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1. 发明公开

EP1066395A1 INDUCIBLE ALPHAVIRAL GENE EXPRESSION SYSTEM 有权
标题翻译：诱导ALPHAVIRENGEN-表达系统
公开(公告)号：EP1066395A1
公开(公告)日：2001-01-10
申请号：EP99909117.6
申请日：1999-03-25
申请人： Cytos Biotechnology AG , Renner, Wolfgand Andreas , Nieba, Lars , Boorsma, Marco
发明人： RENNER, Wolfgang, A. , NIEBA, Lars , BOORSMA, Marco
IPC分类号： C12N15/86 , C12N9/12 , C07K14/18 , A61K48/00 , A01K67/027 , C12N5/10 , C12N7/04
CPC分类号： C07K14/005 , A01K2217/05 , A61K48/00 , C12N9/127 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2840/105
摘要： The present invention provides novel expression vectors which permit tight regulation of gene expression in eucaryotic cells. More specifically, the invention provides DNA vectors comprising nucleotide sequences that are transcribed to form RNA molecules which are then replicated by a temperature-sensitive replicase to form additional RNA molecules. The RNA molecules produced by replication contain a nucleotide sequence which may be translated to produce a protein of interest or which encode one or more untranslated RNA molecules. Also provided are methods for producing heterologous proteins and untranslated RNA molecules. Further provided are methods for administering heterologous proteins and untranslated RNA molecules to individuals. In addition, pharmaceutical compositions are provided comprising the DNA and RNA molecules of the invention and a pharmaceutically acceptable carrier.

2. 发明专利

AU2848199A Inducible alphaviral gene expression system 未知
公开(公告)号：AU2848199A
公开(公告)日：1999-10-18
申请号：AU2848199
申请日：1999-03-25
申请人： CYTOS BIOTECHNOLOGY AG , RENNER WOLFGANG A , NIEBA LARS , BOORSMA MARCO
发明人： RENNER WOLFGANG A , NIEBA LARS , BOORSMA MARCO
IPC分类号： A01K67/027 , A61K48/00 , C07K14/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/09 , C12N15/86
摘要： The present invention provides novel expression vectors which permit tight regulation of gene expression in eucaryotic cells. More specifically, the invention provides DNA vectors comprising nucleotide sequences that are transcribed to form RNA molecules which are then replicated by a temperature-sensitive replicase to form additional RNA molecules. The RNA molecules produced by replication contain a nucleotide sequence which may be translated to produce a protein of interest or which encode one or more untranslated RNA molecules. Also provided are methods for producing heterologous proteins and untranslated RNA molecules. Further provided are methods for administering heterologous proteins and untranslated RNA molecules to individuals. In addition, pharmaceutical compositions are provided comprising the DNA and RNA molecules of the invention and a pharmaceutically acceptable carrier.

3. 发明专利

DE1066395T1 未知
公开(公告)号：DE1066395T1
公开(公告)日：2002-04-04
申请号：DE99909117
申请日：1999-03-25
申请人： CYTOS BIOTECHNOLOGY AG ZUERICH , RENNER WOLFGANG ANDREAS , NIEBA LARS , BOORSMA MARCO
发明人： RENNER A , NIEBA LARS , BOORSMA MARCO
IPC分类号： A01K67/027 , A61K48/00 , C07K14/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/09 , C12N15/86
摘要： The present invention provides novel expression vectors which permit tight regulation of gene expression in eucaryotic cells. More specifically, the invention provides DNA vectors comprising nucleotide sequences that are transcribed to form RNA molecules which are then replicated by a temperature-sensitive replicase to form additional RNA molecules. The RNA molecules produced by replication contain a nucleotide sequence which may be translated to produce a protein of interest or which encode one or more untranslated RNA molecules. Also provided are methods for producing heterologous proteins and untranslated RNA molecules. Further provided are methods for administering heterologous proteins and untranslated RNA molecules to individuals. In addition, pharmaceutical compositions are provided comprising the DNA and RNA molecules of the invention and a pharmaceutically acceptable carrier.

4. 发明申请

WO0130989A3 METHOD FOR CREATING DIVERGENT POPULATIONS OF NUCLEIC ACID MOLECULES AND PROTEINS 审中-公开
标题翻译：用于产生核酸分子和蛋白质的不一致群体的方法
公开(公告)号：WO0130989A3
公开(公告)日：2001-11-22
申请号：PCT/IB0001557
申请日：2000-10-26
申请人： CYTOS BIOTECHNOLOGY AG , RENNER WOLFGANG A , NIEBA LARS
发明人： RENNER WOLFGANG A , NIEBA LARS
IPC分类号： A61K39/21 , A61K48/00 , C12N15/10 , C12N15/86 , A61K31/70
CPC分类号： C12N15/102 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , C12N15/86 , C12N2740/16134 , C12N2770/36143
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides methods for creating divergent populations of nucleic acid molecules and proteins, as well as nucleic acid molecules and proteins produced by these methods. The invention also provides processes for producing populations of antigens and antigenic determinants useful in the production of vaccines for the treatment of infectious diseases and as pharmaccine to prevent cancer.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了产生核酸分子和蛋白质的不同群体的方法，以及由这些方法产生的核酸分子和蛋白质。本发明还提供了用于产生可用于生产治疗感染性疾病的疫苗和作为预防癌症的药物的抗原和抗原决定簇的方法。

5. 发明申请

WO1998002462A1 IMMUNOGLOBULIN SUPERFAMILY DOMAINS AND FRAGMENTS WITH INCREASED SOLUBILITY 审中-公开
标题翻译：具有增强溶解性的免疫球蛋白超家族域和片段
公开(公告)号：WO1998002462A1
公开(公告)日：1998-01-22
申请号：PCT/EP1997003792
申请日：1997-07-16
申请人： MORPHOSYS GESELLSCHAFT FÜR PROTEINOPTIMIERUNG MBH , PLÜCKTHUN, Andreas , NIEBA, Lars , HONEGGER, Annemarie
发明人： MORPHOSYS GESELLSCHAFT FÜR PROTEINOPTIMIERUNG MBH
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K16/44 , C07K2319/00
摘要： The present invention relates to the modification of immunoglobulin superfamily (IgSF) domains, IgSF fragments and fusion proteins thereof, especially to the modification of antibody derivatives, so as to improve their solubility, and hence the yield, and ease of handling. The inventors have found that this can be achieved by making the region which comprises the interface with domains adjoined to said IgSF domain in a larger fragment or a full IgSF protein, and which becomes exposed in the IgSF domain, more hydrophilic by modification. The present invention describes DNA sequences encoding modified IgSF domains or fragments and fusion proteins thereof, vectors and hosts containing these DNA sequences, IgSF domains or fragments or fusion proteins obtainable by expressing said DNA sequences in suitable expression systems, and a method for modifying IgSF domains, so as to improve their solubility, expressibility and ease of handling.
摘要翻译：本发明涉及免疫球蛋白超家族（IgSF）结构域，IgSF片段及其融合蛋白的修饰，特别涉及抗体衍生物的修饰，从而提高其溶解度，从而提高其产量和易于处理。本发明人已经发现，这可以通过使包含与所述IgSF结构域相邻的结构域的界面的区域在更大的片段或完整的IgSF蛋白中实现，并且其在IgSF结构域中暴露，通过修饰更亲水。本发明描述了编码修饰的IgSF结构域或其片段及其融合蛋白的DNA序列，含有这些DNA序列的载体和宿主，通过在合适的表达系统中表达所述DNA序列可获得的IgSF结构域或融合蛋白，以及用于修饰IgSF结构域的方法，以提高其溶解性，表达性和易于处理。

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