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1. 发明授权

US08829001B2 Dopamine D3 receptor ligands and preparation and medical uses of the same 有权
标题翻译：多巴胺D3受体配体及其制备及医疗用途相同
公开(公告)号：US08829001B2
公开(公告)日：2014-09-09
申请号：US13123368
申请日：2009-09-28
申请人： Jin Li , Rifang Yang , Rui Song , Hui Zhu , Ning Wu , Liuhong Yun , Ruibin Su , Rusheng Zhao
发明人： Jin Li , Rifang Yang , Rui Song , Hui Zhu , Ning Wu , Liuhong Yun , Ruibin Su , Rusheng Zhao
IPC分类号： A61K31/496 , A61K31/506 , C07D263/58 , C07D277/68 , C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： A61K31/496 , C07D263/58 , C07D277/68 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction.
摘要翻译：本发明涉及由式I表示的具有调节多巴胺D3受体活性的新型哌嗪衍生物，其立体异构体，药学上可接受的盐或溶剂合物，以及包含该化合物的药物组合物，其制备方法及其用途预防或治疗与中枢神经系统功能障碍相关的疾病，例如帕金森病，精神分裂症，药物成瘾和复发，以及肾脏保护和免疫调节，或用作研究D3R功能或与D3R功能障碍相关的疾病的工具。

2. 发明申请

US20130244245A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids 审中-公开
标题翻译：用于体内并入非天然氨基酸的正交翻译组分
公开(公告)号：US20130244245A1
公开(公告)日：2013-09-19
申请号：US13492296
申请日：2012-06-08
申请人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
发明人： Peter G. Schultz , Lital Alfonta , Johnathan R. Chittuluru , Alexander Deiters , Dan Groff , Daniel Summerer , Meng-Lin Tsao , Jiangyun Wang , Ning Wu , Jianming Xie , Huaqiang Zeng , Mohammad Seyedsayamdost , James Turner
IPC分类号： C12N9/00 , C12N15/10 , C12P21/00
CPC分类号： C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
摘要翻译：本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入在诸如大肠杆菌或真核宿主如酵母细胞中的细胞宿主细胞中产生的蛋白质中。本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。

3. 发明申请

US20120129215A1 Compositions of Orthogonal Lysyl-tRNA and Aminoacyl-tRNA Synthetase Pairs and Uses Thereof 有权
标题翻译：正交Lysyl-tRNA和氨基酰基-tRNA合成酶对的组成及其用途
公开(公告)号：US20120129215A1
公开(公告)日：2012-05-24
申请号：US13246490
申请日：2011-09-27
申请人： J. Christopher Anderson , Ning Wu , Stephen Santoro , Peter G. Schultz
发明人： J. Christopher Anderson , Ning Wu , Stephen Santoro , Peter G. Schultz
IPC分类号： C12N9/00 , C12P21/00
CPC分类号： C12P21/02 , C12N9/93 , C12N15/70 , C12P21/00
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
摘要翻译：提供了蛋白质生物合成机理的组成和方法，其包括正交赖氨酰-tRNA，正交赖氨酰 - 酰基-tRNA合成酶和将高聚谷氨酰胺掺入蛋白质的正交对的赖氨酰-tRNA /合成酶，以响应于四碱基密码子。还提供用于鉴定这些正交对的方法以及使用这些正交对产生具有高谷氨酰胺的蛋白质的方法。

4. 发明申请

US20120051001A1 PRINTED CIRCUIT BOARD 失效
标题翻译：印刷电路板
公开(公告)号：US20120051001A1
公开(公告)日：2012-03-01
申请号：US12916615
申请日：2010-10-31
申请人： NING WU , HSIN-KUAN WU , HOU-YUAN CHOU , SHUN-BO BAI , YAN-MEI ZHU
发明人： NING WU , HSIN-KUAN WU , HOU-YUAN CHOU , SHUN-BO BAI , YAN-MEI ZHU
IPC分类号： H05K1/00
CPC分类号： H05K1/0225 , H05K1/0243
摘要： A PCB includes a number of insulation layers, a number of circuit layers, a signal-interfering component, and a signal-sensitive component. The circuit layers and the insulation layers are stacked alternately. The circuit layers include at least two first circuit layers, a second circuit layer, and a ground layer. The ground layer has a first side and a second side facing away the first side. The first circuit layers are positioned near the first side and include an outmost first circuit layer and at least one inner first circuit layer positioned between the outmost first circuit layer and the ground layer. The second circuit layer is positioned near the second side. The signal-interfering component is positioned on the outmost first circuit layer. The signal-sensitive component is positioned on the second circuit layer. Each inner first circuit layer defines a copper-remove area corresponding to an orthogonal projection of the signal-interfering component thereon.
摘要翻译： PCB包括多个绝缘层，多个电路层，信号干扰部件和信号敏感部件。电路层和绝缘层交替堆叠。电路层包括至少两个第一电路层，第二电路层和接地层。接地层具有朝向第一侧的第一侧和第二侧。第一电路层位于第一侧附近，并且包括位于最外层的第一电路层和接地层之间的最外层的第一电路层和至少一个内部第一电路层。第二电路层位于第二侧附近。信号干扰部件位于最外侧的第一电路层。信号敏感部件位于第二电路层上。每个内部第一电路层限定对应于其上的信号干扰部件的正交投影的铜去除区域。

5. 发明授权

US07998094B1 System and method of microscopic imaging and soft tissue tension measurements 有权
标题翻译：微观成像和软组织张力测量的系统和方法
公开(公告)号：US07998094B1
公开(公告)日：2011-08-16
申请号：US12426012
申请日：2009-04-17
申请人： Li-Qun Zhang , Yi-Ning Wu , Yupeng Ren
发明人： Li-Qun Zhang , Yi-Ning Wu , Yupeng Ren
IPC分类号： A61B5/103 , A61B5/117
CPC分类号： A61B5/0059 , A61B5/4519
摘要： An apparatus and method for examining fiber tension, fiber stress, sarcomere length, etc. in muscle fibers and tension and stress in ligament or tendon tissues as well as brain or nerve fibers by applying a lifting force to lift the fiber or tissue a lifting distance, measuring the lifting force and distance and calculating the axial tension on the fiber bundle or tissue. The apparatus and method also make it possible to illuminate and view the fiber bundle or tissue to examine and characterize visually observable properties.
摘要翻译：通过施加提升力提升纤维或组织提升距离，检查肌纤维中的纤维张力，纤维应力，肌节长度等在韧带或腱组织以及脑或神经纤维中的张力和应力的装置和方法测量提升力和距离并计算纤维束或组织上的轴向张力。该装置和方法还使得可以照亮和观察纤维束或组织以检查和表征视觉可观察的性质。

6. 发明申请

US20110118132A1 Enzymatic Assays Using Umbelliferone Substrates with Cyclodextrins in Droplets of Oil 有权
标题翻译：使用伞形酮底物与环糊精在油滴中的酶检测
公开(公告)号：US20110118132A1
公开(公告)日：2011-05-19
申请号：US13012831
申请日：2011-01-25
申请人： Theodore Winger , Allen E. Eckhardt , Carrie Graham , Ramakrishna Sista , Vamsee K. Pamula , Tong Wang , Yalin Xiong , Ning Wu , Sanjay Saha , Gajendrasinh Balvantsinh Raolji , Raveendra Dayam
发明人： Theodore Winger , Allen E. Eckhardt , Carrie Graham , Ramakrishna Sista , Vamsee K. Pamula , Tong Wang , Yalin Xiong , Ning Wu , Sanjay Saha , Gajendrasinh Balvantsinh Raolji , Raveendra Dayam
IPC分类号： C40B30/00 , C12Q1/00
CPC分类号： C12Q1/00
摘要： The invention is directed to droplet actuator devices and assay methods. The method may include, among other things, a method of conducting enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil, the method including incubating a droplet in oil, the droplet preferably comprising an umbelliferone substrate, a sample, and a cyclodextrin compound. The methods may further include a method of substantially eliminating cross-contamination between droplets in enzymatic containing substrate-based bioassays. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the inclusion complex may be formed using cyclodextrins. In yet another embodiment, the invention may provide a method of enhancing hydrolysis of enzymatic substrates. The methods may further include a method of forming an inclusion complex with the substrate for stabilizing the substrate within an aqueous environment, wherein the substrate may be a 4-MU- or HMU containing substrate. The inclusion complex may be formed using cyclodextrin.
摘要翻译：本发明涉及液滴致动器装置和测定方法。该方法尤其可以包括使用具有环糊精的伞形酮底物在油中的液滴进行酶测定的方法，所述方法包括将液滴在油中孵育，所述液滴优选包含伞形酮底物，样品和环糊精化合物。所述方法还可以包括基本上消除含酶底物生物测定中的液滴之间的交叉污染的方法。该方法可以包括固定酶底物，包括与底物形成包合物以使其在水性环境中稳定，其中包合物可以使用环糊精形成。在另一个实施方案中，本发明可提供增强酶底物水解的方法。所述方法还可以包括在水性环境中与基材形成包含配合物以稳定基材的方法，其中所述基材可以是含有4-MU-或HMU的底物。包合物可以使用环糊精形成。

7. 发明申请

US20110092641A1 Solventless Universal Colorants 有权
标题翻译：无溶剂通用型着色剂
公开(公告)号：US20110092641A1
公开(公告)日：2011-04-21
申请号：US12831691
申请日：2010-07-07
申请人： Juanita Parris , Ning Wu , Jeannette Simoni-Truncellito , Robert Catena , Jitu Modi , William P. Keaveney , Robert Auerbach
发明人： Juanita Parris , Ning Wu , Jeannette Simoni-Truncellito , Robert Catena , Jitu Modi , William P. Keaveney , Robert Auerbach
IPC分类号： C09D11/10
CPC分类号： C09D11/326 , C09B67/0002 , C09B67/0063 , C09D11/102
摘要： A method of preparing a universal base composition disclosed which consists of milling a pigment in a resin that is soluble in both water and organic solvent and wherein the resin contains both hydrophobic and hydrophilic monomers such that the total weight of the hydrophobic and hydrophilic monomers is at least about 20% of the total weight of the resin and the weight ratio of hydrophobic monomers to hydrophilic monomers is from about 1/5 to about 5.
摘要翻译：一种制备通用基础组合物的方法，其通过在可溶于水和有机溶剂的树脂中研磨颜料组成，其中所述树脂含有疏水和亲水单体，使得疏水和亲水单体的总重量在树脂总重量的至少约20％，疏水性单体与亲水性单体的重量比为约1/5至约5。

8. 发明申请

US20090207863A1 METHOD AND APPARATUS OF CLOCK TRANSMISSION BETWEEN NETWORKS 有权
标题翻译：网络之间的时钟传输方法与装置
公开(公告)号：US20090207863A1
公开(公告)日：2009-08-20
申请号：US12433285
申请日：2009-04-30
申请人： Yong CHENG , Xiaodong BAO , Zhan ZHANG , Yinghai HE , Ning WU
发明人： Yong CHENG , Xiaodong BAO , Zhan ZHANG , Yinghai HE , Ning WU
IPC分类号： H04J3/00
CPC分类号： H04J3/0641 , H04J3/0647 , H04J3/0667 , H04J3/0673 , H04J2203/0089
摘要： A method of clock transmission between networks and an apparatus of clock transmission are disclosed, in which a second group of information corresponding to a clock transferred by a first network equipment based on a first protocol, and the second group of information corresponding to a clock transferred by a second network equipment based on a second protocol are acquired, and a source selection is performed in a united way by adopting a source selection manner based on the second protocol according to the second group of information. Therefore, the equipment in different types of networks can conveniently select a clock with a higher class from clocks transferred based on different protocols, so as to realize a normalization management on the clocks transferred based on different protocols.
摘要翻译：公开了一种网络之间的时钟传输方法和时钟传输装置，其中对应于由第一网络设备基于第一协议传送的时钟的第二组信息和对应于传送的时钟的第二组信息获取基于第二协议的第二网络设备，并且根据第二组信息采用基于第二协议的源选择方式，以统一的方式执行源选择。因此，不同类型网络中的设备可以方便地从基于不同协议传输的时钟中选择具有较高等级的时钟，从而实现基于不同协议传输的时钟的归一化管理。

9. 发明申请

US20080151199A1 Projection display system of quasi-axial optical imagery 审中-公开
标题翻译：准轴光学图像投影显示系统
公开(公告)号：US20080151199A1
公开(公告)日：2008-06-26
申请号：US11644395
申请日：2006-12-21
申请人： Bao-gang Wu , Ji-ning Wu , Lu Cheng , Jian-mi Gao , Shuai Zeng , Hong-shou Yu , Yu-kuan Li , Wei Zhang , Zhi-jian Zhang , Shou-ying Liu , Qin Zhao
发明人： Bao-gang Wu , Ji-ning Wu , Lu Cheng , Jian-mi Gao , Shuai Zeng , Hong-shou Yu , Yu-kuan Li , Wei Zhang , Zhi-jian Zhang , Shou-ying Liu , Qin Zhao
IPC分类号： G03B21/20
CPC分类号： G03B21/20 , G03B21/28
摘要： A quasi-axial optical imagery projection system is disclosed in this paper. The system includes optical imagery sets; each may be lenses, mirrors, or a combination of both. The system also has a light source close to an imager, which may be a planar mask with a pattern, a LCD imager, or other suitable imagers. The system also has a display screen. Both the imager and the display screen are set at acute angles with respect to an optical axis so that what is projected on the display screen is a magnified image of the imager by a magnification factor that has a transverse component and a longitudinal component. This quasi-axial projection system may be made thinner than other rear projection system of comparable screen size.
摘要翻译：本文公开了一种准轴向光学投影系统。该系统包括光学图像集; 每个可以是透镜，镜子或两者的组合。该系统还具有靠近成像器的光源，其可以是具有图案的平面掩模，LCD成像器或其他合适的成像器。该系统还具有显示屏。成像器和显示屏都相对于光轴设置成锐角，使得在显示屏上投影的是通过具有横向分量和纵向分量的放大因子的成像器的放大图像。该准轴向投影系统可以制成比具有相当的屏幕尺寸的其它后投影系统更薄。

10. 发明授权

US07338910B2 Method of fabricating semiconductor devices and method of removing a spacer 有权
标题翻译：制造半导体器件的方法和去除间隔物的方法
公开(公告)号：US07338910B2
公开(公告)日：2008-03-04
申请号：US11162952
申请日：2005-09-29
申请人： Chung-Ju Lee , Chih-Ning Wu , Wei-Tsun Shiau
发明人： Chung-Ju Lee , Chih-Ning Wu , Wei-Tsun Shiau
IPC分类号： H01L21/302 , H01L21/461
CPC分类号： H01L21/76834 , H01L21/28518 , H01L21/31111
摘要： A method of fabricating a semiconductor device is disclosed. The method includes defining an electrode on a semiconductor substrate; forming a spacer on at least one sidewall of the electrode; performing a process operation on the semiconductor substrate using the spacer as a mask and forming a material layer on the top or the surface of the semiconductor substrate and the electrode; and removing the spacer by steps of performing a wet etching process at a temperature in a range of 100° C. to 150° C. to etch the spacer using an acid solution containing phosphoric acid as an etchant. With respect to another aspect, a method of removing a spacer is also disclosed. The method includes performing a wet etching process at a temperature in a range of 100° C. to 150° C. to etch the spacer using an acid solution containing phosphoric acid as an etchant.
摘要翻译：公开了制造半导体器件的方法。该方法包括在半导体衬底上限定电极; 在所述电极的至少一个侧壁上形成间隔物; 在所述半导体衬底上使用所述间隔件作为掩模进行处理操作，并在所述半导体衬底和所述电极的顶部或表面上形成材料层; 并且通过在100℃至150℃的温度范围内进行湿蚀刻工艺的步骤去除间隔物，以使用含有磷酸作为蚀刻剂的酸溶液蚀刻间隔物。关于另一方面，还公开了一种去除间隔物的方法。该方法包括在100℃至150℃范围内的温度下进行湿蚀刻工艺，以使用含有磷酸作为蚀刻剂的酸溶液蚀刻间隔物。

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