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1. 发明申请

US20050186471A1 Intrinsically-safe battery power supply for underground mining 审中-公开
标题翻译：用于地下采矿的本质安全电池电源
公开(公告)号：US20050186471A1
公开(公告)日：2005-08-25
申请号：US11042371
申请日：2005-01-25
申请人： Jens Titschert , Norbert Schwarz , Jorg Wagener
发明人： Jens Titschert , Norbert Schwarz , Jorg Wagener
IPC分类号： H01M2/02 , E21F9/00 , E21F17/04 , H01M2/10 , H01M2/34 , H01M10/052 , H01M10/34 , H01M10/36 , H01M10/46 , H02J7/00
CPC分类号： H01M2/1094 , H01M10/052 , Y02E60/122
摘要： An intrinsically-safe battery power supply for electrical equipment in underground mining and in other areas exposed to the danger of explosion is disclosed. The power supply includes at least one chargeable storage battery cell disposed in a battery housing. At least one storage battery cell comprises a chargeable lithium storage battery cell and the battery housing is configured to be pressure-resistant and to receive all lithium storage battery cells in a manner so as to be protected from explosion. The pressure-resistant configuration of the battery housing enables the use of lithium storage battery cells in underground mining. Once the battery power supply fulfils all requirements of ignition protection certification, even modern types of lithium storage battery cell can be disposed in the battery housing.
摘要翻译：公开了一种用于地下采矿和其他暴露于爆炸危险区域的电气设备的本质安全电池电源。电源包括设置在电池壳体中的至少一个可充电蓄电池。至少一个蓄电池单元包括可充电的锂蓄电池单元，并且所述电池壳体被配置为耐压并且以能够防止爆炸的方式接收所有锂蓄电池单元。电池壳体的耐压构造使得能够在地下采矿中使用锂蓄电池。一旦电池电源满足点火保护认证的所有要求，即使现代类型的锂蓄电池可以放置在电池外壳中。

2. 发明授权

US4489092A Prostanoic acid derivatives and their preparation 失效
标题翻译：前列腺酸衍生物及其制备
公开(公告)号：US4489092A
公开(公告)日：1984-12-18
申请号：US413940
申请日：1982-09-01
申请人： Helmut Vorbruggen , Norbert Schwarz , Olaf Loge , Walter Elger
发明人： Helmut Vorbruggen , Norbert Schwarz , Olaf Loge , Walter Elger
IPC分类号： A61K31/27 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61P43/00 , C07C51/38 , C07C57/03 , C07C57/13 , C07C57/52 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07F9/535 , C07C177/00 , A61K31/557
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0016 , C07C405/0025 , C07C405/0041 , C07C51/38 , C07C57/03 , C07C57/13 , C07C57/52 , C07F9/5352
摘要： Prostanoic acid derivatives of the formula ##STR1## wherein R.sub.1 is an acid, ester, amide or hydroxyalkylene group; R.sub.2 and R.sub.3 are H or alkyl; R.sub.4 and R.sub.5 are both CH.sub.3 or one is Cl and the other is CH.sub.3 ; A is CH.sub.2 CH.sub.2 or --CH.dbd.CH; B is CH.sub.2 CH.sub.2, trans-CH.dbd.CH, --C.tbd.C-- or ##STR2## W is free or functionally modified hydroxyalkylene or carbonyl; Z is free or functionally modified hydroxymethylene or carbonyl; X Y is either ##STR3## or, when Z is free or functionally modified hydroxymethylene, ##STR4## or, when Z is free or functionally modified carbonyl, --CH.dbd.CH--, R.sub.12 being H, CH.sub.3, CH or free or functionally modified hydroxy; and physiologically acceptable salts thereof when R.sub.1 is an acid group, possess pharmacological activity, including abortion triggering activity.
摘要翻译：其中R1是酸，酯，酰胺或羟基亚烷基的式IMA曲前酯衍生物; R2和R3是H或烷基; R4和R5都是CH3，一个是Cl，另一个是CH3; A是CH 2 CH 2或-CH = CH; B是CH 2 CH 2，反式-CH = CH，-C 3 D或W是游离或官能改性的羟基亚烷基或羰基; Z是游离的或官能改性的羟基亚甲基或羰基; 或者当Z是游离的或官能改性的羟基亚甲基时，或者当Z是游离的或官能改性的羰基时，-CH = CH-，R 12是H，CH 3，CH或游离或官能改性的羟基 ; 当R1为酸基时，其生理上可接受的盐具有药理活性，包括流产触发活性。

3. 发明授权

US4446147A Azaprostacyclins, their preparation and pharmaceutical use 失效
标题翻译：阿沙普罗环素，其制备和药物用途
公开(公告)号：US4446147A
公开(公告)日：1984-05-01
申请号：US350674
申请日：1982-02-22
申请人： Norbert Schwarz , Werner Skuballa , Helmut Vorbrueggen , Jorge Casals-Stenzel , Ekkehard Schillinger , Michael H. Town
发明人： Norbert Schwarz , Werner Skuballa , Helmut Vorbrueggen , Jorge Casals-Stenzel , Ekkehard Schillinger , Michael H. Town
IPC分类号： A61K31/40 , A61K31/403 , A61K31/557 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/08 , C07C57/03 , C07C57/13 , C07C57/26 , C07C57/52 , C07C405/00 , C07D209/52 , C07D307/935 , C07F9/40
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0041 , C07C57/03 , C07C57/13 , C07C57/26 , C07C57/52 , C07D209/52 , C07F9/4015 , C07F9/4018
摘要： Azaprostacyclins of Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or a phenacyl residue optionally substituted on the phenyl ring by bromine, phenyl, alkoxy, or dialkoxy,W is a free or functionally modified carbonyl group or a ##STR2## wherein R.sub.8 is hydrogen or alkyl of 1-5 carbon atoms and R.sub.9 is hydrogen or a readily cleavable ether or acyl residue and wherein the OR.sub.9 -group can be in the .alpha.- or .beta.-position,R.sub.2 is a free or functionally modified hydroxy group.
摘要翻译：式I的阿沙普罗环素其中R 1是氢，烷基，环烷基，芳基，杂环残基或任选在苯环上被溴，苯基，烷氧基或二烷氧基取代的苯甲酰甲基残基，W是游离或官能改性的羰基或其中R8是氢或1-5个碳原子的烷基，R9是氢或易裂解的醚或酰基残基，其中OR9-基团可以是α-或β-位， R2是游离的或官能改性的羟基。

4. 发明授权

US4359467A Prostanoic acid derivatives and their preparation 失效
标题翻译：前列腺酸衍生物及其制备
公开(公告)号：US4359467A
公开(公告)日：1982-11-16
申请号：US256369
申请日：1981-04-22
申请人： Helmut Vorbruggen , Norbert Schwarz , Olaf Loge , Walter Elger
发明人： Helmut Vorbruggen , Norbert Schwarz , Olaf Loge , Walter Elger
IPC分类号： A61K31/27 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61P43/00 , C07C51/38 , C07C57/03 , C07C57/13 , C07C57/52 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07F9/535 , C07C177/00 , A61K31/557
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0016 , C07C405/0025 , C07C405/0041 , C07C51/38 , C07C57/03 , C07C57/13 , C07C57/52 , C07F9/5352
摘要： Prostanoic acid derivatives of the formula ##STR1## wherein R.sub.1 is an acid, ester, amide or hydroxyalkylene group; R.sub.2 and R.sub.3 are H or alkyl; R.sub.4 and R.sub.5 are both CH.sub.3 or one is Cl and the other is CH.sub.3 ; A is CH.sub.2 CH.sub.2 or --CH.dbd.CH; B is CH.sub.2 CH.sub.2, trans- ##STR2## W is free or functionally modified hydroxyalkylene or carbonyl; Z is free or functionally modified hydroxymethylene or carbonyl; X Y is either ##STR3## or, when Z is free or functionally modified hydroxymethylene, ##STR4## or, when Z is free or functionally modified carbonyl, --CH.dbd.CH--, R.sub.12 being H, CH.sub.3, CN or free or functionally modified hydroxy; and physiologically acceptable salts thereof when R.sub.1 is an acid group, possess pharmacological activity, including abortion triggering activity.
摘要翻译：其中R1是酸，酯，酰胺或羟基亚烷基的式IMA曲前酯衍生物; R2和R3是H或烷基; R4和R5都是CH3，一个是Cl，另一个是CH3; A是CH 2 CH 2或-CH = CH; B是CH 2 CH 2，反式 - W是游离的或官能改性的羟基亚烷基或羰基; Z是游离的或官能改性的羟基亚甲基或羰基; 或者当Z是游离或官能改性的羟基亚甲基时，或者当Z是游离或官能改性羰基时，-CH = CH-，R 12是H，CH 3，CN或游离或官能改性的羟基 ; 当R1为酸基时，其生理上可接受的盐具有药理活性，包括流产触发活性。

5. 发明授权

US4191694A Prostaglandin-I.sub.2 derivatives 失效
标题翻译：前列腺素I2衍生物
公开(公告)号：US4191694A
公开(公告)日：1980-03-04
申请号：US928126
申请日：1978-07-26
申请人： Werner Skuballa , Bernd Raduchel , Norbert Schwarz , Helmut Vorbruggen , Bernd Muller , Gerda Mannesmann , Olaf Loge , Ekkehardt Schillinger , Jorge Casals-Stenzel
发明人： Werner Skuballa , Bernd Raduchel , Norbert Schwarz , Helmut Vorbruggen , Bernd Muller , Gerda Mannesmann , Olaf Loge , Ekkehardt Schillinger , Jorge Casals-Stenzel
IPC分类号： A61K31/557 , A61K31/34 , A61K31/343 , A61K31/5575 , A61P7/02 , A61P7/10 , A61P9/06 , A61P9/12 , A61P43/00 , C07C405/00 , C07D307/935 , C07D307/937 , C07D307/93
CPC分类号： C07D307/937 , C07C405/00 , Y10S514/821 , Y10S514/822 , Y10S514/869
摘要： Prostane derivatives of the formula ##STR1## wherein R.sub.1 is OR.sub.2 or NHR.sub.3 ;R.sub.2 is hydrogen, C.sub.1-10 alkyl, C.sub.4-10 cycloalkyl, C.sub.6-10 aryl, or a 5 or 6 membered heterocyclic ring having 1-3 hetero atoms selected from O, N and S;R.sub.3 is the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms;W is (a) an OH-substituted methylene group, (b) a ##STR2## wherein the OH-groups in (a) or (b) can be in the .alpha.- or .beta.-position, or (c) such a group wherein the H atom of the OH group is replaced by the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms or by a conventional etherifying OH-blocking group;R.sub.4 is OH or hydroxy whose H atom is replaced as defined for W; andR.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 each independently is hydrogen or alkyl of 1-5 carbon atoms; or R.sub.9 and R.sub.10 together represent a direct bond; and, when R.sub.11 is alkyl, R.sub.10 can also be chlorine;and, for a derivative wherein R.sub.2 is hydrogen, the salts thereof with physiologically compatible bases,have improved prostaglandin activity.
摘要翻译：其中R1为OR2或NHR3的式（Ⅰ）所示的前驱体衍生物; R2是氢，C1-10烷基，C4-10环烷基，C6-10芳基或具有1-3个选自O，N和S的杂原子的5或6元杂环; R3是1-15个碳原子的烃羧酸或磺酸的残基; W是（a）OH-取代的亚甲基，（b）其中（a）或（b）中的OH基可以是α或β-位，或（c）这样的基团其中OH基团的H原子被1-15个碳原子的烃羧酸或磺酸的残基或通过常规的醚化OH-封闭基团取代; R4是OH或羟基，其H原子被替换为W定义; R 5，R 6，R 7，R 8，R 9，R 10和R 11各自独立地为氢或1-5个碳原子的烷基; 或R 9和R 10一起代表直接键; 当R 11为烷基时，R 10也可为氯; 并且对于其中R 2是氢的衍生物，其与生理上相容的碱的盐具有改善的前列腺素活性。

6. 发明申请

US20090142629A1 INTRINSICALLY-SAFE BATTERY POWER SUPPLY FOR UNDERGROUND MINING 有权
标题翻译：用于地下采矿的本质安全电池电源
公开(公告)号：US20090142629A1
公开(公告)日：2009-06-04
申请号：US12341745
申请日：2008-12-22
申请人： Jens Titschert , Norbert Schwarz , Jorg Wagener
发明人： Jens Titschert , Norbert Schwarz , Jorg Wagener
IPC分类号： H01M12/00
CPC分类号： H01M2/34 , H01M2/0267 , H01M2/0275 , H01M2/0443 , H01M2/06 , H01M2/1094 , H01M2/32 , H01M10/052 , H01M10/0565 , H01M10/46 , H02J7/0052 , Y02E60/122 , Y10T29/49108
摘要： An intrinsically-safe battery power supply for electrical equipment in underground mining and in other areas exposed to the danger of explosion is disclosed. The power supply includes at least one chargeable storage battery cell disposed in a battery housing. At least one storage battery cell comprises a chargeable lithium storage battery cell and the battery housing is configured to be pressure-resistant and to receive all lithium storage battery cells in a manner so as to be protected from explosion. The pressure-resistant configuration of the battery housing enables the use of lithium storage battery cells in underground mining. Once the battery power supply fulfils all requirements of ignition protection certification, even modern types of lithium storage battery cell can be disposed in the battery housing.
摘要翻译：公开了一种用于地下采矿和其他暴露于爆炸危险区域的电气设备的本质安全电池电源。电源包括设置在电池壳体中的至少一个可充电蓄电池。至少一个蓄电池单元包括可充电的锂蓄电池单元，并且所述电池壳体被配置为耐压并且以能够防止爆炸的方式接收所有锂蓄电池单元。电池壳体的耐压构造使得能够在地下采矿中使用锂蓄电池。一旦电池电源满足点火保护认证的所有要求，即使现代类型的锂蓄电池可以放置在电池外壳中。

7. 发明授权

US5124343A Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents 失效
标题翻译：卡巴菌素，其制备方法及其作为药剂的用途
公开(公告)号：US5124343A
公开(公告)日：1992-06-23
申请号：US141233
申请日：1988-01-06
申请人： Helmut Vorbrueggen , Hernd Raduechel , Werner Skuballa , Norbert Schwarz , Jorge Casals-Stenzel , Gerda Mannesmann , Michael H. Town
发明人： Helmut Vorbrueggen , Hernd Raduechel , Werner Skuballa , Norbert Schwarz , Jorge Casals-Stenzel , Gerda Mannesmann , Michael H. Town
IPC分类号： C07C45/59 , C07C57/26 , C07C57/60 , C07C405/00 , C07D263/14 , C07D317/72 , C07F9/40
CPC分类号： C07D317/72 , C07C405/0083 , C07C45/59 , C07C57/26 , C07C57/60 , C07D263/14 , C07F9/4018
摘要： The invention relates to carbacyclins of general Formula I ##STR1## wherein R.sub.1 is the residue CH.sub.2 OH or ##STR2## with R.sub.2 meaning a hydrogen atom, an alkyl, cycloalkyl, aryl residue, a ##STR3## or heterocyclic residue, or R.sub.1 is the residue ##STR4## with R.sub.3 meaning an alkanoyl or alkanesulfonyl residue of respectively 1-10 carbon atoms or the residue R.sub.2, orR.sub.1 is the residue ##STR5## wherein m is the number 1 or 2, X is an oxygen atom or a CH.sub.2 -group,A is a trans--CH.dbd.CH- or --.tbd.C--group,W is a free or functionally modified hydroxymethylene group wherein the OH-group can be in the .alpha.- or .beta.- position,n is the number 1, 2, or 3,D is a straight-chain alkylene group of 1-5 carbon atoms,E is a --C.tbd.C---bond or a --CR.sub.6 =CR.sub.7 --group wherein R.sub.6 and R.sub.7 are different from each other and mean a hydrogen atom or an alkyl group of 1-5 carbon atoms or a hydrogen atom or a halogen atom, preferably chlorine,R.sub.4 is an alkyl, cycloalkyl, or optionally substituted arly group, or a heterocyclic group,R.sub.5 is a free or functionally modified hydroxy group, andif R.sub.2 means a hydrogen atom, the salts thereof with physiologically compatible bases;to processes for the preparation thereof, and to the use thereof as blood-pressure-lowering agents.
摘要翻译：本发明涉及通式I的碳霉素，其中R 1是残基CH 2 OH或R 2，其中R 2表示氢原子，烷基，环烷基，芳基，芳基或杂环残基，或者R 1是残基其中R3表示分别为1-10个碳原子的烷酰基或烷磺酰基残基或残基R2，或R1为残基，其中m为数1或2，X为氧原子或CH2- 基团，A是反式-CH = CH-或 - 3BOND C-基团，W是游离或官能改性的羟基亚甲基基团，其中OH-基团可以是α或β位置，n是数1，2 或3，D是1-5个碳原子的直链亚烷基，E是-C3OND C键或-CR6 = CR7-基团，其中R6和R7彼此不同，意指氢原子或1-5个碳原子的烷基或氢原子或卤素原子，优选氯，R4是烷基，环烷基或任选取代的芳基或杂环基团 p，R5是游离或功能改性的羟基，如果R 2表示氢原子，则其与生理上相容的碱的盐; 其制备方法及其作为降血压剂的用途。

8. 发明授权

US4708963A Novel carbacyclins, their preparation and use 失效
标题翻译：新型碳霉素，其制备和用途
公开(公告)号：US4708963A
公开(公告)日：1987-11-24
申请号：US738545
申请日：1985-05-28
申请人： Werner Skuballa , Bernd Raduchel , Norbert Schwarz , Helmut Vorbruggen , Jorge Casals-Stenzel , Ekkehard Schillinger , Michael H. Town
发明人： Werner Skuballa , Bernd Raduchel , Norbert Schwarz , Helmut Vorbruggen , Jorge Casals-Stenzel , Ekkehard Schillinger , Michael H. Town
IPC分类号： C07C69/708 , A61K31/16 , A61K31/19 , A61K31/20 , A61K31/23 , A61K31/557 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/12 , A61P11/08 , C07C51/00 , C07C51/367 , C07C59/125 , C07C67/00 , C07C231/00 , C07C231/02 , C07C235/06 , C07C235/88 , C07C301/00 , C07C303/40 , C07C311/51 , C07C405/00 , C07D309/12 , C07D317/72 , C07F9/40 , C07C177/00
CPC分类号： C07D317/72 , C07C405/0083 , C07D309/12 , C07F9/4015 , Y10S514/927
摘要： Carbacyclin derivatives of Formula I ##STR1## wherein R.sub.1 is OR.sub.2, wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or NHR.sub.3, wherein R.sub.3 is an acid residue or hydrogen;X is oxygen;A is --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C--;W is free or functionally modified hydroxymethylene or free or functionally modified ##STR2## wherein the OH-group can be in the .alpha.- or .beta.-position; D is a straight-chain or branched, saturated or unsaturated aliphatic group of 1-10 carbon atoms, which can optionally be substituted by fluorine atoms, 1,2-methylene, 1,1-trimethylene;E is --C.tbd.C-- or --CR.sub.6 .dbd.CH.sub.7 -- wherein R.sub.6 and R.sub.7 are hydrogen or alkyl of 1-5 carbon atoms;R.sub.4 is an aliphatic group, cycloalkyl, optionally substituted aryl, or a heterocyclic group;R.sub.5 is free or functionally modified hydroxy and,when R.sub.2 is hydrogen, the physiologically compatible salts thereof with bases, have valuable pharmacological properties.
摘要翻译：式I的卡巴环素衍生物其中R 1是OR 2，其中R 2是氢，烷基，环烷基，芳基，杂环残基或NHR 3，其中R 3是酸残基或氢; X是氧; A是-CH 2 -CH 2 - ，反式-CH = CH-或-C 3位C; W是游离的或官能改性的羟基亚甲基或游离或功能改性的“IMAGE”，其中OH-基团可以是α-或β-位; D是1-10个碳原子的直链或支链，饱和或不饱和的脂族基团，其可任选被氟原子取代，1,2-亚甲基，1,1-三亚甲基; E是-C 3 C或-CR 6 = CH 7 - ，其中R 6和R 7是氢或1-5个碳原子的烷基; R4是脂族基团，环烷基，任选取代的芳基或杂环基; R5是游离的或官能改性的羟基，当R2是氢时，其与碱的生理上相容的盐具有有价值的药理学性质。

9. 发明授权

US4560786A .DELTA..sup.8,9 -Prostaglandin derivatives, their preparation and use as medicinal agents 失效
标题翻译： DELTA 8,9-前列腺素衍生物，其制备和用作药物
公开(公告)号：US4560786A
公开(公告)日：1985-12-24
申请号：US391734
申请日：1982-06-24
申请人： Werner Skuballa , Bernd Raduechel , Norbert Schwarz , Helmut Vorbrueggen , Walter Elger , Olaf Loge , Michael-Harold Town
发明人： Werner Skuballa , Bernd Raduechel , Norbert Schwarz , Helmut Vorbrueggen , Walter Elger , Olaf Loge , Michael-Harold Town
IPC分类号： A61K31/045 , A61K31/557 , A61K31/5575 , A61P25/04 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00
CPC分类号： C07C405/0016 , C07C405/00 , C07C405/0041
摘要： .DELTA..sup.8,9 -Prostane derivatives of Formula I ##STR1## wherein R.sub.1 is CH.sub.2 OH or ##STR2## wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R.sub.1 is ##STR3## wherein R.sub.3 is an acid residue or R.sub.2 ; A is --CH.sub.2 --CH.sub.2 -- or cis--CH.dbd.CH;B is --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH-- or --C.tbd.C--W is a free or functionally modified hydroxymethylene group or free or functionally modified ##STR4## wherein the OH--group can be in the .alpha.-- or .beta.-- position; D and E jointly are a direct bond orD is straight chain or branched alkylene or alkenylene of 1-10 carbon atoms which can optionally be substituted by fluorine atoms, and E is oxygen, sulfur, a direct bond, --C.tbd.C-- or --CR.sub.6 .dbd.CR.sub.7 --, wherein R.sub.6 and R.sub.7 differ from each other and each is hydrogen, chlorine or alkyl;R.sub.4 is free or functionally modified hydroxy andR.sub.5 is an optionally substituted aliphatic group, cycloalkyl, optionally substituted aryl, or a heterocyclic group, and when R.sub.2 is hydrogen, physiologically compatible salts thereof with bases,have valuable pharmacological properties, e.g. luteolytic and abortifacient activities.
摘要翻译： DELTA 8,9-式I的前驱体衍生物其中R 1是CH 2 OH或其中R 2是氢，烷基，环烷基，芳基或杂环残基; 或R 1为，其中R 3为酸残基或R 2; A是-CH 2 -CH 2 - 或顺式-CH = CH; B是-CH 2 -CH 2 - ，反式-CH = CH-或-C 3BOND C-W是游离或官能改性的羟基亚甲基或游离或官能改性的“IMAGE”，其中OH-基团可以是α或β - 位置 D和E共同是直接键合，或D是可以任选被氟原子取代的1-10个碳原子的直链或支链亚烷基或亚烯基，并且E是氧，硫，直接键，-C 3 D或 -CR 6 = CR 7 - ，其中R 6和R 7彼此不同，各自为氢，氯或烷基; R4是游离的或官能改性的羟基，R 5是任选取代的脂族基，环烷基，任选取代的芳基或杂环基，当R 2是氢时，其与碱的生理上相容的盐具有有价值的药理学性质。 luteolytic和流产活动。

10. 发明授权

US4454339A 9-Fluoroprostaglandin derivatives, and use as medicinal agents 失效
标题翻译： 9-氟前列腺素衍生物，用作药物
公开(公告)号：US4454339A
公开(公告)日：1984-06-12
申请号：US395448
申请日：1982-07-06
申请人： Werner Skuballa , Bernd Raduechel , Norbert Schwarz , Helmut Vorbrueggen , Walter Elger , Olaf Loge , Michael-Harold Town
发明人： Werner Skuballa , Bernd Raduechel , Norbert Schwarz , Helmut Vorbrueggen , Walter Elger , Olaf Loge , Michael-Harold Town
IPC分类号： A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07C177/00
CPC分类号： C07C405/00 , C07C405/0016 , C07C405/0041
摘要： 9-Fluoroprostane derivatives of Formula I ##STR1## wherein R.sub.1 is CH.sub.2 OH or ##STR2## wherein R.sub.2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R.sub.1 is the residue ##STR3## wherein R.sub.3 is an acid residue or R.sub.2 and A is --CH.sub.2 --CH.sub.2 -- or cis--CH.dbd.CH--,B is --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH-- or --C.tbd.C,W is a free or functionally modified hydroxymethylene group wherein the OH-group can be in the .alpha.- or .beta.-position,D and E jointly are a direct bond orD is straight-chain or branched alkylene or alkenylene of 1-10 carbon atoms which can optionally be substituted by fluorine atoms, and E is oxygen or sulfur, a direct bond, --C.tbd.C-- or --CR.sub.6 .dbd.CR.sub.7 -- wherein R.sub.6 and R.sub.7 differ from each other and each is hydrogen, chlorine, or alkyl,R.sub.4 is a free or functionally modified hydroxy group, andR.sub.5 is hydrogen, an optionally substituted aliphatic group, e.g., alkyl or halosubstituted alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group, and, when R.sub.2 is H, physiologically compatible salts thereof with bases,have valuable pharmacological properties, e.g., as luteolytics or abortifacients.
摘要翻译：其中R 1是CH 2 OH或其中R 2是氢，烷基，环烷基，芳基或杂环残基的式I的1-氟代衍生物（Ⅰ）或R1是残基，其中R3是酸残基或R2和A是-CH2-CH2-或顺式-CH = CH-，B是-CH2-CH2-，反式-CH = CH-或-C3BOND C，W是游离的或官能改性的羟基亚甲基，其中OH基可以是α-或β-位，D和E共同是直接键，或D是1-10的直链或支链亚烷基或亚烯基可以任选被氟原子取代的碳原子，E是氧或硫，直接键，-C 3 D或-CR 6 = CR 7 - ，其中R 6和R 7彼此不同，各自是氢，氯或烷基 R4是游离的或官能改性的羟基，R5是氢，任意取代的脂族基团，例如烷基或卤代取代的烷基，环烷基，任选取代的芳基或杂环基，当R 2是H时，其生理上相容的盐具有碱性，具有有价值的药理学性质，例如作为纤溶素或流产。

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