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1. 发明申请

WO2002089771A1 LIPOSOMES 审中-公开
标题翻译：脂质体
公开(公告)号：WO2002089771A1
公开(公告)日：2002-11-14
申请号：PCT/GB2002/002100
申请日：2002-05-10
申请人： AMERSHAM HEALTH AS , CANNING, Lewis, Reuben , FOSSHEIM, Sigrid , ODEGARDSTUEN, Liv, Ingrid
发明人： FOSSHEIM, Sigrid , ODEGARDSTUEN, Liv, Ingrid
IPC分类号： A61K9/127
CPC分类号： A61K51/1234 , A61K9/127 , A61K47/183 , A61K47/22
摘要： Liposomes of a specific bilayer composition containing an entrapped modifying compound are claimed. The liposomes of the invention are suitable for the internalisation of a variety of materials, even following long-term storage. Suitable materials of the invention include radiometals, parmagnetic compounds, radioopaque compounds and prodrugs. Upon internalisation, the material reacts chemically with the entrapped modifying compound such that said material remains internalised within the liposomes of the invention. Also claimed in the present invention are the liposomes containing internalised material and kits for their preparation. Furthermore, the use of said liposomes containing internalised material for the imaging infection, inflammation or tumour in a human is claimed.
摘要翻译：要求保护含有截留的修饰化合物的特定双层组合物的脂质体。本发明的脂质体适用于各种材料的内部化，即使在长期储存之后。本发明的合适材料包括放射性金属，对磁性化合物，不透射线的化合物和前药。在内化后，该材料与被捕获的修饰化合物化学反应，使得所述材料保持内在化在本发明的脂质体内。本发明还要求保护的是含有内在材料的脂质体和用于其制备的试剂盒。此外，要求使用含有内在材料的所述脂质体用于人的成像感染，炎症或肿瘤。

2. 发明申请

WO9811921A3 Method 审中-公开
标题翻译：方法
公开(公告)号：WO9811921A3
公开(公告)日：1998-08-13
申请号：PCT/GB9702072
申请日：1997-07-30
申请人： NYCOMED IMAGING AS , GOLDING LOUISE , PETTERSSON GOERAN , GOLMAN KLAES , JACOBSEN ANNE , ODEGARDSTUEN LIV-INGRID , FAHLVIK ANNE KJERSTI
发明人： PETTERSSON GOERAN , GOLMAN KLAES , JACOBSEN ANNE , ODEGARDSTUEN LIV-INGRID , FAHLVIK ANNE SJERSTI
IPC分类号： A61K49/00 , A61K49/06 , A61K49/18
CPC分类号： A61K49/18 , A61K49/06
摘要： The invention provides the use of a physiologically tolerable manganese compound or a salt thereof, substantially free from hydrophilic polymer components containing a significant amount of a Mn2+- chelating unit, in the manufacture of an enterally, e.g. orally or rectally, administrable MRI contrast medium composition for use in a method of imaging of a human or non-human animal body which has fasted for a period of at least 6, preferably at least 10, more preferably at least 12 hours before enteral administration of said composition. It has been found that diagnostically effective levels of uptake of orally or rectally administered manganese may be achieved using this method.

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