61K31/517 , A61K31/4709 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic anti-proliferative or anti-apoptotic effect compared to administration of one agent alone.
摘要翻译：提供了通过施用p53和MDM2结合的抑制剂与EGFR抑制剂的组合来治疗受试者的增殖性疾病，病症或病症的方法。与单独施用一种试剂相比，所公开方法的各种实施方案提供协同的抗增殖或抗凋亡作用。

4. 发明申请

WO2011085129A3 METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT 审中-公开
标题翻译：靶向药物开发的方法和组合物
公开(公告)号：WO2011085129A3
公开(公告)日：2011-09-01
申请号：PCT/US2011020418
申请日：2011-01-06
申请人： ERRICO JOSEPH P , MUGRAGE BENJAMIN , TURCHI IGNATIUS , SILLS MATTHEW , HERRON JEFFREY D , LODATO NICHOLAS J , ONG JANE , PINE COREY , FEAVER WILLIAM J , ALLOCCO JOHN , WINES PAM
发明人： ERRICO JOSEPH P , MUGRAGE BENJAMIN , TURCHI IGNATIUS , SILLS MATTHEW , HERRON JEFFREY D , LODATO NICHOLAS J , ONG JANE , PINE COREY , FEAVER WILLIAM J , ALLOCCO JOHN , WINES PAM
IPC分类号： A61K31/535
CPC分类号： C07D215/26 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K45/06 , C07C335/26 , C07D207/48 , C07D209/08 , C07D239/42 , C07D239/47 , C07D239/52 , C07D285/135 , C07D295/26 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/14 , G06F19/16
摘要： Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.
摘要翻译：本文提供了具有抗增殖作用的化合物。还提供了可以调节包含二聚化臂和结构域间连接臂（例如EGFR）的多结构域蛋白的活性的化合物，其中未束缚的延长构象是活性状态并且束缚构象是非活性状态，导致自我抑制构型。还提供了用于鉴定这些化合物的方法和药效团。其他方面提供增殖性疾病，障碍或病症（例如与EGFR相关的那些）的方法或治疗性治疗。

5. 发明申请

WO2011085126A3 METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT 审中-公开
标题翻译：目标药物开发的方法和组成
公开(公告)号：WO2011085126A3
公开(公告)日：2012-02-23
申请号：PCT/US2011020414
申请日：2011-01-06
申请人： ERRICO JOSEPH P , MUGRAGE BENJAMIN , TURCHI IGNATIUS , SILLS MATTHEW , ONG JANE , ALLOCCO JOHN , WINES PAM
发明人： ERRICO JOSEPH P , MUGRAGE BENJAMIN , TURCHI IGNATIUS , SILLS MATTHEW , ONG JANE , ALLOCCO JOHN , WINES PAM
IPC分类号： A61K31/555
CPC分类号： C07D215/26 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K45/06 , C07C335/26 , C07D207/48 , C07D209/08 , C07D239/42 , C07D239/47 , C07D239/52 , C07D285/135 , C07D295/26 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/14 , G06F19/16
摘要： Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.
摘要翻译：本文提供具有抗增殖作用的化合物。还提供了可以调节包含二聚化臂和跨域系链例如EGFR的多结构域蛋白质的活性的化合物，其中无阻塞的扩展构象是活性状态，并且系留构象是无活性状态，导致自身抑制构型。还提供了用于鉴定这些化合物的方法和药效团。其他方面为增殖性疾病，病症或病症（例如与EGFR相关的病症）提供方法或治疗方法。

6. 发明申请

WO2011085129A2 METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT 审中-公开
标题翻译：靶向药物开发的方法和组合物
公开(公告)号：WO2011085129A2
公开(公告)日：2011-07-14
申请号：PCT/US2011/020418
申请日：2011-01-06
申请人： ERRICO, Joseph P. , MUGRAGE, Benjamin , TURCHI, Ignatius , SILLS, Matthew , HERRON, Jeffrey D. , LODATO, Nicholas J. , ONG, Jane , PINE, Corey , FEAVER, William J. , ALLOCCO, John , WINES, Pam
发明人： ERRICO, Joseph P. , MUGRAGE, Benjamin , TURCHI, Ignatius , SILLS, Matthew , HERRON, Jeffrey D. , LODATO, Nicholas J. , ONG, Jane , PINE, Corey , FEAVER, William J. , ALLOCCO, John , WINES, Pam
IPC分类号： A61K31/496
CPC分类号： C07D215/26 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K45/06 , C07C335/26 , C07D207/48 , C07D209/08 , C07D239/42 , C07D239/47 , C07D239/52 , C07D285/135 , C07D295/26 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/14 , G06F19/16
摘要： Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.
摘要翻译：本文提供了具有抗增殖作用的化合物。还提供了可以调节包含二聚化臂和结构域间连接臂（例如EGFR）的多结构域蛋白的活性的化合物，其中未束缚的延长构象是活性状态并且束缚构象是非活性状态，导致自我抑制构型。还提供了用于鉴定这些化合物的方法和药效团。其他方面提供增殖性疾病，病症或病症的方法或治疗性治疗，例如与EGFR相关的疾病，病症或病症。

7. 发明申请

WO2011085126A2 METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT 审中-公开
标题翻译：目标药物开发的方法和组成
公开(公告)号：WO2011085126A2
公开(公告)日：2011-07-14
申请号：PCT/US2011/020414
申请日：2011-01-06
申请人： ERRICO, Joseph P. , MUGRAGE, Benjamin , TURCHI, Ignatius , SILLS, Matthew , ONG, Jane , ALLOCCO, John , WINES, Pam
发明人： ERRICO, Joseph P. , MUGRAGE, Benjamin , TURCHI, Ignatius , SILLS, Matthew , ONG, Jane , ALLOCCO, John , WINES, Pam
IPC分类号： C07D401/02
CPC分类号： C07D215/26 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K45/06 , C07C335/26 , C07D207/48 , C07D209/08 , C07D239/42 , C07D239/47 , C07D239/52 , C07D285/135 , C07D295/26 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/14 , G06F19/16
摘要： Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.
摘要翻译：本文提供具有抗增殖作用的化合物。还提供了可以调节包含二聚化臂和跨域系链例如EGFR的多结构域蛋白质的活性的化合物，其中无阻塞的扩展构象是活性状态，并且系留构象是无活性状态，导致自身抑制构型。还提供了用于鉴定这些化合物的方法和药效团。其他方面为增殖性疾病，病症或病症（例如与EGFR相关的病症）提供方法或治疗方法。

8. 发明申请

WO2003020913A2 NUCLEIC ACIDS AND PROTEINS OF ANOPHELES GAMBIAE ODORANT RECEPTOR GENES AND USES THEREOF 审中-公开
标题翻译：游离氨基酸气味受体基因的核酸和蛋白质及其用途
公开(公告)号：WO2003020913A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/028315
申请日：2002-09-04
申请人： SENTIGEN CORP. , LEE, Kevin, J. , ONG, Jane , NGUYEN, Thuy-Ai, T. , KLOSS, Brian
发明人： LEE, Kevin, J. , ONG, Jane , NGUYEN, Thuy-Ai, T. , KLOSS, Brian
IPC分类号： C12N
CPC分类号： C07K14/43563
摘要： The present invention relates to Anopheles gambiae odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of Anopheles gambiae odorant receptor genes, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may be operatively linked to promoter sequences and transformed into host cells. Methods of production of an odorant receptor protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Antibodies to an odorant receptor protein, and derivatives and analogs thereof, are provided. Methods for identifying molecules that bind or modulate the activity of these odorant receptor genes are provided. Molecules found to bind or modulate the activity of odorant receptor genes may be formulated into pest control agents by providing a carrier. In a preferred embodiment, molecules that bind or modulate the activity of an odorant receptor gene from Anopheles gambiae but not others is desired. Methods to modify the insect behavior by modifying an odorant receptor are also provided.
摘要翻译：本发明涉及冈比亚按摩感受器基因和鉴别加味剂受体基因的方法。本发明提供了按蚊冈比亚气味受体基因的核苷酸序列，其编码的蛋白质（包括肽或多肽）的氨基酸序列以及相关产物和方法。本发明的核酸可以可操作地连接到启动子序列并转化到宿主细胞中。提供加味剂受体蛋白质的生产方法（例如，通过重组方法）及其衍生物和类似物。提供了加味剂受体蛋白质的抗体及其衍生物和类似物。提供了鉴定结合或调节这些加味剂受体基因的活性的分子的方法。发现结合或调节加味剂受体基因活性的分子可通过提供载体而配制成害虫控制剂。在优选的实施方案中，期望结合或调节来自冈比亚按蚊的加味剂受体基因的活性而不是其他的分子。还提供了通过改变气味受体来改变昆虫行为的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式