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1. 发明授权

US07615669B2 Process for producing fluoro-compounds 有权
标题翻译：氟化合物的制备方法
公开(公告)号：US07615669B2
公开(公告)日：2009-11-10
申请号：US11887135
申请日：2006-03-22
申请人： Norihisa Kondo , Akio Watanabe , Hiroki Kanezaki , Kosuke Kawada
发明人： Norihisa Kondo , Akio Watanabe , Hiroki Kanezaki , Kosuke Kawada
IPC分类号： C07C31/34 , C07C31/38
CPC分类号： C07C67/307 , C07B39/00 , C07C17/16 , C07C2601/08 , C07C2603/74 , C07C19/08 , C07C23/38 , C07C23/08 , C07C69/65 , C07C69/63
摘要： The present invention provides a process for producing highly pure fluoro-compounds by making use of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products. The present invention provides a process for producing a fluoro-compound, comprising fluorinating an alcohol derivative represented by the following general formula (I): R1R2R3COH (I), (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group; and R2 and R3 are each independently a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group, wherein at least two of R1, R2 and R3 may together form part of a ring structure, either with or without a heteroatom) with N,N-diethyl-2-chloro-1,1,2-trifluoroethylamine to form a fluoro-compound represented by the following general formula (2): R1R2R3CF (2), (wherein R1, R2 and R3 are as defined above), the process being characterized in that an alcohol derivative represented by the following general formula (3): R4OH (3), (wherein R4 represents a substituted or unsubstituted alkyl group or aryl group) is added to the reaction system.
摘要翻译：本发明提供通过使用N-（2-氯-1,1,2-三氟乙基）二乙胺生产高纯度氟化合物的方法。该方法几乎不产生或不产生氯化副产物。本发明提供一种氟化合物的制造方法，其包括将下述通式（I）表示的醇衍生物氟化：R1R2R3COH（I），（其中R1表示氢原子，取代或未取代的烷基，芳基烷基羰基，烷氧基羰基，芳基羰基或芳氧基羰基; R2和R3各自独立地为取代或未取代的烷基，芳基，烷基羰基，烷氧基羰基，芳基羰基或芳氧基羰基，其中R1，R2中的至少两个和R3可以一起形成具有或不具有杂原子的环结构的一部分）与N，N-二乙基-2-氯-1,1,2-三氟乙胺反应，形成由以下通式（2）表示的氟化合物）：R1R2R3CF（2）（其中R1，R2和R3如上定义），其特征在于由以下通式（3）表示的醇衍生物：R4OH（3），（其中R4表示是取代或未取代的烷基或芳基）加入到反应体系中。

2. 发明申请

US20090030228A1 Process for producing fluoro-compounds 有权
标题翻译：氟化合物的制备方法
公开(公告)号：US20090030228A1
公开(公告)日：2009-01-29
申请号：US11887135
申请日：2006-03-22
申请人： Norihisa Kondo , Akio Watanabe , Hiroki Kanezaki , Kosuke Kawada
发明人： Norihisa Kondo , Akio Watanabe , Hiroki Kanezaki , Kosuke Kawada
IPC分类号： C07C69/76 , C07C19/08
CPC分类号： C07C67/307 , C07B39/00 , C07C17/16 , C07C2601/08 , C07C2603/74 , C07C19/08 , C07C23/38 , C07C23/08 , C07C69/65 , C07C69/63
摘要： The present invention provides a process for producing highly pure fluoro-compounds by making use of less costly and readily handleable N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products.Specifically the present invention provides a process for producing a fluoro-compound, comprising fluorinating an alcohol derivative represented by the following general formula (1): R1R2R3COH (1) (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group; and R2 and R3are each independently a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group, wherein at least two of R1, R2 and R3 may together form part of a ring structure, either with or without a heteroatom) with N,N-diethyl-2-chloro-1,1,2-trifluoroethylamine to form a fluoro-compound represented by the following general formula (2): R1R2R3CF (2) (wherein R1, R2 and R3 are as defined above), the process being characterized in that an alcohol derivative represented by the following general formula (3): R4OH (3) (wherein R4 represents a substituted or unsubstituted alkyl group or aryl group) is added to the reaction system.
摘要翻译：本发明提供了通过使用成本较低且易于处理的N-（2-氯-1,1,2-三氟乙基）二乙胺制备高纯度氟化合物的方法。该方法几乎不产生或不产生氯化副产物。具体地说，本发明提供一种氟化合物的制造方法，其特征在于，含氟化下述通式（1）表示的醇衍生物：＆lt;线内式记载=“在线式”末端=“铅” > R1R2R3COH（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>（其中R1表示氢原子，取代或未取代的烷基，芳基，烷基羰基，烷氧基羰基，芳基羰基或芳氧基羰基; R2和R3各自独立地为取代或未取代的烷基，芳基，烷基羰基，烷氧基羰基，芳基羰基或芳氧基羰基，其中R1，R2和R3中的至少两个可以一起形成具有或不具有杂原子的环结构）与N，N-二乙基-2-氯-1,1,2-三氟乙胺反应以形成由以下通式（2）表示的氟化合物： -formulae description =“在线公式”end =“lead”？> R1R2R3 CF（2）<？in-line-formula description =“In-line Formulas”end =“tail”？>（其中R1，R2和R3如上定义），该方法的特征在于，以以下通式（3）：<？in-line-formula description =“In-line Formulas”end =“lead”？> R4OH（3）<？in-line-formula description =“In-line Formulas”end =“尾”→（其中R 4表示取代或未取代的烷基或芳基）加入到反应体系中。

3. 发明授权

US07019162B2 Process for preparing 2-fluoro-3-oxoalkylcarboxylic acid ester 失效
标题翻译： 2-氟-3-氧代烷基羧酸酯的制备方法
公开(公告)号：US07019162B2
公开(公告)日：2006-03-28
申请号：US10451814
申请日：2001-12-25
申请人： Norihisa Kondo , Hideyuki Mimura , Kazunori Nukui , Kosuke Kawada , Shoji Arai
发明人： Norihisa Kondo , Hideyuki Mimura , Kazunori Nukui , Kosuke Kawada , Shoji Arai
IPC分类号： C07C69/66
CPC分类号： C07C67/58 , C07C67/307 , C07C69/738 , C07C69/716
摘要： A process for producing a 2-fluoro-3-oxoalkylcarboxylic acid ester by fluorinating 3-oxoalkylcarboxylic acid ester with a fluorine gas is provided. The process is characterized in that the concentration of 3-oxoalkylcarboxylic acid ester in the reaction mixture for fluorination is maintained at 3 wt % or higher. Also provided is a process for purifying 2-fluoro-3-oxoalkylcarboxylic acid ester characterized in that 2-fluoro-3-oxoalkylcarboxylic acid ester is produced at high yield and with less impurities by washing fluorinated 3-oxoalkylcarboxylic acid ester with 3 or more times as much water as the amount of reaction mixture. According to the processes of the present invention, not only is the generation of unwanted by-products minimized, but fluorinated 3-oxoalkylcarboxylic acid ester can be purified in an efficient manner. Thus, the present invention permits efficient production of considerably pure 2-fluoro-3-oxoalkylcarboxylic acid ester, a useful intermediate material in the production of various medical and agricultural agents.
摘要翻译：提供了通过用氟气氟化3-氧代烷基羧酸酯来制备2-氟-3-氧代烷基羧酸酯的方法。该方法的特征在于用于氟化的反应混合物中3-氧代烷基羧酸酯的浓度保持在3重量％以上。还提供了一种纯化2-氟-3-氧代烷基羧酸酯的方法，其特征在于2-氟-3-氧代烷基羧酸酯以高产率制备，通过用氟化3-氧代烷基羧酸酯洗涤3次或更多次而得到较少的杂质与反应混合物的量一样多的水。根据本发明的方法，不仅产生不想要的副产物最小化，而且氟化的3-氧代烷基羧酸酯可以以有效的方式被纯化。因此，本发明允许有效地生产相当纯的2-氟-3-氧代烷基羧酸酯，这是生产各种医药和农药的有用的中间体材料。

4. 发明授权

US07220878B2 Method of purifying and separating 2-fluoro-3-oxoalkylcarboxylic acid ester 失效
标题翻译：纯化和分离2-氟-3-氧代烷基羧酸酯的方法
公开(公告)号：US07220878B2
公开(公告)日：2007-05-22
申请号：US10490432
申请日：2001-09-27
申请人： Norihisa Kondo , Hideyuki Mimura , Kosuke Kawada , Shoji Arai
发明人： Norihisa Kondo , Hideyuki Mimura , Kosuke Kawada , Shoji Arai
IPC分类号： C07C69/66
CPC分类号： C07C67/54 , C07C69/716
摘要： The present invention concerns a method for purifying/separating a 2-fluoro-3-oxoalkylcarboxylic acid ester from a reaction mixture resulting from the fluorination of a 3-oxoalkylcarboxylic acid ester. The method involves depleting the reaction mixture of a hydrogen fluoride byproduct; and subsequently, separating the 2-fluoro-3-oxoalkylcarboxylic acid ester by distillation. The 2-fluoro-3-oxoalkylcarboxylic acid ester obtained by the method of the invention is highly pure and is thus suitable for use as an intermediate for the production of pharmacological products or agricultural chemicals.
摘要翻译：本发明涉及从3-氧代烷基羧酸酯氟化得到的反应混合物中纯化/分离2-氟-3-氧代烷基羧酸酯的方法。该方法涉及耗尽氟化氢副产物的反应混合物; 随后通过蒸馏分离2-氟-3-氧代烷基羧酸酯。通过本发明方法获得的2-氟-3-氧代烷基羧酸酯是高纯度的，因此适合用作生产药物产品或农药的中间体。

5. 发明授权

US5777007A Brominated p-cumylphenol flame-retardants for resin composition 失效
标题翻译：用于树脂组合物的溴化对枯基苯酚阻燃剂
公开(公告)号：US5777007A
公开(公告)日：1998-07-07
申请号：US814462
申请日：1997-03-10
申请人： Takumi Kagawa , Norihisa Kondo , Noriyuki Kasai , Hideo Sakka
发明人： Takumi Kagawa , Norihisa Kondo , Noriyuki Kasai , Hideo Sakka
IPC分类号： C07C39/367 , C07C43/23 , C08K5/00 , C08K5/136 , C07D303/14
CPC分类号： C08K5/0066 , C07C39/367 , C07C43/23 , C08K5/136
摘要： Brominated p-cumylphenol represented by the formula (1) described hereinafter and derivative thereof represented by the formula (2) described hereinabove, process for the preparation of the same, and flame-retardant resin compositions containing the same, are disclosed. Those compounds are useful flame retardant, and can be blended with various thermosetting resins or thermoplastic resins to obtain flame retardant resin compositions.
摘要翻译：公开了由下述式（1）表示的溴化对枯基苯酚及其由上述式（2）表示的衍生物，其制备方法以及含有它们的阻燃树脂组合物。这些化合物是有用的阻燃剂，并且可以与各种热固性树脂或热塑性树脂共混以获得阻燃树脂组合物。

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