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1. 发明专利

ZA7307458B ANTI-ARRHYTHMIC AGENTS AND PROCESSES FOR THEIR PREPARATION 未知
公开(公告)号：ZA7307458B
公开(公告)日：1974-09-25
申请号：ZA7307458
申请日：1973-09-20
申请人： OHKI S
发明人： MATUO I , OHKI S
IPC分类号： C07D209/76 , A61K31/22 , A61K31/395 , A61K31/40 , C07D20060101 , C07D203/02 , C07D209/02 , C07D209/56 , C07D209/72 , C07D241/02 , C07D401/02 , C07D413/06 , C07D487/08 , C07D

2. 发明专利

IL43261D0 DICARBOXYLIC ACID IMIDE DERIVATIVES AND ANTI-ARRHY THMIC COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：IL43261D0
公开(公告)日：1974-01-14
申请号：IL4326173
申请日：1973-09-18
申请人： OHKI S
IPC分类号： C07D209/76 , A61K31/22 , A61K31/395 , A61K31/40 , C07D20060101 , C07D203/02 , C07D209/02 , C07D209/56 , C07D209/72 , C07D241/02 , C07D401/02 , C07D413/06 , C07D487/08

3. 发明专利

AU2343977A HYDROPHTHALIMIDO DERIVATIVES 未知
公开(公告)号：AU2343977A
公开(公告)日：1978-09-28
申请号：AU2343977
申请日：1977-03-21
申请人： OHKI S PROF
发明人： MATUO ICHIRO , OHKI SADAO
IPC分类号： C07D209/94 , C07D307/77 , C07D401/06 , C07D403/06 , C07D413/06

4. 发明专利

GB1446633A 5-ENDO-HYDROXY-N-SUBSTITUTED-BICYCLO2-2-1-HEPTANE-2,3-DI- ENDO-CARBOXYLIC ACID IMIDES 未知
公开(公告)号：GB1446633A
公开(公告)日：1976-08-18
申请号：GB1213676
申请日：1973-09-19
申请人： OHKI S
IPC分类号： A61K31/40 , A61K31/403 , A61P9/06 , C07D209/76 , C07D307/00 , C07D307/93 , C07D401/06 , C07D413/06
摘要： 1446633 5-Endo-hydroxy-N-substituted-bicyclo-[2,2,1]-heptene-2,3-di-endo-carboxylic acid imides S OHKI 19 Sept 1973 [20 Sept 1972] 12136/76 Divided out of 1446632 Heading C2C Novel compounds of the Formula I wherein Z is CN or -NR 4 R 5 , R 4 and R 5 are H or alkyl or together with the nitrogen to which they are attached form a morpholino, pyrrolidino, piperidino or 4R 6 -substituted piperazino wherein R 6 is alkyl and when Z is CN n is 1 to 3 and when Z is -NR 4 R 5 n is 2 to 4 in which all alkyl groups have 1 to 6 carbon atoms and acid addition salts thereof may be prepared by reacting endo-cis bicyclo-[2,2,1] -hept-5-ene- 2,3-dicarboxylic anhydride or exo-cis-bicyclo- [2,2,1] -hept-5-ene-2,3-dicarboxylic anhydride with concentrated mineral acid to produce the endo-endo compound of the Formula II reacting II with at least a molar equivalent of halogenating agent, reacting the product with NH 2 (CH 2 ) n Z, subjecting the product to base catalysis to produce the desired compound and if desired, reducing a CN group at Z to NH 2 , and/or converting the product to an acid addition salt.

5. 发明专利

AU511433B2 BICYCLO (2,2,1,) HEPTANE-2,3-DI-ENDO CARBOXYLIC ACID IMIDES 未知
公开(公告)号：AU511433B2
公开(公告)日：1980-08-21
申请号：AU2343977
申请日：1977-03-21
申请人： OHKI S
发明人： MATUO I , OHKI S
IPC分类号： C07D209/94 , C07D307/77 , C07D401/06 , C07D403/06 , C07D413/06

6. 发明专利

DK137236C 未知
公开(公告)号：DK137236C
公开(公告)日：1978-07-10
申请号：DK512673
申请日：1973-09-19
申请人： OHKI S
发明人： MATUO I , OHKI S
IPC分类号： C07D209/76 , A61K31/22 , A61K31/395 , A61K31/40 , C07D20060101 , C07D203/02 , C07D209/02 , C07D209/56 , C07D209/72 , C07D241/02 , C07D401/02 , C07D413/06 , C07D487/08

7. 发明专利

DK137236B 未知
公开(公告)号：DK137236B
公开(公告)日：1978-02-06
申请号：DK512673
申请日：1973-09-19
申请人： OHKI S
发明人： MATUO I , OHKI S
IPC分类号： C07D209/76 , A61K31/22 , A61K31/395 , A61K31/40 , C07D20060101 , C07D203/02 , C07D209/02 , C07D209/56 , C07D209/72 , C07D241/02 , C07D401/02 , C07D413/06 , C07D487/08

8. 发明专利

GB1446632A 5-ENDO-BENZOYLOXY-N-AMINO-C2-4 ALKYL- BICYCLO-2,2,1-HEPTANE - 2,3-D-ENDO-CARBOXYLIC ACID IMIDES 未知
公开(公告)号：GB1446632A
公开(公告)日：1976-08-18
申请号：GB4403873
申请日：1973-09-19
申请人： OHKI S
IPC分类号： A61K31/40 , A61K31/403 , A61P9/06 , C07D209/76 , C07D307/00 , C07D307/93 , C07D413/06 , C07D403/06 , C07D401/06 , A61K31/535 , A61K31/495 , A61K31/445
摘要： 1446632 5-Endo-Benzoyloxy-N-[aminoalkyl]- bicyclo - [2,2,1] - heptane - 2,3 - di - endo - carboxylic acid imides S OHKI 19 Sept 1973 [20 Sept 1972] 44038/73 Heading C2C Novel compounds of the Formula I wherein R 1 , R 2 and R 3 are each H, Cl, F, Br, C 1-6 alkyl or alkoxy, NO 2 or OH, n is an integer of 2 to 4 and R 4 and R 5 are each H, C 1-6 alkyl or when taken together with the nitrogen to which they are attached are morpholino, pyrrolidino, piperidino or 4-R 6 substituted pipazino where R 6 is C 1-6 alkyl, hydrates and pharmaceutically acceptable salts thereof may be prepared by a multiple step reaction comprising (1) reacting endo - cis - bicyclo - [2,2,1] - hepto - 5 - ene - 2,3- dicarboxylic anhydride or exo-cis-bicyclo-[2,2,1]- hept-ene-2,3-dicarboxylic anhydride with a concentrated mineral acid to produce the endoendo compound II followed by (ii) reacting II with a halogenating agent at reflux temperature to produce after drying in vacuo an oily residue which is, (iii) reacted with an amine NH 2 (CH 2 ) n Z wherein Z is CN or -NR 4 R 5 in which R 4 and R 5 are other than hydrogen, provided that when Z is CN n is 1 to 3 and optionally treating the product with potassium hydroxide in aqueous alcohol to yield a compound of the Formula III (iv) reacting the compound III or the product of (iii) with a benzoyl halide wherein X is chloro, bromo or iodo and when Z is CN reducing the cyano group to a methylene amino group. Compounds I in which one of R 4 and R 6 is hydrogen may be prepared from compounds I in which both R 4 and R 5 are C 1-6 alkyl by reaction with trihaloalkyl chloroformate to yield the 5-endo-benzoyloxy-N-[3-(trihaloalkoxycarbonyl)]-3-[amino alkyl]-bicyclo-[2,2,1] heptane 2,3-di-endo-carboxylic acid imide followed by removal of the trihaloalkoxycarbonyl group. Pharmaceutical compositions of the compounds I alone or with the usual excipients show arrhythmic and/or anti-fibrillatory activity when administered.

9. 发明专利

PH12308A 5-ENDO-BENZOYLOXY-N-(AMINO-(LOWER)-ALKYL)-BISCYCLO(2,2,1)HEPTANE-2,3,-DI-ENDO-CAROXYLIC ACID IMIDES 未知
公开(公告)号：PH12308A
公开(公告)日：1979-01-16
申请号：PH15035
申请日：1973-09-19
申请人： OHKI S
发明人： MATUO I , OHKI S
IPC分类号： C07D209/76 , A61K31/22 , A61K31/395 , A61K31/40 , C07D20060101 , C07D203/02 , C07D209/02 , C07D209/56 , C07D209/72 , C07D241/02 , C07D401/02 , C07D413/06 , C07D487/08 , C07C119/06

10. 发明专利

IL49658D0 NOVEL BICYCLO(2,2,1)HEPTANE(2,3)DICARBOXIMIDES AND THEIR PREPARATION 未知
公开(公告)号：IL49658D0
公开(公告)日：1976-07-30
申请号：IL4965876
申请日：1976-05-25
申请人： OHKI S
IPC分类号： C07D209/76 , A61K31/22 , A61K31/395 , A61K31/40 , C07D20060101 , C07D203/02 , C07D209/02 , C07D209/56 , C07D209/72 , C07D241/02 , C07D401/02 , C07D413/06 , C07D487/08

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