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1. 发明申请

US20060111551A1 Peptide having HTLV-1-specific CTL-inducing activity 审中-公开
标题翻译：具有HTLV-1特异性CTL诱导活性的肽
公开(公告)号：US20060111551A1
公开(公告)日：2006-05-25
申请号：US11251195
申请日：2005-10-14
申请人： Nanae Harashima , Mari Kannagi
发明人： Nanae Harashima , Mari Kannagi
IPC分类号： C12Q1/68 , C07K14/00 , C07K16/00 , A61K38/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/14022
摘要： The present invention provides a peptide having HTLV-I-specific CTL-inducing activity that can induce cytotoxic T cells (CTL) having anti-tumor effect to human T cell leukemia virus-I (HTLV-I) tumor such as adult T-cell leukemia (ATL); a vaccine to induce immune response by using these; a diagnostic agent to examine immune function or the like. By investigating cellular immune response of ATL patient having obtained complete remission after hematopoietic stem cell transplantation (HSCT) from a HLA-identical sibling donor, HTLV-I-specific CTLs were induced only to HLA-A2 restricted Tax301-309 epitope that have proliferated actively by responding to auto-HTLV-I infected T cells constructed in vitro before HSCT, in the culture solution of peripheral blood mononuclear cells (PBMC) of post-HSCT ATL patient. This suggests that this epitope was strongly expressed in the patient body suggesting that the epitope is useful as vaccine antigen.
摘要翻译：本发明提供具有HTLV-1特异性CTL诱导活性的肽，其能够诱导对人T细胞白血病病毒I（HTLV-1）肿瘤具有抗肿瘤作用的细胞毒性T细胞（CTL），例如成人T细胞白血病（ATL）; 通过使用这些疫苗诱导免疫反应; 检查免疫功能等的诊断剂。通过研究来自HLA相同同胞供者的造血干细胞移植（HSCT）获得完全缓解的ATL患者的细胞免疫应答，HTLV-1特异性CTL仅诱导积极增殖的HLA-A2限制性的Tax301-309表位通过在HSCT ATL患者的外周血单核细胞（PBMC）的培养液中响应在HSCT之前体外构建的自身HTLV-1感染的T细胞。这表明该表位在患者体内强烈表达，表明表位可用作疫苗抗原。

2. 发明授权

US08921050B2 Methods of diagnosing renal cell carcinoma 有权
标题翻译：诊断肾细胞癌的方法
公开(公告)号：US08921050B2
公开(公告)日：2014-12-30
申请号：US12293180
申请日：2007-03-16
申请人： Richard William Wyatt Childs , Yoshiyuki Takahashi , Sachiko Kajigaya , Nanae Harashima
发明人： Richard William Wyatt Childs , Yoshiyuki Takahashi , Sachiko Kajigaya , Nanae Harashima
IPC分类号： A61K39/00 , C12N5/0783 , A61K35/12 , C12N5/0784 , A61P35/00 , C12Q1/70 , A61K39/21 , C07K14/005
CPC分类号： C12N5/0638 , A61K35/12 , A61K35/17 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/585 , C07K14/005 , C12N2740/10022 , C12N2740/10034
摘要： Compositions and methods are provided for preventing or treating neoplastic disease in a mammalian subject. A composition is provided which comprises an enriched immune cell population reactive to a human endogenous retrovirus type E antigen on a tumor cell. A method of treating a neoplastic disease in a mammalian subject is provided which comprises administering to a mammalian subject a composition comprising an enriched immune cell population reactive to a human endogenous retrovirus type E antigen, in an amount effective to reduce or eliminate the neoplastic disease or to prevent its occurrence or recurrence.
摘要翻译：提供用于预防或治疗哺乳动物受试者的肿瘤疾病的组合物和方法。提供了一种组合物，其包含对肿瘤细胞上的人内源性逆转录病毒E型抗原具有反应性的富集的免疫细胞群体。提供了治疗哺乳动物受试者中的肿瘤疾病的方法，其包括向哺乳动物受试者施用包含有效减少或消除肿瘤性疾病的量的包含对人内源性逆转录病毒E型抗原具有反应性的富集的免疫细胞群的组合，或以防止其发生或复发。

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