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1. 发明申请

WO2004080404A3 IL-2 TRANSMEMBRANE CONSTRUCTS 审中-公开
标题翻译： IL-2 TRANSMEMBRANE结构
公开(公告)号：WO2004080404A3
公开(公告)日：2006-09-28
申请号：PCT/US2004007012
申请日：2004-03-08
申请人： UNIV UTAH RES FOUND , SAMLOWSKI WOLFRAM , ADAMS NATHAN BRADLEY , MCGREGOR JOHN
发明人： SAMLOWSKI WOLFRAM , ADAMS NATHAN BRADLEY , MCGREGOR JOHN
IPC分类号： C12N5/10 , A61K38/00 , A61K48/00 , B65D51/28 , C07K14/54 , C07K14/55 , C07K14/735 , C12N15/12 , C12N15/26 , C12N15/63 , C12N15/64
CPC分类号： C07K14/55 , A61K38/00 , C07K14/70535 , C07K2319/03 , C07K2319/20
摘要： Compounds, genetic constructs, and cancer treatment methods 035 provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fce-? transmembrane anchor derived from a subunit of the FC epsilon receptor. mRNA and the IL2tm fusion protein was expressed in transfected RD995 tumor cells. Expression of the IL2tm protein on the tumor A511 surface membrane was confirmed by microscopy. RD995 ce11s transfected with IL-2tm or pCMV2b (empty expression vector) were implanted subcutaneously into C3H /HEN mice. Tumors in groups of mice implanted with 10 6 or 10 5 RD995 ce11s transfected with IL-2tm grew slower than controls. Without being limited to any one theory, it is believed that selective expression of cytokines such as IL-2 on the surface of tumors is likely to stimulate tumor-infiltrating lymphocytes that are primed and already recognize tumor antigens, enhancing tumor recognition and killing, potentially avoiding toxicity associated with known cytokine therapies.
摘要翻译：提供化合物，遗传构建体和癌症治疗方法035。设计表达载体表达融合基因，包括hIL-2与Fce- 源自FC epsilon受体亚基的跨膜锚。 mRNA和IL2tm融合蛋白在转染的RD995肿瘤细胞中表达。通过显微镜证实IL2tm蛋白在肿瘤A511表面膜上的表达。将用IL-2tm或pCMV2b（空载体）转染的RD995 ce11s皮下植入C3H / HEN小鼠。植入用IL-2tm转染的10×10 6个或10 5个RD995 ce11的小鼠组的肿瘤生长慢于对照组。不限于任何一种理论，认为在肿瘤表面上的细胞因子如IL-2的选择性表达可能刺激被引发并已经识别肿瘤抗原的肿瘤浸润淋巴细胞，增强肿瘤识别和杀死潜力避免与已知细胞因子疗法相关的毒性。

2. 发明申请

WO2004080404A2 IL-2 TRANSMEMBRANE CONSTRUCTS 审中-公开
标题翻译： IL-2 TRANSMEMBRANE结构
公开(公告)号：WO2004080404A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/007012
申请日：2004-03-08
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , SAMLOWSKI, Wolfram , ADAMS, Nathan, Bradley , MCGREGOR, John
发明人： SAMLOWSKI, Wolfram , ADAMS, Nathan, Bradley , MCGREGOR, John
IPC分类号： A61K
CPC分类号： C07K14/55 , A61K38/00 , C07K14/70535 , C07K2319/03 , C07K2319/20
摘要： Compounds, genetic constructs, and cancer treatment methods 035 provided. Expression vectors were designed to express fusion genes including hIL-2 with 0 FcT- ? transmembrane anchor derived from 0 subunit of the FC epsilon receptor. mRN 0nd the IL2tm fusion protein was expressed in transfected RD995 tumor cells. Expression of the IL2tm protein on the tumor A511 surface membrane was confirmed by microscopy. RD995 ce11s transfected with IL-2tm or pCMV2b (empty expression vector) were implanted subcutaneously into !3 /HEN mice. Tumors in groups of mice implanted with 10 6 or 10 5 RD995 ce11s transfected with IL-2tm grew slower than controls. Without being limited to any one theory, it is believed that selective expression >f cytokines such as IL-2 on the surface >f tumors is likely to stimulate tumor-infiltrating lymphocytes that are primed and already recognize tumor antigens, enhancing tumor recognition 0nd killing, potentially avoiding toxicity associated with known cytokine therapies.
摘要翻译：提供化合物，遗传构建体和癌症治疗方法035。设计表达载体以表达融合基因，包括hIL-2与来自FCε受体的0亚基的0 FcT-跨膜锚。 mRN 0，IL2tm融合蛋白在转染的RD995肿瘤细胞中表达。通过显微镜证实IL2tm蛋白在肿瘤A511表面膜上的表达。将用IL-2tm或pCMV2b（空表达载体）转染的RD995 ce11s皮下植入！3 / HEN小鼠。植入用IL-2tm转染的10 6或10 5 RD995 ce11s的小鼠组的肿瘤生长慢于对照组。不限于任何一种理论，认为在表面> f肿瘤上的选择性表达> f细胞因子如IL-2可能刺激被引发并已经识别肿瘤抗原的肿瘤浸润性淋巴细胞，增强肿瘤识别第0次杀死，可能避免与已知的细胞因子疗法相关的毒性。

3. 发明授权

US08926257B2 Gripping device for articulated work machine 有权
标题翻译：铰接式工作机械夹紧装置
公开(公告)号：US08926257B2
公开(公告)日：2015-01-06
申请号：US13343781
申请日：2012-01-05
申请人： Nathan Bradley , Matthew J. Hennemann , Michael R. Heiar , Bradley O'Connor , David J. Sanning , Matthew Wagenbach
发明人： Nathan Bradley , Matthew J. Hennemann , Michael R. Heiar , Bradley O'Connor , David J. Sanning , Matthew Wagenbach
IPC分类号： E02F3/40
CPC分类号： E02F3/404 , E02F3/364 , E02F3/38
摘要： A work machine includes a pivotable arm having a first gripping device formed therein, the arm operatively connected to an attachment for securing an object between the first gripping device and the attachment. A second gripping device is removably securable to the arm near the first gripping device, the second gripping device configured to at least partially secure an object between the second gripping device and the attachment.
摘要翻译：工作机器包括具有形成在其中的第一夹紧装置的可枢转臂，所述臂可操作地连接到用于将物体固定在第一夹持装置和附件之间的附件。第二夹持装置可移除地固定到靠近第一夹持装置的臂上，第二夹持装置构造成至少部分地将物体固定在第二夹持装置和附件之间。

4. 发明申请

US20130177382A1 GRIPPING DEVICE FOR ARTICULATED WORK MACHINE 有权
标题翻译：用于工程机械的搬运装置
公开(公告)号：US20130177382A1
公开(公告)日：2013-07-11
申请号：US13343781
申请日：2012-01-05
申请人： Nathan BRADLEY , Matthew J. Hennemann , Michael R. Heiar , Bradley O'connor , David J. Sanning , Matthew Wagenbach
发明人： Nathan BRADLEY , Matthew J. Hennemann , Michael R. Heiar , Bradley O'connor , David J. Sanning , Matthew Wagenbach
IPC分类号： B66C1/42 , E02F3/96
CPC分类号： E02F3/404 , E02F3/364 , E02F3/38
摘要： A work machine includes a pivotable arm having a first gripping device formed therein, the arm operatively connected to an attachment for securing an object between the first gripping device and the attachment. A second gripping device is removably securable to the arm near the first gripping device, the second gripping device configured to at least partially secure an object between the second gripping device and the attachment.
摘要翻译：工作机器包括具有形成在其中的第一夹持装置的可枢转臂，所述臂可操作地连接到用于将物体固定在第一夹持装置和附件之间的附件。第二夹持装置可移除地固定到靠近第一夹持装置的臂上，第二夹持装置构造成至少部分地将物体固定在第二夹持装置和附件之间。

5. 外观设计

USD646306S1 Equipment boom 有权
标题翻译：设备繁荣
公开(公告)号：USD646306S1
公开(公告)日：2011-10-04
申请号：US29386010
申请日：2011-02-23
申请人： Nathan Bradley , Matthew Wagenbach , Daniel Morrow , Carl Hagele
设计人： Nathan Bradley , Matthew Wagenbach , Daniel Morrow , Carl Hagele

6. 发明授权

US09334624B2 Articulated work machine 有权
标题翻译：铰接式作业机
公开(公告)号：US09334624B2
公开(公告)日：2016-05-10
申请号：US13554522
申请日：2012-07-20
申请人： Nathan Bradley , Matthew D. Wagenbach , Jason Mattice , Ronald C. Natzke , Ralph D. Galloway
发明人： Nathan Bradley , Matthew D. Wagenbach , Jason Mattice , Ronald C. Natzke , Ralph D. Galloway
IPC分类号： E02F3/38 , E02F3/96
CPC分类号： E02F3/964 , E02F3/38
摘要： An articulating member of a work machine includes a side plate of an opposed pair of side plates, each side plate of the pair of side plates having a surface facing the other side plate. At least one mount forming a pivot joint is secured to corresponding portions of each facing surface of a side plate of the pair of side plates. A separator plate is positioned between the pair of side plates. A reinforcement member has a peripheral edge collectively secured to one side plate surface, the at least one mount and the separator plate. The reinforcement member forms a continuous compartment spaced from the surface of the side plate, the peripheral edge forms a continuous connection with the one side plate surface, the at least one mount and the separator plate, and the at least one mount is fully secured to the one side plate surface.
摘要翻译：作业机械的铰接构件包括相对的一对侧板的侧板，该对侧板的每个侧板具有面对另一侧板的表面。形成枢转接头的至少一个安装件固定到一对侧板的侧板的每个相对表面的对应部分。分隔板位于一对侧板之间。加强构件具有集中地固定到一个侧板表面的外围边缘，至少一个安装件和隔板。加强构件形成与侧板的表面间隔开的连续隔室，周边边缘与一个侧板表面，至少一个安装件和隔离板形成连续连接，并且至少一个安装件完全固定到一侧板表面。

7. 发明申请

US20130051965A1 ARTICULATED WORK MACHINE 有权
标题翻译：工艺机械
公开(公告)号：US20130051965A1
公开(公告)日：2013-02-28
申请号：US13554522
申请日：2012-07-20
申请人： Nathan BRADLEY , Matthew D. Wagenbach , Jason Mattice , Ronald C. Natzke , Ralph D. Galloway
发明人： Nathan BRADLEY , Matthew D. Wagenbach , Jason Mattice , Ronald C. Natzke , Ralph D. Galloway
IPC分类号： E02F9/14 , B23K31/02 , E02F3/38
CPC分类号： E02F3/964 , E02F3/38
摘要： An articulating member of a work machine includes a side plate of an opposed pair of side plates, each side plate of the pair of side plates having a surface facing the other side plate. At least one mount forming a pivot joint is secured to corresponding portions of each facing surface of a side plate of the pair of side plates. A separator plate is positioned between the pair of side plates. A reinforcement member has a peripheral edge collectively secured to one side plate surface, the at least one mount and the separator plate. The reinforcement member forms a continuous compartment spaced from the surface of the side plate, the peripheral edge forms a continuous connection with the one side plate surface, the at least one mount and the separator plate, and the at least one mount is fully secured to the one side plate surface.
摘要翻译：作业机械的铰接构件包括相对的一对侧板的侧板，该对侧板的每个侧板具有面对另一侧板的表面。形成枢转接头的至少一个安装件固定到一对侧板的侧板的每个相对表面的对应部分。分隔板位于一对侧板之间。加强构件具有集中地固定到一个侧板表面的外围边缘，至少一个安装件和隔板。加强构件形成与侧板的表面间隔开的连续隔室，周边边缘与一个侧板表面，至少一个安装件和隔离板形成连续连接，并且至少一个安装件完全固定到一侧板表面。

8. 发明申请

US20080011839A1 Material hauling and delivery monitoring system 审中-公开
标题翻译：物料运输和运输监控系统
公开(公告)号：US20080011839A1
公开(公告)日：2008-01-17
申请号：US11243013
申请日：2005-10-03
申请人： Joseph David Noll , Nathan Bradley Noll
发明人： Joseph David Noll , Nathan Bradley Noll
IPC分类号： G07B15/02 , G05D1/00
CPC分类号： G06Q10/08
摘要： A system and apparatus monitors dump truck loads and activity. A truck picks up a load and haul ticket at one location, such as a gravel or sand pit, and delivers them to another, such as a job fill site. An operator at the job site scans a bar code on the truck to log arrival of the load and creates a scan record of the arriving or departing truck. A touch screen on the scanner may be used to enter optional numeric data from other sources such as the haul ticket or truck odometer. The operator's hand-held, cellular- or radio-based scanner connects directly to a centralized data processor and uploads scan records through a wireless, internet-based communication link. From such truck and load data, the processor provides contemporaneous reports via internet connection about truck identifications, load sizes and actual delivery times of loads, enabling efficient, automated job management and accounting for invoicing and job site volume of hauling activity, while displacing the laborious handling of manual haul tickets issued at the pickup site and collected by the operator.
摘要翻译：系统和设备监测自卸车的负载和活动。一辆卡车在一个位置（例如砾石或沙坑）拾起装载和运送车票，并将其运送到另一个位置，例如填补工地。作业现场的操作人员扫描卡车上的条形码以记录装载的到达，并创建到达或离开的卡车的扫描记录。扫描仪上的触摸屏可用于从其他来源（例如运输车票或卡车里程表）输入可选的数字数据。操作员的手持式，基于蜂窝式或基于无线电的扫描仪直接连接到集中式数据处理器，并通过无线，基于互联网的通信链路上传扫描记录。从这样的卡车和负载数据，处理器通过互联网连接提供有关卡车识别，负载大小和负载实际交货时间的同期报告，实现高效，自动化的工作管理和会计发票和作业现场的运输活动量，同时取代费力处理提货地点发出的手动运输车票，由运营人收集。

9. 外观设计

USD678919S1 Equipment dipperstick 有权
标题翻译：设备手杖
公开(公告)号：USD678919S1
公开(公告)日：2013-03-26
申请号：US29385995
申请日：2011-02-23
申请人： Nathan Bradley , Matthew Wagenbach , Daniel Morrow , Michael Heiar , Carl Hagele
设计人： Nathan Bradley , Matthew Wagenbach , Daniel Morrow , Michael Heiar , Carl Hagele

10. 发明授权

US07407777B2 IL-2 transmembrane construct 失效
标题翻译： IL-2跨膜构建体
公开(公告)号：US07407777B2
公开(公告)日：2008-08-05
申请号：US10548153
申请日：2004-03-08
申请人： Wolfram Samlowski , Nathan Bradley Adams , John McGregor
发明人： Wolfram Samlowski , Nathan Bradley Adams , John McGregor
IPC分类号： C12N5/10 , C12N15/62 , C12N15/63
CPC分类号： C07K14/55 , A61K38/00 , C07K14/70535 , C07K2319/03 , C07K2319/20
摘要： Compounds, genetic constructs, and cancer treatment methods are provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fcε-γ transmembrane anchor derived from a subunit of the FC epsilon receptor. mRNA and the IL-2tm fusion protein was expressed in transfected RD995 tumor cells. Expression of the IL-2tm protein on the tumor cell surface membrane was confirmed by microscopy. RD995 cells transfected with IL-2tm or pCMV2b (empty expression vector) were implanted subcutaneously into C3H/HEN mice. Tumors of mice implanted with 106 or 105 RD995 cells transfected with IL-2tm grew slower than controls. It is believed that selective expression of cytokines such as IL-2 on the surface of tumors is likely to stimulate tumor-infiltrating lymphocytes that are primed and already recognize tumor antigens, enhancing tumor recognition and killing, potentially avoiding toxicity associated with known cytokine therapies.
摘要翻译：提供了化合物，遗传构建体和癌症治疗方法。设计表达载体用来源自FCε受体亚基的Fcepsilon-gamma跨膜锚来表达包括hIL-2的融合基因。 mRNA和IL-2tm融合蛋白在转染的RD995肿瘤细胞中表达。通过显微镜证实IL-2tm蛋白在肿瘤细胞表面膜上的表达。将用IL-2tm或pCMV2b（空载体）转染的RD995细胞皮下植入C3H / HEN小鼠。植入用IL-2tm转染的10×10 6或10×10 4 RD995细胞的小鼠的肿瘤生长慢于对照。据信，在肿瘤表面的细胞因子如IL-2的选择性表达可能刺激被引发并已经识别肿瘤抗原的肿瘤浸润淋巴细胞，增强肿瘤识别和杀死，潜在地避免与已知的细胞因子疗法相关的毒性。

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