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1. 发明申请

WO2013039621A2 METHODS AND SYSTEMS FOR MAKING MICROTABLETS FOR DRUG DELIVERY 审中-公开
标题翻译：制备用于药物递送的微阵列的方法和系统
公开(公告)号：WO2013039621A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/050244
申请日：2012-08-10
申请人： ON DEMAND THERAPEUTICS, INC. , COPPETA, Jonathan, R. , DYER, Robert , STEVENSON, Cynthia, L.
发明人： COPPETA, Jonathan, R. , DYER, Robert , STEVENSON, Cynthia, L.
IPC分类号： A61K39/395 , A61J3/10 , F26B19/00 , F26B5/06 , B01D9/04
CPC分类号： A61K9/19 , A61J3/10 , A61K9/2072 , A61K9/2095 , B30B11/027
摘要： Methods and systems are provided for making a drag micro tablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilizalion capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the !yophilization capillary channel, or in a compression, capillary channel, to form a microtablet: and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
摘要翻译：提供了用于制造拖拉微片的方法和系统。该方法包括用液体药物溶液加载冻干毛细管通道; 将液体药物溶液冻干在冻干毛细管通道中以产生冻干药物制剂; 在冻干毛细管通道或压缩毛细管通道中压缩冻干药物制剂以形成微片，并从冻干毛细通道或压缩毛细管通道喷出微片。所述方法和系统可以提供具有改善的含量均匀性和降低的重量变异性的药物微片。

2. 发明申请

WO2011050250A1 VISUAL INDICATION OF RUPTURE OF DRUG RESERVOIR 审中-公开
标题翻译：药物残留破裂的可视化指标
公开(公告)号：WO2011050250A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053705
申请日：2010-10-22
申请人： ON DEMAND THERAPEUTICS, INC. , HORNE, Kenneth, N. , SPOONER, Gregory, J.R. , SCHOLL, John, A. , SANTINI, John, T. Jr.
发明人： HORNE, Kenneth, N. , SPOONER, Gregory, J.R. , SCHOLL, John, A. , SANTINI, John, T. Jr.
IPC分类号： A61F2/00
CPC分类号： A61F9/0017 , A61F2002/30714 , A61F2250/0068 , A61F2250/0089 , A61F2250/0097 , A61K9/0009 , A61K9/0051
摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.
摘要翻译：本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。所述方法包括将药物递送装置植入受试者的解剖结构内。药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

3. 发明申请

US20130064886A1 Microtablets for Drug Delivery 有权
标题翻译：用于药物递送的微量片剂
公开(公告)号：US20130064886A1
公开(公告)日：2013-03-14
申请号：US13672043
申请日：2012-11-08
申请人： On Demand Therapeutics, Inc.
发明人： Jonathan R. Coppeta , Robert Dyer , Cynthia L. Stevenson
IPC分类号： A61K9/20 , A61K39/395 , A61K48/00 , A61K38/02
CPC分类号： A61K9/19 , A61J3/10 , A61K9/2072 , A61K9/2095 , B30B11/027
摘要： Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
摘要翻译：提供了制备药物微片的方法和系统。该方法包括用液体药物溶液加载冻干毛细管通道; 将液体药物溶液冻干在冻干毛细管通道中以产生冻干药物制剂; 在冻干毛细管通道或压缩毛细管通道中压缩冻干药物制剂以形成微片; 并从冻干毛细通道或压缩毛细管通道中喷出微片。所述方法和系统可以提供具有改善的含量均匀性和降低的重量变异性的药物微片。

4. 发明专利

AU2011213616A1 Low-permeability, laser-activated drug delivery device 未知
公开(公告)号：AU2011213616A1
公开(公告)日：2012-09-06
申请号：AU2011213616
申请日：2011-02-08
申请人： ON DEMAND THERAPEUTICS INC , MICROCHIPS INC
发明人： COPPETA JONATHAN ROBERT , HORNE KENNETH N , SANTINI JOHN T , SCHOLL JOHN A , SPOONER GREGORY J R , STEVENSON CYNTHIA L , SHAMS NAVEED , POUTIATINE ANDREW
IPC分类号： A61F9/00 , A61K9/00
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low- permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

5. 发明专利

CA2789033A1 LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 未知
公开(公告)号：CA2789033A1
公开(公告)日：2011-08-11
申请号：CA2789033
申请日：2011-02-08
申请人： ON DEMAND THERAPEUTICS INC , MICROCHIPS INC
发明人： COPPETA JONATHAN ROBERT , HORNE KENNETH N , SANTINI JOHN T , SCHOLL JOHN A , SPOONER GREGORY J R , STEVENSON CYNTHIA L , SHAMS NAVEED , POUTIATINE ANDREW
IPC分类号： A61F9/00 , A61K9/00
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low- permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

6. 发明申请

US20140135712A1 Visual Indication of Rupture of Drug Reservoir 审中-公开
标题翻译：药物油藏破裂的视觉指征
公开(公告)号：US20140135712A1
公开(公告)日：2014-05-15
申请号：US14160040
申请日：2014-01-21
申请人： On Demand Therapeutics, Inc.
发明人： Kenneth N. Horne , Gregory J.R. Spooner , John A. Scholl , John T. Santini, JR.
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61F2002/30714 , A61F2250/0068 , A61F2250/0089 , A61F2250/0097 , A61K9/0009 , A61K9/0051
摘要： Devices and methods are provided for visualizing the opening of a drug reservoir of an implantable medical device. The disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker, and a plurality of barrier layers for separating the contents of the reservoirs from the anatomy. The method further includes irradiating at least one of the barrier layers such that at least one of the reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.
摘要翻译：提供了用于可视化可植入医疗装置的药物储存器的开口的装置和方法。本公开提供了观察从放置在受试者眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。所述方法包括将药物递送装置植入受试者的解剖结构内。该装置包括多个储存器，每个储存器装载有治疗剂和标记物，以及用于将储存器的内容物与解剖结构分离的多个阻挡层。该方法还包括照射至少一个阻挡层，使得至少一个储存器被破坏，从而引发治疗剂和标记从装置释放。通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

7. 发明专利

AU2011213616B2 Low-permeability, laser-activated drug delivery device 未知
公开(公告)号：AU2011213616B2
公开(公告)日：2013-08-15
申请号：AU2011213616
申请日：2011-02-08
申请人： MICROCHIPS INC , ON DEMAND THERAPEUTICS INC
发明人： COPPETA JONATHAN ROBERT , HORNE KENNETH N , SANTINI JOHN T , SCHOLL JOHN A , SPOONER GREGORY J R , STEVENSON CYNTHIA L , SHAMS NAVEED , POUTIATINE ANDREW
IPC分类号： A61F9/00 , A61K9/00
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low- permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

8. 发明申请

US20140148792A1 Laser-Activated Drug Delivery Device 审中-公开
标题翻译：激光激活药物输送装置
公开(公告)号：US20140148792A1
公开(公告)日：2014-05-29
申请号：US14170994
申请日：2014-02-03
申请人： On Demand Therapeutics Inc.
发明人： Jonathan R. Coppeta , Robert Dyer , Vipul Taneja , John T. Santini, JR.
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61L27/54 , A61L2430/16
摘要： Devices and methods are provided for selectively delivering a drug by laser activation. The device includes structural elements forming a hermetic, enclosed reservoir, and at least one drug unit contained in the enclosed reservoir. The at least one drug unit includes a drug. The device is able to absorb laser irradiation effective to open the enclosed reservoir to permit release of the drug. The method includes implanting a drug delivery device into a tissue site of a patient, and irradiating at least a portion of the drug delivery device to breach the enclosed reservoir to permit the drug to be released in tissues at the tissue site.
摘要翻译：提供了用于通过激光激活选择性递送药物的装置和方法。该装置包括形成密封的封闭储存器的结构元件和包含在封闭储存器中的至少一个药物单元。至少一种药物单元包括药物。该装置能够吸收有效打开封闭储存器的激光照射以允许释放药物。该方法包括将药物递送装置植入患者的组织部位，以及照射药物递送装置的至少一部分以破坏封闭的容器以允许药物在组织部位的组织中释放。

9. 发明授权

US08597680B2 Microtablets for drug delivery 有权
标题翻译：用于药物递送的微粒
公开(公告)号：US08597680B2
公开(公告)日：2013-12-03
申请号：US13672043
申请日：2012-11-08
申请人： On Demand Therapeutics, Inc.
发明人： Jonathan R. Coppeta , Robert Dyer , Cynthia L. Stevenson
IPC分类号： A61K9/20
CPC分类号： A61K9/19 , A61J3/10 , A61K9/2072 , A61K9/2095 , B30B11/027
摘要： Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
摘要翻译：提供了制备药物微片的方法和系统。该方法包括用液体药物溶液加载冻干毛细管通道; 将液体药物溶液冻干在冻干毛细管通道中以产生冻干药物制剂; 在冻干毛细管通道或压缩毛细管通道中压缩冻干药物制剂以形成微片; 并从冻干毛细通道或压缩毛细管通道中喷出微片。所述方法和系统可以提供具有改善的含量均匀性和降低的重量变异性的药物微片。

10. 发明申请

WO2013039621A3 METHODS AND SYSTEMS FOR MAKING MICROTABLETS FOR DRUG DELIVERY 审中-公开
标题翻译：制备用于药物递送的微阵列的方法和系统
公开(公告)号：WO2013039621A3
公开(公告)日：2014-05-08
申请号：PCT/US2012050244
申请日：2012-08-10
申请人： ON DEMAND THERAPEUTICS INC , COPPETA JONATHAN R , DYER ROBERT , STEVENSON CYNTHIA L
发明人： COPPETA JONATHAN R , DYER ROBERT , STEVENSON CYNTHIA L
IPC分类号： A61K9/54
CPC分类号： A61K9/19 , A61J3/10 , A61K9/2072 , A61K9/2095 , B30B11/027
摘要： Methods and systems are provided for making a drag micro tablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilizalion capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the !yophilization capillary channel, or in a compression, capillary channel, to form a microtablet: and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
摘要翻译：提供了用于制造拖拉微片的方法和系统。该方法包括用液体药物溶液加载冻干毛细管通道; 将液体药物溶液冻干在冻干毛细管通道中以产生冻干药物制剂; 在冻干毛细管通道或压缩毛细管通道中压缩冻干药物制剂以形成微片，并从冻干毛细通道或压缩毛细管通道喷出微片。所述方法和系统可以提供具有改进的含量均匀性和降低的重量变异性的药物微片。

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