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1. 发明专利

GB189602268A Improvements in Riding Saddles. 未知
公开(公告)号：GB189602268A
公开(公告)日：1896-12-05
申请号：GB189602268D
申请日：1896-01-31
申请人： O'CONNOR STEPHEN
发明人： O'CONNOR STEPHEN

2. 发明申请

WO2020056249A1 ORAL FORMULATIONS OF KAPPA OPIOID RECEPTOR AGONISTS 审中-公开
公开(公告)号：WO2020056249A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/051002
申请日：2019-09-13
申请人： CARA THERAPEUTICS, INC. , WILSON, Bryan, R. , O'CONNOR, Stephen, J.
发明人： WILSON, Bryan, R. , O'CONNOR, Stephen, J.
IPC分类号： A61K38/07 , A61K38/08 , C07K7/02
摘要： The invention provides formulations for oral delivery of a therapeutic agent wherein the formulation comprises a kappa opioid receptor agonist and an absorption enhancer, the absorption enhancer includes a medium chain fatty acid or a salt of a medium chain fatty acid; and a medium chain fatty acid glyceride. The kappa opioid receptor agonist may be embedded in an oligosaccharide, such as trehalose. Also provided are capsules containing the oral formulations of the kappa opioid receptor agonists and the absorption enhancer of the invention and methods use of these formulations for the prophylaxis and treatment of variety of kappa opioid receptor-associated diseases and conditions such as pain, pruritus and inflammation; the method comprising administering to the mammal the formulation comprising the kappa opioid receptor agonist and an absorption enhancer.

3. 发明申请

WO2011117651A2 COMPOSITIONS 审中-公开
标题翻译：组合物
公开(公告)号：WO2011117651A2
公开(公告)日：2011-09-29
申请号：PCT/GB2011/050611
申请日：2011-03-25
申请人： INNOSPEC LIMITED , O'CONNOR, Stephen, Moss , COTRELL, Phillip, Loraine
发明人： O'CONNOR, Stephen, Moss , COTRELL, Phillip, Loraine
CPC分类号： A61K8/466 , A61K8/44 , A61K2800/596 , A61Q5/02 , A61Q19/10 , C11D1/126 , C11D1/88 , C11D1/90 , C11D1/92 , C11D1/94
摘要： An aqueous composition comprising: (a) an acyl isethionate of formula (I): wherein R 1 is an alkyl or alkenyl group having from (7) to (21) carbon atoms and M+ a cation; and (b) an amphoteric, betaine or sultaine surfactant; wherein the weight ratio of component (a) to component (b) is more than 3:1.
摘要翻译：一种水性组合物，其包含：（a）式（I）的酰基羟乙基磺酸盐：其中R 1是具有（7）至（21）碳原子和M + a阳离子的烷基或烯基; 和（b）两性，甜菜碱或磺胺素表面活性剂; 其中组分（a）与组分（b）的重量比大于3:1。

4. 发明申请

WO2011117650A2 COMPOSITIONS 审中-公开
标题翻译：组合物
公开(公告)号：WO2011117650A2
公开(公告)日：2011-09-29
申请号：PCT/GB2011/050610
申请日：2011-03-25
申请人： INNOSPEC LIMITED , O'CONNOR, Stephen, Moss , COTRELL, Phillip, Loraine
发明人： O'CONNOR, Stephen, Moss , COTRELL, Phillip, Loraine
CPC分类号： A61K8/466 , A61K2800/596 , A61Q5/02 , A61Q19/10 , C11D1/10 , C11D1/126 , C11D1/146 , C11D1/29 , C11D1/528 , C11D1/74 , C11D1/90 , C11D1/92 , C11D1/94
摘要： An aqueous composition comprising: (a) an acyl isethionate of formula (I): wherein R 1 is an alkyl or alkenyl group having from (7) to (21) carbon atoms and M + is a cation; and (b) a further surfactant selected from nonionic surfactants, cationic surfactants and anionic surfactants other than those of formula (I); wherein component (a) and component (b) together comprise more than (12) wt% of the composition.
摘要翻译：一种水性组合物，其包含：（a）式（I）的酰基羟乙基磺酸盐：其中R 1是具有（7）至（21）碳原子并且M +是阳离子的烷基或烯基; 和（b）选自非离子表面活性剂，阳离子表面活性剂和除式（I）的那些之外的阴离子表面活性剂的另外的表面活性剂; 其中组分（a）和组分（b）一起包含组合物的多于（12）wt％。

5. 发明申请

WO2010150200A1 METHOD AND APPARATUS FOR PROVIDING UNIFORM CONTENT MANAGEMENT 审中-公开
标题翻译：提供统一内容管理的方法和装置
公开(公告)号：WO2010150200A1
公开(公告)日：2010-12-29
申请号：PCT/IB2010/052838
申请日：2010-06-23
申请人： NOKIA CORPORATION , NOKIA INC. , YLINEN, Samuli , KANKAANPÄÄ, Teemu , HIRVONEN, Ari-Pekka , HUOTARI, Jaana , DAYMOND, Andrew , TAMMINEN, Aki , LEHTO, Aki , OJALA, Kalle , LINDGREN, Marko , NYFFELER, Christopher, Michael , ARMENDARIZ, Nerea , SIMSARIAN, Kristian, Russell, Thomas , CRUSE II, Energy , PASCUAL, Anne, Sybille , HAUER, Marcus , DON, Abbe , VAN DER FLIER, Astrid, Jantina , TONG, Scott, Yiu-Lun , GLAZIER, Adam , CUNNINGHAM, Jeffrey, John , O'CONNOR, Stephen , GOSLING, Katrin, B.
发明人： YLINEN, Samuli , KANKAANPÄÄ, Teemu , HIRVONEN, Ari-Pekka , HUOTARI, Jaana , DAYMOND, Andrew , TAMMINEN, Aki , LEHTO, Aki , OJALA, Kalle , LINDGREN, Marko , NYFFELER, Christopher, Michael , ARMENDARIZ, Nerea , SIMSARIAN, Kristian, Russell, Thomas , CRUSE II, Energy , PASCUAL, Anne, Sybille , HAUER, Marcus , DON, Abbe , VAN DER FLIER, Astrid, Jantina , TONG, Scott, Yiu-Lun , GLAZIER, Adam , CUNNINGHAM, Jeffrey, John , O'CONNOR, Stephen , GOSLING, Katrin, B.
IPC分类号： G06F17/30 , G06F3/048 , H04L29/08 , H04M1/247 , H04M1/725
CPC分类号： G06Q10/10 , G06F9/451 , G06Q10/06
摘要： An approach is provided for providing uniform content management for a user equipment. A uniform content management platform determines new content from a plurality of content of different categories. The uniform content management platform further initiates presentation of the new content via a graphical user interface that includes: a dashboard providing a layout of the new content, a content manager that is invoked upon selection of a particular one of the new content for managing a group of content of a common category, and a content editor that is invoked upon selection of one of the content in the group for editing the selected content.
摘要翻译：提供了一种用于为用户设备提供统一的内容管理的方法。统一的内容管理平台从不同类别的多个内容中确定新的内容。统一内容管理平台还通过图形用户界面进一步发起新内容的呈现，该图形用户界面包括：提供新内容的布局的仪表板，内容管理器，其在选择用于管理组的新内容中的特定一个时被调用的内容，以及内容编辑器，其在选择组中的一个内容以便编辑所选择的内容时被调用。

6. 发明申请

WO2010068520A3 SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES 审中-公开
标题翻译：取代的咪唑环型衍生物
公开(公告)号：WO2010068520A3
公开(公告)日：2010-09-16
申请号：PCT/US2009066172
申请日：2009-12-01
申请人： CARA THERAPEUTICS INC , O'CONNOR STEPHEN J , NEWCOM JASON S , RALBOVSKY JANET L , GUSTAFSON GARY R , BECKETT R PAUL , LUO ROBERT XHIYONG
发明人： O'CONNOR STEPHEN J , NEWCOM JASON S , RALBOVSKY JANET L , GUSTAFSON GARY R , BECKETT R PAUL , LUO ROBERT XHIYONG
IPC分类号： C07D487/04 , A61K31/4162 , A61P17/04 , A61P29/00
CPC分类号： C07D487/04 , A61K31/553 , C07D498/04
摘要： The present invention provides substituted imidazoheterocycles having the general structure of formula (I), wherein Y is chosen from -O-, -OCRgRh-, -CRgRhO-, -CRgRh-, -(CRgRh)2-, -NRi-, -CRgRhNRi- and -NRiCRgRh-. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
摘要翻译：本发明提供具有通式（I）的通式结构的取代的咪唑杂环，其中Y选自-O - ， - OCRgRh - ， - CRgRhO - ， - CRgRh - ， - （CRgRh）2 - ， - NRi - ， - CRgRhNRi - 和-NRiCRgRh-。本发明还提供了式I化合物的药学上可接受的盐，酸式盐，水合物，溶剂化物和立体异构体。所述化合物可用作大麻素受体的调节剂并用于预防和治疗大麻素受体相关疾病和病症，例如疼痛，炎症和瘙痒。

7. 发明申请

WO2010048036A3 SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
标题翻译：用于管理实用消费的系统和方法
公开(公告)号：WO2010048036A3
公开(公告)日：2010-07-22
申请号：PCT/US2009060925
申请日：2009-10-15
申请人： TERRATRIM INC , O'CONNOR STEPHEN D , GAMBLE RONALD C , SUCHTER RICHARD A
发明人： O'CONNOR STEPHEN D , GAMBLE RONALD C , SUCHTER RICHARD A
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06
摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.
摘要翻译：一种用于监测和管理公用事业消耗的系统和方法包括使用（A）布置成监测第一设施的至少一个段或设备的运行状况和/或公用事业消耗的一个或多个传感器; （B）存储器，其包括以下中的至少一个：（i）与影响公用事业消耗的至少一个指定参数相关联或归一化的存储的公用设施消耗信息;（ii）假设的公用事业消费; （C）处理器，用于将所监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。存储的消费信息可能与第一设施或第二设施有关。假设效用消耗信息可以涉及根据优化条件操作的第一设施的段或设备，或升级的段或设备。

8. 发明申请

WO2009120660A3 SUBSTITUTED PYRIDOXAZINES 审中-公开
公开(公告)号：WO2009120660A3
公开(公告)日：2009-10-01
申请号：PCT/US2009/038037
申请日：2009-03-24
申请人： CARA THERAPEUTICS, INC. , NEWCOM, Jason, S. , O'CONNOR, Stephen, J. , GUSTAFSON, Gary, R.
发明人： NEWCOM, Jason, S. , O'CONNOR, Stephen, J. , GUSTAFSON, Gary, R.
IPC分类号： C07D487/04 , C07D413/04 , C07D413/02 , C07D403/04 , C07D403/02
摘要： The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R 1 , R 2 , R 3 and R 4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.

9. 发明申请

WO2006127287A3 PYRROLOPYRIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS 审中-公开
标题翻译：基于吡咯基吡啶的DIPEPTIDYL PEPTIDASE IV和方法的抑制剂
公开(公告)号：WO2006127287A3
公开(公告)日：2007-06-07
申请号：PCT/US2006018185
申请日：2006-05-11
申请人： SQUIBB BRISTOL MYERS CO , DEVASTHALE PRATIK , WANG WEI , HAMANN LAWRENCE G , O'CONNOR STEPHEN P , FEVIG JOHN M
发明人： DEVASTHALE PRATIK , WANG WEI , HAMANN LAWRENCE G , O'CONNOR STEPHEN P , FEVIG JOHN M
IPC分类号： C07D487/04 , A61K31/407
CPC分类号： C07D471/04
摘要： Compounds are provided having the formula (I): wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases.
摘要翻译：提供具有式（I）的化合物：其中R，X，Y，Z，A和n如本文所定义，其是二肽基肽酶IV的抑制剂，因此可用于治疗糖尿病和相关疾病。

10. 发明申请

WO2006127287A2 PYRROLOPYRIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS 审中-公开
标题翻译：基于吡咯基吡啶的DIPEPTIDYL PEPTIDASE IV和方法的抑制剂
公开(公告)号：WO2006127287A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/018185
申请日：2006-05-11
申请人： BRISTOL-MYERS SQUIBB COMPANY , DEVASTHALE, Pratik , WANG, Wei , HAMANN, Lawrence G. , O'CONNOR, Stephen P. , FEVIG, John M.
发明人： DEVASTHALE, Pratik , WANG, Wei , HAMANN, Lawrence G. , O'CONNOR, Stephen P. , FEVIG, John M.
IPC分类号： C07D487/04 , A61K31/407
CPC分类号： C07D471/04
摘要： Compounds are provided having the formula (I): wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases.
摘要翻译：提供具有式（I）的化合物：其中R，X，Y，Z，A和n如本文所定义，其是二肽基肽酶IV的抑制剂，因此可用于治疗糖尿病和相关疾病。

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