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1. 发明公开

EP1041705A2 Charge pump circuit 审中-公开
标题翻译： Ladungspumpenschaltung
公开(公告)号：EP1041705A2
公开(公告)日：2000-10-04
申请号：EP00302606.9
申请日：2000-03-29
申请人： Nguyen, Tam
发明人： Nguyen, Tam
IPC分类号： H02M3/07
CPC分类号： H02M3/073 , H02M2003/075
摘要： The charge pump circuit (10) includes a plurality of successively coupled pump stages (14a, 14b, 14c). Each of these successively coupled charge pump stages (14a, 14b, 14c) receives at least one input signal and at least one clock input signal (CLK1, CLK2, CLK3, CLK4), and in accordance therewith, conveys at least one output signal. Significantly, at least one output signal of a prior charge pump stage (14a) is substantially equal to at least one input signal of a next adjacent charge pump stage (14b), so that the prior adjacent charge pump stage (14a) will be effectively shut off, so that reverse current flow can be prevented through the charge pump circuit. Each stage (14, Fig. 4) includes transistors (110a, 110b) which are coupled to receive the input signals and to provide the output signals of the stage, and are coupled to a clock signal (CLK2, CLK4) by a bootstrap capacitor (100b).
摘要翻译：电荷泵电路（10）包括多个连续耦合的泵级（14a，14b，14c）。这些连续耦合的电荷泵级（14a，14b，14c）中的每一个接收至少一个输入信号和至少一个时钟输入信号（CLK1，CLK2，CLK3，CLK4），并且根据其传送至少一个输出信号。重要的是，现有电荷泵级（14a）的至少一个输出信号基本上等于下一相邻电荷泵级（14b）的至少一个输入信号，使得先前相邻的电荷泵级（14a）将被有效地关闭，从而可以通过电荷泵电路防止反向电流流动。每个级（14，图4）包括晶体管（110a，110b），其被耦合以接收输入信号并提供级的输出信号，并且通过自举电容器耦合到时钟信号（CLK2，CLK4）（100B）。

2. 发明专利

CA2493151A1 ADJUSTABLE DOOR STRIKE PLATE ASSEMBLY 未知
公开(公告)号：CA2493151A1
公开(公告)日：2006-07-19
申请号：CA2493151
申请日：2005-01-19
申请人： NGUYEN TAM
发明人： NGUYEN TAM
IPC分类号： E05B15/02 , E05C19/00
摘要： The present invention is an adjustable strike plate assembly for a doorja mb that includes a first portion defining a rectangular opening for receiving a deadbolt and a second portion that is mounted between the first portion and the doorjamb to define one edge of the rectangular opening. The second portion is adjustable in the adjustment direction that is at right angles to the side edge of the opening . The second portion comprises elongated horizontal openings having teeth on the upper and lower edges of the openings. Protruding from the abutting surface of the first portion are keys or gears adapted to engage the teeth of the elongated openings. The second portion's position is secured in relation to the first portion when t he teeth of the elongated openings engage the gears protruding from the first portion.

3. 发明专利

IL288039D0 Heart valve sealing devices, delivery devices therefor, and retrieval devices 未知
公开(公告)号：IL288039D0
公开(公告)日：2022-01-01
申请号：IL28803921
申请日：2021-11-11
申请人： EDWARDS LIFESCIENCES CORP , DIXON ERIC ROBERT , FRESCHAUF LAUREN R , OBERWISE ERIC MICHAEL , FORD STEVEN M , STEARNS GRANT MATTHEW , METCHIK ASHER L , NGUYEN TAM VAN , MONTOYA DANIEL JAMES , KWON RHAYOUNG , TYLER II GREGORY SCOTT , GOHRES RACHEL ANN
发明人： DIXON ERIC ROBERT , FRESCHAUF LAUREN R , OBERWISE ERIC MICHAEL , FORD STEVEN M , STEARNS GRANT MATTHEW , METCHIK ASHER L , NGUYEN TAM VAN , MONTOYA DANIEL JAMES , KWON RHAYOUNG , TYLER II GREGORY SCOTT , GOHRES RACHEL ANN
摘要： A method and system for implanting and repositioning an implantable device for a native valve of a patient's heart includes a delivery catheter, a collar, a coupler, and an actuation element. The actuation element extends through the delivery catheter and attaches to the device to open the device. The collar is connected to the device and the coupler is connected to the delivery catheter. The collar and coupler are tied together via one or more coupling tethers which can be used to reengage the device after an initial deployment.

4. 发明申请

WO2011163557A2 ACCUMULATION OF OMEGA-7 FATTY ACIDS IN PLANT SEEDS 审中-公开
标题翻译：植物种子中OMEGA-7脂肪酸的累积
公开(公告)号：WO2011163557A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041759
申请日：2011-06-24
申请人： DOW AGROSCIENCES LLC , BROOKHAVEN SCIENCE ASSOCIATES, LLC , SHANKLIN, John , NGUYEN, Tam Huu , WALSH, Terence A.
发明人： SHANKLIN, John , NGUYEN, Tam Huu , WALSH, Terence A.
IPC分类号： C12N15/53 , C12N9/02 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8247 , C12N9/0071 , C12N9/0083 , C12Y114/19001
摘要： Compositions and methods include genetically encoding and expressing a novel Δ 9 -18:0 ACP desaturase in plant cells. In some embodiments, nucleic acid molecules encode the novel Δ 9 -18:0 ACP desaturase. In other embodiments, amino acid sequences have Δ 9 -18:0 ACP desaturase activity. Methods can involve expression of Δ 9 -18:0 ACP desaturase in plant cells, plant materials, and whole plants for the purpose of increasing the amount of unusual fatty acids in whole plants, plant seeds, and plant materials, for example, seeds.
摘要翻译：组合物和方法包括在植物细胞中遗传编码和表达新型Δ-9：18：0 ACP去饱和酶。在一些实施方案中，核酸分子编码新型α-9 -18：0 ACP去饱和酶。在其它实施方案中，氨基酸序列具有α-9 -18：0 ACP去饱和酶活性。方法可以包括在植物细胞，植物材料和整株植物中表达α-9 -18：0 ACP去饱和酶，目的是增加整株植物，植物种子和植物材料例如种子中异常脂肪酸的量。

5. 发明申请

WO2008013833A3 ORALLY DISSOLVABLE/DISINTEGRABLE LYOPHILIZED DOSAGE FORMS CONTAINING PROTECTED PARTICLES 审中-公开
标题翻译：含有受保护颗粒的ORRYY溶解/不可分散的冻干剂型
公开(公告)号：WO2008013833A3
公开(公告)日：2008-07-17
申请号：PCT/US2007016690
申请日：2007-07-24
申请人： CIMA LABS INC , CEPHALON FRANCE , HAMED EHAB , HILLMAN LISA , KHANKARI RAJENDRA K , MOE DEREK , NGUYEN TAM
发明人： HAMED EHAB , HILLMAN LISA , KHANKARI RAJENDRA K , MOE DEREK , NGUYEN TAM
IPC分类号： A61K9/00 , A61K9/16
CPC分类号： A61K31/135 , A61K9/0056 , A61K9/1635 , A61K9/1694 , A61K9/19 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2081 , A61K9/2095 , A61K9/5078 , A61K31/165 , A61K31/426 , A61K31/445
摘要： The present invention provides an orally dissolvable/ disintegrable, lyophilized, dosage form adapted for direct oral dosing, including an active pharmaceutical ingredient ("API") containing particle which is coated with a lyophilizing solvent protective coating, which protects the form and/or attributes of the particle and/or API, and a matrix. There is also provided a method of making an orally dissolvable/disintegrable lyophilized dosage form in accordance with the present invention, and a method of treating a patient with a dosage form in accordance with the present invention.
摘要翻译：本发明提供适用于直接口服给药的口腔可溶解/可崩解，冻干剂型，包括含有冻干溶剂保护涂层的活性药物成分（“API”）颗粒，其保护形式和/或特性颗粒和/或API和基质。还提供了根据本发明制备可口服溶解/崩解的冻干剂型的方法，以及根据本发明用剂型治疗患者的方法。

6. 发明申请

WO2008013808A2 HIGH DOSE ORALLY DISSOLVABLE/DISINTEGRABLE LYOPHILIZED DOSAGE FORM 审中-公开
标题翻译：高剂量ORA可溶性/不可分离的LYOPHILIZED剂型
公开(公告)号：WO2008013808A2
公开(公告)日：2008-01-31
申请号：PCT/US2007016638
申请日：2007-07-24
申请人： CIMA LABS INC , CEPHALON FRANCE , HAMED EHAB , KHANKARI RAJENDRA K , MOE DEREK , NGUYEN TAM
发明人： HAMED EHAB , KHANKARI RAJENDRA K , MOE DEREK , NGUYEN TAM
IPC分类号： A61K9/00 , A61K9/16
CPC分类号： A61K31/135 , A61K9/0056 , A61K9/1635 , A61K9/1694 , A61K9/19 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2081 , A61K9/2095 , A61K9/5078 , A61K31/165 , A61K31/426 , A61K31/445
摘要： The present invention provides an orally dissolvable/disintegrable, lyophilized dosage form including a protected granulate comprising an active ingredient and a protective granulation binder, which substantially protects the form and/or attributes of a granulate and/or active ingredient, and participates in masking bad tasting active ingredients, such as sulfur-containing materials, and a matrix, and a method for making same. There is also provided a method of treating a patient using any orally dissolvable/disintegrable lyophilized dosage form comprising the steps of placing the dosage form in the mouth of a patient in need of treatment, allowing the dosage form to disintegrate/dissolve sufficiently to allow it, and in particular, the protected granulate, to be swallowed as a solution, suspension or slurry, and swallowing the at least partially disintegrated/dissolved dosage form.
摘要翻译：本发明提供口服可溶解/崩解的冻干剂型，其包括受保护的颗粒，其包含活性成分和保护性造粒粘合剂，其基本上保护颗粒和/或活性成分的形式和/或属性，并参与掩蔽不良品尝活性成分，如含硫材料和基质，以及制备它们的方法。还提供了使用任何口服可溶解/可崩解的冻干剂型治疗患者的方法，包括以下步骤：将剂型放置在需要治疗的患者的口中，允许剂型充分分解/溶解以允许，特别是受保护的颗粒，作为溶液，悬浮液或浆液吞咽，并吞咽至少部分崩解/溶解的剂型。

7. 发明申请

WO2023091796A1 SOLUTIONS AND GELS OF ONE-DIMENSIONAL METAL OXIDES 审中-公开
公开(公告)号：WO2023091796A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050770
申请日：2022-11-22
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , CIOTA, David , SEO, Dong-Kyun , NGUYEN, Tam
发明人： CIOTA, David , SEO, Dong-Kyun , NGUYEN, Tam
IPC分类号： C04B38/00 , C04B35/515 , B01J13/00
摘要： Preparing a metal-containing solution or gel includes combining a metal oxide and a liquid comprising a polar organic solvent to yield a mixture, wherein the metal oxide comprises hydrogen-bonded molecular chains, and each molecular chain comprises: a metal from Groups 4 – 6; at least one oxyanion of a main group element from Groups 15 and 16 bound to the metal through a polar covalent bond, wherein the at least one oxyanion is optionally protonated; and at least one water molecule bound to the metal through a polar covalent bond; and heating the mixture to yield a solution or gel comprising the polar organic solvent and the metal. The solution or gel can be acidic.

8. 发明申请

WO2012109167A1 IMMUNOGENIC COMPOSITION COMPRISING ALPHA-HEMOLYSIN OLIGOPEPTIDES 审中-公开
标题翻译：包含ALPHA-HEMOLYSIN寡核苷酸的免疫组化
公开(公告)号：WO2012109167A1
公开(公告)日：2012-08-16
申请号：PCT/US2012/024031
申请日：2012-02-06
申请人： INTEGRATED BIOTHERAPEUTICS, INC. , AMAN, Mohammad Javad , ADHIKARI, Rajan Prasad , KARAUZUM, Hatice , WARFIELD, Kelly Lyn , NGUYEN, Tam Luong
发明人： AMAN, Mohammad Javad , ADHIKARI, Rajan Prasad , KARAUZUM, Hatice , WARFIELD, Kelly Lyn , NGUYEN, Tam Luong
IPC分类号： A61K39/02 , A61K38/00 , C07K5/00 , C07H21/04 , C12N15/00
CPC分类号： C07K14/31 , A61K38/00 , A61K39/085 , A61K39/39 , A61K2039/505 , A61K2039/55505 , A61K2039/55572 , C07K16/1271 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2319/20 , C07K2319/21 , C07K2319/22 , C07K2319/24 , C07K2319/33 , C07K2319/40 , C07K2319/43 , C07K2319/60
摘要： The present invention provides immunogenic compositions useful in prevention and treatment of Staphylococcus aureus infection. In particular, the present invention provides methods of inducing an immune response against an alpha-hemolysin-expressing S. aureus, methods of preventing or treating S. aureus infections, and composition for preventing or treating S. aureus infections.
摘要翻译：本发明提供了可用于预防和治疗金黄色葡萄球菌感染的免疫原性组合物。特别地，本发明提供诱导针对表达α-溶血素的金黄色葡萄球菌的免疫应答的方法，预防或治疗金黄色葡萄球菌感染的方法，以及用于预防或治疗金黄色葡萄球菌感染的组合物。

9. 发明申请

WO2011143013A2 METHOD FOR INTEGRATED CIRCUIT DESIGN AND MANUFACTURE USING DIAGONAL MINIMUM-WIDTH PATTERNS 审中-公开
标题翻译：集成电路设计与制造方法使用对角最小宽度图案
公开(公告)号：WO2011143013A2
公开(公告)日：2011-11-17
申请号：PCT/US2011/035082
申请日：2011-05-03
申请人： D2S, INC. , FUJIMURA, Akira , CHAU, Larry Lam , NGUYEN, Tam Dinh Thanh
发明人： FUJIMURA, Akira , CHAU, Larry Lam , NGUYEN, Tam Dinh Thanh
IPC分类号： G06F17/50
CPC分类号： G06F17/5072 , G06F17/5077 , H01L27/0207 , H01L27/11
摘要： Methods for designing and manufacturing an integrated circuit are disclosed, in which the physical design process for a standard cell or cells utilizes a preferred diagonal direction for minimum-width patterns on at least one layer, where the standard cell or cells are used in the layout of an integrated circuit. The methods also include forming the patterns on a photomask using model-based fracturing techniques with charged particle beam simulation, and forming the patterns on a substrate such a silicon wafer using the photomask and an optical lithographic process with directional illumination which is optimized for the preferred diagonal direction.
摘要翻译：公开了用于设计和制造集成电路的方法，其中标准单元或单元的物理设计过程在至少一层上利用最小宽度图案的优选对角线方向，其中在布局中使用标准单元或单元的集成电路。所述方法还包括使用基于压缩技术的带有带电粒子束模拟的基于模型的压裂技术在光掩模上形成图案，以及使用光掩模和光定向照明的光学方法在诸如硅晶片的衬底上形成图案，所述光刻工艺针对优选对角方向。

10. 发明申请

WO2008127679A1 LYOPHILIZED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开
公开(公告)号：WO2008127679A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/004755
申请日：2008-04-11
申请人： CEPHALON, INC. , CEPHALON FRANCE , DULIEU, Claire , DURFEE, Steve, L. , HOLL, Richard, J. , NGUYEN, Tam
发明人： DULIEU, Claire , DURFEE, Steve, L. , HOLL, Richard, J. , NGUYEN, Tam
IPC分类号： A61K9/00 , A61K9/19 , A61K9/14 , A61K31/4178 , A61K31/135 , A61K31/4045 , A61K38/11
CPC分类号： A61K38/11 , A61K9/006 , A61K9/19 , A61K31/135 , A61K31/4045 , A61K31/4178 , A61K31/435 , A61K38/23 , A61K38/26 , A61K38/28 , A61K47/36 , A61K47/38
摘要： The present invention relates to a new lyophilized pharmaceutical composition capable of adhering to oral mucosal tissue for an extended period of time for delivering active pharmaceutical ingredient through the oral mucosal tissue using transmucosal absorption.
摘要翻译：本发明涉及一种新的冻干药物组合物，其能够通过使用经粘膜吸收通过口腔粘膜组织递送活性药物成分延长的时间段粘附于口腔粘膜组织。

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