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1. 发明申请

US20120045773A1 CELL ADHESION INHIBITOR AND APPLICATIONS THEREOF 审中-公开
标题翻译：细胞粘附抑制剂及其应用
公开(公告)号：US20120045773A1
公开(公告)日：2012-02-23
申请号：US13203073
申请日：2010-01-28
申请人： Kazuhiro Morishita , Norio Yamakawa
发明人： Kazuhiro Morishita , Norio Yamakawa
IPC分类号： G01N33/53 , C07H21/04 , C07K16/18
CPC分类号： C07K16/2839 , A61K31/7088 , C07K2317/76 , C12N15/113 , C12N2310/11 , G01N2500/00
摘要： PROBLEMProvided is a prevention/treatment means for cancer, by controlling expression/function of a target molecule different from a conventional one, as a novel method in the molecularly-targeted treatment method for a cancer. In addition, provided is a screening means for a substance having prevention/treatment activity for cancer, using the above target molecule.SOLUTIONAccording to one aspect of the present invention, there is provided a cell adhesion inhibitor for a cancer cell, containing an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence, represented by SEQ ID No: 2 or represented by SEQ ID No: 4 or represented by SEQ ID No: 6 or a partial peptide thereof. According to another aspect of the present invention, there is provided a cell adhesion inhibitor for a cancer cell, containing an antisense polynucleotide containing a complementary or substantially complementary base sequence to a base sequence of a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence as the amino acid sequence, represented by SEQ ID No: 2 or represented by SEQ ID No: 4 or represented by SEQ ID No: 6 or apart thereof. According to further another aspect of the present invention, there is provided a cell adhesion inhibitor for a cancer cell, containing a substance to inhibit expression and/or activity of protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID No: 2 or represented by SEQ ID No: 4 or represented by SEQ ID No: 6.
摘要翻译：问题提供作为癌症的分子靶向治疗方法中的新方法，通过控制与常规靶分子不同的靶分子的表达/功能来提供癌症的预防/治疗手段。此外，使用上述靶分子，提供了具有癌症预防/治疗活性的物质的筛选方法。解决方案根据本发明的一个方面，提供了一种癌细胞的细胞粘附抑制剂，其含有与氨基酸序列相同或基本相同的氨基酸序列的蛋白质的抗体，所述氨基酸序列由SEQ ID No： 2或由SEQ ID No：4表示或由SEQ ID No：6表示或其部分肽表示。根据本发明的另一方面，提供了一种癌细胞的细胞粘附抑制剂，其含有含有与编码含有相同或基本相同的蛋白质的多核苷酸的碱基序列的互补或基本上互补的碱基序列的反义多核苷酸作为氨基酸序列的氨基酸序列，由SEQ ID No：2表示或由SEQ ID No：4表示或由SEQ ID No：6表示或其间的氨基酸序列。根据本发明的另一方面，提供了一种癌细胞的细胞粘附抑制剂，其含有抑制与表示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的表达和/或活性的物质由SEQ ID No：2或由SEQ ID No：4表示或由SEQ ID No：6表示。

2. 发明授权

US4409508A Brush holder with coated clamp for dynamo-electric machine 失效
标题翻译：用于发电机的电刷夹具
公开(公告)号：US4409508A
公开(公告)日：1983-10-11
申请号：US375102
申请日：1982-05-05
申请人： Norihiro Ooki , Noriyoshi Takahashi , Yasuyuki Wachi , Yoshio Takikawa , Norio Yamakawa , Shoji Motegi
发明人： Norihiro Ooki , Noriyoshi Takahashi , Yasuyuki Wachi , Yoshio Takikawa , Norio Yamakawa , Shoji Motegi
IPC分类号： H01R39/38 , H01R39/40 , H01R39/46 , H02K13/00
CPC分类号： H01R39/38 , H01R39/46 , H01R39/40
摘要： A brush holder for dynamo-electric machine has the following parts: a brush making sliding contact with the surface of a rotary collector; a stationary holder part fixed to the stationary part of the dynamo-electric machine opposite to the collector; and a detachable holder part detachably secured to the stationary holder part and holding the brush when separated from the stationary holder part, the detachable holder part being provided with a retainer that clamps the brush when the detachable holder part is separated from the stationary holder part and unclamps the brush when it is attached to the stationary holder part, the brush clamping portion and the portion of the retainer therearound being coated with a coating film of a material having a friction coefficient smaller than the material of the retainer. This arrangement obviates various unfavorable phenomena such as jumping of the brush, sparking on the sliding surface, cracking in the brush and so forth.
摘要翻译：发电机用电刷架具有以下部件：与旋转集电体的表面滑动接触的刷子; 固定在与收集器相对的发电机的静止部分上的固定支架部分; 以及可拆卸地保持器部分，其可拆卸地固定到固定保持器部分并且当与固定保持器部分分离时保持刷子，所述可拆卸保持器部分设置有保持器，当可拆卸保持器部分与固定保持器部分分离时，该保持器夹持刷子，当刷子附接到固定保持器部分时，刷子夹紧部分和保持器周围的部分涂覆有具有小于保持器材料的摩擦系数的材料的涂膜，使刷子松开。这种布置避免了各种不利的现象，例如刷子的跳动，滑动表面上的火花，刷子中的开裂等等。

3. 发明授权

US4355254A Brush holding device for electric rotary machine 失效
标题翻译：电动旋转机刷子保持装置
公开(公告)号：US4355254A
公开(公告)日：1982-10-19
申请号：US204047
申请日：1980-11-04
申请人： Norihiro Oki , Shoji Motegi , Yasuyuki Wachi , Yoshio Takikawa , Norio Yamakawa
发明人： Norihiro Oki , Shoji Motegi , Yasuyuki Wachi , Yoshio Takikawa , Norio Yamakawa
IPC分类号： H01R39/38 , H01R39/40 , H02K13/00
CPC分类号： H01R39/40
摘要： A brush holding device for an electric rotary machine for holding a brush electrically connecting the stationary part of the electric rotary machine to a rotating slip ring, the device comprising a brush box supported on the stationary part to accommodate the brush therein, a main wall detachably mounted on a main post extending from the brush box, a brush retaining element in the form of a band for retaining the brush in the brush box, a handle for carrying the main wall together with the brush, and a manipulating lever for unlockably locking the main wall to the brush box, whereby the brush can be easily and simply replaced.
摘要翻译：一种用于保持将电动旋转机械的静止部分电连接到旋转滑环上的电刷的电动旋转机器的刷子保持装置，该装置包括：支撑在固定部分上以容纳刷子的刷盒;可拆卸的主壁安装在从刷盒延伸的主柱上，用于将刷子保持在刷盒中的带状形式的刷子保持元件，用于与刷子一起承载主壁的手柄和用于可解锁地锁定主墙到刷盒，从而可以容易地和简单地更换刷子。

4. 发明授权

US4296346A Brush holding apparatus for rotary electric machine 失效
标题翻译：旋转电机刷持机
公开(公告)号：US4296346A
公开(公告)日：1981-10-20
申请号：US95951
申请日：1979-11-20
申请人： Norihiro Ooki , Shoji Motegi , Yasuyuki Wachi , Yoshio Takikawa , Norio Yamakawa
发明人： Norihiro Ooki , Shoji Motegi , Yasuyuki Wachi , Yoshio Takikawa , Norio Yamakawa
IPC分类号： H01R39/38 , H01R39/40 , H01R39/42 , H02K5/14 , H02K13/00
CPC分类号： H01R39/42 , H02K5/141
摘要： A brush holding apparatus for a rotary electric machine permitting removal and replacement of brushes without stopping the rotation of the rotary electric machine comprises a brush holder which can be detached from a stationary unit, and a securing device for detachably securing the brush holder to the stationary unit. A manipulating lever is provided on the stationary unit to actuate the securing device. The brush holder can easily be mounted on or detached from the stationary unit by the manipulation of the manipulating lever for the puppose of removal and replacement of the brushes while the rotary electric machine is in operation.
摘要翻译：一种用于旋转电机的刷保持装置，其允许在不停止旋转电机的旋转的情况下移除和更换电刷包括可从固定单元拆卸的电刷架，以及用于将电刷架可拆卸地固定到固定件的固定装置单元。操纵杆设置在固定单元上以致动固定装置。电刷架可以通过操纵操作杆而容易地安装在固定单元上或从固定单元拆卸下来，以便在旋转电机运行时用于移除和更换电刷。

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