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1. 发明授权

US10112000B2 Method for reducing amyloid beta concentration in blood 有权
公开(公告)号：US10112000B2
公开(公告)日：2018-10-30
申请号：US13178790
申请日：2011-07-08
申请人： Nobuya Kitaguchi , Kazunori Kawaguchi
发明人： Nobuya Kitaguchi , Kazunori Kawaguchi
IPC分类号： B01D71/68 , B01D69/08 , B01D71/26 , B01D71/16 , B01D71/42 , B01D71/10 , B01D61/24 , B01D71/40 , A61M1/36 , B01D63/02 , B01D71/44
摘要： The present invention relates to a method for reducing a β-amyloid concentration in blood. Specifically, the present invention relates to a method for reducing a β-amyloid concentration in blood, comprising the steps of; removing blood out of a body, passing the blood that is removed through a hollow fiber membrane, and returning the blood that is passed through into the body, wherein the blood containing a β-amyloid-albumin complex is passed through the hollow fiber membrane to allow β-amyloid to adsorb to the hollow fiber membrane so that the β-amyloid concentration in blood is reduced.

2. 发明申请

US20120031840A1 METHOD FOR REDUCING AMYLOID BETA CONCENTRATION IN BLOOD 审中-公开
标题翻译：降低血液中淀粉样蛋白浓度的方法
公开(公告)号：US20120031840A1
公开(公告)日：2012-02-09
申请号：US13178790
申请日：2011-07-08
申请人： Nobuya KITAGUCHI , Kazunori KAWAGUCHI
发明人： Nobuya KITAGUCHI , Kazunori KAWAGUCHI
IPC分类号： B01D71/68 , B01D69/08 , B01D71/26 , B01D71/16 , B01D71/42 , B01D71/10 , B01D61/24 , B01D71/40
CPC分类号： A61M1/3679 , B01D63/02 , B01D71/10 , B01D71/16 , B01D71/40 , B01D71/44 , B01D71/68
摘要： The present invention relates to a method for reducing a β-amyloid concentration in blood. Specifically, the present invention relates to a method for reducing a β-amyloid concentration in blood, comprising the steps of; removing blood out of a body, passing the blood that is removed through a hollow fiber membrane, and returning the blood that is passed through into the body, wherein the blood containing a β-amyloid-albumin complex is passed through the hollow fiber membrane to allow β-amyloid to adsorb to the hollow fiber membrane so that the β-amyloid concentration in blood is reduced.
摘要翻译：本发明涉及降低血液中淀粉样蛋白浓度的方法。具体地说，本发明涉及降低血液中淀粉样蛋白浓度的方法，其特征在于，包括以下步骤：从身体排出血液，使通过中空纤维膜除去的血液通过，并将通过的血液返回到体内，其中含有β-淀粉样蛋白 - 白蛋白复合物的血液通过中空纤维膜以使β-淀粉样蛋白吸附到中空纤维膜上，使得血液中的淀粉样蛋白浓度降低。

3. 发明申请

US20110274594A1 AB-REMOVER, AB-REMOVING APPARATUS, AND AB REMOVAL METHOD 审中-公开
标题翻译： AB去除器，AB去除装置和AB去除方法
公开(公告)号：US20110274594A1
公开(公告)日：2011-11-10
申请号：US13166431
申请日：2011-06-22
申请人： Nobuya Kitaguchi , Kazunori Kawaguchi
发明人： Nobuya Kitaguchi , Kazunori Kawaguchi
IPC分类号： B01D21/00 , C07F7/02 , C08F116/06 , C01B31/08 , B01J20/26 , C08B1/00 , C01B33/12
CPC分类号： A61M1/3679 , G01N2333/4709 , G01N2800/2821
摘要： An object is to provide a material capable of removing Aβ from a body fluid efficiently and use of the material, which are developed for the purpose of establishing a therapeutic or preventive method for Alzheimer's disease. Provided is an amyloid β protein remover, containing a carrier made of any one material selected from the group consisting of cellulose, silica, polyvinyl alcohol, and activated carbon, wherein the carrier does not have an alkyl chain on the surface thereof or has an alkyl chain having 1 to 18 carbon atoms on the surface thereof.
摘要翻译：目的是提供能够去除A＆bgr的材料; 从体液中有效地利用材料，这些材料是为了建立阿尔茨海默病的治疗或预防方法而开发的。提供淀粉样蛋白蛋白质去除剂，其含有由选自纤维素，二氧化硅，聚乙烯醇和活性炭组成的组中的任何一种材料制成的载体，其中载体在其表面上不具有烷基链或具有1至18个的烷基链碳原子在其表面。

4. 发明授权

US07625760B2 Analyzing cartridge and liquid feed control device 失效
标题翻译：分析墨盒和液体进料控制装置
公开(公告)号：US07625760B2
公开(公告)日：2009-12-01
申请号：US11056247
申请日：2005-02-14
申请人： Nobuya Kitaguchi , Akira Kiguchi
发明人： Nobuya Kitaguchi , Akira Kiguchi
IPC分类号： G01N21/00 , G01N30/02 , G01N1/10 , G01N21/03
CPC分类号： B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/523 , B01L2200/027 , B01L2200/0621 , B01L2200/0684 , B01L2200/148 , B01L2200/16 , B01L2300/047 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683 , B01L2400/0694 , G01N2035/1044 , Y10T436/2575
摘要： An analyzing cartridge and method for using it to analyze a sample having a plurality of reservoirs and capillaries connected for communication between these reservoirs and is provided therein with a reagent required for analysis. The reservoirs are provided with openings leading to the outside of the cartridge, and the openings are covered with vents each consisting of a gas-permeable/non-liquid-permeable, hydrophobic, porous membrane. The analyzing cartridge requires only trace amounts of a sample and a reagent and no maintenance. It is provided with a non-fluid reagent in vent-carrying reservoirs thereby making it possible to formulate a very trace amount of reagent solution in the cartridge by injecting a reagent dissolving liquid into the reservoirs immediately before analyzing. A liquid feed control device controls the feeding of the liquid between the reservoirs via the capillaries when it is attached to the cartridge to allow or control the entry/exit of air via the vents.
摘要翻译：一种分析盒及其使用方法，用于分析具有连接用于这些储存器之间连通的多个储存器和毛细管的样品，并在其中提供分析所需的试剂。储存器设置有通向盒的外部的开口，并且开口被每个由透气/非液体可渗透的疏水多孔膜组成的排气口覆盖。分析盒只需要微量的样品和试剂，无需维护。在通气容器中设置有非流体试剂，从而可以在分析前立即将试剂溶解液注入储存器中，从而配制微量的试剂溶液。液体供给控制装置通过毛细管连接到墨盒来控制储存器之间的液体进给，以允许或控制通过通风口进入/离开空气。

5. 发明授权

US4414079A Process for the preparation of a 4-butanolide compound 失效
标题翻译： 4-丁醇酯化合物的制备方法
公开(公告)号：US4414079A
公开(公告)日：1983-11-08
申请号：US398604
申请日：1982-07-15
申请人： Kazunori Yamataka , Toshiro Isoya , Nobuya Kitaguchi
发明人： Kazunori Yamataka , Toshiro Isoya , Nobuya Kitaguchi
IPC分类号： C07D307/33 , B01J27/00 , B01J31/00 , B01J31/02 , C07D307/58 , C07D315/00 , C25B3/04 , C25B3/10 , C25B3/00
CPC分类号： C07D315/00 , C25B3/04
摘要： The electrolytic reduction of a mixture of an acrylic ester and an aldehyde in the form of an aqueous emulsion in the presence of at least one phase-transfer catalyst using a lead or lead alloy cathode has been found to be very effective for preparing a 4-butanolide compound simply and safely in high yield with a high current efficiency.
摘要翻译：已经发现，在使用铅或铅合金阴极的至少一种相转移催化剂的存在下，水性乳液形式的丙烯酸酯和醛的混合物的电解还原是制备4- 丁醇化合物以高产率以高电流效率简单安全地进行。

6. 发明申请

US20050148091A1 Analyzing cartridge and liquid feed control device 失效
标题翻译：分析墨盒和液体进料控制装置
公开(公告)号：US20050148091A1
公开(公告)日：2005-07-07
申请号：US11056247
申请日：2005-02-14
申请人： Nobuya Kitaguchi , Akira Kiguchi
发明人： Nobuya Kitaguchi , Akira Kiguchi
IPC分类号： B01L3/00 , G01N33/487 , G01N33/49 , G01N35/10 , G01N21/00
CPC分类号： B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/523 , B01L2200/027 , B01L2200/0621 , B01L2200/0684 , B01L2200/148 , B01L2200/16 , B01L2300/047 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683 , B01L2400/0694 , G01N2035/1044 , Y10T436/2575
摘要： An analyzing cartridge and method for using it to analyze a sample having a plurality of reservoirs and capillaries connected for communication between these reservoirs and is provided therein with a reagent required for analysis. The reservoirs are provided with openings leading to the outside of the cartridge, and the openings are covered with vents each consisting of a gas-permeable/non-liquid-permeable, hydrophobic, porous membrane. The analyzing cartridge requires only trace amounts of a sample and a reagent and no maintenance. It is provided with a non-fluid reagent in vent-carrying reservoirs thereby making it possible to formulate a very trace amount of reagent solution in the cartridge by injecting a reagent dissolving liquid into the reservoirs immediately before analyzing. A liquid feed control device controls the feeding of the liquid between the reservoirs via the capillaries when it is attached to the cartridge to allow or control the entry/exit of air via the vents.
摘要翻译：一种分析盒及其使用方法，用于分析具有连接用于这些储存器之间连通的多个储存器和毛细管的样品，并在其中提供分析所需的试剂。储存器设置有通向盒的外部的开口，并且开口被每个由透气/非液体可渗透的疏水多孔膜组成的排气口覆盖。分析盒只需要微量的样品和试剂，无需维护。在通气容器中设置有非流体试剂，从而可以在分析前立即将试剂溶解液注入储存器中，从而配制微量的试剂溶液。液体供给控制装置通过毛细管连接到墨盒来控制储存器之间的液体进给，以允许或控制通过通风口进入/离开空气。

7. 发明申请

US20060257456A1 Material promoting wound healing 审中-公开
标题翻译：材料促进伤口愈合
公开(公告)号：US20060257456A1
公开(公告)日：2006-11-16
申请号：US10559572
申请日：2004-06-07
申请人： Ushio Iwamoto , Yasuo Tokushima , Nobuya Kitaguchi
发明人： Ushio Iwamoto , Yasuo Tokushima , Nobuya Kitaguchi
IPC分类号： A61K35/14 , A61L15/00
CPC分类号： A61L26/0085 , A61K9/7007 , A61K35/15 , A61K35/19 , A61L15/40 , A61L15/425 , A61L26/0066 , A61L31/005 , A61L31/146 , A61L2300/412 , A61L2300/64
摘要： The object of the present invention is to provide a means for utilizing cells that have effects on wound healing as wound-healing promoting materials by efficiently concentrating such cells within a short period of time. The present invention provides a wound-healing promoting material which comprises a sheet-like porous body having on its surface at least leukocytes and/or platelets, a method for producing the same, a device for producing the same, and a method for treating wound sites using the same.
摘要翻译：本发明的目的是提供一种在短时间内有效地浓缩这些细胞的方法，其中使用对伤口愈合具有作为伤口愈合促进材料的作用的细胞。本发明提供一种伤口愈合促进材料，其包括其表面至少具有白细胞和/或血小板的片状多孔体，其制造方法，其制造方法以及伤口治疗方法使用相同的网站

8. 发明申请

US20060128016A1 Fibrin-containing composition 审中-公开
标题翻译：含纤维蛋白的组合物
公开(公告)号：US20060128016A1
公开(公告)日：2006-06-15
申请号：US10525503
申请日：2003-08-25
申请人： Yasuo Tokushima , Nobuya Kitaguchi , Shuichiro Inadome , Takahiro Hori
发明人： Yasuo Tokushima , Nobuya Kitaguchi , Shuichiro Inadome , Takahiro Hori
IPC分类号： C12N5/06
CPC分类号： A61L27/3895 , A61K38/00 , A61L27/225 , A61L27/3616 , A61L27/50 , A61L31/10 , C07K14/75 , C12M21/08 , C12M25/14 , C12M29/16 , C12N5/0068 , C12N2533/56
摘要： It is intended to provide a scaffold material having favorable properties and being appropriate for cell proliferation and differentiation in regeneration therapy. Namely, a fibrin-containing biological scaffold material to be used in the case of employing a fibrin composition for the regeneration of a human tissue and cell proliferation, characterized by containing a mixture of a fibrinogen concentrate, which is obtained from human plasma by a quick and rough purification method, with a fibrinogen activator.
摘要翻译：旨在提供具有良好性能并适合于再生治疗中的细胞增殖和分化的支架材料。即，在使用纤维蛋白组合物用于人体组织再生的情况下使用的含纤维蛋白的生物支架材料和细胞增殖，其特征在于，含有通过快速从人血浆获得的纤维蛋白原浓缩物的混合物和粗提纯法，用纤维蛋白原激活剂。

9. 发明授权

US06458347B1 Drug complex 有权
标题翻译：药物复合体
公开(公告)号：US06458347B1
公开(公告)日：2002-10-01
申请号：US09172085
申请日：1998-10-14
申请人： Shuichi Sugawara , Masahiro Kajiki , Hiroshi Kuriyama , Nobuya Kitaguchi
发明人： Shuichi Sugawara , Masahiro Kajiki , Hiroshi Kuriyama , Nobuya Kitaguchi
IPC分类号： A61K3177
CPC分类号： A61K47/61 , A61K47/60
摘要： Disclosed is a drug complex of a drug having a hydroxyl group, which is capable of controlling the rate of the release of the drug therefrom in blood, the drug complex being represented by the following formula (1): A—B—C (1) wherein A represents at least one carrier selected from the group consisting of saccharides each having a carboxyl group, polyethylene glycols each having a carboxyl group, aliphatic carboxylic acids each having a carboxyl group, and derivatives thereof each having a carboxyl group; B represents at least one spacer comprised of a compound having a amino group and a carboxyl group; C represents at least one drug having a hydroxyl group, wherein the carrier A is bonded to the spacer B through an amide bond formed between the carboxyl group of the carrier A and the amino group of the spacer B; and the spacer B is bonded to the drug C through an ester bond formed between the carboxyl group of the spacer B and the hydroxyl group of the drug C.
摘要翻译：公开了具有羟基的药物的药物复合物，其能够控制药物在血液中的释放速率，药物复合物由下式（1）表示：其中A表示至少一种载体选自具有羧基的糖类，各自具有羧基的聚乙二醇，各自具有羧基的脂肪族羧酸，以及各自具有羧基的衍生物; B表示至少一个由具有氨基和羧基的化合物组成的间隔物; C表示至少一种具有羟基的药物，其中载体A通过形成在载体A的羧基和间隔基B的氨基之间的酰胺键与间隔基B结合; 并且间隔物B通过在间隔物B的羧基和药物C的羟基之间形成的酯键与药物C结合。

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