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1. 发明申请

WO2004093821A3 TREATMENT OF ANTHRAX INFECTION USING INHIBITORS OF LETHAL FACTOR PROTEASE ACTIVITY 审中-公开
标题翻译：使用抑制因子的因子蛋白酶活性治疗神经传染
公开(公告)号：WO2004093821A3
公开(公告)日：2005-10-27
申请号：PCT/US2004013737
申请日：2004-04-22
申请人： HAWAII BIOTECH INC , GOLDMAN MARK EVAN , O'MALLEY SEAN , SIMO ONDREJ , NAGATA MELISSA , JIAO GUAN-SHENG , HEMSCHEIDT KLAUS THOMAS , TANG PENG CHO , CREGAR LYNNE
发明人： GOLDMAN MARK EVAN , O'MALLEY SEAN , SIMO ONDREJ , NAGATA MELISSA , JIAO GUAN-SHENG , HEMSCHEIDT KLAUS THOMAS , TANG PENG CHO , CREGAR LYNNE
IPC分类号： A61K20060101 , A61K31/70 , C07H15/20 , C07H15/22
CPC分类号： A61K31/70 , C07K7/06
摘要： Compounds containing spaced N and/or O, by virtue of their ability to inhibit the protease activity of lethal factor from B. anthracis, are useful in the prevention and treatment of anthrax toxicity. Libraries of these compounds are also useful as substrates for screening methods to identify LF inhibitors.
摘要翻译：含有间隔N和/或O的化合物由于能够抑制炭疽芽孢杆菌致死因子的蛋白酶活性而被用于预防和治疗炭疽毒性。这些化合物的文库也可用作鉴定LF抑制剂的筛选方法的底物。

2. 发明申请

WO2007027834A1 CAROTENOID ANALOGS OR DERIVATIVES FOR THE INHIBITION AND AMELIORATION OF INFLAMMATION 审中-公开
标题翻译：用于抑制和改善炎症的毛细血管细胞模拟物或衍生物
公开(公告)号：WO2007027834A1
公开(公告)日：2007-03-08
申请号：PCT/US2006/033948
申请日：2006-08-29
申请人： CARDAX PHARMACEUTICALS INC. , LOCKWOOD, Samuel, Fournier , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
发明人： LOCKWOOD, Samuel, Fournier , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
IPC分类号： A61K31/661 , A61K31/6615 , A61K31/225 , A61P35/00 , A61P11/06 , A61P29/00
CPC分类号： A61K31/015 , A61K31/12 , A61K31/225 , A61K31/66 , A61K31/661 , A61K31/6615
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering the analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of 5-LO-catalyzed eicosanoid metabolites. In an embodiment, 5-LO-catalyzed eicosanoid metabolites that may be controlled or affected by administering analogs or derivatives of carotenoids to a subject may include proinflammatory effector molecules (e.g., leukotrienes).
摘要翻译：一种抑制和/或改善人类受试者中疾病发生的方法，其中受试者单独或与另一种类胡萝卜素类似物或衍生物组合施用类胡萝卜素类似物或衍生物。在一些实施方案中，类胡萝卜素类似物或衍生物的施用可以抑制和/或改善受试者中疾病的发生。在一些实施方案中，类胡萝卜素的类似物或衍生物可以是水溶性的和/或水分散的。可用本文体现的类胡萝卜素类似物或衍生物治疗的疟疾可能包括引发或触发炎性反应的疾病。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗哮喘。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响类花生酸的生物利用度。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗动脉粥样硬化。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响5-LO催化的类花生酸酯代谢物的生物利用度。在一个实施方案中，可以通过向受试者施用类胡萝卜素的类似物或衍生物来控制或影响的5-LO-催化的类花生酸代谢物可以包括促炎效应分子（例如白三烯）。

3. 发明申请

WO2005102356A1 CAROTENOID ANALOGS OR DERIVATIVES FOR THE INHIBITION AND AMELIORATION OF INFLAMMATION 审中-公开
标题翻译：用于抑制和改善炎症的毛细血管细胞模拟物或衍生物
公开(公告)号：WO2005102356A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/012811
申请日：2005-04-14
申请人： HAWAII BIOTECH, INC. , LOCKWOOD, Samuel, F. , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
发明人： LOCKWOOD, Samuel, F. , O'MALLEY, Sean , JACKSON, Henry , NADOLSKI, Geoff
IPC分类号： A61K31/6615
CPC分类号： A61K31/015 , A61K31/12 , A61K31/225 , A61K31/341 , A61K31/66 , A61K31/6615
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases in a human subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative. In some embodiments, the administration of analogs or derivatives of carotenoids may inhibit and/or ameliorate the occurrence of diseases in subjects. In some embodiments, analogs or derivatives of carotenoids may be water-soluble and/or water dispersible. Maladies that may be treated with analogs or derivatives of carotenoids embodied herein may include diseases that provoke or trigger an inflammatory response. In an embodiment, asthma may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of eicosanoids. In an embodiment, atherosclerosis may be treated with analogs or derivatives of carotenoids embodied herein. In an embodiment, administering the analogs or derivatives of carotenoids embodied herein to a subject may control or affect the bioavailability of 5-LO-catalyzed eicosanoid metabolites. In an embodiment, 5-LO-catalyzed eicosanoid metabolites that may be controlled or affected by administering analogs or derivatives of carotenoids to a subject may include proinflammatory effector molecules (e.g., leukotrienes).
摘要翻译：一种抑制和/或改善人类受试者中疾病发生的方法，其中受试者单独或与另一种类胡萝卜素类似物或衍生物组合施用类胡萝卜素类似物或衍生物。在一些实施方案中，类胡萝卜素类似物或衍生物的施用可以抑制和/或改善受试者中疾病的发生。在一些实施方案中，类胡萝卜素的类似物或衍生物可以是水溶性的和/或水分散的。可用本文体现的类胡萝卜素类似物或衍生物治疗的疟疾可能包括引发或触发炎性反应的疾病。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗哮喘。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响类花生酸的生物利用度。在一个实施方案中，可以用本文所体现的类胡萝卜素类似物或衍生物来治疗动脉粥样硬化。在一个实施方案中，将本文体现的类胡萝卜素的类似物或衍生物施用于受试者可以控制或影响5-LO催化的类花生酸酯代谢物的生物利用度。在一个实施方案中，可以通过向受试者施用类胡萝卜素的类似物或衍生物来控制或影响的5-LO-催化的类花生酸代谢物可以包括促炎效应分子（例如白三烯）。

4. 发明申请

WO2004093821A2 TREATMENT OF ANTHRAX INFECTION USING INHIBITORS OF LETHAL FACTOR PROTEASE ACTIVITY 审中-公开
标题翻译：使用抑制因子的因子蛋白酶活性治疗神经传染
公开(公告)号：WO2004093821A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/013737
申请日：2004-04-22
申请人： HAWAII BIOTECH, INC. , GOLDMAN, Mark, Evan , O'MALLEY, Sean , SIMO, Ondrej , NAGATA, Melissa , JIAO, Guan-Sheng , HEMSCHEIDT, Klaus, Thomas , TANG, Peng, Cho , CREGAR, Lynne
发明人： GOLDMAN, Mark, Evan , O'MALLEY, Sean , SIMO, Ondrej , NAGATA, Melissa , JIAO, Guan-Sheng , HEMSCHEIDT, Klaus, Thomas , TANG, Peng, Cho , CREGAR, Lynne
IPC分类号： A61K
CPC分类号： A61K31/70 , C07K7/06
摘要： Compounds containing spaced N and/or O, by virtue of their ability to inhibit the protease activity of lethal factor from B. anthracis, are useful in the prevention and treatment of anthrax toxicity. Libraries of these compounds are also useful as substrates for screening methods to identify LF inhibitors.
摘要翻译：含有间隔N和/或O的化合物由于能够抑制炭疽芽孢杆菌致死因子的蛋白酶活性而被用于预防和治疗炭疽毒性。这些化合物的文库也可用作鉴定LF抑制剂的筛选方法的底物。

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