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1. 发明专利

JP2009127182A Salon apron with towel 审中-公开
标题翻译： SALON APRON WITH TOWEL
公开(公告)号：JP2009127182A
公开(公告)日：2009-06-11
申请号：JP2007333120
申请日：2007-11-27
申请人： Noriko Kodama , 祀子児玉
发明人： KODAMA NORIKO
IPC分类号： A41D13/04 , A47K10/02
摘要： PROBLEM TO BE SOLVED: To provide a salon apron with a towel, which has a thick towel cloth of 100% cotton attached on the rear side of a salon apron of 100% cotton. SOLUTION: The salon apron with a towel is provided by sewing a thick towel 2 on the rear side of a salon apron 1. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为沙龙围裙提供毛巾，100％棉布的沙龙围裙背面装有100％棉质粗毛巾布。
解决方案：毛巾的沙龙围裙是通过在沙龙围裙1的后面缝一条粗毛巾2提供的。版权所有（C）2009，JPO＆INPIT

2. 发明申请

US20110196133A1 GRIFOLA-DERIVED LOW-MOLECULAR-WEIGHT SUBSTANCE HAVING IMMUNOPOTENTIATING ACTIVITY AND ANTITUMOR ACTIVITY 审中-公开
标题翻译： GRIFOLA衍生的具有免疫活性和抗肿瘤活性的低分子量物质
公开(公告)号：US20110196133A1
公开(公告)日：2011-08-11
申请号：US12867144
申请日：2009-02-13
申请人： Noriko Kodama , Hiroaki Nanba
发明人： Noriko Kodama , Hiroaki Nanba
IPC分类号： C07K14/00
CPC分类号： A61K36/07 , A23K20/10 , A23K20/147 , A23K20/163 , A23L5/00 , A23L31/00 , A23L33/10
摘要： It is an objective of the present invention to develop a Grifola-derived substance having advanced immunopotentiating activity and antitumor activity, which has a molecular weight lower than that of a conventionally known glucan-protein complex and is structurally different from such complex. A Grifola-derived low-molecular-weight substance is produced by the following steps 1) to 4): 1) a step of thermally extracting mycelia or fruit bodies of Grifola with water; 2) a step of adding alcohol to the obtained water-soluble extract fraction to a final concentration between 10% and 80% by volume, allowing the resulting solution to stand at a temperature between 1° C. and 40° C., and removing matter floating on or in the solution or adhering to the wall surface of a vessel and a precipitate formed therein; 3) a step of removing alcohol from the water-soluble fraction containing alcohol obtained in step 2) and collecting an adsorbed fraction from the obtained water-soluble fraction by anion-exchange column chromatography; 4) a step of collecting a fraction with a molecular weight of 5000 or less by subjecting the adsorbed fraction to molecular sieving.
摘要翻译：本发明的目的是开发具有先进的免疫增强活性和抗肿瘤活性的吉非他衍生物质，其分子量低于常规已知的葡聚糖 - 蛋白质复合物，其结构上不同于该复合物。通过以下步骤1）〜4）生产来自三叉柄的低分子量物质：1）用水热提取奇果菌的菌丝体或果实的步骤; 2）向得到的水溶性提取液馏分中添加醇至10体积％〜80体积％的终浓度的步骤，使得到的溶液在1℃〜40℃的温度下放置，除去浮在溶液中或溶液中的物质或附着在容器的壁表面上，以及形成在其中的沉淀物; 3）从步骤2）中得到的含有醇的水溶性馏分中除去醇的步骤，并通过阴离子交换柱色谱法从得到的水溶性馏分中收集吸附部分; 4）通过使吸附部分进行分子筛分，收集分子量为5000以下的馏分的工序。

3. 发明申请

US20070027069A1 Glucan-protein complex extracted from grifola (Maitake) 审中-公开
标题翻译：从小叶提取的葡聚糖蛋白复合物（Maitake）
公开(公告)号：US20070027069A1
公开(公告)日：2007-02-01
申请号：US11342904
申请日：2006-01-30
申请人： Yuki Masuda , Hazuki Ikumoto , Noriko Kodama , Hiroaki Nanba
发明人： Yuki Masuda , Hazuki Ikumoto , Noriko Kodama , Hiroaki Nanba
IPC分类号： A61K38/16 , C07K14/375
CPC分类号： C07K14/375 , A61K38/00
摘要： It is an objective of the present invention to develop a Grifola-derived glucan-protein complex that has a molecular weight lower than that of a conventionally known high-molecular-weight glucan-protein complex and has advanced immunopotentiating activity and antitumor activity. The glucan-protein complex of interest was obtained through the following 1) to 5): 1) a step of thermally extracting mycelia or fruit bodies of Grifola with water; 2) a step of adding alcohol to the obtained water-soluble extract fraction to a final concentration between 20% and 70% by volume, allowing the resulting solution to stand at a temperature between 1° C. and 25° C., and collecting matter floating on or in the solution or adhering to the wall surface of a vessel; 3) a step of dissolving the collected matter in water and collecting non-adsorbed fraction by anion-exchange column chromatography; 4) a step of adding alcohol to the resulting solution to a final concentration between 20% and 50% by volume, allowing the solution to stand at a temperature between 1° C and 25° C., and removing the precipitate that had formed therein; and 5) a step of adding alcohol to the resulting solution to a final concentration between 40% to 99% by volume, allowing the resultant to stand at a temperature between 1° C. to 25° C., and collecting the precipitate that had formed therein.
摘要翻译：本发明的目的是开发具有比常规已知的高分子量葡聚糖 - 蛋白复合物低的分子量的Grifola衍生的葡聚糖蛋白复合物，并且具有先进的免疫增强活性和抗肿瘤活性。通过以下1）至5）获得目的葡聚糖蛋白复合物：1）用水热提取奇果菌的菌丝体或果实的步骤; 2）向得到的水溶性提取液馏分中添加醇至20体积％〜70体积％的终浓度的步骤，使得到的溶液在1℃〜25℃的温度下放置，收集漂浮在溶液中或溶液中的物质或附着在容器的壁表面上; 3）将收集的物质溶解在水中并通过阴离子交换柱层析收集非吸附级分的步骤; 4）向所得溶液中加入醇至终浓度为20体积％至50体积％的步骤，使溶液在1℃至25℃之间的温度下静置，并除去其中形成的沉淀物 ; 和5）向所得溶液中加入醇至终浓度为40体积％至99体积％之间的步骤，使其在1℃至25℃之间的温度下静置，并收集具有在其中形成。

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