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1. 发明专利

JP2011147797A Method and apparatus for performing intra-operative angiography 有权
标题翻译：用于执行手术血管造影的方法和装置
公开(公告)号：JP2011147797A
公开(公告)日：2011-08-04
申请号：JP2011053502
申请日：2011-03-10
申请人： Natl Research Council Of Canada , ナショナル・リサーチ・カウンシル・オブ・カナダ
发明人： DOCHERTY JOHN C , HEWKO MARK , MANGAT GURPREET , FLOWER ROBERT W , CHARI SESHADRI M
IPC分类号： A61B5/00 , A61B10/00 , A61B1/00 , A61B5/026 , A61B5/0275
CPC分类号： A61B5/0275 , A61B5/0261
摘要： PROBLEM TO BE SOLVED: To provide methods for evaluate the patency of vessels that have undergone an invasive procedure such as a bypass graft procedure, and for evaluating the extent of blood flow downstream of a graft. SOLUTION: A device includes a laser 1 which emits radiation at a wavelength, that causes any of agent located within the vasculature or tissue of interest 3 irradiated thereby to emit radiation of a particular wavelength, to excite a fluorescent imaging agent. A camera capable of obtaining multiple images over a period of time, such as a CCD camera 2, may be used to capture the emissions from the imaging agent. A bandpass filter 6 prevents capture of radiation other than that emitted by the imaging agent. A distance sensor 9 incorporates a visual display 9a which provides feedback to a physician so that the laser is located a distance from the vessel of interest that is optimal for the capture of high quality images. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于评估已经经历诸如旁路移植手术的侵入性手术的血管的通畅以及用于评估移植物下游的血流程度的方法。解决方案：装置包括发射波长的辐射的激光器1，其使得位于由其照射的脉管系统或感兴趣组织3内的任何药剂发射特定波长的辐射，以激发荧光成像剂。可以使用能够在一段时间内获得多个图像（例如CCD照相机2）的相机来捕获来自成像剂的发射。带通滤波器6防止除了由成像剂发射的辐射之外的辐射。距离传感器9包括视觉显示器9a，其向医师提供反馈，使得激光器位于与捕获高质量图像最佳的感兴趣的血管之间的距离处。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2008285675A Modified meningococcal polysaccharide conjugate vaccine 审中-公开
标题翻译：改良肉桂酸多糖联合疫苗
公开(公告)号：JP2008285675A
公开(公告)日：2008-11-27
申请号：JP2008126880
申请日：2008-05-14
申请人： Natl Research Council Of Canada , ナショナル・リサーチ・カウンシル・オブ・カナダ
发明人： JENNINGS HAROLD J , PON ROBERT , LUSSIER MICHELE , MICHON FRANCIS
IPC分类号： A61K39/02 , C08B37/00 , A61K20060101 , A61K39/08 , A61K39/095 , A61K39/108 , A61K39/385 , A61P31/04 , A61P37/04 , C07K14/22 , C07K14/33 , C07K14/34 , C07K16/12
CPC分类号： A61K39/08 , A61K39/095 , A61K2039/55505 , A61K2039/6037 , Y10S424/831
摘要： PROBLEM TO BE SOLVED: To provide a polysaccharide derivative useful for producing a vaccine preventing meningitis caused by group B Neisseria meningitidis or E. coli K1.
SOLUTION: Disclosed are: a polysaccharide of group B Neisseria meningitidis or E. coli K1 having a sialic acid residue substituted with an unsaturated acyl group (C3-4); a conjugate molecule of the unsaturated C2-4N-acyl derivative polysaccharide covalently bound with an immunologically pertinent proteins (a modified toxin of Clostridium tetani, a modified toxin of diphtheria, envelope proteins of CRM197 and meningococcus, etc.); and further a vaccine composition including the conjugate molecule having higher immunogenicity and lower induction of cross-reacting antibodies compared with natural polysaccharides.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供可用于制备由B组脑膜炎奈瑟氏球菌或大肠杆菌K1引起的预防脑膜炎疫苗的多糖衍生物。解决方案：公开了具有被不饱和酰基（C3-4）取代的唾液酸残基的B组脑膜炎奈瑟氏球菌或大肠杆菌K1的多糖; 与免疫相关蛋白（破伤风梭菌的修饰毒素，白喉的修饰毒素，CRM197和脑膜炎球菌的包膜蛋白等）共价结合的不饱和C2-4N酰基衍生多糖的共轭分子; 并且还包含与天然多糖相比具有更高免疫原性的共轭分子和交叉反应抗体诱导较低的疫苗组合物。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2009132727A Group b streptococcus-type ii and type v polysaccharide-protein conjugate vaccine 审中-公开
标题翻译： B组STREPTOCOCCUS-II型和V型多糖 - 蛋白质结合疫苗
公开(公告)号：JP2009132727A
公开(公告)日：2009-06-18
申请号：JP2009055767
申请日：2009-03-09
申请人： Brigham & Women's Hospital Inc , Natl Research Council Of Canada , ナショナル・リサーチ・カウンシル・オブ・カナダNational Research Council Of Canada , ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド
发明人： JENNINGS HAROLD J , KASPER DENNIS L
IPC分类号： A61K39/09 , C07K14/33 , A61K20060101 , A61K39/00 , A61K39/102 , A61K39/108 , A61K39/116 , A61K39/385 , A61K47/48 , A61P3/10 , A61P31/04 , A61P35/00 , A61P37/04 , C07K14/315 , C07K14/34 , C12P21/00
CPC分类号： A61K39/092 , A61K47/646 , A61K2039/55 , A61K2039/6037 , Y10S530/813 , Y10S530/825
摘要： PROBLEM TO BE SOLVED: To provide vaccines and methods of immunizing mammals including humans against infection by Group B streptococcus type II (GBS II) and/or Group B streptococcus type V (GBS V).
SOLUTION: There are provided antigenic conjugate molecules comprising a capsular polysaccharide derived from a Group B streptococcus (GBS) type V bacteria and a protein component, wherein two or more side chains terminating in sialic acid residues are each linked through a secondary amine bond to protein. The molecular weight of the polysaccharide is at least 5,000 Daltons.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供免疫哺乳动物（包括人）免疫B型链球菌II型（GBS II）和/或B型V链球菌（GBS V）感染的疫苗和方法。提供了包含衍生自B型链球菌（GBS）V型细菌的荚膜多糖和蛋白质组分的抗原性缀合物分子，其中两个或更多个终止于唾液酸残基的侧链各自通过仲胺连接与蛋白质结合。多糖的分子量至少为5,000道尔顿。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2006192280A Method and apparatus for performing intra-operative angiography 审中-公开
标题翻译：用于执行手术血管造影的方法和装置
公开(公告)号：JP2006192280A
公开(公告)日：2006-07-27
申请号：JP2006016878
申请日：2006-01-25
申请人： Natl Research Council Of Canada , ナショナル・リサーチ・カウンシル・オブ・カナダ
发明人： DOCHERTY JOHN C , HEWKO MARK , MANGAT GURPREET , FLOWER ROBERT W , CHARI SESHADRI M
IPC分类号： A61B5/00 , A61B10/00 , A61B1/00 , A61B5/026 , A61B5/0275
CPC分类号： A61B5/0275 , A61B5/0261
摘要： PROBLEM TO BE SOLVED: To provide an apparatus to display a diagnosis procedure by which a physician can evaluate the patency of a blood vessel subjected an invasive procedure such as the bypass graft procedure. SOLUTION: The apparatus is provided with a laser (1) for exciting the fluorescent imaging agent which emits radiation at a wavelength that causes any of the agent located within the vasculature or tissue of interest (3) irradiated thereby to emit radiation of a particular wavelength. Advantageously, a camera capable of obtaining multiple images over a period of time, such as a CCD camera (2) may be used to capture the emissions from the imaging agent. A band-pass filter (6) prevents the capture of radiation other than that emitted by the imaging agent. A distance sensor (9) incorporates a visual display (9a) providing feedback to the physician saying that the laser be located at a distance from the vessel of interest that is optimal for the capture of high quality images. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种显示诊断程序的装置，通过该诊断程序，医师可以评估经受诸如旁路移植手术的侵入性手术的血管的通畅。解决方案：该装置设置有用于激发荧光成像剂的激光（1），该荧光成像剂以一定波长发射辐射，该波长使得位于由其照射的脉管系统或感兴趣组织（3）内的任何药剂发射辐射一个特定的波长。有利地，可以使用能够在一段时间内获得多个图像（例如CCD照相机（2））的相机来捕获来自成像剂的发射。带通滤波器（6）防止除了由成像剂发射的辐射之外的辐射的捕获。距离传感器（9）包括向医师提供反馈的视觉显示器（9a），其指示激光器位于与捕获高质量图像最佳的感兴趣的血管相距一定距离处。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2005306884A Group b streptococcus type ii and type v polysaccharide-protein conjugate vaccine 有权
标题翻译： B型STREPTOCOCCUS II型和V型多糖 - 蛋白质结合疫苗
公开(公告)号：JP2005306884A
公开(公告)日：2005-11-04
申请号：JP2005196902
申请日：2005-07-05
申请人： Brigham & Women's Hospital Inc , Natl Research Council Of Canada , ナショナル・リサーチ・カウンシル・オブ・カナダNational Research Council Of Canada , ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド
发明人： JENNINGS HAROLD J , KASPER DENNIS L
IPC分类号： A61K39/09 , A61K20060101 , A61K39/102 , A61K39/108 , A61K39/116 , A61K39/385 , A61K47/48 , A61P3/10 , A61P31/04 , A61P35/00 , A61P37/04 , C07K14/315 , C12P21/00
CPC分类号： A61K39/092 , A61K47/646 , A61K2039/55 , A61K2039/6037 , Y10S530/813 , Y10S530/825
摘要： PROBLEM TO BE SOLVED: To provide a vaccine and a method for immunizing mammals, including humans against infection with Group B streptococcus type II (GBS II) and/or Group B streptococcus type V (GBS V).
SOLUTION: This invention relates to an antigenic conjugate molecule comprising a capsular polysaccharide originating from type V group B Streptococcus cocei (GBS) and a protein component wherein two or more side chains terminating in sialic acid residues of the polysaccharide component are each linked through a secondary amine bond to the protein and wherein the molecular weight of the polysaccharide is at least 5000 daltons.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供疫苗和用于免疫哺乳动物（包括人）免受B组链球菌II型（GBS II）和/或B族链球菌V型（GBS V）感染的方法。解决方案：本发明涉及包含源自V族B族链球菌（GBS）的荚膜多糖的抗原性缀合物分子和蛋白质成分，其中以多糖成分的唾液酸残基终止的两个或更多个侧链各自连接通过与蛋白质的仲胺键，并且其中多糖的分子量为至少5000道尔顿。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2011151019A Phase contrast imaging and preparing tem for phase contrast imaging 有权
标题翻译：相位对比成像和准备相位对比成像的TEM
公开(公告)号：JP2011151019A
公开(公告)日：2011-08-04
申请号：JP2011007213
申请日：2011-01-17
申请人： Natl Research Council Of Canada , ナショナル・リサーチ・カウンシル・オブ・カナダ
发明人： MALAC MAREK , BELEGGIA MARCO , KAWASAKI MASAHIRO , EGERTON RAY
IPC分类号： H01J37/295 , H01J37/12 , H01J37/26
CPC分类号： H01J37/26 , H01J37/04 , H01J2237/2614
摘要： PROBLEM TO BE SOLVED: To provide a new method for phase contrast imaging in transmission electron microscopy. SOLUTION: In the method, an imaging electron beam itself is used to prepare a hole-free thin film for use as an effective phase plate, in some cases eliminating the need for ex-situ fabrication of a hole and reducing requirements for the precision of the ZPP hardware. The electron optical properties of the ZPP hardware are modified primarily in two ways: by boring a hole using the electron beam; and/or by modifying the electro-optical properties by charging induced by the primary beam. Furthermore a method where the sample is focused by a lens downstream from the ZPP hardware is disclosed. A method for transferring a back focal plane of the objective lens to a selected area aperture plane and optional plane conjugated with the back focal plane of the objective lens is also provided. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供透射电子显微镜相位成像的新方法。解决方案：在该方法中，使用成像电子束本身来制备用作有效相位板的无孔薄膜，在一些情况下消除了对孔的非原位制造的需要，并且减少了对 ZPP硬件的精度。 ZPP硬件的电子光学特性主要通过两种方式进行修改：通过使用电子束钻孔; 和/或通过由主光束引起的充电来改变电光特性。此外，公开了一种通过ZPP硬件下游的透镜来聚焦样品的方法。还提供了将物镜的后焦平面转移到与物镜的后焦平面共轭的选定区域孔径平面和可选平面的方法。版权所有（C）2011，JPO＆INPIT

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