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1. 发明公开

EP0634896A1 EVALUATION AND TREATMENT OF PATIENTS WITH PROGRESSIVE IMMUNOSUPPRESSION 失效
标题翻译：评估具有渐进免疫病患者
公开(公告)号：EP0634896A1
公开(公告)日：1995-01-25
申请号：EP93908649.0
申请日：1993-04-06
申请人： OCHOA, Augusto C. , MIZOGUCHI, Hiromoto , O'SHEA, John J. , Longo, Dan L. , LOEFFLER, Cynthia M. , GHOSH, Paritosh , YOUNG, Howard A.
发明人： OCHOA, Augusto C. , MIZOGUCHI, Hiromoto , O'SHEA, John J. , Longo, Dan L. , LOEFFLER, Cynthia M. , GHOSH, Paritosh , YOUNG, Howard A.
IPC分类号： G01N33 , A61K31 , A61K35 , A61K38 , A61K39 , A61K45 , A61K48 , A61K49 , A61P5 , A61P17 , A61P29 , A61P31 , A61P33 , A61P35 , A61P37 , A61P43 , C07H21 , C07K14 , C07K16 , C12N5 , C12N15 , C12Q1
CPC分类号： C07K16/18 , A61K38/2013 , A61K39/00 , C07K14/4702 , C07K14/4703 , A61K2300/00
摘要： A soluble immunosuppressive factor present in serum derived from tumor-bearing mammals, is associated with changes in TCR protein subunit levels, T lymphocyte signal transduction pathway proteins. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, a protein in the T lymphocyte signal transduction pathway, or of the NF-λB/rel family and comparing the level and pattern to that found in non-immunosuppressed individuals. The method is useful to identify patients having T lymphocytes capable of activation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppressive factor associated with the level of expression of the proteins is useful for suppressing the immune response, for example, in organ transplantation.

2. 发明授权

EP0634896B1 EVALUATION OF PATIENTS WITH PROGRESSIVE IMMUNOSUPPRESSION 失效
标题翻译：评估具有渐进免疫病患者
公开(公告)号：EP0634896B1
公开(公告)日：2005-02-16
申请号：EP93908649.2
申请日：1993-04-06
申请人： OCHOA, Augusto C. , MIZOGUCHI, Hiromoto , O'SHEA, John J. , Longo, Dan L. , LOEFFLER, Cynthia M. , GHOSH, Paritosh , YOUNG, Howard A.
发明人： OCHOA, Augusto C. , MIZOGUCHI, Hiromoto , O'SHEA, John J. , Longo, Dan L. , LOEFFLER, Cynthia M. , GHOSH, Paritosh , YOUNG, Howard A.
IPC分类号： A61K38/00 , A61K39/00 , C07K14/725 , C12Q1/00 , G01N33/53
CPC分类号： C07K16/18 , A61K38/2013 , A61K39/00 , C07K14/4702 , C07K14/4703 , A61K2300/00

3. 发明专利

DE69333760D1 未知
公开(公告)号：DE69333760D1
公开(公告)日：2005-03-24
申请号：DE69333760
申请日：1993-04-06
申请人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA M , GHOSH PARITOSH , YOUNG HOWARD A
发明人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA M , GHOSH PARITOSH , YOUNG HOWARD A
IPC分类号： G01N33/50 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K35/16 , A61K35/24 , A61K35/26 , A61K35/28 , A61K35/30 , A61K38/00 , A61K38/20 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K49/00 , A61P5/14 , A61P17/00 , A61P29/00 , A61P31/04 , A61P31/08 , A61P31/18 , A61P31/20 , A61P33/06 , A61P33/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/577 , C07K14/725 , C12Q1/00
摘要： A soluble immunosuppressive factor present in serum derived from tumor-bearing mammals, is associated with changes in TCR protein subunit levels, T lymphocyte signal transduction pathway proteins. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, a protein in the T lymphocyte signal transduction pathway, or of the NF- kappa B/rel family and comparing the level and pattern to that found in non-immunosuppressed individuals. The method is useful to identify patients having T lymphocytes capable of activation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppressive factor associated with the level of expression of the proteins is useful for suppressing the immune response, for example, in organ transplantation.

4. 发明专利

AT289202T 未知
公开(公告)号：AT289202T
公开(公告)日：2005-03-15
申请号：AT93908649
申请日：1993-04-06
申请人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA M , GHOSH PARITOSH , YOUNG HOWARD A
发明人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA M , GHOSH PARITOSH , YOUNG HOWARD A
IPC分类号： G01N33/50 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K35/16 , A61K35/24 , A61K35/26 , A61K35/28 , A61K35/30 , A61K38/00 , A61K38/20 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K49/00 , A61P5/14 , A61P17/00 , A61P29/00 , A61P31/04 , A61P31/08 , A61P31/18 , A61P31/20 , A61P33/06 , A61P33/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/577 , C07K14/725 , C12Q1/00
摘要： A soluble immunosuppressive factor present in serum derived from tumor-bearing mammals, is associated with changes in TCR protein subunit levels, T lymphocyte signal transduction pathway proteins. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, a protein in the T lymphocyte signal transduction pathway, or of the NF- kappa B/rel family and comparing the level and pattern to that found in non-immunosuppressed individuals. The method is useful to identify patients having T lymphocytes capable of activation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppressive factor associated with the level of expression of the proteins is useful for suppressing the immune response, for example, in organ transplantation.

5. 发明专利

CA2133759C EVALUATION AND TREATMENT OF PATIENTS WITH PROGRESSIVE IMMUNOSUPPRESSION 未知
公开(公告)号：CA2133759C
公开(公告)日：2003-09-30
申请号：CA2133759
申请日：1993-04-06
申请人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA T , GHOSH PARITOSH , YOUNG HOWARD A
发明人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA T , GHOSH PARITOSH , YOUNG HOWARD A
IPC分类号： G01N33/50 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K35/16 , A61K35/24 , A61K35/26 , A61K35/28 , A61K35/30 , A61K38/00 , A61K38/20 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K49/00 , A61P5/14 , A61P17/00 , A61P29/00 , A61P31/04 , A61P31/08 , A61P31/18 , A61P31/20 , A61P33/06 , A61P33/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/577 , C12N15/12 , C07H21/00 , A61K38/16
摘要： A soluble immunosuppressive factor present in serum derived from tumor-beari ng mammals, is associated with changes in TCR protein subunit levels, T lymphocyte signal transduction pathway protein s. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, a protein in the T lymphocyte signal transduction pathway, or of the NF-KB/r el family and comparing the level and pattern to chat found in non-immunosuppressed individuals: The method is useful to identify patients having T lymphocytes capable of acti- vation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppres- sive factor associated with the level of expression of the proteins is usefu l for suppressing the immune response, for example, in organ transplantation.

6. 发明专利

DE69333760T2 未知
公开(公告)号：DE69333760T2
公开(公告)日：2006-03-23
申请号：DE69333760
申请日：1993-04-06
申请人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA M , GHOSH PARITOSH , YOUNG HOWARD A
发明人： OCHOA AUGUSTO C , MIZOGUCHI HIROMOTO , O'SHEA JOHN J , LONGO DAN L , LOEFFLER CYNTHIA M , GHOSH PARITOSH , YOUNG HOWARD A
IPC分类号： A61K38/00 , G01N33/50 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K35/16 , A61K35/24 , A61K35/26 , A61K35/28 , A61K35/30 , A61K38/20 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K49/00 , A61P5/14 , A61P17/00 , A61P29/00 , A61P31/04 , A61P31/08 , A61P31/18 , A61P31/20 , A61P33/06 , A61P33/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/725 , C07K16/18 , C12N5/10 , C12N15/09 , C12Q1/00 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/577
摘要： A soluble immunosuppressive factor present in serum derived from tumor-bearing mammals, is associated with changes in TCR protein subunit levels, T lymphocyte signal transduction pathway proteins. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, a protein in the T lymphocyte signal transduction pathway, or of the NF- kappa B/rel family and comparing the level and pattern to that found in non-immunosuppressed individuals. The method is useful to identify patients having T lymphocytes capable of activation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppressive factor associated with the level of expression of the proteins is useful for suppressing the immune response, for example, in organ transplantation.

7. 发明申请

WO1993019605A1 EVALUATION AND TREATMENT OF PATIENTS WITH PROGRESSIVE IMMUNOSUPPRESSION 审中-公开
标题翻译：具有渐进性免疫抑制作用的患者的评估和治疗
公开(公告)号：WO1993019605A1
公开(公告)日：1993-10-14
申请号：PCT/US1993002936
申请日：1993-04-06
申请人： OCHOA, Augusto, C. , MIZOGUCHI, Hiromoto , O'SHEA, John, J. , LONGO, Dan, L. , LOEFFLER, Cynthia, M. , GHOSH, Paritosh , YOUNG , Howard, A.
IPC分类号： A01N63/00
CPC分类号： C07K16/18 , A61K38/2013 , A61K39/00 , C07K14/4702 , C07K14/4703 , A61K2300/00
摘要： A soluble immunosuppressive factor present in serum derived from tumor-bearing mammals, is associated with changes in TCR protein subunit levels, T lymphocyte signal transduction pathway proteins. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, a protein in the T lymphocyte signal transduction pathway, or of the NF- kappa B/rel family and comparing the level and pattern to that found in non-immunosuppressed individuals. The method is useful to identify patients having T lymphocytes capable of activation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppressive factor associated with the level of expression of the proteins is useful for suppressing the immune response, for example, in organ transplantation.
摘要翻译：存在于源自荷瘤哺乳动物的血清中的可溶性免疫抑制因子与TCR蛋白亚基水平，T淋巴细胞信号转导途径蛋白质的变化相关。这些变化提供了通过确定至少一种选择的TCR亚基蛋白，T淋巴细胞信号转导途径中的蛋白质或NF-κB/ rel家族的表达水平来确定哺乳动物免疫抑制水平的方法，以及将水平和模式与非免疫抑制个体的水平和模式进行比较。该方法可用于鉴定具有能够激活免疫治疗的T淋巴细胞的患者和用于鉴定引起或逆转免疫抑制的药物。与蛋白质表达水平相关的分离的免疫抑制因子可用于抑制免疫应答，例如在器官移植中。

8. 发明授权

US816248A Furnace. 失效
公开(公告)号：US816248A
公开(公告)日：1906-03-27
申请号：US1905292110
申请日：1905-12-16
申请人： O'SHEA JOHN J
发明人： O'SHEA JOHN J
CPC分类号： F23G5/245 , F22B13/04

9. 发明授权

US811867A Furnace. 失效
公开(公告)号：US811867A
公开(公告)日：1906-02-06
申请号：US1903293326
申请日：1903-12-18
申请人： O'SHEA JOHN J , O'SHEA JEREMIAH
发明人： O'SHEA JOHN J , O'SHEA JEREMIAH
CPC分类号： F23G5/245 , F22B13/04

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