专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008008732A2 SUBSTITUTED AMINOPYRIDINES AS FLUORESCENT REPORTERS FOR AMIDE HYDROLASES 审中-公开
标题翻译：取代的氨基吡啶作为荧光报告用于酰胺水解物
公开(公告)号：WO2008008732A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073076
申请日：2007-07-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HAMMOCK, Bruce D. , HUANG, Huazhang , NISHI, Kosuke
发明人： HAMMOCK, Bruce D. , HUANG, Huazhang , NISHI, Kosuke
IPC分类号： C07K5/06
CPC分类号： C07D213/75
摘要： The present invention provides conjugates comprising a substituted aminopyridine covalently attached to an organic molecule via an amide bond. Such conjugates find utility as substrates for amide hydrolases, where the substituted aminopyridine acts as a fluorescent reporter of amide hydrolase activity. As a result, the conjugates described herein can advantageously be used in assays to detect amide hydrolase activity based upon measuring the fluorescence of a substituted aminopyridine that is released after amide hydrolysis. The conjugates of the present invention are also particularly useful in screening assays, which enable the identification of inhibitory molecules for amide hydrolases and other enzymes. The identified amide hydrolase inhibitors can be used in the treatment of a variety of diseases and disorders associated with aberrant amide hydrolase activity.
摘要翻译：本发明提供包含通过酰胺键共价连接至有机分子的取代氨基吡啶的缀合物。这种缀合物可用作酰胺水解酶的底物，其中取代的氨基吡啶充当酰胺水解酶活性的荧光报道分子。结果，基于测量酰胺水解后释放的取代的氨基吡啶的荧光，本文所述的缀合物可有利地用于测定中以检测酰胺水解酶活性。本发明的缀合物在筛选测定中也特别有用，其能够鉴定酰胺水解酶和其它酶的抑制性分子。所鉴定的酰胺水解酶抑制剂可用于治疗与异常酰胺水解酶活性相关的多种疾病和病症。

2. 发明申请

WO2008008732A3 SUBSTITUTED AMINOPYRIDINES AS FLUORESCENT REPORTERS FOR AMIDE HYDROLASES 审中-公开
标题翻译：作为酰胺水溶液的荧光报告物的替代氨基亚胺
公开(公告)号：WO2008008732A3
公开(公告)日：2008-12-18
申请号：PCT/US2007073076
申请日：2007-07-09
申请人： UNIV CALIFORNIA , HAMMOCK BRUCE D , HUANG HUAZHANG , NISHI KOSUKE
发明人： HAMMOCK BRUCE D , HUANG HUAZHANG , NISHI KOSUKE
IPC分类号： C12Q1/34 , C07D213/75 , C07K2/00 , C12Q1/37
CPC分类号： C07D213/75
摘要： The present invention provides conjugates comprising a substituted aminopyridine covalently attached to an organic molecule via an amide bond. Such conjugates find utility as substrates for amide hydrolases, where the substituted aminopyridine acts as a fluorescent reporter of amide hydrolase activity. As a result, the conjugates described herein can advantageously be used in assays to detect amide hydrolase activity based upon measuring the fluorescence of a substituted aminopyridine that is released after amide hydrolysis. The conjugates of the present invention are also particularly useful in screening assays, which enable the identification of inhibitory molecules for amide hydrolases and other enzymes. The identified amide hydrolase inhibitors can be used in the treatment of a variety of diseases and disorders associated with aberrant amide hydrolase activity.
摘要翻译：本发明提供包含通过酰胺键共价连接到有机分子上的取代的氨基吡啶的缀合物。这种缀合物可用作酰胺水解酶的底物，其中取代的氨基吡啶用作酰胺水解酶活性的荧光报告物。结果，本文所述的缀合物可有利地用于测定酰胺水解酶活性的测定中，其基于测量酰胺水解后释放的取代的氨基吡啶的荧光。本发明的缀合物在筛选测定中也是特别有用的，其能够鉴定酰胺水解酶和其它酶的抑制分子。鉴定的酰胺水解酶抑制剂可用于治疗与异常酰胺水解酶活性相关的各种疾病和病症。

3. 发明专利

JP2000157427A RICE WASHING VESSEL 失效
公开(公告)号：JP2000157427A
公开(公告)日：2000-06-13
申请号：JP37568998
申请日：1998-11-26
申请人： NISHI KOSUKE
发明人： NISHI KOSUKE
IPC分类号： A47J43/24 , B02B1/04
摘要： PROBLEM TO BE SOLVED: To tastefully cook rice without touching rice and water with hands directly by mounting a mesh cover which has a mesh that can not pass through rice at a transparent cylindrical vessel whose bottom is round and which is soft and has restoring force with a screw. SOLUTION: A mesh cover 3 is opened then rice is put in a vessel 1 and the mesh cover 3 is closed when a user washes rice. Water is poured from a mesh part of the mesh cover 3 by closing the mesh cover 3. When the user discharges water, water is discharged from the mesh cover 3 in the same way by turning the vessel 1 upside down. When the user washes rice, rice are washed with rubbing from an outside of the vessel 1 by collecting rice at a lower part turning the mesh cover 3 upward after water is discharged. When the user rinses rice, water is poured from the mesh part of the mesh cover 3 again, then discharged by rubbing the vessel 1 several times while receding rice and water in the vessel 1. A fixed quantity of water is added by using a scale 4 which is provided at the vessel 1, then water and rice are poured in an inner pot of a rice cooker by opening the mesh cover 3.

4. 发明专利

JPH1181017A EXCLUSIVE POCKET FOR PORTABLE TELEPHONE-PHS 失效
公开(公告)号：JPH1181017A
公开(公告)日：1999-03-26
申请号：JP27636097
申请日：1997-09-01
申请人： NISHI KOSUKE
发明人： NISHI KOSUKE
IPC分类号： A41D27/20 , H04M1/02 , H04M1/05 , H04W88/00 , H04Q7/32
摘要： PROBLEM TO BE SOLVED: To provide an exclusive pocket of clothing for a portable telephone.PHS. SOLUTION: An exclusive pocket 2 for a portable telephone.PHS, having a narrow width and a shallow deepness is made on one side of the inner face of a usual pocket 1 and a band 3 for preventing jumping out is made above the exclusive pocket. The jumping out-preventing band 3 can be fixed by Velcro 4. The Velcro is made a little longer and capable of being fixed even when the portable telephone or the PHS is not in the exclusive pocket and the exclusive pocket 2 for the portable telephone or the PHS is made to be uncatchable when the usual pocket 1 is solely used.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式