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    • 6. 发明申请
    • Benzazepine Compound
    • 苯扎西平化合物
    • US20110269744A1
    • 2011-11-03
    • US13044080
    • 2011-03-09
    • Hiroyuki KOSHIONorio ASAITaisuke TAKAHASHITakafumi SHIMIZUYasuhito NAGAIKeiko KAWABATAKarl Bruce THOR
    • Hiroyuki KOSHIONorio ASAITaisuke TAKAHASHITakafumi SHIMIZUYasuhito NAGAIKeiko KAWABATAKarl Bruce THOR
    • A61K31/55C07D487/04A61P13/00C07D498/04
    • C07D498/04A61K31/55C07D471/04C07D487/04
    • [Problem] Provided is a compound which is useful as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.[Means for Solution] The present inventors have investigated compounds having a 5-HT2C receptor agonist activity, which is promising as an active ingredient of a pharmaceutical composition for treating or preventing incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like, and have found that the benzazepine compounds of the present invention have an excellent 5-HT2C receptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HT2C receptor agonist activity and can be used as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.
    • [问题]提供可用作治疗或预防5-HT 2C受体相关疾病,特别是尿失禁,尿失禁尿,尿失禁等尿失禁的药物的化合物,勃起功能障碍 功能障碍综合征等,肥胖等。 [解决方案]本发明人研究了具有5-HT 2C受体激动剂活性的化合物,其有希望作为用于治疗或预防失禁的药物组合物的活性成分,例如压力性尿失禁,敦促性尿失禁,混合性尿失禁, 性功能障碍如勃起功能障碍综合征等,肥胖等,并且发现本发明的苯并氮杂化合物具有优异的5-HT 2C受体激动剂活性,从而完成了本发明。 也就是说,本发明的苯并氮杂化合物具有5-HT 2C受体激动剂活性,可用作治疗或预防5-HT 2C受体相关疾病的药剂,特别是尿失禁,压力性尿失禁,压力性尿失禁,混合型 尿失禁等,性功能障碍如勃起功能障碍综合征等,肥胖等。
    • 10. 发明授权
    • Vehicular air-conditioner providing a comfortable condition for a passenger
    • 车载空调为乘客提供舒适的条件
    • US07556090B2
    • 2009-07-07
    • US11068273
    • 2005-02-28
    • Norio AsaiYuji Honda
    • Norio AsaiYuji Honda
    • B60H1/00B60H3/00
    • B60H1/00792B60H1/00864
    • When a target blown air temperature TAO is in a predetermined intermediate temperature zone, a blower is automatically stopped (S80), an outside air mode is selected when the blower 8 is automatically stopped. When an outside air temperature Tam is a first predetermined temperature (15° C.) or lower, an opening degree of an air mix door is corrected to a high temperature side in comparison with the time of the operation of the blower (S120), and when the outside air temperature Tam is a second predetermined temperature (25° C.) or higher, the opening degree of the air mix door is corrected to the low temperature side in comparison with the time of the operation of the blower (S130).
    • 当目标吹风温度TAO处于预定的中间温度区域时,鼓风机自动停止(S80),当鼓风机8自动停止时选择外部空气模式。 当外部空气温度Tam是第一预定温度(15℃)或更低时,与鼓风机的操作时间相比,空气混合门的开度被校正到高温侧(S120) 并且当外部空气温度Tam是第二预定温度(25℃)或更高时,与鼓风机的操作时间相比,空气混合门的开度被校正到低温侧(S130) 。