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1. 发明申请

US20070020729A1 Novel collectin 审中-公开
标题翻译：小说收藏
公开(公告)号：US20070020729A1
公开(公告)日：2007-01-25
申请号：US11526445
申请日：2006-09-25
申请人： Nobutaka Wakamiya
发明人： Nobutaka Wakamiya
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4726 , A61K38/00 , C07K14/47 , C07K14/78 , C12Q1/6876
摘要： Novel collectin related molecules i.e., a novel collectin gene comprising a nucleotide sequence set out in SEQ ID NO: 1, and a novel collectin comprising an amino acid sequence set out in SEQ ID NO: 2, which are expected to exhibit anti-bacterial, anti-viral activity or the like especially in human body, and methods in which these molecules are used are provided.
摘要翻译：新的集合蛋白相关分子，即包含SEQ ID NO：1所示核苷酸序列的新型聚集蛋白基因，以及包含SEQ ID NO：2所示氨基酸序列的新型聚集蛋白，其预期显示抗细菌，特别是在人体内的抗病毒活性等，以及使用这些分子的方法。

2. 发明申请

US20110065177A1 Novel Collectin 审中-公开
标题翻译：小提琴
公开(公告)号：US20110065177A1
公开(公告)日：2011-03-17
申请号：US12730647
申请日：2010-03-24
申请人： Nobutaka WAKAMIYA
发明人： Nobutaka WAKAMIYA
IPC分类号： C12N5/00 , C07K14/435 , C07H21/04 , C12N15/63
CPC分类号： C07K14/4726 , A61K38/00 , C07K14/47 , C07K14/78 , C12Q1/6876
摘要： Novel collectin related molecules i.e., a novel collectin gene comprising a nucleotide sequence set out in SEQ ID NO: 1, and a novel collectin comprising an amino acid sequence set out in SEQ ID NO: 2, which are expected to exhibit anti-bacterial, anti-viral activity or the like especially in human body, and methods in which these molecules are used are provided.
摘要翻译：新的集合蛋白相关分子，即包含SEQ ID NO：1所示核苷酸序列的新型聚集蛋白基因，以及包含SEQ ID NO：2所示氨基酸序列的新型聚集蛋白，其预期显示抗细菌，特别是在人体内的抗病毒活性等，以及使用这些分子的方法。

3. 发明申请

US20100113749A1 NOVEL SCAVENGER RECEPTOR 失效
标题翻译：新的SCAVENGER受体
公开(公告)号：US20100113749A1
公开(公告)日：2010-05-06
申请号：US12579948
申请日：2009-10-15
申请人： Nobutaka Wakamiya
发明人： Nobutaka Wakamiya
IPC分类号： C07K16/18
CPC分类号： C07K16/28 , A01K2217/05 , A61K38/00 , C07K14/705 , G01N2500/00 , G01N2800/00 , G01N2800/32
摘要： Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper β-lipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypo α-lipoproteinemia, transplantation, atherectomy, post angiogenic restenosis, bacterial infections; in the diagnostic, prophylactic and therapeutic methods thereof; and in the development of reagents and drugs for the same. The novel scavenger receptors include proteins comprising an amino acid sequence set out in SEQ ID NO: 2, 4 or 24 or proteins having equivalent properties to the same, or derivatives or fragments thereof as well as isolated polynucleotides comprising a nucleotide sequence encoding these proteins, and related molecules such as antibodies, antagonists and the like. Also disclosed are methods for the treatment using the same.
摘要翻译：提供具有SR结构和集合蛋白样结构的新型清道夫受体，其可用于阐明巨噬细胞和基本免疫的机制; 阐明各种疾病如动脉硬化，糖尿病并发症和阿尔茨海默氏病，高胆固醇血症，高胆固醇血症，高甘油三酯血症，低α脂蛋白血症，移植，粥样斑块切除术，血管生成后再狭窄，细菌感染等各种疾病的发展机制; 在其诊断，预防和治疗方法中; 并在开发试剂和药物方面相同。新型清道夫受体包括包含SEQ ID NO：2,4或24所示的氨基酸序列的蛋白质或与其相同性质的蛋白质或其衍生物或片段，以及包含编码这些蛋白质的核苷酸序列的分离的多核苷酸，和相关分子如抗体，拮抗剂等。还公开了使用其处理的方法。

4. 发明授权

US07189809B2 Scavenger receptors 失效
标题翻译：清道夫受体
公开(公告)号：US07189809B2
公开(公告)日：2007-03-13
申请号：US10203860
申请日：2001-02-08
申请人： Nobutaka Wakamiya
发明人： Nobutaka Wakamiya
IPC分类号： C01K14/705 , G07N33/53 , A61K39/00 , C12N15/06
CPC分类号： C07K16/28 , A01K2217/05 , A61K38/00 , C07K14/705 , G01N2500/00 , G01N2800/00 , G01N2800/32
摘要： Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper β-lipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypo α-lipoproteinemia, transplantation, atherectomy, post angiogenic restenosis, bacterial infections; in the diagnostic, prophylactic and therapeutic methods thereof; and in the development of reagents and drugs for the same. The novel scavenger receptors include proteins comprising an amino acid sequence set out in SEQ ID NO: 2, 4 or 24 or proteins having equivalent properties to the same, or derivatives or fragments thereof as well as isolated polynucleotides comprising a nucleotide sequence encoding these proteins, and related molecules such as antibodies, antagonists and the like. Also disclosed are methods for the treatment using the same.
摘要翻译：提供具有SR结构和集合蛋白样结构的新型清道夫受体，其可用于阐明巨噬细胞和基本免疫的机制; 在阐明各种疾病如动脉硬化，糖尿病并发症和阿尔茨海默病，高β脂蛋白血症，高胆固醇血症，高甘油三酯血症，低α脂蛋白血症，移植，粥样斑块切除术，血管生成后再狭窄，细菌感染等各种疾病的发展机制之后; 在其诊断，预防和治疗方法中; 并在开发试剂和药物方面相同。新型清道夫受体包括包含SEQ ID NO：2,4或24所示的氨基酸序列的蛋白质或与其相同性质的蛋白质或其衍生物或片段，以及包含编码这些蛋白质的核苷酸序列的分离的多核苷酸，和相关分子如抗体，拮抗剂等。还公开了使用其处理的方法。

5. 发明申请

US20050123899A1 Anti-hiv agent 审中-公开
标题翻译：抗艾滋病毒药物
公开(公告)号：US20050123899A1
公开(公告)日：2005-06-09
申请号：US10500774
申请日：2003-06-30
申请人： Nobutaka Wakamiya , Katsuki Ohtani , Takashi Sakamoto , Hiroyuki Keshi
发明人： Nobutaka Wakamiya , Katsuki Ohtani , Takashi Sakamoto , Hiroyuki Keshi
IPC分类号： A61K38/17 , A61P31/18 , A61P37/04 , A61P43/00 , C12Q1/70 , C07K14/705
CPC分类号： A61K38/1709
摘要： Disclosed are anti-HIV agents which comprise a mannose binding protein (MBP) as an active component and are useful for effectively inhibiting progress of diseases state in and useful in therapy for individuals infected with human immunodeficiency virus (HIV). Also disclosed are a method for evaluating an anti-HIV activity of MBP comprising the step of culturing HIV infected cells under the presence of MBP.
摘要翻译：公开了包含作为活性成分的甘露糖结合蛋白（MBP）的抗HIV剂，并且可有效地有效地抑制感染人类免疫缺陷病毒（HIV）的个体的疾病状态并用于治疗。还公开了评估MBP的抗HIV活性的方法，包括在MBP存在下培养HIV感染细胞的步骤。

6. 发明授权

US06787639B1 Collectin 失效
标题翻译：集体
公开(公告)号：US06787639B1
公开(公告)日：2004-09-07
申请号：US09600932
申请日：2000-09-08
申请人： Nobutaka Wakamiya
发明人： Nobutaka Wakamiya
IPC分类号： C07K100
CPC分类号： A01N37/46 , C07K14/47 , C07K14/78
摘要： A gene encoding a novel collectin protein which is expected to exhibit an antibacterial activity, an antiviral activity, etc. particularly in the human body, and its amino acid sequence.
摘要翻译：编码预期具有抗菌活性，抗病毒活性等特别是人体的新型集合蛋白的基因及其氨基酸序列。

7. 发明授权

US08604162B2 Collectin 失效
标题翻译：集体
公开(公告)号：US08604162B2
公开(公告)日：2013-12-10
申请号：US13160091
申请日：2011-06-14
申请人： Nobutaka Wakamiya , Katsuki Ohtani , Takashi Sakamoto , Yuichiro Kishi
发明人： Nobutaka Wakamiya , Hiroyuki Keshi , Katsuki Ohtani , Takashi Sakamoto , Yuichiro Kishi
IPC分类号： C07K14/00
CPC分类号： C07K14/4726 , A01K2217/05 , C07K14/785
摘要： Provided are isolated collectin (CL-L2s) genes including a base sequence set out in SEQ ID NO: 1, 3, 5, 7, 9, 12, 36, 38 or 40 relating to a novel collectin which are expected to exhibit an antibacterial activity, an antiviral activity and the like particularly in a human body; and isolated collectin proteins including an amino acid sequence set out in SEQ ID NO: 2, 4, 6, 8, 10, 13, 37, 39 or 41 and derivatives and fragments thereof.
摘要翻译：提供了分离的集合蛋白（CL-L2）基因，其包括与预期显示抗细菌剂的新型聚集蛋白相关的SEQ ID NO：1,3,5,7,9,12,32,38或40所示的碱基序列活动，抗病毒活性等，特别是在人体内; 和分离的集合蛋白，包括SEQ ID NO：2,4,6,8,10,13,37,39或41所示的氨基酸序列及其衍生物和片段。

8. 发明申请

US20130065817A1 POLYPEPTIDE ACTING TO ENHANCE ISCHEMIC DISEASES 失效
标题翻译：多肽致力于加强疾病
公开(公告)号：US20130065817A1
公开(公告)日：2013-03-14
申请号：US13582495
申请日：2010-03-04
申请人： Nobutaka Wakamiya , Katsuki Otani
发明人： Nobutaka Wakamiya , Katsuki Otani
IPC分类号： A61K38/17 , A61P9/10
CPC分类号： C07K14/47 , C07K14/4726
摘要： Disclosed is a polypeptide of use in the development of reagents or medicines favourable to application for prevention or treatment of ischemic disorders such as conditions caused by ateriosclerosis. The polypeptide has at least one part containing an amino acid of sequence ID 1, and also enhances expression levels of the amino acid in mammalian blood vessels removed from ischemic conditions by means of blood reperfusion.
摘要翻译：公开了用于开发有利于预防或治疗缺血性疾病例如由动脉硬化引起的病症的试剂或药物的多肽。多肽具有至少一部分含有序列ID 1的氨基酸的部分，并且还通过血液再灌注增强从缺血条件中移除的哺乳动物血管中氨基酸的表达水平。

9. 发明申请

US20120015400A1 HCL-K1 Polypeptide Which Offers Collectin Activity 审中-公开
标题翻译： HCL-K1多肽，提供集体活动
公开(公告)号：US20120015400A1
公开(公告)日：2012-01-19
申请号：US13087989
申请日：2011-04-15
申请人： Nobutaka Wakamiya , Katsuki Otani , Takashi Sakamoto , Yuichiro Kishi , Hiroyuki Keshi , Aya Keshi
发明人： Nobutaka Wakamiya , Katsuki Otani , Takashi Sakamoto , Yuichiro Kishi , Hiroyuki Keshi , Aya Keshi
IPC分类号： C12P21/00 , C12N15/63
CPC分类号： C07K14/4726 , A61K38/00
摘要： Disclosed is the novel hCL-K1 polypeptide which offers collectin activity. This polypeptide consists of consecutive 271 amino acids set out in SEQ ID NO: 2 and does not bind to both maltose and N-acetylgalactosamine.
摘要翻译：公开了提供凝集素活性的新型hCL-K1多肽。该多肽由SEQ ID NO：2所示的连续271个氨基酸组成，不与麦芽糖和N-乙酰半乳糖胺结合。

10. 发明申请

US20090305341A1 HCL-K1 Polypeptide Which Offers Collectin Activity 审中-公开
标题翻译： HCL-K1多肽，提供集体活动
公开(公告)号：US20090305341A1
公开(公告)日：2009-12-10
申请号：US12296085
申请日：2007-04-05
申请人： Nobutaka Wakamiya , Katsuki Otani , Takashi Sakamoto , Yuichiro Kishi , Hiroyuki Keshi , Aya Keshi
发明人： Nobutaka Wakamiya , Katsuki Otani , Takashi Sakamoto , Yuichiro Kishi , Hiroyuki Keshi , Aya Keshi
IPC分类号： C12P21/06 , C07K14/00 , C07H21/04 , C12N15/63 , C12N5/00 , C07K16/00
CPC分类号： C07K14/4726 , A61K38/00
摘要： Disclosed is the novel hCL-K1 polypeptide which offer collectin activity. This polypeptide consists of consecutive 271 amino acids set out in SEQ ID NO: 2 and does not bind to both maltose and N-acetylgalactosamine.
摘要翻译：公开了提供聚集蛋白活性的新型hCL-K1多肽。该多肽由SEQ ID NO：2所示的连续271个氨基酸组成，不与麦芽糖和N-乙酰半乳糖胺结合。

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