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1. 发明专利

GB2459079A An air engine 未知
公开(公告)号：GB2459079A
公开(公告)日：2009-10-14
申请号：GB0800480
申请日：2008-01-14
申请人： O'BRIEN SEAN
发明人： O'BRIEN SEAN
IPC分类号： F01B23/00 , F01B1/02 , F01B25/14 , F16C3/06
摘要： An air engine is characterised by an inline arrangement of pistons and cylinders. Compressed air is injected and exhausted by valves controlled by the engine electronic control unit (ECU). Air is injected during the compression stroke and shut off when the piston is at top dead centre (TDC), at which point the air expands and drives the power stroke. After reaching bottom dead centre (BDC) the exhaust valve opens allowing the expanded air to escape. The exhaust valve is held open depending on the speed of the engine. Also disclosed is a crank shaft having cranks positioned at 90 degree radial intervals about the axis of rotation.

2. 发明专利

GB2465177A Spider and insect catcher 未知
公开(公告)号：GB2465177A
公开(公告)日：2010-05-12
申请号：GB0820384
申请日：2008-11-07
申请人： O'BRIEN SEAN , O'BRIEN MICHELLE JANE
发明人： O'BRIEN SEAN , O'BRIEN MICHELLE JANE
IPC分类号： A01M3/00
摘要： A spider and insect catcher comprises a container with an openable window and a handle. The handle may have an inner section slidable within an outer section. The inner section maybe operatively connected to the window so that when the inner part is pulled, the window opens. The container may be made of a translucent material enabling an operator to see when the insect has been picked up. The container may also have an air ventilator through which insecticides may be sprayed to kill the insect. The catcher may also be suitable for catching frogs.

3. 发明申请

WO2016174112A1 ODONTALGIC PREPARATION 审中-公开
标题翻译：空白制备
公开(公告)号：WO2016174112A1
公开(公告)日：2016-11-03
申请号：PCT/EP2016/059445
申请日：2016-04-27
申请人： O'BRIEN, Sean Liam
发明人： O'BRIEN, Sean Liam
IPC分类号： A61K9/00 , A61K36/53 , A61K36/61 , A61P1/02
CPC分类号： A61K36/61 , A61K8/9783 , A61K9/006 , A61K36/53 , A61Q11/00 , A61K2300/00
摘要： A liquid formulation or preparation comprising tea tree oil, lavender oil and Manuka oil for use in the treatment of oral and dental disease and for providing pain relief from dental or oral disease. The formulation is also for use as a mouthwash for maintaining general oral hygiene and health. The formulation of the present invention has anti-inflammatory and anti-microbial or anti-septic properties and is of use in the treatment of conditions such as oral abscesses, gingivitis, periodontal disease, pulpitis, dental sensitivity, pericoronitis, ulcers and thrush and other painful conditions or infections of the oral / buccal cavity and for maintaining general oral and dental health.
摘要翻译：一种液体制剂或制剂，其包含茶树油，薰衣草油和麦卢卡油，用于治疗口腔和牙科疾病，并提供牙科或口腔疾病的疼痛缓解。该制剂也可用作维持口腔卫生和健康的漱口水。本发明的制剂具有抗炎和抗微生物或抗脓毒性质，并且可用于治疗诸如口腔脓肿，牙龈炎，牙周病，牙髓炎，牙齿敏感性，牙周炎，溃疡和鹅口疮等的病症口腔/口腔的疼痛状况或感染，并保持口腔和牙齿健康。

4. 发明申请

WO2010121225A3 METHOD OF TREATING DISORDERS ASSOCIATED WITH PROTEIN KINASE CK2 ACTIVITY 审中-公开
标题翻译：治疗与蛋白激酶CK2活性相关的疾病的方法
公开(公告)号：WO2010121225A3
公开(公告)日：2011-01-06
申请号：PCT/US2010031520
申请日：2010-04-16
申请人： CYLENE PHARMACEUTICALS INC , HADDACH MUSTAPHA , O'BRIEN SEAN , ANDERES KENNA
发明人： HADDACH MUSTAPHA , O'BRIEN SEAN , ANDERES KENNA
IPC分类号： A61K31/4375 , A61K31/519 , A61P7/00 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/16 , A61P31/18 , A61P31/22 , A61P33/02 , A61P35/02
CPC分类号： A61K31/4375 , A61K31/519
摘要： The invention provides methods for the treatment or amelioration of disorders associated with undesired activity of protein kinase CK2, using compounds of Formula (I) that are potent, selective inhibitors of CK2, and pharmaceutical compositions of such compounds, wherein Z5, R6B, R6D, R8, n, R9 and p are defined as further described herein,
摘要翻译：本发明提供了使用作为CK2有效的选择性抑制剂的式（I）化合物和这些化合物的药物组合物来治疗或改善与蛋白激酶CK2的不期望的活性相关的疾病的方法，其中Z5，R6B，R6D， R8，n，R9和p如本文进一步描述的定义，

5. 发明申请

WO2008046045A1 DRUG BIOVAILABILITY SCREENS 审中-公开
标题翻译：药物生物可利用筛选
公开(公告)号：WO2008046045A1
公开(公告)日：2008-04-17
申请号：PCT/US2007/081237
申请日：2007-10-12
申请人： CYLENE PHARMACEUTICALS, INC. , DARJANIA, Levan , O'BRIEN, Sean
发明人： DARJANIA, Levan , O'BRIEN, Sean
IPC分类号： A61K49/00 , C12N13/00
CPC分类号： G01N33/94
摘要： Provided herein are methods for ranking compounds by predicted bioavailability, methods for predicting bioavailability, and kits for predicting bioavailability of compounds.
摘要翻译：本文提供了通过预测的生物利用度来评估化合物的方法，用于预测生物利用度的方法和用于预测化合物的生物利用度的试剂盒。

6. 发明申请

WO2006091881A2 MERGING SUB-RESOLUTION ASSIST FEATURES OF A PHOTOLITHOGRAPHIC MASK 审中-公开
标题翻译：合成分辨率辅助特征的光刻胶面
公开(公告)号：WO2006091881A2
公开(公告)日：2006-08-31
申请号：PCT/US2006006726
申请日：2006-02-24
申请人： TEXAS INSTRUMENTS INC , O'BRIEN SEAN C , ZHANG GUOHONG
发明人： O'BRIEN SEAN C , ZHANG GUOHONG
IPC分类号： G03C5/00 , G03F1/00
CPC分类号： G03F1/36
摘要： Merging sub-resolution assist features includes receiving a mask pattern (10) that includes the sub-resolution assist features. A first sub-resolution assist feature is selected to merge with a second sub-resolution assist feature. A merge bar (16) width of a merge bar is established. A distance between the first sub-resolution assist feature and the second sub-resolution assist feature is determined. A merging technique is determined in accordance with the distance and the merge bar width. The first sub-resolution assist feature and the second sub-resolution assist feature are merged according to the identified merging.
摘要翻译：合并子分辨率辅助功能包括接收包括子分辨率辅助特征的掩模图案（10）。选择第一子分辨率辅助特征以与第二子分辨率辅助特征合并。合并条的宽度合并条（16）建立。确定第一子分辨率辅助特征和第二子分辨率辅助特征之间的距离。根据距离和合并条宽确定合并技术。根据识别的合并，第一次分辨率辅助特征和第二子分辨率辅助特征被合并。

7. 发明申请

WO2005011675A1 DERIVATIVES OF 3-HYDROXY-PYRROLE-2,4-DICARBOXYLIC ACID AND USES THEREOF 审中-公开
标题翻译： 3-羟基吡咯烷-2,4-二羧酸的衍生物及其用途
公开(公告)号：WO2005011675A1
公开(公告)日：2005-02-10
申请号：PCT/US2004/024473
申请日：2004-07-28
申请人： AVALON PHARMACEUTICALS , CHOLODY, Wieslaw, M. , PETUKHOVA, Valentina , O'BRIEN, Sean , OHLER, Norman , PIKUL, Stanislaw
发明人： CHOLODY, Wieslaw, M. , PETUKHOVA, Valentina , O'BRIEN, Sean , OHLER, Norman , PIKUL, Stanislaw
IPC分类号： A61K31/40
CPC分类号： C07D401/12 , C07D207/36 , C07D405/12 , C07D453/02 , C07D487/08
摘要： Chemical agents of the general formula (1) and (11), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
摘要翻译：公开了通式（1）和（11）的化学试剂，例如含有羟基异羟肟酸的3-羟基吡咯的衍生物及其盐，其调节包括癌细胞在内的细胞系统中的基因表达水平制备这种试剂的方法，以及含有这些试剂如活性成分的药物组合物和使用它们作为治疗剂的方法。

8. 发明申请

WO2011041785A1 BIOMARKERS FOR PREDICTING THE SENSITIVITY AND RESPONSE OF PROTEIN KINASE CK2-MEDIATED DISEASES TO CK2 INHIBITORS 审中-公开
标题翻译：用于预测蛋白激酶CK2介导的疾病对CK2抑制剂的敏感性和反应的生物标志物
公开(公告)号：WO2011041785A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/051341
申请日：2010-10-04
申请人： CYLENE PHARMACEUTICALS, INC. , DRYGIN, Denis , O'BRIEN, Sean , ANDERES, Kenna , VONHOFF, Daniel, D. , LIM, John, K., C. , PADGETT, Claire, S. , BLIESATH, Joshua, R. , HO, Caroline, B. , RICE, William G.
发明人： DRYGIN, Denis , O'BRIEN, Sean , ANDERES, Kenna , VONHOFF, Daniel, D. , LIM, John, K., C. , PADGETT, Claire, S. , BLIESATH, Joshua, R. , HO, Caroline, B. , RICE, William G.
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/574 , G01N2333/91205 , G01N2440/14 , G01N2800/52
摘要： Disclosed are biomarkers for determining the sensitivity of protein kinase CK2-mediated diseases, such as proliferative and/or inflammatory disorders, to treatment with CK2 inhibitors. These biomarkers can be used to predict or select subjects likely to be responsive to treatment with a CK2 inhibitor, and to treat or monitor subjects undergoing treatment with a CK2 inhibitor.
摘要翻译：公开了用于确定蛋白激酶CK2介导的疾病如增殖和/或炎性疾病对用CK2抑制剂治疗的敏感性的生物标志物。这些生物标志物可用于预测或选择可能对CK2抑制剂治疗有反应的受试者，以及治疗或监测接受CK2抑制剂治疗的受试者。

9. 发明申请

WO2011011199A1 COMBINATION THERAPIES WITH CK2 MODULATORS 审中-公开
标题翻译：与CK2调节器的组合治疗
公开(公告)号：WO2011011199A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/041244
申请日：2010-07-07
申请人： CYLENE PHARMACEUTICALS, INC. , DRYGIN, Denis , ANDERES, Kenna , HO, Caroline B. , BLIESATH, Joshua R. , PROFFITT, Christopher B. , O'BRIEN, Sean , RICE, William G.
发明人： DRYGIN, Denis , ANDERES, Kenna , HO, Caroline B. , BLIESATH, Joshua R. , PROFFITT, Christopher B. , O'BRIEN, Sean , RICE, William G.
IPC分类号： A61K31/4745 , A61K31/519 , A61K45/06 , A61P35/00
CPC分类号： A61K45/06 , A61K31/337 , A61K31/35 , A61K31/395 , A61K31/404 , A61K31/4045 , A61K31/436 , A61K31/4375 , A61K31/44 , A61K31/4745 , A61K31/475 , A61K31/498 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K33/24 , A61K2300/00
摘要： The present application is generally directed to compounds, compositions and methods of combination therapy for the treatment of neoplastic, inflammatory, autoimmune or infectious disorders.
摘要翻译：本申请一般涉及用于治疗肿瘤，炎症，自身免疫或感染性疾病的组合疗法的化合物，组合物和方法。

10. 发明申请

WO2007022474A3 HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF 审中-公开
公开(公告)号：WO2007022474A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/032508
申请日：2006-08-18
申请人： CYLENE PHARMACEUTICALS, INC. , DRYGIN, Denis , MICHELOTTI, Emil , O'BRIEN, Sean , RICE, William, G. , SIDDIQUI-JAIN, Adam , WHITTEN, Jeffrey, P.
发明人： DRYGIN, Denis , MICHELOTTI, Emil , O'BRIEN, Sean , RICE, William, G. , SIDDIQUI-JAIN, Adam , WHITTEN, Jeffrey, P.
IPC分类号： A01N43/04 , A61K31/70 , C07H21/04
摘要： Provided herein are isolated nucleic acids that comprise a human rRNA or rDNA subsequence and related compositions and methods of use.

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