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1. 发明授权

US10532046B2 Multi-phase delivery compositions and products incorporating such compositions 有权
公开(公告)号：US10532046B2
公开(公告)日：2020-01-14
申请号：US14958555
申请日：2015-12-03
申请人： Niconovum USA, Inc.
发明人： James William Rogers , Michael F. Davis , Percy D. Phillips , Karen V. Taluskie , Stephen Benson Sears , Ercilia Hernandez Garcia
IPC分类号： A61K9/70 , A61K31/465 , A61K9/00 , A24F23/00 , A24D3/06 , A24D3/04 , A23L27/00 , A61K9/68 , A24B13/00 , A24B15/16 , A24B15/18 , A24B15/28 , A24D1/00 , A24D1/02 , A24F15/00 , A24F47/00
摘要： The present disclosure relates to compositions that are useful in the delivery of various materials. In particular, the compositions comprise a suspension wherein an internal phase material is surrounded by an external phase material. The internal phase specifically can be a hydrophilic material, and the external phase specifically can be a hydrophobic material. The materials are combined so that the internal phase is substantially encapsulated by the external phase such that release can be controlled in relation to osmotic pressure differentials. The suspension can be combined with a carrier, and various systems and products can be formed with the suspension and optional carrier, such as oral strips, spray delivery systems, smokeless tobacco products, aerosol delivery devices, cigarettes, and packaging.

2. 外观设计

USD785277S1 Lozenge 有权
公开(公告)号：USD785277S1
公开(公告)日：2017-05-02
申请号：US29555061
申请日：2016-02-18
申请人： Niconovum USA, Inc.
设计人： E. Matthew Reddick , Travis Swede

3. 发明申请

US20190117779A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITION 审中-公开
公开(公告)号：US20190117779A1
公开(公告)日：2019-04-25
申请号：US16220387
申请日：2018-12-14
申请人： Niconovum USA, Inc.
发明人： Darrell Holton, JR. , Nelly Fransén , Matt Reddick
IPC分类号： A61K47/26 , A23L27/40 , A23L27/30 , A23L27/20 , A61K31/465 , A61K9/20 , A61K9/70 , A61K9/00 , A23L27/10
摘要： A composition intended to be employed for therapeutic purposes incorporates a nicotinic compound, a sugar substitute, and a sugar alcohol syrup. Representative forms of nicotine include free base (e.g., as a mixture of nicotine and microcrystalline cellulose), a nicotine salt (e.g., as nicotine bitartrate) or nicotine polacrilex. The composition is useful for treatment of central nervous system conditions, diseases, and disorders, and as a nicotine replacement therapy.

4. 发明申请

US20170326138A1 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITIONS 审中-公开
公开(公告)号：US20170326138A1
公开(公告)日：2017-11-16
申请号：US15617849
申请日：2017-06-08
申请人： NICONOVUM USA, INC.
发明人： August J. Borschke
IPC分类号： A61K31/498 , A61K9/20 , A61K9/12 , A61K9/00 , A61K9/68 , A61K31/465 , A61K9/16
CPC分类号： A61K31/498 , A61K9/0053 , A61K9/0058 , A61K9/009 , A61K9/12 , A61K9/1652 , A61K9/20 , A61K31/455 , A61K31/465 , A61K2300/00
摘要： A composition intended to be employed for therapeutic purposes incorporates nicotine and at least one other nicotinic compound. Representative forms of nicotine can be as a free base (e.g., as a mixture of nicotine and microcrystalline cellulose), as a form of nicotine salt (e.g., as nicotine bitartrate) or as nicotine polacrilex. The other nicotinic compound is a compound that can be considered to bind selectively to certain nicotinic receptor subtypes, and particularly those of the central nervous system. For example, the other nicotinic compound can be a compound that binds selectively to the nicotinic receptor subtypes α7 or α4β2. The composition is useful for treatment of central nervous system conditions, diseases and disorders, and as a nicotine replacement therapy.

5. 发明申请

US20170157106A1 MULTI-PHASE DELIVERY COMPOSITIONS AND PRODUCTS INCORPORATING SUCH COMPOSITIONS 审中-公开
公开(公告)号：US20170157106A1
公开(公告)日：2017-06-08
申请号：US14958555
申请日：2015-12-03
申请人： Niconovum USA, Inc.
发明人： James William Rogers , Michael F. Davis , Percy D. Phillips , Karen V. Taluskie , Stephen Benson Sears , Ercilia Hernandez Garcia
IPC分类号： A61K31/465 , A24B15/18 , A24F47/00 , A24D1/00 , A24D3/04 , A61K9/00 , A24D1/02 , A24B15/28 , A24F15/00 , A24F23/00 , A24B15/16 , A61K9/70 , A24B13/00 , A24D3/06
CPC分类号： A61K31/465 , A23L27/79 , A24B13/00 , A24B15/10 , A24B15/16 , A24B15/186 , A24B15/282 , A24B15/301 , A24D1/002 , A24D1/025 , A24D3/048 , A24D3/061 , A24F15/00 , A24F23/00 , A24F47/006 , A24F47/008 , A61K9/0053 , A61K9/0056 , A61K9/0058 , A61K9/10 , A61K9/7007 , A61K36/00 , A61K47/44 , B65D85/10 , B65D85/1081 , B65D2203/12
摘要： The present disclosure relates to compositions that are useful in the delivery of various materials. In particular, the compositions comprise a suspension wherein an internal phase material is surrounded by an external phase material. The internal phase specifically can be a hydrophilic material, and the external phase specifically can be a hydrophobic material. The materials are combined so that the internal phase is substantially encapsulated by the external phase such that release can be controlled in relation to osmotic pressure differentials. The suspension can be combined with a carrier, and various systems and products can be formed with the suspension and optional carrier, such as oral strips, spray delivery systems, smokeless tobacco products, aerosol delivery devices, cigarettes, and packaging.

6. 发明授权

US09629832B2 Physically and chemically stable nicotine-containing particulate material 有权
公开(公告)号：US09629832B2
公开(公告)日：2017-04-25
申请号：US14263569
申请日：2014-04-28
申请人： Niconovum USA, Inc.
发明人： Henri Hansson , Arne Kristensen
IPC分类号： A61K9/14 , A61K9/50 , A61K31/4439 , A61K9/68 , A61K9/16 , A61K31/465
CPC分类号： A61K31/4439 , A61K9/0058 , A61K9/146 , A61K9/1617 , A61K9/1652 , A61K31/465
摘要： A nicotine-containing particulate material for release of nicotine, the material comprising a combination of nicotine or a pharmaceutically acceptable salt, complex or solvate thereof and a microcrystalline cellulose, The particulate material is stable upon storage and releases nicotine relatively fast. The particulate material can be used in the manufacture of nicotine-containing pharmaceutical composition, wherein the release of nicotine can be designed to be relatively fast so as to obtain a fast onset of action.

7. 发明申请

WO2017098443A1 PROTEIN-ENRICHED THERAPEUTIC COMPOSITION OF A NICOTINIC COMPOUND 审中-公开
标题翻译：烟碱化合物的富含蛋白质的治疗组合物
公开(公告)号：WO2017098443A1
公开(公告)日：2017-06-15
申请号：PCT/IB2016/057458
申请日：2016-12-09
申请人： NICONOVUM USA, INC.
发明人： MUA, John-Paul , CHEN, Gong , JACKSON, Thaddeus Jude , GERARDI, Anthony Richard , FORD, Kyle , FAGG, Barry Smith , CLARK, Melissa Ann
IPC分类号： A61K47/46 , A61K9/16 , A61K9/20 , A61K31/465
CPC分类号： A61K31/465 , A61K9/0053 , A61K9/0056 , A61K9/1623 , A61K9/1658 , A61K9/1664 , A61K9/2018 , A61K9/2063 , A61K9/2068 , A61K36/81 , A61K45/06 , A61K47/10 , A61K47/26 , A61K47/36 , A61K47/46 , A61K2300/00
摘要： The present disclosure provides protein-enriched, nicotine-containing products, suitable for use as oral formulations. Products of the present disclosure typically include at least one nicotinic compound, at least one protein-enriched material (e.g., a tobacco-derived protein-enriched material), and at least one sugar alcohol.
摘要翻译：本公开提供适合用作口服制剂的富含蛋白质的含尼古丁的产品。本发明的产品通常包含至少一种烟碱化合物，至少一种富含蛋白质的物质（例如烟草衍生的富含蛋白质的物质）和至少一种糖醇。

8. 发明申请

WO2013059592A1 EXCIPIENTS FOR NICOTINE-CONTAINING THERAPEUTIC COMPOSITIONS 审中-公开
标题翻译：含NICOTINE的治疗组合物的成分
公开(公告)号：WO2013059592A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/061023
申请日：2012-10-19
申请人： NICONOVUM USA, INC. , BORSCHKE, August Joseph , HOLTON, JR., Darrell
发明人： BORSCHKE, August Joseph , HOLTON, JR., Darrell
IPC分类号： A61K9/00 , A61K31/465
CPC分类号： A61K9/0056 , A61K9/0043 , A61K9/0058 , A61K31/465
摘要： A composition intended to be employed for therapeutic purposes incorporates an active ingredient (e.g., a source of nicotine) and at a non-active ingredient that is carried by a porous substrate. The non-active ingredient can be a substance that has the capability of affecting the pH of the biological system to which it is applied (e.g., basic substance and/or buffering agent is sorbed onto the porous carrier, so as to be in intimate contact with that carrier). Representative forms of nicotine include free base (e.g., as a mixture of nicotine and microcrystalline cellulose), a nicotine salt (e.g., as nicotine bitartrate) and nicotine polacrilex. The basic substance can be sodium carbonate, and the porous substrate can be microcrystalline cellulose. The composition is useful for treatment of central nervous system conditions, diseases, and disorders, and can be used as a nicotine replacement therapy.
摘要翻译：旨在用于治疗目的的组合物包含活性成分（例如，尼古丁来源）和由多孔底物携带的非活性成分。非活性成分可以是具有影响其所施用的生物系统的pH的能力的物质（例如，碱性物质和/或缓冲剂被吸附到多孔载体上，以便紧密接触与该承运人）。尼古丁的代表性形式包括游离碱（例如，作为尼古丁和微晶纤维素的混合物），尼古丁盐（例如作为酒石酸烟碱）和尼古丁polacrilex。碱性物质可以是碳酸钠，多孔基材可以是微晶纤维素。该组合物可用于治疗中枢神经系统疾病和疾病，并可用作尼古丁替代疗法。

9. 发明申请

US20200121670A1 MULTI-PHASE DELIVERY COMPOSITIONS AND PRODUCTS INCORPORATING SUCH COMPOSITIONS 审中-公开
公开(公告)号：US20200121670A1
公开(公告)日：2020-04-23
申请号：US16718562
申请日：2019-12-18
申请人： Niconovum USA, Inc.
发明人： James William Rogers , Michael F. Davis , Percy D. Phillips , Karen V. Taluskie , Stephen Benson Sears , Ercilia Hernandez Garcia
IPC分类号： A61K31/465 , A24D1/02 , A24D1/00 , A24B15/28 , A24B15/18 , A24B15/16 , A24B13/00 , A61K9/70 , A61K9/00 , A24F23/00 , A24F15/00 , A24D3/06 , A24D3/04 , A24F42/10 , A24F40/00
摘要： The present disclosure relates to compositions that are useful in the delivery of various materials. In particular, the compositions comprise a suspension wherein an internal phase material is surrounded by an external phase material. The internal phase specifically can be a hydrophilic material, and the external phase specifically can be a hydrophobic material. The materials are combined so that the internal phase is substantially encapsulated by the external phase such that release can be controlled in relation to osmotic pressure differentials. The suspension can be combined with a carrier, and various systems and products can be formed with the suspension and optional carrier, such as oral strips, spray delivery systems, smokeless tobacco products, aerosol delivery devices, cigarettes, and packaging.

10. 发明授权

US10219999B2 Snuff composition 有权
公开(公告)号：US10219999B2
公开(公告)日：2019-03-05
申请号：US13690531
申请日：2012-11-30
申请人： Niconovum USA, Inc.
发明人： Anders Axelsson , Arne Kristensen , Henri Hansson
IPC分类号： A61K9/00 , A24B13/00 , A24B15/14 , A61K31/465 , A61K9/14
摘要： Use of a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.

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